[MCQ] HIV / AIDS- Part 2

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HIV / AIDS- Part 2

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Congratulations - you have completed HIV / AIDS- Part 2. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Major co-receptors for HIV-1 is ?

A	CCR5
B	CXCR4
C	A+B
D	Neither A, nor B

Question 2

CCR5 & CXCR4 belong to which family of cellular receptors ?

A	G protein–coupled receptors
B	Tyrosine kinase receptors
C	Cytokine receptors
D	Serine kinase receptors

Question 2 Explanation:

The two major co-receptors for HIV-1 are CCR5 and CXCR4. Both receptors belong to the family of seven-transmembrane-domain G protein–coupled cellular receptors.

Question 3

Which of the following cells express C-type lectin receptors on their surface ?

A	T lymphocytes
B	Monocytes
C	Macrophages
D	Dendritic cells

Question 3 Explanation:

Certain dendritic cells express C-type lectin receptors on their surface, one of which is called DCSIGN that bind with high affinity to HIV gp120 envelope protein. When dendritic cells engage with CD4+ T cells, HIV virus is presented to CD4+ T cells.

Question 4

Preintegration complex is composed of ?

A	Viral RNA
B	Viral enzymes
C	Capsid protein coat
D	All of the above

Question 4 Explanation:

Following fusion, the preintegration complex, composed of viral RNA and viral enzymes and surrounded by a capsid protein coat, is released into the cytoplasm of the target cell.

Question 5

Protein coat of the preintegration complex opens ?

A	Before reverse transcription of genomic RNA into DNA
B	During reverse transcription of genomic RNA into DNA
C	After reverse transcription of genomic RNA into DNA
D	None of the above

Question 5 Explanation:

As the preintegration complex traverses the cytoplasm to reach the nucleus, viral reverse transcriptase enzyme catalyzes reverse transcription of genomic RNA into DNA and protein coat opens to release double-stranded HIV-DNA.

Question 6

Antiretroviral effect of the cellular protein APOBEC3G (or CEM15) is counteracted by ?

A	HIV-1 Vif
B	HIV-1 Nef
C	HIV-1 vpu
D	HIV-1 vpr

Question 6 Explanation:

APOBEC family of cellular proteins inhibits progression of virus infection after virus has entered the cell. APOBEC proteins bind to nascent reverse transcripts and deaminate viral cytidine, causing hypermutation of HIV genomes. HIV protects itself from APOBEC through its viral protein Vif that targets APOBEC.

Question 7

HIV viral uncoating involves which of the viral proteins ?

A	MA
B	Nef
C	Vif
D	All of the above

Question 8

Which of the following HIV gene products possess antiapoptotic properties ?

A	Envelope
B	Tat
C	Nef
D	Vpr

Question 9

HIV virus replicates mainly in ?

A	Blood
B	Bone marrow
C	Lymphoid tissue
D	All of the above

Question 9 Explanation:

Regardless of the portal of entry of HIV, lymphoid tissues are the major anatomic sites for the establishment and propagation of HIV infection. Virus replication occurs mainly in lymphoid tissue and not in blood. Level of plasma viremia directly reflects virus production in lymphoid tissue.

Question 10

The HIV viral RNA genome is converted into a full-length doublestranded DNA by viral RT by a process called ?

A	Retrotranscription
B	Transcription
C	Duplication
D	Deletion

Question 11

HIV virus preintegration complex docks to nuclear membrane and is directed by ?

A	HIV-1 vpr
B	HIV-1 Nef
C	HIV-1 vpu
D	HIV-1 vif

Question 12

Which of the following HIV-1 genes encode structural proteins of the virus ?

A	gag
B	pol
C	env
D	All of the above

Question 13

Which of the following HIV-1 gene that encodes the proteins that form the core of the virion ?

A	gag
B	pol
C	env
D	All of the above

Question 13 Explanation:

gag encodes the proteins that form the core of the virion (including p24 antigen)

Question 14

Which of the following HIV-1 gene encodes enzymes responsible for reverse transcription & integration ?

A	gag
B	pol
C	env
D	All of the above

Question 14 Explanation:

pol encodes the enzymes responsible for protease processing of viral proteins, reverse transcription and integration.

Question 15

Which of the following HIV-1 gene encodes the envelope glycoproteins ?

A	gag
B	pol
C	env
D	All of the above

Question 15 Explanation:

env encodes the envelope glycoproteins.

Question 16

Which of the HIV-1 genes code for proteins involved in modification of host cell to enhance virus growth and regulation of viral gene expression ?

A	tat
B	rev
C	nef
D	All of the above

Question 16 Explanation:

HIV-1 contains six genes named tat, rev, nef, vif, vpr & vpu which code for proteins involved in the modification of the host cell to enhance virus growth and the regulation of viral gene expression.

Question 17

HIV viral linear double-stranded DNA in the preintegration complex is inserted into the host chromosome by ?

A	Viral IN
B	Viral EN
C	Viral FN
D	Viral KN

Question 17 Explanation:

From cytoplasm HIV viral DNA enters the nucleus through nuclear pore where it is integrated into host cell chromosomes (introns of active genes & regional hotspots) through the action of virally encoded enzyme integrase (IN).

Question 18

Lipid rafts is related to ?

A	HIV-1 cell membrane
B	Host cell membrane
C	Host nuclear membrane
D	All of the above

Question 18 Explanation:

Budding of progeny virion occurs through specialized regions in lipid bilayer of host cell membrane known as lipid rafts, where the core acquires its external envelope.

Question 19

Which of the following is not a HIV-1 group ?

A	L
B	M
C	N
D	O

Question 20

Which of the following HIV-1 groups is responsible for most HIV infections in world ?

A	M
B	N
C	O
D	None of the above

Question 20 Explanation:

HIV-1 is most closely related to viruses isolated from chimpanzees & gorillas. There are three groups of HIV-1 - group M (major), which is responsible for most of the infections in the world, group O (outlier), a relatively rare viral form found originally in Cameroon, Gabon, and France and group N, first identified in a Cameroonian woman with AIDS.

Question 21

The chimpanzee subspecies Pan troglodytes troglodytes is not the natural reservoir of ?

A	HIV-1 M
B	HIV-1 N
C	HIV-1 O
D	None of the above

Question 21 Explanation:

The chimpanzee subspecies Pan troglodytes troglodytes is the natural reservoir of the HIV-1 M and N groups. HIV-1 O group is most closely related to viruses found in Cameroonian gorillas.

Question 22

Which of the following is not a subtype of HIV-1 M group ?

A	A
B	B
C	E
D	F

Question 22 Explanation:

The HIV-1 M group comprises nine subtypes, or clades, designated A, B, C, D, F, G, H, J and K, as well as a number of major & minor circulating recombinant forms (CRFs). Seven strains account for the majority of HIV infections globally: HIV-1 subtypes A, B, C, D, G and two CRFs, CRF01_AE and CRF02_AG.

Question 23

Which of the following about circulating recombinant forms (CRFs) is false ?

A	Generated by infection with two subtypes
B	CRF01_AE is predominant in southeast Asia
C	CRF02_AG is predominant in west & central Africa
D	None of the above

Question 23 Explanation:

CRFs are generated by infection in one patient with two subtypes that recombine & create a different virus. AE virus or CRF01_AE is common in southeast Asia & is often called as E. CRF02_AG is common in west & central Africa.

Question 24

Which of the following HIV subtypes are closely related to each other ?

A	A & B
B	A & C
C	B & C
D	B & D

Question 24 Explanation:

HIV-1 M group subtypes A & F are now subdivided into A1 & A2, F1 & F2. Subtypes B & D are too close to be separate subtypes & should be considered sub-subtypes.

Question 25

Which subtype of M group of HIV-1 is prevalent in USA ?

A	A
B	B
C	C
D	D

Question 25 Explanation:

Subtype B viruses are the predominant viruses seen in United States, Canada, certain countries in South America, western Europe and Australia.

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See all quizzes of HIV / AIDS- Part 2 here:

1 Major co-receptors for HIV-1 is ?
A. CCR5
B. CXCR4
C. A+B
D. Neither A, nor B
2 CCR5 & CXCR4 belong to which family of cellular receptors ?
A. G protein–coupled receptors
B. Tyrosine kinase receptors
C. Cytokine receptors
D. Serine kinase receptors

3 Which of the following cells express C-type lectin receptors on
their surface ?
A. T lymphocytes
B. Monocytes
C. Macrophages
D. Dendritic cells

4 Preintegration complex is composed of ?
A. Viral RNA
B. Viral enzymes
C. Capsid protein coat
D. All of the above

5 Protein coat of the preintegration complex opens ?
A. Before reverse transcription of genomic RNA into DNA
B. During reverse transcription of genomic RNA into DNA
C. After reverse transcription of genomic RNA into DNA
D. None of the above

6 Antiretroviral effect of the cellular protein APOBEC3G (or CEM15)
is counteracted by ?
A. HIV-1 Vif
B. HIV-1 Nef
C. HIV-1 vpu
D. HIV-1 vpr

7 HIV viral uncoating involves which of the viral proteins ?
A. MA
B. Nef
C. Vif
D. All of the above
8 Which of the following HIV gene products possess antiapoptotic
properties ?
A. Envelope
B. Tat
C. Nef
D. Vpr
9 HIV virus replicates mainly in ?
A. Blood
B. Bone marrow
C. Lymphoid tissue
D. All of the above

10 The HIV viral RNA genome is converted into a full-length doublestranded
DNA by viral RT by a process called ?
A. Retrotranscription
B. Transcription
C. Duplication
D. Deletion
11 HIV virus preintegration complex docks to nuclear membrane
and is directed by ?
A. HIV-1 vpr
B. HIV-1 Nef
C. HIV-1 vpu
D. HIV-1 vif
12 Which of the following HIV-1 genes encode structural proteins of
the virus ?
A. gag
B. pol
C. env
D. All of the above

13 Which of the following HIV-1 gene that encodes the proteins that
form the core of the virion ?
A. gag
B. pol
C. env
D. All of the above

14 Which of the following HIV-1 gene encodes enzymes responsible
for reverse transcription & integration ?
A. gag
B. pol
C. env
D. All of the above

15 Which of the following HIV-1 gene encodes the envelope
glycoproteins ?
A. gag
B. pol
C. env
D. All of the above

16 Which of the HIV-1 genes code for proteins involved in modification
of host cell to enhance virus growth and regulation of viral gene
expression ?
A. tat
B. rev
C. nef
D. All of the above

17 HIV viral linear double-stranded DNA in the preintegration
complex is inserted into the host chromosome by ?
A. Viral IN
B. Viral EN
C. Viral FN
D. Viral KN

18 Lipid rafts is related to ?
A. HIV-1 cell membrane
B. Host cell membrane
C. Host nuclear membrane
D. All of the above

19 Which of the following is not a HIV-1 group ?
A. L
B. M
C. N
D. O
20 Which of the following HIV-1 groups is responsible for most HIV
infections in world ?
A. M
B. N
C. O
D. None of the above

21 The chimpanzee subspecies Pan troglodytes troglodytes is not
the natural reservoir of ?
A. HIV-1 M
B. HIV-1 N
C. HIV-1 O
D. None of the above

22 Which of the following is not a subtype of HIV-1 M group ?
A. A
B. B
C. E
D. F

23 Which of the following about circulating recombinant forms (CRFs)
is false ?
A. Generated by infection with two subtypes
B. CRF01_AE is predominant in southeast Asia
C. CRF02_AG is predominant in west & central Africa
D. None of the above

24 Which of the following HIV subtypes are closely related to each
other ?
A. A & B
B. A & C
C. B & C
D. B & D

25 Which subtype of M group of HIV-1 is prevalent in USA ?
A. A
B. B
C. C
D. D

HIV / AIDS

[MCQ] HIV / AIDS- Part 2

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HIV / AIDS- Part 2

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[MCQ] HIV / AIDS- Part 1

[MCQ] HIV / AIDS- Part 3

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