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Asthma- Part 5
See all quizzes of Asthma at here:
Asthma- Part 1 | Asthma- Part 2 | Asthma- Part 3 | Asthma- Part 4 | Asthma- Part 5 | Asthma- Part 6 | Asthma- Part 7 | Asthma- Part 8
1.Theophylline activates which of the following ?
A. Growth factor – related receptor tyrosine kinase
B. Histone deacetylase-2
C. DNA methyltransferase
D. All-trans-retinoic acid (ATRA)
2. Nausea, vomiting & headaches produced by theophylline are due to ?
A. Adenosine receptor antagonism
B. Phosphodiesterase inhibition
C. Muscarinic receptor antagonis
D. All of the above
3. Cardiac arrhythmias produced by theophylline is due to ?
A. Adenosine A1 receptor antagonism
B. Phosphodiesterase inhibition
C. Muscarinic receptor antagonis
D. All of the above
4. Theophylline side effects are rare at plasma concentrations below ?
A. 10 mg/L
B. 20 mg/L
C. 30 mg/L
D. 40 mg/L
5. Therapeutic plasma concentration of theophylline is ?
A. 5 – 15 µg/mL
B. 20 – 40 µg/mL
C. 5 – 15 µg/mL
D. 20 – 40 µg/mL
6. Plasma concentrations of theophylline may be elevated by ?
A. Erythromycin
B. Ciprofloxacin
C. Zafirlukast
D. All of the above
7. All of the following drugs increase theophylline level except ?
A. Rifampin
B. Erythromycin
C. Ciprofloxacin
D. Cimetidine
8. All of the following drugs increase theophylline level except ?
A. Allopurinol
B. Propranolol
C. Cephalosporins
D. Phenytoin
9. Which of the following does not belong to the controller therapy of asthma ?
A. Long-acting beta2-agonists (LABAs)
B. Inhaled corticosteroids (ICSs)
C. Cromolyn sodium
D. Antileukotrienes
10. Which of the following is an action of corticosteroids in asthma ?
A. Inhibition of transcription factor NF-B
B. Inhibition of transcription factor activator protein (AP)-1
C. Recruitment of histone deacetylase-2 (HDAC2) to
inflammatory gene complex
D. All of the above
11. First-line therapy for patients with persistent asthma is ?
A. Beta2-adrenergic agonists
B. Anticholinergics
C. Inhaled Corticosteroids (ICSs)
D. Theophylline
12. Which of the following is a major problem in therapy with intramuscular triamcinolone acetonide ?
A. Osteoporosis
B. Depression
C. Cataracts
D. Proximal myopathy
13. In asthma, cysteinyl-leukotrienes are produced mainly by ?
A. Mast cells
B. Neutrophils
C. Macrophages
D. Basophils
13. Antileukotrienes (montelukast & zafirlukast) block which of the following ?
A. cys-LT1-receptors
B. cys-LT2-receptors
C. cys-LT3-receptors
D. All of the above
14. Which of the following medicine is used as steroid-sparing therapy ?
A. Methotrexate
B. Cyclosporin A
C. IV gamma globulin
D. All of the above
15. Anti IgE monoclonal antibody used in bronchial asthma is ?
A. Mepolizumab
B. Omalizumab
C. Keliximab
D. Altrakincept
16. Omalizumab is given in bronchial asthma by which route ?
A. Subcutaneous
B. Intravenous
C. Intramuscular
D. Aerosol
17. Which of the following about Omalizumab is false ?
A. Recombinant humanized IgG1 monoclonal anti-IgE antibody
B. Not anaphylactogenic
C. Total serum IgE levels will increase during treatment
D. None of the above
18. Omalizumab cannot be given if the total IgE is ?
A. > 100 IU/L
B. > 300 IU/L
C. > 500 IU/L
D. > 700 IU/L
19. Speleotherapy is best related to ?
A. Mountain
B. Lagoon
C. Cave
D. Iceberg
20. How frequent use of a reliever medication indicates the need for regular controller therapy ?
A. > once a week
B. > three times a week
C. > five times a week
D. > seven times a week
