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Tuberculosis- Part 8
See all quizzes of Tuberculosis- Part 8 here:
1 “Pseudojaundice” is an adverse effect of ?
A. Isoniazid
B. Ethambutol
C. Pyrazinamide
D. Rifabutin
2 Which of the following antitubercular drug is not bacteriostatic ?
A. Amikacin
B. Ethionamide
C. Pyrazinamide
D. Ethambutol
3 Which of the following antitubercular drug is bactericidal ?
A. Streptomycin
B. Rifampin
C. Pyrazinamide
D. All of the above
4 Which of the following antitubercular drug acts only against
extracellular M. tuberculosis ?
A. Rifampin
B. Isoniazid
C. Streptomycin
D. All of the above
5 Resistance to rifampin results from spontaneous point mutations
related to which of the following genes ?
A. katG
B. rpoV
C. rpoB
D. erp
6 Resistance to isoniazid is related to which gene ?
A. katG
B. rpoV
C. rpoB
D. erp
7 Resistance to pyrazinamide is related to which gene ?
A. katG
B. rpoV
C. rpoB
D. pncA
8 Resistance to ethambutol is related to which gene ?
A. katG
B. rpoV
C. embB
D. pncA
9 Which of the following anti-tuberculous agents is not available
for parenteral use ?
A. Rifampin
B. Isoniazid
C. Streptomycin
D. Pyrazinamide
10 Active form of Pyrazinamide is ?
A. Pyrazoic acid
B. Pyrazine acid
C. Pyranoic acid
D. Pyrazinoic acid
11 Pyrazinamide is converted to its active form by ?
A. Liver
B. Kidney
C. Skin
D. Tubercle bacillus
12 Which of the following anti-tuberculous agent is a derivative of
isonicotinic acid ?
A. Ethionamide
B. Isoniazid
C. Pyrazinamide
D. All of the above
13 Which of the following antimycobacterial agents need no change
in dosage in patients with hepatic disease ?
A. Rifampin
B. Rifabutin
C. Rifapentine
D. All of the above
14 Which of the following antimycobacterial agents has no evidence
of risk when used in pregnancy ?
A. Rifampin
B. Rifabutin
C. Rifapentine
D. All of the above
15 “DOTS” stands for ?
A. Directly observed treatment – supervised
B. Directly observed treatment – short course
C. Directly observed treatment – safe
D. Directly observed treatment – sure
16 Which of the following is not an element of WHO DOTS strategy
?
A. Political commitment
B. Case detection by sputum microscopy
C. Specific therapy for patients with drug-resistant TB
D. Standard recording and reporting system
17 Tubercular markers in pleural fluid include ?
A. Adenosine deaminase > 45 IU/L
B. Interferon > 140 pg/mL
C. Positive polymerase chain reaction (PCR) for TB DNA
D. All of the above
18 Pyuria in the absence of bacteriuria (sterile pyuria) indicates
infection with ?
A. C. trachomatis
B. U. urealyticum
C. Mycobacterium tuberculosis
D. All of the above
19 Bilateral hilar adenopathy on chest x-ray indicates ?
A. Sarcoidosis
B. Lymphoma
C. Tuberculosis
D. All of the above
20 Bilateral hilar adenopathy on chest x-ray indicates ?
A. Coccidioidomycosis
B. Brucellosis
C. Bronchogenic carcinoma
D. All of the above
21 Poncet’s disease refers to ?
A. Polyarthritis in disseminated tuberculosis
B. Anterior uveitis in disseminated tuberculosis
C. Posterior uveitis in disseminated tuberculosis
D. Meningitis in disseminated tuberculosis
22 Which of the following drug resistance is observed in M.
tuberculosis ?
A. Acquired resistance
B. Transmitted resistance
C. Amplified resistance
D. All of the above
23 Phenomenon of transmission of drug resistant M. tuberculosis
to new patients leading to drug resistance at the onset is called ?
A. In-situ resistance
B. Primary resistance
C. Adhered resistance
D. Any of the above
24 The global prevalence in new patients of MDR-TB is ?
A. < 1 %
B. < 3 %
C. < 5 %
D. < 8 %
25 Drug resistant tuberculosis refers to ?
A. Resistance to any first line Anti TB drug
B. Resistance to at least INH & rifampicin
C. Resistance to at least INH, rifampicin & fluoroquinolone
D. Resistance to at least INH, rifampicin, fluoroquinolone & a
second line injectable agent
26 Multidrug resistant tuberculosis (MDR-TB) refers to ?
A. Resistance to any first line Anti TB drug
B. Resistance to at least INH & rifampicin
C. Resistance to at least INH, rifampicin & fluoroquinolone
D. Resistance to at least INH, rifampicin, fluoroquinolone & asecond line injectable agent
27 Extensively drug resistant tuberculosis (XDR-TB) refers to ?
A. Resistance to any first line Anti TB drug
B. Resistance to at least INH & rifampicin
C. Resistance to at least INH, rifampicin & fluoroquinolone
D. Resistance to at least INH, rifampicin, fluoroquinolone & a
second line injectable agent
28 Which of the following is not an antitubercular drug ?
A. Prothionamide
B. Terizidone
C. Cyclozidone
D. Thioacetazone
