[MCQ] Disorders of Absorption- Part 4

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Disorders of Absorption- Part 4

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Congratulations - you have completed Disorders of Absorption- Part 4. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Cobalamin is present primarily in ?

A	Fruits
B	Green vegetables
C	Meat
D	Egg

Question 1 Explanation:

Cobalamin is present primarily in meat

Question 2

R-binder protein is synthesized in ?

A	Salivary glands
B	Jejunum
C	Pancreas
D	Ileum

Question 3

R-binder protein is synthesized in ?

A	Stomach
B	Jejunum
C	Pancreas
D	Ileum

Question 3 Explanation:

Dietary cobalamin is bound in stomach to a glycoprotein called R-binder protein, which is synthesized in stomach and salivary glands.

Question 4

Intrinsic factor is synthesized and released by ?

A	Gastric parietal cells
B	Gastric oxyntic cells
C	Gastric chief cells
D	Gastric G cells

Question 4 Explanation:

Intrinsic factor (IF) is absolutely required for the absorption of cobalamin. IF is a glycoprotein synthesized & released by gastric parietal cells, to promote its uptake by specific cobalamin receptors on the brush border of ileal enterocytes. Pancreatic protease enzymes split the cobalamin– R binder complex to release cobalamin in proximal small intestine, where cobalamin is then bound by intrinsic factor (IF).

Question 5

Cobalamin absorption may be abnormal in which of the following ?

A	Pernicious anemia
B	Chronic pancreatitis
C	Bacterial overgrowth syndromes
D	All of the above

Question 5 Explanation:

Cobalamin absorption may be abnormal in Pernicious anemia, Chronic pancreatitis, Achlorhydria, Bacterial overgrowth syndromes, and Ileal dysfunction

Question 6

Which isotope is used in Schilling test ?

A	58Co-labeled cobalamin
B	68Co-labeled cobalamin
C	78Co-labeled cobalamin
D	88Co-labeled cobalamin

Question 6 Explanation:

Schilling test is performed by administering 58Co-labeled cobalamin orally and collecting urine for 24 hours. It is dependent on normal renal and bladder function.

Question 7

The Schilling test is termed abnormal if oral 58Co-labeled cobalamin excretion in urine is ?

A	<10% in 24 hours
B	<15% in 24 hours
C	<20% in 24 hours
D	<20% in 24 hours

Question 7 Explanation:

Schilling test is termed abnormal if oral 58Co-labeled cobalamin excretion in urine is <10% in 24 hours.

Question 8

Abnormal Schilling test may be found in all except ?

A	Pernicious anemia
B	Chronic pancreatitis
C	Blind loop syndrome
D	Cirrhosis of liver

Question 9

58Co-cobalamin excretion is reduced with intrinsic factor, with pancreatic enzymes, and after 5 days of antibiotics in ?

A	Pernicious anemia
B	Chronic pancreatitis
C	Blind loop syndrome
D	Ileal disease

Question 10

Which of the following is false about urinary D-xylose test ?

A	Assesses proximal small-intestinal mucosal function
B	D-Xylose is a pentose carbohydrate
C	D-Xylose is a pentose carbohydrate
D	< 12 gm excretion means an abnormal test

Question 10 Explanation:

Urinary D-xylose test (<4.5 gram excretion) reflects presence of duodenal / jejunal mucosal disease.

Question 11

Urinary D-xylose test can be false-positive in ?

A	Head injury
B	Myocardial infarction
C	Ascitis
D	Pneumonia

Question 11 Explanation:

Urinary D-xylose test is false-positive in large fluid collections in third space (ascites, pleural fluid)

Question 12

Bentiromide test is used for ?

A	Pancreatic exocrine function
B	Pancreatic endocrine function
C	Pancreatic neural function
D	All of the above

Question 13

Which of the following is used in Bentiromide test ?

A	D-Xylose
B	GABA
C	PABA
D	All of the above

Question 14

Synonym of Celiac sprue is ?

A	Nontropical sprue
B	Celiac disease
C	Gluten sensitive enteropathy
D	All of the above

Question 14 Explanation:

Celiac sprue has also been known as nontropical sprue, celiac disease (in children), adult celiac disease, and gluten sensitive enteropathy.

Question 15

Which of the following about Celiac disease is false ?

A	Systemic disorder
B	Immune-mediated disorder
C	Triggered by dietary gluten
D	None of the above

Question 15 Explanation:

Celiac disease is a systemic immune-mediated disorder triggered by dietary gluten in genetically susceptible persons

Question 16

The word “sprue” comes from which language ?

A	Dutch
B	Latin
C	Greek
D	English

Question 17

Which of the following respond to elimination of gluten from the diet in celiac sprue ?

A	Symptoms
B	Evidence of malabsorption
C	Histopathologic changes in small-intestinal biopsy
D	All of the above

Question 17 Explanation:

In celiac sprue, symptoms, evidence of malabsorption and histopathologic changes on smallintestinal biopsy respond to elimination of gluten from diet.

Question 18

Gliadin (a component of gluten) is present in all except ?

A	Wheat
B	Barley
C	Rice
D	Oats

Question 18 Explanation:

Gluten is a protein complex. Gliadin is a component of gluten present in wheat, barley, rye & in smaller amounts in oats. Antiendomysial antibody tTG deaminates gliadin

Question 19

Which of the following is considered as “safe grains” (gluten free) ?

A	Rice
B	Corn
C	Millet
D	All of the above

Question 19 Explanation:

Safe grains (gluten-free) include rice, amaranth, buckwheat, corn, millet, quinoa, sorghum, teff (an Ethiopian cereal grain), & oats.

Question 20

Gliadin is which component of gluten ?

A	Heat resistant fraction
B	Alcohol-soluble fraction
C	Water soluble fraction
D	Water soluble fraction
E	Contaminated fraction

Question 20 Explanation:

“Gluten” refers to the entire protein component of wheat. Gliadin is the alcohol-soluble fraction of gluten that contains bulk of toxic components.

Question 21

Which of the following enzyme in intestine deamidates gliadin peptides ?

A	Tissue transaminase
B	Tissue transmurase
C	Tissue transglutaminase
D	Tissue transpeptidase

Question 21 Explanation:

Enzyme tissue transglutaminase in intestine deamidates gliadin peptides increasing their immunogenicity

Question 22

The most sensitive antibody tests for the diagnosis of celiac disease are of which class ?

A	IgA
B	IgG
C	IgM
D	IgE

Question 22 Explanation:

Most sensitive antibody tests for diagnosis of celiac disease are of IgA class

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1.Cobalamin is present primarily in ?
A. Fruits
B. Green vegetables
C. Meat
D. Egg

2. R-binder protein is synthesized in ?
A. Salivary glands
B. Jejunum
C. Pancreas
D. Ileum
3. R-binder protein is synthesized in ?
A. Stomach
B. Jejunum
C. Pancreas
D. Ileum

4.Intrinsic factor is synthesized and released by ?
A. Gastric parietal cells
B. Gastric oxyntic cells

C. Gastric chief cells
D. Gastric G cells

5. Cobalamin absorption may be abnormal in which of the following ?
A. Pernicious anemia
B. Chronic pancreatitis
C. Bacterial overgrowth syndromes
D. All of the above

6. Which isotope is used in Schilling test ?
A. 58Co-labeled cobalamin
B. 68Co-labeled cobalamin
C. 78Co-labeled cobalamin
D. 88Co-labeled cobalamin

7. The Schilling test is termed abnormal if oral 58Co-labeled
cobalamin excretion in urine is ?
A. <10% in 24 hours
B. <15% in 24 hours
C. <20% in 24 hours
D. <20% in 24 hours

8. Abnormal Schilling test may be found in all except ?
A. Pernicious anemia
B. Chronic pancreatitis
C. Blind loop syndrome
D. Cirrhosis of liver

9. 58Co-cobalamin excretion is reduced with intrinsic factor, with
pancreatic enzymes, and after 5 days of antibiotics in ?
A. Pernicious anemia
B. Chronic pancreatitis
C. Blind loop syndrome
D. Ileal disease
10. Which of the following is false about urinary D-xylose test ?
A. Assesses proximal small-intestinal mucosal function
B. D-Xylose is a pentose carbohydrate

C. 25 gm of D-xylose & collecting urine for 5 hours
D. < 12 gm excretion means an abnormal test

11. Urinary D-xylose test can be false-positive in ?
A. Head injury
B. Myocardial infarction
C. Ascitis
D. Pneumonia

12. Bentiromide test is used for ?
A. Pancreatic exocrine function
B. Pancreatic endocrine function
C. Pancreatic neural function
D. All of the above
13. Which of the following is used in Bentiromide test ?
A. D-Xylose
B. GABA
C. PABA
D. All of the above
14. Synonym of Celiac sprue is ?
A. Nontropical sprue
B. Celiac disease
C. Gluten sensitive enteropathy
D. All of the above

15. Which of the following about Celiac disease is false ?
A. Systemic disorder
B. Immune-mediated disorder
C. Triggered by dietary gluten
D. None of the above

16. The word “sprue” comes from which language ?
A. Dutch
B. Latin
C. Greek
D. English
17. Which of the following respond to elimination of gluten from
the diet in celiac sprue ?
A. Symptoms

B. Evidence of malabsorption
C. Histopathologic changes in small-intestinal biopsy
D. All of the above

18. Gliadin (a component of gluten) is present in all except ?
A. Wheat
B. Barley
C. Rice
D. Oats

19. Which of the following is considered as “safe grains” (gluten
free) ?
A. Rice
B. Corn
C. Millet
D. All of the above

20. Gliadin is which component of gluten ?
A. Heat resistant fraction
B. Alcohol-soluble fraction
C. Water soluble fraction
D. Contaminated fraction

21. Which of the following enzyme in intestine deamidates gliadin peptides ?
A. Tissue transaminase
B. Tissue transmurase
C. Tissue transglutaminase
D. Tissue transpeptidase

22. The most sensitive antibody tests for the diagnosis of celiac
disease are of which class ?
A. IgA
B. IgG
C. IgM
D. IgE

[MCQ] Disorders of Absorption- Part 4

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Disorders of Absorption- Part 4

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