[MCQ] Asthma- Part 3

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Asthma- Part 3

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Question 1

Evidence for increased oxidative stress in asthma is provided by increased concentrations of which of the following in exhaled breath condensates ?

A	6-isoprostane
B	7-isoprostane
C	8-isoprostane
D	9-isoprostane

Question 1 Explanation:

Evidence for increased oxidative stress in asthma is provided by increased concentrations of 8- isoprostane (product of oxidized arachidonic acid) in exhaled breath condensates and increased ethane (product of lipid peroxidation) in the expired air of asthmatic patients

Question 2

In airways, Nitric Oxide (NO) is produced mainly by ?

A	Epithelial cells
B	Fibroblasts
C	Smooth muscle
D	All of the above

Question 2 Explanation:

Nitric oxide (NO) is produced by airway epithelial cells & macrophages in the airway by NO synthases. Its level in expired air of asthma patients is higher than normal due to eosinophilic inflammation

Question 3

Level of NO in expired air in asthma is related to ?

A	Bronchoconstriction
B	Mucus Hypersecretion
C	Eosinophilic inflammation
D	Airway Hyperresponsiveness (AHR)

Question 3 Explanation:

Nitric oxide (NO) is produced particularly by airway epithelial cells and macrophages. Its level NO in expired air in asthmatics is higher than normal and is related to eosinophilic inflammation

Question 4

Which of the following favours Th2 phenotype ?

A	Transcription factor GATA-3
B	c-maf
C	Prostaglandin E2
D	All of the above

Question 4 Explanation:

Proinflammatory transcription factors like nuclear factor kB & activator protein 1 (AP-1) are activated in asthmatic airways leading to expression of multiple inflammatory genes. Specific transcription factor GATA-3 regulates expression of TH2 cytokines in T cells.

Question 5

Thunderstorm asthma is due to ?

A	Fungal spores
B	Domestic pets
C	Pollen grains
D	Cockroaches

Question 5 Explanation:

Pollens cause allergic rhinitis rather than asthma. In thunderstorms, pollen grains are disrupted & particles that are released can trigger severe asthma exacerbations (thunderstorm asthma).

Question 6

Which of the following upper respiratory tract virus is the most common trigger of acute severe asthma exacerbation ?

A	Rhinovirus
B	Respiratory syncytial virus
C	Coronavirus
D	All of the above

Question 6 Explanation:

Rhinovirus, respiratory syncytial virus, and coronavirus are the most common triggers of acute severe asthma exacerbations.

Question 7

Cough associated with angiotensin-converting enzyme inhibitors best relates to ?

A	Type I interferons
B	Kinins
C	Cysteinyl leukotrienes
D	All of the above

Question 7 Explanation:

Angiotensin-converting enzyme inhibitors inhibit breakdown of kinins, which are bronchoconstrictors and produce the characteristic cough.

Question 8

Severity of exercise induced asthma depends on ?

A	Level of ventilation achieved
B	Temperature of environment
C	Humidity of inspired air
D	All of the above

Question 8 Explanation:

EIA is worse in cold, dry climates than in hot, humid conditions

Question 9

Which of the following is false about exercise induced asthma (EIA) ?

A	No long-term sequelae
B	Does not increase airway reactivity
C	Attacks follow exertion
D	None of the above

Question 10

Which of the following is false about exercise induced asthma (EIA) ?

A	Begins after exercise has ended
B	Begins after exercise has ended
C	Best prevented by inhaled glucocorticoids
D	None of the above

Question 11

Which of the following may also be a trigger of asthma ?

A	Anger
B	Orgasm
C	Laughter
D	All of the above

Question 11 Explanation:

Laughter may also be a trigger of asthma

Question 12

Patients with aspirin-induced asthma may benefit from ?

A	Salt free diet
B	Pepper free diet
C	Salicylate free diet
D	Sulphar free diet

Question 12 Explanation:

Patients with aspirin-induced asthma may benefit from a salicylate-free diet

Question 13

After what length of time, aspirin-induced asthma develops after drug administration ?

A	Within 1 hour
B	Within 6 hours
C	Within 12 hours
D	Within 24 hour

Question 13 Explanation:

Most NSAIDs, including aspirin, cause immediate, allergy-like symptoms in susceptible individuals. Urticaria/angioedema may be delayed up to 24 hours. The rhinosinusitis-asthma syndrome generally develops within 1 hour of drug administration

Question 14

Which of the following is supposedly protective for the occurrence of childhood-onset asthma ?

A	M. tuberculosis
B	Chlamydia trachomatis
C	H. pylori
D	All of the above

Question 14 Explanation:

Recent studies have shown an inverse association of cagA+ H. pylori with childhood-onset asthma, hay fever, and atopic disorders. Whether H. pylori status is merely a marker or is causally associated with protection against these diseases remains to be determined

Question 15

Sulfur dioxide triggers asthma symptoms by ?

A	Mast cell activation
B	Adrenergic reflex
C	Cholinergic reflex
D	All of the above

Question 15 Explanation:

Most of the triggers for asthma symptoms act indirectly. Allergens, exercise, hyperventilation, fog (via mast cell activation), irritant dusts, and sulfur dioxide (via a cholinergic reflex). Direct bronchoconstrictors are histamine & methacholine.

Question 16

The characteristic symptom of asthma is ?

A	Wheezing
B	Dyspnea
C	Coughing
D	All of the above

Question 16 Explanation:

The characteristic symptoms of asthma are wheezing, dyspnea & coughing.

Question 17

Prodromal symptom that may precede an asthma attack is ?

A	Itching under the axilla
B	Itching over epigastrium
C	Itching under the chin
D	Itching behind the ears

Question 17 Explanation:

Prodromal symptoms that may precede an asthma attack are itching under the chin, discomfort between scapulae or inexplicable fear (impending doom).

Question 18

Which of the following symptoms is considered ‘sine qua non’ for asthma ?

A	Dyspnea
B	Cough
C	Wheezing
D	All of the above

Question 19

Which of the following is most common & characteristic feature of asthma ?

A	Cough
B	Nocturnal awakening with dyspnea and/or wheeze
C	Constriction feeling in chest
D	Perspiration

Question 20

Bronchial reactivity reaches its peak around ?

A	3 AM
B	6 AM
C	12 Noon
D	12 Midnight

Question 21

Cough-variant asthma is seen in ?

A	Children
B	Adolescents
C	Adults
D	Elderly

Question 21 Explanation:

Cough due to asthma in the absence of wheezing, shortness of breath, and chest tightness is referred to as “cough-variant asthma.” Children particularly may present with a predominant nonproductive cough or cough-variant asthma that ties the onset of cough to typical triggers for asthma and resolution of cough upon withdrawal from exposure to them. Cough-variant asthma typically responds well to inhaled glucocorticoids and intermittent use of inhaled beta-agonist bronchodilators

Question 22

Asthma is a feature of which of the following ?

A	Cogan’s Syndrome
B	Polyarteritis Nodosa
C	Churg-Strauss syndrome
D	Henoch-Schönlein Purpura

Question 22 Explanation:

Churg-Strauss syndrome (allergic angiitis & granulomatosis), is characterized by asthma, peripheral & tissue eosinophilia, extravascular granuloma formation, and vasculitis of multiple organ systems

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See all quizzes of Asthma at here:

1.Evidence for increased oxidative stress in asthma is provided by increased concentrations of which of the following in exhaled breath condensates ?
A. 6-isoprostane
B. 7-isoprostane
C. 8-isoprostane
D. 9-isoprostane

2. In airways, Nitric Oxide (NO) is produced mainly by ?
A. Epithelial cells
B. Fibroblasts
C. Smooth muscle
D. All of the above

3. Level of NO in expired air in asthma is related to ?
A. Bronchoconstriction
B. Mucus Hypersecretion
C. Eosinophilic inflammation
D. Airway Hyperresponsiveness (AHR)

4. Which of the following favours Th2 phenotype ?
A. Transcription factor GATA-3
B. c-maf
C. Prostaglandin E2
D. All of the above

5. Thunderstorm asthma is due to ?
A. Fungal spores
B. Domestic pets
C. Pollen grains
D. Cockroaches

6. Which of the following upper respiratory tract virus is the most common trigger of acute severe asthma exacerbation ?
A. Rhinovirus
B. Respiratory syncytial virus
C. Coronavirus
D. All of the above

7. Cough associated with angiotensin-converting enzyme inhibitors best relates to ?
A. Type I interferons
B. Kinins
C. Cysteinyl leukotrienes
D. All of the above
.
8. Severity of exercise induced asthma depends on ?
A. Level of ventilation achieved
B. Temperature of environment
C. Humidity of inspired air
D. All of the above

9. Which of the following is false about exercise induced asthma (EIA) ?
A. No long-term sequelae
B. Does not increase airway reactivity
C. Attacks follow exertion
D. None of the above
10. Which of the following is false about exercise induced asthma (EIA) ?
A. Begins after exercise has ended
B. Recovers spontaneously within ~30 minutes
C. Best prevented by inhaled glucocorticoids
D. None of the above
11. Which of the following may also be a trigger of asthma ?
A. Anger
B. Orgasm
C. Laughter
D. All of the above

12. Patients with aspirin-induced asthma may benefit from ?
A. Salt free diet
B. Pepper free diet

C. Salicylate free diet
D. Sulphar free diet

13. After what length of time, aspirin-induced asthma develops after drug administration ?
A. Within 1 hour
B. Within 6 hours
C. Within 12 hours
D. Within 24 hour

14. Which of the following is supposedly protective for the occurrence of childhood-onset asthma ?
A. M. tuberculosis
B. Chlamydia trachomatis
C. H. pylori
D. All of the above

15. Sulfur dioxide triggers asthma symptoms by ?
A. Mast cell activation
B. Adrenergic reflex
C. Cholinergic reflex
D. All of the above

16. The characteristic symptom of asthma is ?
A. Wheezing
B. Dyspnea
C. Coughing
D. All of the above

17. Prodromal symptom that may precede an asthma attack is ?
A. Itching under the axilla
B. Itching over epigastrium
C. Itching under the chin
D. Itching behind the ears

18. Which of the following symptoms is considered ‘sine qua non’ for asthma ?
A. Dyspnea

B. Cough
C. Wheezing
D. All of the above
19. Which of the following is most common & characteristic feature of asthma ?
A. Cough
B. Nocturnal awakening with dyspnea and/or wheeze
C. Constriction feeling in chest
D. Perspiration
20. Bronchial reactivity reaches its peak around ?
A. 3 AM
B. 6 AM
C. 12 Noon
D. 12 Midnight
21. Cough-variant asthma is seen in ?
A. Children
B. Adolescents
C. Adults
D. Elderly

21. Asthma is a feature of which of the following ?
A. Cogan’s Syndrome
B. Polyarteritis Nodosa
C. Churg-Strauss syndrome
D. Henoch-Schönlein Purpura

Asthma

[MCQ] Asthma- Part 3

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Asthma- Part 3

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