[MCQ] Asthma- Part 2

I. Start the exam by click the “Start” button

Asthma- Part 2

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Asthma- Part 2. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

Mechanism by which aspirin produces bronchospasm is ?

A	Induction of Haptines
B	Chronic overexcretion of cysteinyl leukotrienes
C	Production of T cell derived cytokines
D	All of the above

Question 1 Explanation:

Aspirin-sensitive asthma is a well defined subtype of asthma that is usually preceded by perennial rhinitis and nasal polyps in nonatopic patients with a late onset of the disease. Aspirin, even in small doses, characteristically provokes rhinorrhea, conjunctival irritation, facial flushing, and wheezing. There is a genetic predisposition to increased production of cysteinyl-leukotrienes with functional polymorphism of cys-leukotriene C synthase. Asthma is triggered by COX inhibitors, but is persistent even in their absence. All nonselective COX inhibitors should be avoided, but selective COX2 inhibitors are safe to use when an anti-inflammatory analgesic is needed. Aspirin-sensitive asthma responds to usual therapy with ICS. Although antileukotrienes should be effective in these patients, they are no more effective than in allergic asthma. Occasionally, aspirin desensitization is necessary, but this should only be undertaken in specialized centers

Question 2

Which of the following is a cysteinyl leukotriene ?

A	LTC 4
B	LTD4
C	LTE4
D	All of the above

Question 3

Cysteinyl leukotrienes were earlier known as ?

A	Structural inflammatory cell
B	Slow-reacting substance of anaphylaxis
C	Crystal structure molecule
D	Exacerbation molecule

Question 3 Explanation:

Cysteinyl leukotrienes C4, D4 & E4 were previously termed “slow-reacting substance of anaphylaxis”

Question 4

“Trienes” in word leukotriene stand for ?

A	Three conjugated double bonds
B	Three cysteinyl molecules
C	Three metabolic pathways
D	Three sulphar molecules

Question 4 Explanation:

Leukotrienes (“leuko” - WBCs & “trienes” - 3 conjugated double bonds) is a family of products of 5- lipoxygenase pathway of arachidonic acid metabolism. Capacity to form leukotrienes from arachidonate is confined to leukocytes

Question 5

Synthesis of leukotrienes from arachidonic acid is initiated by 5-lipoxygenase in concert with ?

A	5-lipoxygenase - activating protein (FLAP)
B	5-lipoxygenase - associated protein (FLAP)
C	5-lipoxygenase - augmenting protein (FLAP)
D	5-lipoxygenase - assisted protein (FLAP)

Question 5 Explanation:

Synthesis of leukotrienes from substrate arachidonic acid is initiated by 5-lipoxygenase enhanced by 5-lipoxygenase - activating protein (FLAP).

Question 6

Products of 5-lipoxygenase pathway besides leukotrienes are ?

A	5-hydroxyeicosatetraenoic acid
B	5-oxo-eicosatetraenoic acid
C	Lipoxins
D	All of the above

Question 6 Explanation:

Products of the 5-lipoxygenase pathway besides leukotrienes are 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and lipoxins.

Question 7

FcεRI-αε is intracellular in which of the following ?

A	Mast cells
B	Basophils
C	Eosinophils
D	All of the above

Question 7 Explanation:

Fc portion of circulating IgE binds to high-affinity receptors (FcRI) present on the surfaces of mast cells and basophils. Chemokines are involved in attracting inflammatory cells from the bronchial circulation into the airways. Eotaxin (CCL11) is selectively attractant to eosinophils via CCR3 and is expressed by epithelial cells of asthmatics, whereas CCL17 (TARC) and CCL22 (MDC) from epithelial cells attract TH2 cells via CCR4

Question 8

Macrophages are derived from ?

A	Eosinophils
B	Basophils
C	Monocytes
D	Any of the above

Question 8 Explanation:

Macrophages are derived from blood monocytes.

Question 9

Dendritic cells are ?

A	Specialized eosinophil-like cells
B	Specialized basophil-like cells
C	Specialized macrophage-like cells
D	All of the above

Question 9 Explanation:

Dendritic cells are specialized macrophage-like cells in airway epithelium, which are the major antigen-presenting cells

Question 10

Which of the following about macrophages is false ?

A	Activated by allergens
B	Initiate inflammatory response
C	Release anti-inflammatory mediators
D	None of the above

Question 10 Explanation:

None of the above

Question 11

In asthmatic patients, which of the following instructs dendritic cells to release chemokines that attract TH2 cells into airway

A	IL-12
B	Tumor necrosis factor (TNF-)
C	Thymic stromal lymphopoietin (TSLP)
D	All of the above

Question 11 Explanation:

Dendritic cells take up allergens, process them to peptides, and migrate to local lymph nodes to present allergenic peptides to uncommitted T-lymphocytes for programming to allergen-specific T cells. Cytokine thymic stromal lymphopoietin (TSLP) released from epithelial cells in asthmatic patients instructs dendritic cells to release chemokines that attract TH2 cells into airways

Question 12

Blocking antibodies to which of the following causes a profound and prolonged reduction in circulating and sputum eosinophils ?

A	Interleukin-2
B	Interleukin-4
C	Interleukin-5
D	Interleukin-13

Question 12 Explanation:

Blocking antibodies to IL-5 causes a profound & prolonged reduction in circulating & sputum eosinophils, but is not associated with reduced AHR or asthma symptoms.

Question 13

Which of the following cells predominate in normal airways ?

A	TH1
B	TH2
C	TH3
D	TH4

Question 14

Which of the following cells predominate in asthmatics ?

A	TH1
B	TH2
C	TH3
D	TH4

Question 15

Which of the following leads to eosinophilic inflammation in asthmatics ?

A	IL-5
B	IL-4
C	IL-13
D	All of the above

Question 15 Explanation:

The naïve immune system and immune system of asthmatics express TH2 phenotype, whereas in normal airways TH1 cells predominate. TH2 cells, through the release of IL-5, are associated with eosinophilic inflammation and, through the release of IL-4 and IL-13, are associated with increased IgE formation.

Question 16

Differentiation of Th1 cells depends on ?

A	Interleukin-12
B	Interleukin-4
C	Interferon-γ
D	All of the above

Question 16 Explanation:

IL-10 & IL-12 are anti-inflammatory and may be deficient in asthma

Question 17

Differentiation of Th2 cells depends on?

A	Interleukin-12
B	Interleukin-4
C	Interferon-γ
D	All of the above

Question 18

Which of the following is not produced by Th2 cells ?

A	Interleukin-2
B	Interleukin-4
C	Interleukin-5
D	Interleukin-13

Question 18 Explanation:

TH 2 cytokines IL-4, IL-5 & IL-13 mediate allergic inflammation, whereas proinflammatory cytokines tumor necrosis factor alpha and IL-1beta amplify the inflammatory response

Question 19

Which of the following in bronchial asthma is false ?

A	Interferon- from Th1 cells inhibits Th2 cells
B	Interleukin-4 from Th2 cells inhibits Th1 cells
C	Bronchial lymphocytes in asthma lack T-bet transcription factor
D	None of the above

Question 20

Which of the following cytokines may be deficient in asthma ?

A	IL-4
B	IL-5
C	IL-12
D	IL-12

Question 20 Explanation:

Cytokines IL-10 & IL-12 are anti-inflammatory and may be deficient in asthma

Question 21

Which of the following is selectively attractant to eosinophils in asthmatics ?

A	Eotaxin
B	Chemotaxin
C	Bronchotaxin
D	Pulmotaxin

Question 21 Explanation:

Chemokine Eotaxin (CCL11), expressed by epithelial cells of asthmatics, is attractant to eosinophils via CCR3, whereas CCL17 (TARC) and CCL22 (MDC) from epithelial cells attract TH2 cells via CCR4

Question 22

Stimulating factor for eosinophils is ?

A	Interleukin 3
B	Interleukin 4
C	Interleukin 5
D	Interleukin 8

Question 22 Explanation:

Interleukin 5 stimulates the release of eosinophils into the circulation & extends their survival

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 22 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	End

Return

See all quizzes of Asthma at here:

1.Mechanism by which aspirin produces bronchospasm is ?
A. Induction of Haptines
B. Chronic overexcretion of cysteinyl leukotrienes
C. Production of T cell derived cytokines
D. All of the above

2. Which of the following is a cysteinyl leukotriene ?
A. LTC4
B. LTD4
C. LTE4
D. All of the above
3. Cysteinyl leukotrienes were earlier known as ?
A. Structural inflammatory cell
B. Slow-reacting substance of anaphylaxis

C. Crystal structure molecule
D. Exacerbation molecule

4. “Trienes” in word leukotriene stand for ?
A. Three conjugated double bonds
B. Three cysteinyl molecules
C. Three metabolic pathways
D. Three sulphar molecules

5. Synthesis of leukotrienes from arachidonic acid is initiated by 5-lipoxygenase in concert with ?
A. 5-lipoxygenase – activating protein (FLAP)
B. 5-lipoxygenase – associated protein (FLAP)
C. 5-lipoxygenase – augmenting protein (FLAP)
D. 5-lipoxygenase – assisted protein (FLAP)

6. Products of 5-lipoxygenase pathway besides leukotrienes are ?
A. 5-hydroxyeicosatetraenoic acid
B. 5-oxo-eicosatetraenoic acid
C. Lipoxins
D. All of the above

7. FcRI- is intracellular in which of the following ?
A. Mast cells
B. Basophils
C. Eosinophils
D. All of the above

8. Macrophages are derived from ?
A. Eosinophils
B. Basophils
C. Monocytes
D. Any of the above

9. Dendritic cells are ?
A. Specialized eosinophil-like cells
B. Specialized basophil-like cells

C. Specialized macrophage-like cells
D. All of the above

10. Which of the following about macrophages is false ?
A. Activated by allergens
B. Initiate inflammatory response
C. Release anti-inflammatory mediators
D. None of the above

11. In asthmatic patients, which of the following instructs dendritic cells to release chemokines that attract TH2 cells into airways ?
A. IL-12
B. Tumor necrosis factor (TNF-)
C. Thymic stromal lymphopoietin (TSLP)
D. All of the above

12. Blocking antibodies to which of the following causes a profound and prolonged reduction in circulating and sputum eosinophils ?
A. Interleukin-2
B. Interleukin-4
C. Interleukin-5
D. Interleukin-13

13. Which of the following cells predominate in normal airways ?
A. TH1
B. TH2
C. TH3
D. TH4
14. Which of the following cells predominate in asthmatics ?
A. TH1
B. TH2
C. TH3
D. TH4
15. Which of the following leads to eosinophilic inflammation in asthmatics ?
A. IL-5
B. IL-4

C. IL-13
D. All of the above

16. Differentiation of Th1 cells depends on ?
A. Interleukin-12
B. Interleukin-4
C. Interferon-
D. All of the above

17. Differentiation of Th2 cells depends on ?
A. Interleukin-12
B. Interleukin-4
C. Interferon-
D. All of the above
18. Which of the following is not produced by Th2 cells ?
A. Interleukin-2
B. Interleukin-4
C. Interleukin-5
D. Interleukin-13

19. Which of the following in bronchial asthma is false ?
A. Interferon- from Th1 cells inhibits Th2 cells
B. Interleukin-4 from Th2 cells inhibits Th1 cells
C. Bronchial lymphocytes in asthma lack T-bet transcription factor
D. None of the above
20. Which of the following cytokines may be deficient in asthma ?
A. IL-4
B. IL-5
C. IL-12
D. IL-13

21. Which of the following is selectively attractant to eosinophils in asthmatics ?
A. Eotaxin
B. Chemotaxin
C. Bronchotaxin
D. Pulmotaxin

22. Stimulating factor for eosinophils is ?
A. Interleukin 3
B. Interleukin 4
C. Interleukin 5
D. Interleukin 8

Asthma

[MCQ] Asthma- Part 2

I. Start the exam by click the “Start” button

Asthma- Part 2

Share this:

Related

[MCQ] Asthma- Part 1

[MCQ] Asthma- Part 3

You may also like

Leave a Comment Cancel Reply