[MCQ] Inflammatory bowel disease- Part 1

I. Start the exam by click the “Start” button

Inflammatory bowel disease- Part 1

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Inflammatory bowel disease- Part 1. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

Which out of the following countries has the highest incidence of IBD ?

A	Sweden
B	Israel
C	Greece
D	China

Question 1 Explanation:

United States, United Kingdom, Norway and Sweden have the highest rates

Question 2

Out of the following, which ethnic group has the highest prevalence of IBD ?

A	Jewish
B	African American
C	Hispanic
D	Asian

Question 2 Explanation:

Prevalence of IBD in Ashkenazi Jews is ~twice that of Israeli-born, Sephardic, or Oriental Jews. Prevalence decreases progressively in non-Jewish Caucasian, African-American, Hispanic, and Asian populations

Question 3

Nonmalignant mortality in IBD cases is maximum during ?

A	First year of disease
B	After five years of disease
C	After ten years of disease
D	After fifteen years of disease

Question 3 Explanation:

Highest mortality is during first years of IBD & in long-duration disease due to risk of colon cance

Question 4

If a patient has IBD, the lifetime risk that a first degree relative will be similarly affected is ?

A	10 %
B	20 %
C	30 %
D	40 %

Question 4 Explanation:

Lifetime risk of a first-degree relative of IBD patient is ~10%. If two parents have IBD, each child has a 36% chance of being affected. In twin studies, 58% of monozygotic twins are concordant for CD and 6% are concordant for UC, whereas 4% of dizygotic twins are concordant for CD and none are concordant for UC.

Question 5

Which of the following statements about Ulcerative colitis (UC) and Crohn’s disease (CD) is false ?

A	Peak age of onset of UC & CD is 15 - 30 years
B	Second peak occurs between 60 - 80 years
C	Appendectomy aggravates UC
D	IBD runs in families

Question 5 Explanation:

Appendectomy is protective against UC but increases the risk of CD.

Question 6

Which genetic disorder is a predisposing factor for IBD ?

A	Turner’s syndrome
B	Down syndrome
C	Patau syndrome
D	Edward syndrome

Question 7

IBD is associated with all of the following except ?

A	Turner’s syndrome
B	Down syndrome
C	Selective IgA deficiency
D	Hereditary angioedema

Question 8

All of the following are predisposing factors for UC except ?

A	Jewish ethnicity
B	High socio-economic status
C	Smoking
D	Hermansky-Pudlak syndrome

Question 9

If two parents have IBD, what chance does each child has of being affected ?

A	36 %
B	45 %
C	66 %
D	72 %

Question 9 Explanation:

If two parents have IBD, each child has a 36% chance of being affected

Question 10

Which of the following is not associated with increased risk of UC ?

A	Urban domicile
B	High socio-economic status
C	Former smoker
D	Appendectomy

Question 10 Explanation:

Urban areas, high socioeconomic classes have a higher prevalence of IBD. Former smokers have a 1.7-fold increased risk for UC than people who have never smoked. Appendectomy is protective against UC

Question 11

Disease that are shares genetic risk factors with IBD is ?

A	Rheumatoid arthritis
B	Psoriasis
C	Systemic lupus erythematosus
D	All of the above

Question 11 Explanation:

Diseases and genetic risk factors that are shared with IBD include rheumatoid arthritis (TNFAIP3), psoriasis (IL23R,IL12B), ankylosing spondylitis (IL23R), type 1 diabetes mellitus (IL10,PTPN2), asthma (ORMDL3), and systemic lupus erythematosus (TNFAIP3,IL10)

Question 12

NOD1 gene is now known as ?

A	CARD1
B	CARD2
C	CARD3
D	CARD4

Question 13

NOD2 gene is now known as ?

A	CARD1
B	CARD5
C	CARD15
D	CARD18

Question 13 Explanation:

Gene CARD4 was formerly called NOD1, and CARD15 was formerly called NOD2. CARD15 means caspase-associated recruitment domain containing protein 15, while NOD2 refers to nucleotide oligomerisation domain 2

Question 14

The disease-related gene of IBD1 on chromosome 16 is ?

A	NOD-1
B	NOD-2
C	NOD-3
D	NOD-4

Question 14 Explanation:

The IBD1 locus encodes NOD2 (also designated CARD 15).

Question 15

Which of the following IBD subtype has its loci on chromosome 16 ?

A	IBD 6
B	IBD 7
C	IBD 8
D	IBD 9

Question 15 Explanation:

IBD loci are on chromosomes 16q12 (IBD1), 12q13 (IBD2), 6p13 (IBD3), 14q11 (IBD4), 5q31-33 (IBD5), 19p13 (IBD6), 1p36 (IBD7), 16p (IBD8), 3p (IBD9).

Question 16

CARD15 is constitutively expressed in ?

A	Paneth cells
B	Parietal or oxyntic cells
C	G cells
D	D cells

Question 16 Explanation:

Paneth cells are specialised epithelial cells selectively expressed in ileum, located mainly in crypts in close proximity to epithelial stem cells. Paneth cells secrete antibacterial substances. Main antimicrobial factors secreted by Paneth cell include lysozyme, phospholipase A2, trypsin, alphadefensins & angiogenins

Question 17

CARD15 protein is expressed in the cytoplasm of ?

A	Peripheral blood monocytes
B	Paneth cells
C	Dendritic cells
D	All of the above

Question 17 Explanation:

CARD15 is expressed by intestinal epithelial cells (Paneth cells, monocytes, macrophages & dendritic cells)

Question 18

Which of the following is false about CARD15 protein ?

A	CARD15 was formerly called NOD1
B	Intracellular recognition protein for bacterial components
C	. Activates nuclear factor kappa B pathway
D	Gain-of-function mutations are associated with CD

Question 18 Explanation:

CARD15 protein acts as an intracellular recognition protein for bacterial components such as peptidoglycans and activates nuclear factor kappa B pathway which regulates apoptosis and inflammation. Loss-of-function mutations in CARD15 are highly associated with CD

Question 19

Which of the following genes is associated with innate immunity and autophagy ?

A	NOD2
B	ATG16L1
C	IRGM
D	All of the above

Question 19 Explanation:

Genes that are associated with innate immunity and autophagy are NOD2, ATG16L1, IRGM, JAK2, STAT3 that function in innate immune cells (both parenchymal and hematopoietic) to respond to and clear bacteria, mycobacteria and viruses.

Question 20

Which of the following genes is associated with endoplasmic reticulum (ER) and metabolic stress ?

A	XBP1
B	ORMDL3
C	OCTN
D	All of the above

Question 20 Explanation:

Genes that are associated with endoplasmic reticulum (ER) and metabolic stress are XBP1, ORMDL3, OCTN, which serve to regulate the secretory activity of cells involved in responses to the commensal microbiota such as Paneth and goblet cells and the manner in which intestinal cells respond to the metabolic products of bacteria

Question 21

Which of the following genes is associated with regulation of adaptive immunity ?

A	IL23R
B	IL12B
C	IL10
D	All of the above

Question 21 Explanation:

Genes that are associated with regulation of adaptive immunity are IL23R, IL12B, IL10, PTPN2, which regulate the balance between inflammatory and regulatory cytokines.

Question 22

Which of the following genes is involved in the development and resolution of inflammation ?

A	MST1
B	CCR6
C	TNFAIP3
D	All of the above

Question 22 Explanation:

Genes that are involved in the development and resolution of inflammation are MST1, CCR6, TNFAIP3, PTGER4 and ultimately leukocyte recruitment and inflammatory mediator production

Question 23

Lack of immune responsiveness of gut mucosal immune system to dietary antigens is best related to ?

A	Intestinal tolerance
B	Gastric tolerance
C	Oral tolerance
D	All of the above

Question 23 Explanation:

The gut mucosal immune system is normally unreactive to luminal contents due to oral (mucosal) tolerance. In IBD this suppression of inflammation is altered, leading to uncontrolled inflammation

Question 24

CD4+ T helper (TH) cell that promotes inflammation is ?

A	TH1 cells
B	TH2 cells
C	TH17 cells
D	All of the above

Question 24 Explanation:

CD4+ T helper (TH) cells that promote inflammation are of three major types namely TH1 cells, TH2 cells and T H17 cells.

Question 25

Which of the following is a type of CD4+ T cell ?

A	TH1 cells
B	TH2 cells
C	TH17 cells
D	All of the above

Question 26

TH2 of CD4 + T cells produce all except ?

A	Interferon- (IFN-)
B	Interleukin -4 (IL-4)
C	Interleukin -5 (IL-5)
D	Interleukin -13 (IL-13)

Question 26 Explanation:

CD4+ T cells are composed of Th1 cells, that produce interferon-gamma (IFN-), and Th2 cells that produce interleukin-4, IL-5 and IL-13

Question 27

Interferon (IFN) gamma is secreted by which of the following ?

A	TH1 cells
B	TH2 cells
C	TH17 cells
D	All of the above

Question 27 Explanation:

TH1 cells secrete interferon (IFN) gamma, TH2 cells secrete IL-4, IL-5, IL-13, and TH17 cells secrete IL-17, IL-21

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 27 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	24	25
26	27	End

Return

See all quizzes of Peptic Ulcer Disease at here:

1.Which out of the following countries has the highest incidence
of IBD ?
A. Sweden
B. Israel
C. Greece

D. China

2. Out of the following, which ethnic group has the highest
prevalence of IBD ?
A. Jewish
B. African American
C. Hispanic
D. Asian

3. Nonmalignant mortality in IBD cases is maximum during ?
A. First year of disease
B. After five years of disease
C. After ten years of disease
D. After fifteen years of disease

4. If a patient has IBD, the lifetime risk that a first degree relative
will be similarly affected is ?
A. 10 %
B. 20 %
C. 30 %
D. 40 %

5. Which of the following statements about Ulcerative colitis (UC)
and Crohn’s disease (CD) is false ?
A. Peak age of onset of UC & CD is 15 – 30 years
B. Second peak occurs between 60 – 80 years
C. Appendectomy aggravates UC
D. IBD runs in families

6. Which genetic disorder is a predisposing factor for IBD ?
A. Turner’s syndrome
B. Down syndrome
C. Patau syndrome
D. Edward syndrome
7.IBD is associated with all of the following except ?

A. Turner’s syndrome
B. Down syndrome
C. Selective IgA deficiency
D. Hereditary angioedema
8.All of the following are predisposing factors for UC except ?
A. Jewish ethnicity
B. High socio-economic status
C. Smoking
D. Hermansky-Pudlak syndrome
9. If two parents have IBD, what chance does each child has of
being affected ?
A. 36 %
B. 45 %
C. 66 %
D. 72 %

10. Which of the following is not associated with increased risk of
UC ?
A. Urban domicile
B. High socio-economic status
C. Former smoker
D. Appendectomy

11. Disease that are shares genetic risk factors with IBD is ?
A. Rheumatoid arthritis
B. Psoriasis
C. Systemic lupus erythematosus
D. All of the above

12. NOD1 gene is now known as ?
A. CARD1
B. CARD2
C. CARD3
D. CARD4
13. NOD2 gene is now known as ?
A. CARD1
B. CARD5
C. CARD15
D. CARD18

14. The disease-related gene of IBD1 on chromosome 16 is ?
A. NOD-1
B. NOD-2
C. NOD-3
D. NOD-4

15. Which of the following IBD subtype has its loci on chromosome 16 ?
A. IBD 6
B. IBD 7
C. IBD 8
D. IBD 9

16. CARD15 is constitutively expressed in ?
A. Paneth cells
B. Parietal or oxyntic cells
C. G cells
D. D cells

17. CARD15 protein is expressed in the cytoplasm of ?
A. Peripheral blood monocytes
B. Paneth cells
C. Dendritic cells
D. All of the above

18. Which of the following is false about CARD15 protein ?
A. CARD15 was formerly called NOD1
B. Intracellular recognition protein for bacterial components
C. Activates nuclear factor kappa B pathway
D. Gain-of-function mutations are associated with CD

19. Which of the following genes is associated with innate
immunity and autophagy ?
A. NOD2
B. ATG16L1
C. IRGM
D. All of the above

20.Which of the following genes is associated with endoplasmic
reticulum (ER) and metabolic stress ?
A. XBP1
B. ORMDL3
C. OCTN
D. All of the above

21. Which of the following genes is associated with regulation of
adaptive immunity ?
A. IL23R
B. IL12B
C. IL10
D. All of the above

22. Which of the following genes is involved in the development
and resolution of inflammation ?
A. MST1
B. CCR6
C. TNFAIP3
D. All of the above

23. Lack of immune responsiveness of gut mucosal immune
system to dietary antigens is best related to ?
A. Intestinal tolerance
B. Gastric tolerance
C. Oral tolerance
D. All of the above

24. CD4+ T helper (TH) cell that promotes inflammation is ?
A. TH1 cells
B. TH2 cells
C. TH17 cells
D. All of the above

25. Which of the following is a type of CD4+ T cell ?
A. TH1 cells
B. TH2 cells
C. TH17 cells
D. All of the above

Inflammatory bowel disease

[MCQ] Inflammatory bowel disease- Part 1

I. Start the exam by click the “Start” button

Inflammatory bowel disease- Part 1

Share this:

Related

[MCQ] Disorders of Absorption- Part 6

[MCQ] Inflammatory bowel disease- Part 2

You may also like

Leave a Comment Cancel Reply