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Toxic and drug-induced hepatitis Part 3
See all quizzes of Acute viral hepatitis at here:
1.Which of the following are associated with angiosarcoma of
the liver ?
A. Arsenic intoxication
B. Vinyl chloride
C. Thorium dioxide
D. All of the above
2. Peliosis hepatis refers to ?
A. Trauma of liver
B. Blood cysts of liver
C. Ectopic liver
D. Unilobular liver
3.Peliosis hepatis is seen in patients treated with ?
A. Halothane
B. Anabolic steroids
C. Chlorpromazine
D. Methotrexate
4. Fatal fulminant liver disease is usually associated with
ingestion of what amount of acetaminophen ?
A. 5 grams
B. 10 grams
C. 20 grams
D. 25 grams
5.What level of acetaminophen in blood is predictive of severe
liver damage ?
A. >100 µg/mL
B. >150 µg/mL
C. >200 µg/mL
D. >300 µg/mL
6. Maximal hepatic injury and hepatic failure occurs after how
many days of acetaminophen ingestion ?
A. 1 – 2 days
B. 2 – 4 days
C. 4 – 6 days
D. 7 – 9 days
7.Which of the following is “hepatoprotective” ?
A. Activated charcoal
B. Cholestyramine
C. Glutathione
D. All of the above
8.N-acetyl-benzoquinone-imine (NAPQI) is best related to which
of the following ?
A. Acetaminophen
B. Quinidine
C. Azathioprine
D. Carbamazine
9.Oral activated charcoal or cholestyramine is useless how much
time after ingestion ?
A. > 30 minutes
B. > 60 minutes
C. > 90 minutes
D. > 120 minutes
10.Which of the following have a role in the management of
acetaminophen hepatotoxicity ?
B. 10 grams
C. 20 grams
D. 25 grams
A. Cysteamine
B. Cysteine
C. N-acetylcysteine
D. All of the above
11. Which of the following is false about methyldopa
hepatotoxicity ?
Harrison’s 18th Ed. 2563
A. Toxic reaction
B. Idiosyncratic reaction
C. Resolves with discontinuation of drug
D. None of the above
12. Isoniazid hepatotoxicity is enhanced by ?
A. Alcohol
B. Rifampin
C. Pyrazinamide
D. All of the above
13.IV administration of carnitine may be ameliorate hepatotoxicity
due to ?
A. Valproate
B. Isoniazid
C. Halothane
D. Acetaminophen
15.Which metabolite of sodium valproate may be responsible for
hepatic injury ?
A. 1-pentenoic acid
B. 2-pentenoic acid
C. 3-pentenoic acid
D. 4-pentenoic acid
16. A defect in epoxide hydrolase activity could cause
hepatotoxicity due to which drug ?
A. Valproate
B. Phenytoin
C. Halothane
D. Acetaminophen
17. Stevens-Johnson syndrome may be a presentation of toxicity
due to ?
A. Valproate
B. Phenytoin
C. Halothane
D. Acetaminophen
18.Which of the following is a major metabolite of Amiodarone ?
A. Desmethylamiodarone
B. Desethylamiodarone
C. Levomethylamiodarone
D. Levoethylamiodarone
19. Amiodarone metabolite desethylamiodarone accumulate in
which of the following ?
A. Hepatocyte lysosomes
B. Hepatocyte mitochondria
C. Bile duct epithelium
D. All of the above
20. Toxicity with which of the following produces cholestatic
idiosyncratic reaction ?
A. Acetaminophen
B. Erythromycin
C. Azathioprine
D. Carbamazine
21. Drugs producing cholestatic reaction and portal inflammation is ?
A. Erythromycin
B. Oral contraceptive
C. Chlorpromazine
D. 17, -Alkyl-Substituted Anabolic Steroids
22. In Trimethoprim-Sulfamethoxazole toxicity, hepatotoxicity is
attributable to which component of the drug ?
A. Sulfamethoxazole
B. Trimethoprim
C. Sulfamethoxazole + Trimethoprim
D. None of the above
23. The risk of trimethoprim-sulfamethoxazole hepatotoxicity is
increased in persons with ?
Harrison’s 18th Ed. 2565
A. HIV infection
B. Severe anemia
C. Chronic renal failure
D. Congestive heart failure
