I. Start the exam by click the “Start” button
Disorders of Absorption- Part 5
See all quizzes of Peptic Ulcer Disease at here:
Disorders of Absorption- Part 1| Disorders of Absorption- Part 2| Disorders of Absorption- Part 3 | Disorders of Absorption- Part 4| Disorders of Absorption- Part 5| Disorders of Absorption- Part 6
1. Serum antibodies found in celiac sprue include all except ?
A. IgA antigliadin
B. IgA antiendomysial antibodies
C. IgA anti-tissue transglutaminase
D. IgA anti-tissue transpeptidase
2. Antiendomysial antibodies are directed against ?
A. Epithelial tissue
B. Enzyme
C. Connective-tissue
D. All of the above
3. Antigen recognized by the antiendomysial antibody test is ?
A. Tissue transaminase
B. Tissue transmurase
C. Tissue transglutaminase
D. Tissue transpeptidase
4. Negative predictive value of which of the following HLA allele
is almost 100% in celiac sprue ?
A. HLA-DQ2
B. HLA-DQ3
C. HLA-DQ4
D. HLA-DQ5
5. The HLA-DQ2 haplotype (DQA1*0501/DQB1*0201) is expressed
in what proportion of the general population ?
A. One third
B. One half
C. Three fourth
D. None
6. Which of the following tests have a high negative predictive
value in the diagnosis of celiac disease ?
A. IgA anti-tTG antibodies
B. IgG anti-tTG antibodies
C. IgA antiendomysial antibodies
D. HLA-DQ2 or HLA-DQ8
7. Which of the following tests have usefulness in patients with
IgA deficiency ?
A. IgA anti-tTG antibodies
B. IgG anti-tTG antibodies
C. IgA antiendomysial antibodies
D. HLA-DQ2 or HLA-DQ8
8.Which of the following tests have usefulness in patients with
an uncertain diagnosis ?
A. IgA anti-tTG antibodies
B. IgG anti-tTG antibodies
C. IgA antiendomysial antibodies
D. HLA-DQ2 or HLA-DQ8
9. Which of the following is false about duodenal/jejunal biopsy
histopathology in celiac sprue ?
A. Reduced height of villi
B. Crypt hyperplasia
C. Increased lymphocytes & plasma cells in lamina propria
D. None of the above
10. Histopathologic features characteristic of celiac sprue can also
be seen in all except ?
A. Tropical sprue
B. Ulcerative colitis
C. Milk-protein intolerance in children
D. Eosinophilic enteritis
11. Histopathologic features characteristic of celiac sprue can also
be seen in all except ?
A. Lymphoma
B. Intestinal lymphangiectasis
C. Crohn’s disease
D. Gastrinoma with acid hypersecretion
12. Which of the following about “Celiac crisis” is false ?
A. Mostly observed in adults
B. Severe diarrhea
C. Hypoproteinemia
D. Metabolic and electrolyte imbalances
13. After how many months of a strict gluten free diet, celiac disease
is termed refractory ?
A. 3 months
B. 6 months
C. 9 months
D. 12 months
14. Which of the following is true for refractory celiac disease type 2 ?
A. Abnormal intraepithelial lymphocytes
B. Clonal intraepithelial lymphocytes without CD3
C. Clonal intraepithelial lymphocytes without CD8
D. All of the above
15. In celiac disease, the lowest amount of daily gluten that causes
damage to celiac intestinal mucosa over time (gluten threshold)
is ?
A. 1 to 5 mg per day
B. 10 to 50 mg per day
C. 100 to 500 mg per day
D. 1000 to 2500 mg per day
16. Interval between exposure to gluten and onset of symptoms in
Celiac disease is ?
A. Minutes to hours
B. Hours to days
C. Weeks to years
D. Any of the above
17. Interval between exposure to gluten and onset of symptoms in
Wheat allergy is ?
N Engl J Med 2012;367:2419-26
A. Minutes to hours
B. Hours to days
C. Weeks to years
D. Any of the above
18. Interval between exposure to gluten and onset of symptoms in
Gluten sensitivity is ?
A. Minutes to hours
B. Hours to days
C. Weeks to years
D. Any of the above
19. Mechanism of diarrhea in celiac disease is ?
A. Steatorrhea
B. Secondary lactase deficiency
C. Bile acid malabsorption
D. All of the above
20. The diarrhea in celiac sprue is due to all except ?
A. Steatorrhea
B. Lipase deficiency
C. Bile acid malabsorption
D. Endogenous fluid secretion
21. Celiac sprue may be associated with following diseases except ?
A. Dermatitis herpetiformis (DH)
B. Type 1 diabetes mellitus
C. IgA deficiency
D. Chronic pancreatitis
22. Prevalence of celiac disease is increased in which of the
following conditions ?
A. Hashimoto’s thyroiditis
B. Turner’s syndrome
C. IgA deficiency
D. All of the above
23. Complications of Celiac sprue include all except ?
A. Malignancy
B. Intestinal ulceration
C. Collagenous sprue
D. Fistulas