[MCQs] Malignancies of Lymphoid Cells

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Malignancies of Lymphoid Cells

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Question 1

What was the first name of Hodgkin ?

A	Micheal
B	John
C	Clarke
D	Thomas

Question 1 Explanation:

Sir Thomas Hodgkin presented seven autopsy cases in his famous paper “On some morbid appearances of the absorbent glands and spleen” to the Royal Medical and Chirurgical Society of London on January 10 and 24, 1832. In 1898 and 1902, Carl Sternberg and Dorothy Reed independently described the typical “diagnostic” cells. In 1944, Jackson and Parker proposed the first comprehensive classification of the tumour

Question 2

Ann Arbor staging system for Hodgkin’s Disease was made in which year ?

A	1951
B	1961
C	1971
D	1981

Question 2 Explanation:

The concept of staging Hodgkin’s lymphoma was made at the Ann Arbor Conference in 1971

Question 3

Which of the following statements about Hodgkin’s Disease is false ?

A	Disease not increasing in frequency
B	Most patients present with palpable lymphadenopathy
C	Subdiaphragmatic presentation is unusual
D	None of the above

Question 3 Explanation:

Hodgkin’s disease does not appear to be increasing in frequency. Most patients present with palpable lymphadenopathy (contiguous, nontender, in neck, supraclavicular area, and axilla). 50% patients will have mediastinal adenopathy at diagnosis. Subdiaphragmatic presentation of Hodgkin’s disease is unusual and more common in older males.

Question 4

Unusual manifestations of Hodgkin’s disease include ?

A	Erythema nodosum
B	Paraneoplastic cerebellar degeneration
C	Pain in lymph nodes on alcohol ingestion
D	All of the above

Question 4 Explanation:

Hodgkin’s disease can present with unusual manifestations that are severe & unexplained itching, erythema nodosum, ichthyosiform atrophy, paraneoplastic cerebellar degeneration, nephrotic syndrome, immune hemolytic anemia, thrombocytopenia, hypercalcemia, and pain in lymph nodes on alcohol ingestion.

Question 5

Which of the following about Pel and Ebstein is false ?

A	Their names were Wilhelm Ebstein and P.K. Pel
B	Both published papers in in the same journal in 1887 about fever in Hodgkin’s disease
C	Long-term dispute persisted between Pel & Ebstein on the etiology of Hodgkin’s disease
D	None of the above

Question 5 Explanation:

Pel-Ebstein fever is named after Wilhelm Ebstein & P.K. Pel who both published papers in 1887 in the same journal, though Pel published first by several months. A long-term dispute persisted between Pel and Ebstein on the etiology of the condition

Question 6

Most patients of Hodgkin’s disease have which of the following ?

A	Mixed-cellularity Hodgkin’s disease
B	Nodular sclerosing Hodgkin’s disease
C	Lymphocyte-predominant Hodgkin’s disease
D	Lymphocyte-depleted Hodgkin’s disease

Question 6 Explanation:

In the US, most patients have nodular sclerosing Hodgkin’s disease. Lymphocyte-predominant and lymphocyte-depleted Hodgkin’s disease are rare. Mixed-cellularity Hodgkin’s disease or lymphocyte-depletion Hodgkin’s disease are seen more frequently in patients infected by HIV

Question 7

Nucleus in Reed-Sternberg cell is also described as ?

A	Owl’s eyes” appearance
B	“Spectacle” appearance
C	“Ghost” appearance
D	Moon” appearance

Question 7 Explanation:

A Reed-Sternberg cell is present near the center of the field; a large cell with a bilobed nucleus and prominent nucleoli giving an “owl’s eyes” appearance.

Question 8

What is the diameter of Reed-Sternberg (RS) cells ?

A	5 - 10 µm
B	8 - 16 µm
C	12 - 20 µm
D	20 - 60 µm

Question 8 Explanation:

Reed-Sternberg (RS) measure 20 - 60 µm in diameter and display a large rim of cytoplasm and at least two nuclei with acidophilic or amphophilic nucleoli, covering more than 50% of the nuclear area.

Question 9

Reed-Sternberg (RS) cells are seen in ?

A	Infectious mononucleosis
B	B and T cell lymphomas
C	Melanomas
D	All of the above

Question 9 Explanation:

RS cells are not exclusive to HL because similar elements can be seen in reactive lesions (infectious mononucleosis), B & T cell lymphomas, carcinomas, melanomas, and sarcomas

Question 10

Which of the following is false about classic Hodgkin’s disease ?

A	Typical bimodal age distribution
B	. One peak at 10 - 35 years of age
C	Second peak in late life
D	None of the above

Question 10 Explanation:

Classic Hodgkin’s disease has a typical bimodal age distribution, with a peak at 10 - 35 years of age and a second peak in late life.

Question 11

Hodgkin’s disease is related to ?

A	Neoplastic cells of B cell origin
B	Polyclonal inflammatory infiltrate
C	Monoclonal antibody Ki-1 reactivity to RS cells
D	All of the above

Question 11 Explanation:

Hodgkin’s disease is a tumor characterized by rare neoplastic cells of germinal centre B cell origin in a tumor mass with largely polyclonal inflammatory infiltrate. Monoclonal antibody Ki-1 has reactivity restricted to RS cells. Expression of the CD30 molecule by RS cells is seen in more than 98% of classical Hodgkin’s disease. CD15 is a valuable marker for RS cells and is detected in ~80% of patients with classical Hodgkin’s disease. RS cells usually lack CD45 and epithelial membrane antigen (EMA) expression.

Question 12

Which of the following chemotherapy regimens is used in Hodgkin’s disease ?

A	ABVD
B	MOPP
C	BEACOPP
D	All of the above

Question 12 Explanation:

Chemotherapy regimens used in Hodgkin’s disease include ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), MOPP (mechlorethamine, vincristine, procarbazine, and prednisone), and BEACOPP (bleomycin, cyclophosphamide, doxorubicin, etoposide, prednisone, procarbazine, and vincristine)

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II. Preview all questions below

1.What was the first name of Hodgkin ?
A. Micheal
B. John
C. Clarke
D. Thomas

2. Ann Arbor staging system for Hodgkin’s Disease was made in which year ?
A. 1951
B. 1961
C. 1971
D. 1981

3. Which of the following statements about Hodgkin’s Disease is false ?
A. Disease not increasing in frequency
B. Most patients present with palpable lymphadenopathy
C. Subdiaphragmatic presentation is unusual
D. None of the above

4. Unusual manifestations of Hodgkin’s disease include ?
A. Erythema nodosum
B. Paraneoplastic cerebellar degeneration
C. Pain in lymph nodes on alcohol ingestion
D. All of the above

5. Which of the following about Pel and Ebstein is false ?
A. Their names were Wilhelm Ebstein and P.K. Pel

B. Both published papers in in the same journal in 1887
about fever in Hodgkin’s disease
C. Long-term dispute persisted between Pel & Ebstein on the
etiology of Hodgkin’s disease
D. None of the above

6. Most patients of Hodgkin’s disease have which of the following ?
A. Mixed-cellularity Hodgkin’s disease
B. Nodular sclerosing Hodgkin’s disease
C. Lymphocyte-predominant Hodgkin’s disease
D. Lymphocyte-depleted Hodgkin’s disease

7. Nucleus in Reed-Sternberg cell is also described as ?
A. “Owl’s eyes” appearance
B. “Spectacle” appearance
C. “Ghost” appearance
D. “Moon” appearance

8. What is the diameter of Reed-Sternberg (RS) cells ?
A. 5 – 10 µm
B. 8 – 16 µm
C. 12 – 20 µm
D. 20 – 60 µm

9. Reed-Sternberg (RS) cells are seen in ?
A. Infectious mononucleosis
B. B and T cell lymphomas
C. Melanomas
D. All of the above

10. Which of the following is false about classic Hodgkin’s disease ?
A. Typical bimodal age distribution
B. One peak at 10 – 35 years of age
C. Second peak in late life
D. None of the above

11. Hodgkin’s disease is related to ?
A. Neoplastic cells of B cell origin
B. Polyclonal inflammatory infiltrate
C. Monoclonal antibody Ki-1 reactivity to RS cells
D. All of the above

12. Which of the following chemotherapy regimens is used in Hodgkin’s disease ?
A. ABVD
B. MOPP
C. BEACOPP
D. All of the above

Malignancies of Lymphoid

[MCQs] Malignancies of Lymphoid Cells

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Malignancies of Lymphoid Cells

II. Preview all questions below

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