[MCQ] Asthma- Part 6

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Asthma- Part 6

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Congratulations - you have completed Asthma- Part 6. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

The mainstay of treatment in acute severe asthma is ?

A	High dose short-acting inhaled beta2-agonists
B	High dose inhaled corticosteroids (ICSs)
C	Intravenous beta2-agonists
D	Intravenous corticosteroids

Question 1 Explanation:

The mainstay of treatment is high doses of short-acting inhaled Beta2-agonists.

Question 2

Treatment of choice in severely ill asthma patients with impending respiratory failure is ?

A	High dose short-acting inhaled beta2-agonists
B	High dose inhaled corticosteroids (ICSs)
C	Intravenous beta2-agonists
D	Intravenous corticosteroids

Question 2 Explanation:

In severely ill patients with impending respiratory failure, intravenous Beta2-agonists may be given.

Question 3

Refractory asthma is defined as difficult to control asthma despite ?

A	Maximal inhaled therapy
B	Maximal inhaled + oral therapy
C	Maximal inhaled + oral + IV therapy
D	All of the above

Question 3 Explanation:

Approximately 5% of asthmatics are difficult to control despite maximal inhaled therapy

Question 4

The most common reason for poor control of asthma is ?

A	Continued exposure to allergens
B	Use of cyclooxygenase (COX) inhibitors
C	Noncompliance with medication
D	Gastroesophageal reflux

Question 4 Explanation:

Gastroesophageal reflux

Question 5

Premenstrual worsening of asthma is treated by ?

A	Corticosteroids
B	Progesterone
C	Oestrogen
D	Anticholinergics

Question 5 Explanation:

Severe premenstrual worsening of asthma, unresponsive to corticosteroids requires treatment with progesterone or gonadotropin-releasing factors

Question 6

Corticosteroid resistant asthma is defined as failure to respond to what dose & duration of oral prednisolone ?

A	40 mg OD for 2 weeks
B	60 mg OD for 2 weeks
C	80 mg OD for 2 weeks
D	100 mg OD for 2 weeks

Question 6 Explanation:

Corticosteroid resistant asthma is defined as failure to respond to 40 mg OD for 2 weeks of oral prednisolone

Question 7

Mechanism of corticosteroid resistant asthma may be ?

A	Excess of transcription factor AP-1
B	Increase in glucocorticoid receptor (GR)-
C	Reduction in histone deacetylase activity
D	All of the above

Question 7 Explanation:

Mechanism of corticosteroid resistant asthma may be excess of transcription factor AP-1, increase in glucocorticoid receptor-, abnormal pattern of histone acetylation in response to corticosteroids, defect in IL-10 production and reduction in histone deacetylase activity

Question 8

Treatment of choice in type 2 brittle asthma is ?

A	Oral corticosteroids
B	Continuous infusion of beta2-agonists
C	Continuous infusion of corticosteroids
D	Subcutaneous epinephrine

Question 8 Explanation:

Type I brittle asthma - chaotic variations in lung function despite appropriate therapy. Some show a persistent pattern of variability and may require oral corticosteroids or, at times, continuous infusion of Beta 2-agonists. Type II brittle asthma - normal or near-normal lung function but precipitous, unpredictable falls in lung function that may result in death, do not respond well to corticosteroids and inhaled bronchodilators, most effective therapy is subcutaneous epinephrine.

Question 9

Aspirin sensitive asthma is associated with ?

A	Extrinsic asthma
B	Urticaria
C	Nasal polyp
D	Obesity

Question 9 Explanation:

Aspirin-sensitive asthma is a well-defined subtype of late onset asthma that is preceded by perennial rhinitis & nasal polyps in nonatopic patients.

Question 10

In aspirin sensitive asthma, which of the following drugs is not well tolerated ?

A	Acetaminophen
B	Sodium salicylate
C	Naproxen
D	Propoxyphene

Question 10 Explanation:

Aspirin-sensitive asthma responds to usual therapy with an ICS

Question 11

Drugs for asthma that are safe and without teratogenic potential include all except ?

A	Short-acting beta2-agonists
B	Long-acting beta2-agonists
C	ICSs
D	Theophylline

Question 11 Explanation:

Drugs for asthma that are safe and without teratogenic potential include SABAs, ICSs & theophylline. There is less safety information about LABAs, antileukotrienes & anti-IgE

Question 12

Early onset bronchial asthma is associated with all except ?

A	Rhinitis
B	Family history of urticaria
C	Personal history of eczema
D	Normal levels of IgE in serum

Question 13

Heightened airway responsiveness in bronchial asthma can be demonstrated by the use of ?

A	Histamine
B	Methacholine
C	Isocapnic hyperventilation of cold air
D	All of the above

Question 14

When sleep disruption is a prominent side effect of asthma treatment, which drug is preferred ?

A	Theophylline sustained release preparations
B	Inhaled beclomethasone
C	Inhaled Adrenergic agonists
D	Oral glucocorticoids

Question 14 Explanation:

Prominent daily variation in airway resistance in asthmatics results in marked increases in asthmatic symptoms at night, especially during sleep. Treatment with theophylline, adrenergic agonists or glucocorticoids can independently disrupt sleep. When sleep disruption is a side effect of asthma treatment, inhaled glucocorticoids (beclomethasone) that do not disrupt sleep may be useful.

Question 15

Most successful means of bronchial asthma management is ?

A	Glucocorticoids
B	Glucocorticoids + 2 agonists
C	Desensitization / Immunotherapy
D	Elimination of provocative agent

Question 16

Bronchial asthma occuring in women at specific predictable time during menstrual cycle is called ?

A	Functional asthma
B	Periodic asthma
C	Mittelschmerz asthma
D	Catamenial asthma

Question 17

All are “quick relief medications” for bronchial asthma except ?

A	β adrenergic agonists
B	Methylxanthines
C	Anticholinergics
D	Glucocorticoids

Question 17 Explanation:

Glucocorticoids

Question 18

All are “long-term control medications” for bronchial asthma except ?

A	Glucocorticoids
B	All β adrenergic agonists
C	Mast cell stabilizing agents
D	Leukotriene modifiers

Question 18 Explanation:

“Long-term control medications” for bronchial asthma are glucocorticoids, long-acting 2-agonists, combined medications, mast cell stabilizing agents, leukotriene modifiers and methylxanthines

Question 19

Which of the following is a bronchodilator ?

A	β2-adrenergic agonists
B	Anticholinergics
C	Theophylline
D	All of the above

Question 19 Explanation:

Three classes of bronchodilator are 2-adrenergic agonists, anticholinergics & theophylline.

Question 20

Non-bronchodilator effect of beta-2 agonists is ?

A	Inhibition of mast cell mediator release
B	Reduction in plasma exudation
C	Inhibition of sensory nerve activation
D	All of the above

Question 20 Explanation:

Non-bronchodilator effects of beta-2 agonists are inhibition of mast cell mediator release, reduction in plasma exudation & inhibition of sensory nerve activation.

Question 21

Which of the following about asthma treatment is false ?

A	Increased use of SABAs means asthma is not controlled
B	LABAs do not control underlying inflammation
C	LABAs should not be given without ICS therapy
D	None of the above

Question 22

Adrenergic stimulants include ?

A	Catecholamines
B	Resorcinols
C	Saligenins
D	All of the above

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See all quizzes of Asthma at here:

1.The mainstay of treatment in acute severe asthma is ?
A. High dose short-acting inhaled beta2-agonists
B. High dose inhaled corticosteroids (ICSs)
C. Intravenous beta 2-agonists
D. Intravenous corticosteroids
2. Treatment of choice in severely ill asthma patients with impending respiratory failure is ?
A. High dose short-acting inhaled beta2-agonists
B. High dose inhaled corticosteroids (ICSs)
C. Intravenous beta 2-agonists
D. Intravenous corticosteroids
3. Refractory asthma is defined as difficult to control asthma despite ?
A. Maximal inhaled therapy
B. Maximal inhaled + oral therapy
C. Maximal inhaled + oral + IV therapy
D. All of the above

4. The most common reason for poor control of asthma is ?
A. Continued exposure to allergens
B. Use of cyclooxygenase (COX) inhibitors
C. Noncompliance with medication

D. Gastroesophageal reflux

5. Premenstrual worsening of asthma is treated by ?
A. Corticosteroids
B. Progesterone
C. Oestrogen
D. Anticholinergics

6. Corticosteroid resistant asthma is defined as failure to respond to what dose & duration of oral prednisolone ?
A. 40 mg OD for 2 weeks
B. 60 mg OD for 2 weeks
C. 80 mg OD for 2 weeks
D. 100 mg OD for 2 weeks

7. Mechanism of corticosteroid resistant asthma may be ?
A. Excess of transcription factor AP-1
B. Increase in glucocorticoid receptor (GR)-
C. Reduction in histone deacetylase activity
D. All of the above

8. Treatment of choice in type 2 brittle asthma is ?
A. Oral corticosteroids
B. Continuous infusion of beta2-agonists
C. Continuous infusion of corticosteroids
D. Subcutaneous epinephrine

9. Aspirin sensitive asthma is associated with ?
A. Extrinsic asthma
B. Urticaria
C. Nasal polyp
D. Obesity

10. In aspirin sensitive asthma, which of the following drugs is not well tolerated ?
A. Acetaminophen

B. Sodium salicylate
C. Naproxen
D. Propoxyphene

11. Drugs for asthma that are safe and without teratogenic potential include all except ?
A. Short-acting beta2-agonists
B. Long-acting beta2-agonists
C. ICSs
D. Theophylline

12. Early onset bronchial asthma is associated with all except ?
A. Rhinitis
B. Family history of urticaria
C. Personal history of eczema
D. Normal levels of IgE in serum
13. Heightened airway responsiveness in bronchial asthma can be demonstrated by the use of ?
A. Histamine
B. Methacholine
C. Isocapnic hyperventilation of cold air
D. All of the above
14. When sleep disruption is a prominent side effect of asthma treatment, which drug is preferred ?
A. Theophylline sustained release preparations
B. Inhaled beclomethasone
C. Inhaled Adrenergic agonists
D. Oral glucocorticoids

15. Most successful means of bronchial asthma management is ?
A. Glucocorticoids
B. Glucocorticoids + 2 agonists
C. Desensitization / Immunotherapy
D. Elimination of provocative agent
16. Bronchial asthma occuring in women at specific predictable time during menstrual cycle is called ?
A. Functional asthma
B. Periodic asthma
C. Mittelschmerz asthma
D. Catamenial asthma

17. All are “quick relief medications” for bronchial asthma except ?
A.  adrenergic agonists
B. Methylxanthines
C. Anticholinergics
D. Glucocorticoids

18. All are “long-term control medications” for bronchial asthma except ?
A. Glucocorticoids
B. All  adrenergic agonists
C. Mast cell stabilizing agents
D. Leukotriene modifiers

19. Which of the following is a bronchodilator ?
A. 2-adrenergic agonists
B. Anticholinergics
C. Theophylline
D. All of the above

20. Non-bronchodilator effect of beta-2 agonists is ?
A. Inhibition of mast cell mediator release
B. Reduction in plasma exudation
C. Inhibition of sensory nerve activation
D. All of the above

21. Which of the following about asthma treatment is false ?
A. Increased use of SABAs means asthma is not controlled
B. LABAs do not control underlying inflammation
C. LABAs should not be given without ICS therapy
D. None of the above
22. Adrenergic stimulants include ?
A. Catecholamines
B. Resorcinols
C. Saligenins
D. All of the above

Asthma

[MCQ] Asthma- Part 6

I. Start the exam by click the “Start” button

Asthma- Part 6

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