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Myasthenia Gravis and Diseases of the Neuromuscular Junction- Part 3
See all quizzes of Myasthenia Gravis and Diseases of the Neuromuscular Junction here:
1 Muscle testing reveals “jerky release” or “give-away weakness”
in which of the following ?
A. Lambert-Eaton myasthenic syndrome (LEMS)
B. Botulism
C. Hyperthyroidism
D. Neurasthenia
2 Which of the following cause weeakness of somatic musculature
due to presynaptic neuromuscular junction abnormality ?
A. Lambert-Eaton myasthenic syndrome (LEMS)
B. Botulism
C. Congenital myasthenic syndromes (CMS)
D. All of the above
3 Muscarinic side effects of anticholinesterase medication include
all except ?
A. Diarrhea
B. Abdominal cramps
C. Dry mouth
D. Nausea
4 Thymoma is suspected if thymus is enlarged after ?
A. > 10 years
B. > 20 years
C. > 30 years
D. > 40 years
5 By consensus, thymectomy should be done in all patients with
generalized MG between ?
A. Puberty and 55 years
B. 30 and 55 years
C. 40 and 65 years
D. 50 and 75 years
6 If immediate improvement is essential, which of the following is
used to manage MG ?
A. Thymectomy
B. High-dose cyclophosphamide
C. Glucocorticoids
D. Intravenous immunoglobulin (IVIg)
7 Which of the following produce clinical improvement within a
period of 1 – 3 months ?
A. Glucocorticoids
B. Cyclosporine
C. Tacrolimus
D. All of the above
8 Which of the following immunosuppressive agents is preferred
(toxicity & cost) in treatment of MG ?
A. Azathioprine
B. Cyclosporine
C. Mycophenolate mofetil
D. Cyclophosphamide
9 Beneficial effect of azathioprine takes how long to appear ?
A. 7 – 21 days
B. 1 – 3 months
C. 3 to 6 months
D. 18 months
10 Which of the following is used in MG patients refractory to optimal
treatment with immunosuppressive agents ?
A. Tacrolimus
B. High-dose cyclophosphamide
C. Mycophenolate mofetil
D. Intravenous immunoglobulin (IVIg)
11 Drug of choice for long-term treatment of myasthenic patients
is ?
A. Azathioprine
B. Mycophenolate mofetil
C. Cyclosporine
D. Tacrolimus
12 In patients taking azathioprine, which out of the following drugs
should not be used ?
A. Paracetamol
B. Allopurinol
C. Cephalosporins
D. Terfenadine
13 Which of the following may be used as indications of adequacy of
azathioprine dosage ?
A. Increase in hemoglobin
B. Decrease in ESR
C. Increase in hematocrit
D. Increase of RBC mean corpuscular volume
14 Which of the following drug is useful in the treatment of anti-
MuSK antibody positive MG ?
A. Tacrolimus
B. Rituximab
C. Cyclophosphamide
D. Azathioprine
15 Most common cause of myasthenic crisis is ?
A. Hyperthyroidism
B. Hypothyroidism
C. Intercurrent infection
D. Drug underdose
16 Which of the following is useful to assess MG patient’s clinical
status ?
A. Forward arm abduction time (5 min)
B. Forced vital capacity
C. Time to development of ptosis on upward gaze
D. All of the above
