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The Pathogenesis, Prevention, and Treatment of Atherosclerosis- Part 2
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The Pathogenesis, Prevention, and Treatment of Atherosclerosis – Part 1| The Pathogenesis, Prevention, and Treatment of Atherosclerosis – Part 2| The Pathogenesis, Prevention, and Treatment of Atherosclerosis – Part 3
1.Which of the following Type I hyperlipidemia does not increase risk for developing coronary artery disease ?
A. Type I
B. Type IIa
C. Type IIb
D. Type III
2. Type III hyperlipidemia is also known as ?
A. Dysbetalipoproteinemia
B. Remnant removal disease
C. Broad-beta disease
D. All of the above
3. Type IV hyperlipidemia is characterized by ?
A. Elevations of VLDL
B. Elevations of triglycerides
C. Normal serum cholesterol
D. All of the above
4. When triglyceride levels >1000 mg/dL, most likely cause is ?
A. Type II hyperlipidemia
B. Type III hyperlipidemia
C. Type IV hyperlipidemia
D. Type V hyperlipidemia
5. Triglyceride content is least in which of the following ?
A. Chylomicrons
B. LDL
C. VLDL
D. IDL
6. Conditions that cause hyperlipidemia are all except ?
A. Obesity
B. Diabetes mellitus
C. Hypothyroidism
D. Pheochromocytoma
7. Conditions that cause hyperlipidemia are all except ?
A. Nephrotic syndrome
B. Alcohol ingestion
C. Oral progesterone
D. Oral estrogen
8. Drug that causes hyperlipidemia include ?
A. Isotretinoin
B. Sertraline hydrochloride
C. Human immunodeficiency virus protease inhibitors
D. All of the above
9. Drug that causes hyperlipidemia include ?
A. Beta-adrenergic antagonists
B. Thiazide diuretics
C. Cyclosporine
D. All of the above
10. To convert the values for LDL cholesterol to millimoles per liter, multiply by ?
A. 0.05863
B. 0.08651
C. 0.02586
D. 0.02861
11. What is not true for Lipoprotein (a) ?
A. Consists of apo B-100 and apo (a)
B. It is a spherical particle of 250 Å diameter
C. It closely resembles HDL
D. Lp(a) has proatherosclerotic and prothrombotic actions
12. Surface-bound von Willebrand factor binds to ?
A. GpIb located on circulating platelets
B. GpIIb located on circulating platelets
C. GpIIIb located on circulating platelets
D. GpIVb located on circulating platelets
13. Which of the following are essential to increase the cell-to-cell contact and facilitate platelet aggregation ?
A. Fibrinogen
B. Fibronectin
C. GpI-IX
D. All of the above
13.Platelet aggregation and further activation is done by ?
A. ADP
B. Adrenaline
C. Thromboxane A2
D. All of the above
14. The major hepatic isoenzyme involved in simvastatin / atorvastatin metabolism is ?
A. CYP 2C9
B. CYP 2C19
C. CYP 2D6
D. CYP 3A
15. The major hepatic isoenzyme involved in nifedipine metabolism is ?
A. CYP 2C9
B. CYP 2C19
C. CYP 2D6
D. CYP 3A
16. Major hepatic isoenzyme involved in lidocaine metabolism is ?
A. CYP 2C9
B. CYP 2C19
C. CYP 2D6
D. CYP 3A
17. The major hepatic isoenzyme involved in quinidine metabolism is ?
A. CYP 2C9
B. CYP 2C19
C. CYP 2D6
D. CYP 3A
18. CYP enzyme activity inducers lower plasma levels of which of the following drugs ?
A. Warfarin
B. Quinidine
C. Mexiletine
D. All of the above
19. Heparin cofactor is also called ?
A. Protein C
B. Protein S
C. Antithrombin III
D. APLA
20. Which component of red wine has anti-inflammatory and antioxidant properties ?
A. Tyrosine
B. Phenolic
C. Methyl
D. Phenyl
21. Angiotensin I is converted by angiotensin-converting enzyme to angiotensin II mainly in ?
A. Kidney
B. Liver
C. Lung
D. Heart
22. Which of the following is a ‘heptapeptide’ ?
A. Angiotensinogen
B. Angiotensin I
C. Angiotensin II
D. Angiotensin III
