[MCQs] Plasma Cell Disorders- Part 4

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See all quizzes of  the Plasma Cell Disorders  at here:

Plasma Cell Disorders Part 1 | Plasma Cell Disorders Part 2 | Plasma Cell Disorders Part  3 | Plasma Cell Disorders Part  4

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1.Hematologic diseases causeing massive splenomegaly, anemia and without hyperviscosity include all except ?
A. Chronic myeloid leukemia
B. Agnogenic myeloid metaplasia (with myelofibrosis)
C. POEMS syndrome
D. Chronic lymphocytic leukemia
2.  Hematologic diseases causeing massive splenomegaly, anemia and without hyperviscosity include all except ?
A. Waldenström’s macroglobulinemia
B. Hodgkin’s disease
C. Heavy-chain diseases
D. Amyloidosis (associated with plasma-cell dyscrasias)
3.  Causes of massive splenomegaly include all except ?
A. Gaucher’s disease
B. Niemann-Pick disease
C. Leishmaniasis
D. Toxoplasmosis
4.  Diseases that can cause “massive splenomegaly” are ?
A. Chronic malaria
B. Kala-azar
C. Leishmaniasis
D. All of the above
5.  Which of the following diseases can cause “massive splenomegaly” ?
A. Gaucher disease
B. Hairy cell leukemia
C. Polycythemia vera
D. All of the above

6.  Which of the following statements about Waldenström’s macroglobulinemia is false ?
A. Lymphoplasmacytoid malignancy secreting IgM
B. Hepatosplenomegaly & lymphadenopathy common
C. Hyperviscosity syndrome common
D. None of the above
7.  Waldenström’s Macroglobulinemia resembles which of the following diseases ?
A. Chronic lymphocytic leukemia
B. Myeloma
C. Lymphocytic lymphoma
D. All of the above

8.  Waldenström’s Macroglobulinemia originates from ?
A. Post – germinal center B cell
B. Post – germinal center T cell
C. Pre – germinal center B cell
D. Pre – germinal center T cell

9.  Clinical course of Waldenström’s macroglobulinemia is similar to ?
A. IgA myeloma
B. IgG myeloma
C. IgD myeloma
D. IgM myeloma

10.  IgM in Waldenström’s Macroglobulinemia have specificity for which protein ?
A. Myelin basic protein (MBP)
B. Myelin-associated glycoprotein (MAG)
C. Myelin oligodendrocyte glycoprotein (MOG)
D. All of the above

11.  Which of the following statements about Waldenström’s macroglobulinemia is false ?
A. Renal disease is uncommon
B. Lytic bone lesions are frequent
C. Does not cause hypercalcemia
D. Impairment of vision is a major symptom

12.  Neurologic abnormalities that may be associated with Waldenström’s macroglobulinemia include all except ?
A. Peripheral neuropathy
B. Encephalopathy
C. Ataxia
D. Subarachnoid hemorrhage

13.  Which of the following drugs is useful in Waldenström’s macroglobulinemia ?
A. Fludarabine
B. Cladribine
C. Rituximab (anti-CD20)
D. All of the above

14.  Which of the following is not a feature of POEMS syndrome ?
A. Polyneuropathy
B. Orthostatic hypotension
C. Endocrinopathy
D. Multiple myeloma

15. Which of the following is not a feature of POEMS syndrome ?
A. Polyneuropathy
B. Organomegaly
C. Multiple sclerosis
D. Skin changes

16. Endocrine manifestations seen in POEMS syndrome include ?
A. Amenorrhea
B. Gynecomastia
C. Type 2 diabetes mellitus
D. All of the above

17.  Skin changes seen in POEMS syndrome include ?
A. Hyperpigmentation
B. Hypertrichosis
C. Digital clubbing
D. All of the above

18. Levels of which of the following is low in POEMS syndrome ?
A. IL-1
B. TGF-

C. VEGF
D. TNF

19.  Plasmapheresis is not beneficial in which of the following ?
A. POEMS syndrome
B. Multiple Myeloma
C. TTP/HUS
D. Waldenström’s Macroglobulinemia

20.  Franklin’s disease is also called ?
A. Alpha heavy chain disease
B. Gamma heavy chain disease
C. Mu heavy chain disease
D. None of the above

21.  Seligmann’s disease is also called ?
A. Alpha heavy chain disease
B. Gamma heavy chain disease
C. Mu heavy chain disease
D. None of the above

22. Palatal edema is the distinctive symptom of ?
A. Alpha heavy chain disease
B. Gamma heavy chain disease
C. Mu heavy chain disease
D. None of the above

23.  Which of the following diseases is related to Mediterranean lymphoma ?
A. Alpha heavy chain disease
B. Gamma heavy chain disease
C. Mu heavy chain disease
D. None of the above

24.  Sandhoff disease is nearly identical to which of the following diseases ?
A. Gaucher disease
B. Tay-Sachs disease
C. Neimann-Pick disease
D. Fabry disease

25. Enlarged, grayish yellow or orange tonsils are pathognomonic of ?
A. Waldenström’s macroglobulinemia
B. Polycythemia vera
C. Wolman disease
D. Tangier disease

26.  Which of the following statements about Schnitzler’s syndrome is false ?
A. Associated with IgM monoclonal protein
B. Erythematous, urticarial skin lesions
C. Dermis is infiltrated by malignant lymphocytic and
plasmacytic cells
D. None of the above

27.  Clinical features of Schnitzler’s syndrome all except ?
A. Bone pain
B. Urticarial skin lesions
C. Lymphadenopathy
D. Alopecia

28. Schnitzler’s syndrome includes all except ?

A. IgM monoclonal protein
B. Infiltration of dermis by malignant lymphocytic &
plasmacytic cells
C. Erythematous urticarial skin lesions
D. Serum IgM M component >1000 mg/dL