[MCQs] Plasma Cell Disorders- Part 1

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Plasma Cell Disorders- Part 1

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Question 1

Multiple myeloma is also known as ?

A	Kahler’s disease
B	Strohl’s disease
C	Kayle’s disease
D	Migasha disease

Question 1 Explanation:

After Otto Kahler.

Question 2

Which of the following is not a plasma cell disorder ?

A	Multiple myeloma
B	Waldenstrom’s macroglobulinemia
C	Primary amyloidosis
D	Light chain diseases

Question 2 Explanation:

Plasma cell disorders also called monoclonal gammopathies or paraproteinemias or plasma cell dyscrasias or dysproteinemias comprise of Multiple myeloma, Waldenström’s macroglobulinemia, Primary amyloidosis & Heavy chain diseases

Question 3

Multiple myeloma originates from ?

A	Post - germinal center B cell
B	Post - germinal center T cell
C	Pre - germinal center B cell
D	Pre - germinal center T cell

Question 3 Explanation:

Pre - germinal center T cell

Question 4

Which of the following secondary translocations are common in multiple myeloma but rare in MGUS ?

A	MYC (8q24)
B	MAFB (20q12)
C	IRF4 (6p25)
D	All of the above

Question 4 Explanation:

Secondary translocations involving MYC (8q24), MAFB (20q12), and IRF4 (6p25) are common in multiple myeloma but rare in MGUS

Question 5

Which of the following genetic abnormalities are found in multiple myeloma ?

A	Mutations of RAS or FGFR3
B	MYC dysregulation
C	Loss of expression or mutation in TP53
D	All of the above

Question 5 Explanation:

Mutations of RAS or FGFR3, MYC dysregulation, deletion in p18, or loss of expression or mutation in TP53 are found only in multiple myeloma and play a key role in determining tumor progression and drug resistance

Question 6

Which of the following about Plasma Cell Disorders is false ?

A	Monoclonal neoplasms
B	Progenitors in B lymphocyte lineage
C	Manifest clinically by expansion of neoplastic cells
D	None of the above

Question 6 Explanation:

Plasma cell disorders are monoclonal neoplasms, develop from common progenitors in B lymphocyte lineage. Their clinical manifestations are due to expansion of neoplastic cells, to secretion of cell products (immunoglobulin molecules or subunits, lymphokines), and to host’s response to the tumor.

Question 7

Which of the following is not a heavy chain isotype of immunoglobulin molecule ?

A	A
B	B
C	M
D	N

Question 7 Explanation:

There are 5 heavy chain isotypes (M, G, A, D, E) & two light chain isotypes (kappa & lambda).

Question 8

Antibody molecule is composed of ?

A	2 heavy chains and 2 light chains
B	2 heavy chains and 1 light chain
C	1 heavy chain and 2 light chains
D	Any of the above

Question 8 Explanation:

Antibody molecules are composed of two heavy chains (mol wt ~ 50,000) and two light chains (mol wt ~ 25,000).

Question 9

Antigenic determinants formed by the unique structure of the antigen-binding portion of the molecule are called ?

A	Isotypes
B	Allotypes
C	Idiotypes
D	None of the above

Question 9 Explanation:

Isotypes are those antigenic determinants that distinguish among the main classes of antibodies of a given species and are the same in all normal individuals of that species. Allotypes are distinct determinants that reflect regular small differences between individuals of the same species in the amino acid sequences of otherwise similar immunoglobulins. These differences are determined by allelic genes; by definition, they are detected by antibodies made in the same species. Idiotypes are unique to the molecules produced by a given clone of antibody-producing cells. Idiotypes are formed by the unique structure of the antigen-binding portion of the molecule.

Question 10

Immunoglobulins constitute what percentage of plasma proteins ?

A	2 %
B	5 %
C	10 %
D	20 %

Question 10 Explanation:

20 %

Question 11

Light & heavy chains in antibody molecule are linked by ?

A	Phosphate bond
B	Disulfide bond
C	Sulphar bond
D	Any of the above

Question 11 Explanation:

Any of the above

Question 12

Normally, quantity of light chains excreted daily by kidney is ?

A	< 10 mg
B	< 20 mg
C	< 30 mg
D	< 40 mg

Question 12 Explanation:

<10 mg of free light chains secreted by plasma cells is excreted by kidney per day.

Question 13

In serum electrophoresis, immunoglobulins form a broad peak in ?

A	Alpha region
B	Beta region
C	Gamma region
D	Delta region

Question 13 Explanation:

Immunoglobulins move heterogeneously in electric field & form a broad peak in gamma region

Question 14

“M” in M component stands for ?

A	Myeloma
B	Monocomponent
C	Monoclonal
D	Miscellaneous

Question 14 Explanation:

M stands for monoclonal. M component is a tumor marker

Question 15

In serum electrophoresis, the antibody must be present at what concentration to be detectable ?

A	0.3 g / dL
B	0.4 g / d
C	0.5 g / dL
D	0.6 g / dL

Question 15 Explanation:

Antibody must be present at a concentration of at least 0.5 gram/dL to be detectable by immunoelectrophoresis. This corresponds to ~109 cells producing the antibody

Question 16

In electrophoretic analysis, M component may be detected in ?

A	Plasma cell disorders
B	Chronic lymphocytic leukemia
C	Chronic myeloid leukemia
D	All of the above

Question 17

In electrophoretic analysis, M component may be detected in ?

A	Plasma cell disorders
B	Breast cancer
C	Colon cancer
D	All of the above

Question 18

In electrophoretic analysis, M component may be detected in ?

A	Cirrhosis
B	Sarcoidosis
C	Gaucher disease
D	All of the above

Question 19

In electrophoretic analysis, M component may be detected in ?

A	Rheumatoid arthritis
B	Myasthenia gravis
C	Lichen myxedematosus
D	All of the above

Question 19 Explanation:

In addition to the plasma cell disorders, M components may be detected in chronic lymphocytic leukemia, lymphomas of B or T cell origin, chronic myeloid leukemia, breast cancer, and colon cancer, cirrhosis, sarcoidosis, parasitic diseases, Gaucher disease, and pyoderma gangrenosum, rheumatoid arthritis, myasthenia gravis, cold agglutinin disease, lichen myxedematosus, and necrobiotic xanthogranuloma.

Question 20

In serum electrophoresis, church spire sharp peak is seen in ?

A	Normal individuals
B	Polyclonal immunoglobulinopathy
C	Monoclonal gammopathy
D	None of the above

Question 20 Explanation:

In monoclonal gammopathies, the predominance of a product of a single cell produces a “church spire” sharp peak, usually in the globulin region.

Question 21

M component is composed of ?

A	Intact antibody molecule of any heavy chain subclass
B	Altered antibody
C	Antibody fragment
D	Any of the above

Question 21 Explanation:

M component may be an intact antibody molecule of any heavy chain subclass, or it may be an altered antibody or fragment.

Question 22

Bence Jones protein in urine of myeloma patients represents ?

A	Light chains
B	Heavy chains
C	Altered antibody
D	Any of the above

Question 22 Explanation:

In ~20% of myelomas, only light chains are produced and in most cases are secreted in the urine as Bence Jones proteins

Question 23

Which is the most common form of myeloma ?

A	IgG myeloma
B	IgA myeloma
C	IgD myeloma
D	None of the above

Question 23 Explanation:

The frequency of myelomas of a particular heavy chain class is roughly proportional to the serum concentration, and therefore IgG myelomas are more common than IgA and IgD myelomas

Question 24

Plasma cells are produced in ?

A	Lymph glands
B	Spleen
C	Thymus
D	All of the above

Question 24 Explanation:

Lymphocytes and plasma cells are produced mainly in lymphogenous tissues like lymph glands, spleen, thymus, tonsils, and Peyer’s patches.

Question 25

Which of the following interleukins are called B-cell stimulating factors or B-cell growth factors ?

A	4
B	5
C	6
D	All of the above

Question 25 Explanation:

All of the above

Question 26

Which of the following interleukins may play a role in driving myeloma cell proliferation ?

A	1
B	2
C	4
D	6

Question 26 Explanation:

Interleukin (IL)-6 may play a role in driving myeloma cell proliferation

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See all quizzes of the Plasma Cell Disorders at here:

Plasma Cell Disorders Part 1 | Plasma Cell Disorders Part 2 | Plasma Cell Disorders Part 3 | Plasma Cell Disorders Part 4

II. Preview all questions below

1. Multiple myeloma is also known as ?
A. Kahler’s disease
B. Strohl’s disease
C. Kayle’s disease
D. Migasha disease

2. Which of the following is not a plasma cell disorder ?
A. Multiple myeloma
B. Waldenstrom’s macroglobulinemia
C. Primary amyloidosis
D. Light chain diseases

3. Multiple myeloma originates from ?
A. Post – germinal center B cell
B. Post – germinal center T cell
C. Pre – germinal center B cell
D. Pre – germinal center T cell

4. Which of the following secondary translocations are common in multiple myeloma but rare in MGUS ?

A. MYC (8q24)
B. MAFB (20q12)
C. IRF4 (6p25)
D. All of the above

5. Which of the following genetic abnormalities are found in multiple myeloma ?
A. Mutations of RAS or FGFR3
B. MYC dysregulation
C. Loss of expression or mutation in TP53
D. All of the above

6. Which of the following about Plasma Cell Disorders is false ?
A. Monoclonal neoplasms
B. Progenitors in B lymphocyte lineage
C. Manifest clinically by expansion of neoplastic cells
D. None of the above

7. Which of the following is not a heavy chain isotype of immunoglobulin molecule ?
A. A
B. D
C. M
D. N

8. Antibody molecule is composed of ?
A. 2 heavy chains and 2 light chains
B. 2 heavy chains and 1 light chain
C. 1 heavy chain and 2 light chains
D. Any of the above

9. Antigenic determinants formed by the unique structure of the antigen-binding portion of the molecule are called ?
A. Isotypes
B. Allotypes
C. Idiotypes
D. None of the above

10. Immunoglobulins constitute what percentage of plasma proteins ?
A. 2 %
B. 5 %
C. 10 %
D. 20 %

11. Light & heavy chains in antibody molecule are linked by ?
A. Phosphate bond
B. Disulfide bond
C. Sulphar bond
D. Any of the above

12. Normally, quantity of light chains excreted daily by kidney is ?
A. < 10 mg
B. < 20 mg
C. < 30 mg
D. < 40 mg

13. In serum electrophoresis, immunoglobulins form a broad peak in ?
A. Alpha region
B. Beta region
C. Gamma region
D. Delta region

14. “M” in M component stands for ?
A. Myeloma
B. Monocomponent
C. Monoclonal
D. Miscellaneous

15. In serum electrophoresis, the antibody must be present at what concentration to be detectable ?
A. 0.3 g / dL
B. 0.4 g / dL
C. 0.5 g / dL
D. 0.6 g / dL

16. In electrophoretic analysis, M component may be detected in ?
A. Plasma cell disorders
B. Chronic lymphocytic leukemia
C. Chronic myeloid leukemia
D. All of the above
17. In electrophoretic analysis, M component may be detected in ?
A. Plasma cell disorders
B. Breast cancer
C. Colon cancer
D. All of the above
18. In electrophoretic analysis, M component may be detected in ?
A. Cirrhosis
B. Sarcoidosis
C. Gaucher disease
D. All of the above
19. In electrophoretic analysis, M component may be detected in ?
A. Rheumatoid arthritis
B. Myasthenia gravis
C. Lichen myxedematosus
D. All of the above

20. In serum electrophoresis, church spire sharp peak is seen in ?
A. Normal individuals
B. Polyclonal immunoglobulinopathy
C. Monoclonal gammopathy
D. None of the above

21. M component is composed of ?
A. Intact antibody molecule of any heavy chain subclass
B. Altered antibody
C. Antibody fragment
D. Any of the above

22. Bence Jones protein in urine of myeloma patients represents ?
A. Light chains
B. Heavy chains
C. Altered antibody

D. Any of the above
In ~20% of myelomas, only light chains are produced and in most cases are secreted in the
urine as Bence Jones proteins.
733 Which is the most common form of myeloma ?
Harrison’s 18th Ed. 937
A. IgG myeloma
B. IgA myeloma
C. IgD myeloma
D. None of the above
The frequency of myelomas of a particular heavy chain class is roughly proportional to the
serum concentration, and therefore IgG myelomas are more common than IgA and IgD myelomas.
734 Plasma cells are produced in ?
A. Lymph glands
B. Spleen
C. Thymus
D. All of the above
Lymphocytes and plasma cells are produced mainly in lymphogenous tissues like lymph
glands, spleen, thymus, tonsils, and Peyer’s patches.
735 Which of the following interleukins are called B-cell
stimulating factors or B-cell growth factors ?
A. 4
B. 5
C. 6
D. All of the above

Plasma Cell Disorders

[MCQs] Plasma Cell Disorders- Part 1

I. Start the exam by click the “Start” button

Plasma Cell Disorders- Part 1

II. Preview all questions below

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