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Myasthenia Gravis and Diseases of the Neuromuscular Junction- Part 1
See all quizzes of Myasthenia Gravis and Diseases of the Neuromuscular Junction here:
1 Myasthenia gravis (MG) is a neuromuscular disorder involving ?
A. Skeletal muscle
B. Smooth muscle
C. Cardiac muscle
D. All of the above
2 At neuromuscular junctions in myasthenia gravis, the defect in
acetylcholine receptors (AChRs) is ?
A. Decrease in their number
B. Decrease in their size
C. Alteration in their shape
D. All of the above
3 Which of the following is false about neuromuscular junction in
MG ?
A. Normal nerve terminal
B. Flattened, simplified postsynaptic folds
C. Widened synaptic space
D. None of the above
4 Structure of AChR consists of ?
A. 1-alpha, 2-beta, 1-delta, and 1-gamma or epsilon
B. 1-alpha, 1-beta, 2-delta, and 1-gamma or epsilon
C. 1-alpha, 1-beta, 1-delta, and 2-gamma or epsilon
D. 2-alpha, 1-beta, 1-delta, and 1-gamma or epsilon
5 Which of the following about Myasthenia gravis is false ?
A. Acetylcholine receptor consists of five subunits – 1alpha,
2beta, 1gamma, 1delta or 1epsilon
B. Pathologic antibodies are IgG & are T cell dependent
C. Absence of anti AChR antibodies does not exclude diagnosis
D. Mycophenolate mofetil is useful
6 With the opening of the channel in AChR, which of the following
cation gains rapid entry ?
A. Sodium
B. Potassium
C. Calcium
D. Magnesium
7 Acetylcholinesterase (AChE) rapidly terminates the action of ACh
by ?
A. Oxidation
B. Reduction
C. Hydrolysis
D. Phosphorylation
8 Which of the following about myasthenia gravis is false ?
A. ACh is released normally
B. Decrease in number of available ACh receptors
C. Increased presynaptic rundown
D. Thymus abnormal in ~ 75 % of patients
9 In MG, the autoimmune antibody is targetted against ?
A. Acetylcholine
B. Acetylcholine receptor (AChR)
C. Acetylcholinesterase (AChE)
D. All of the above
10 In MG, anti-AChR antibodies reduce the number of available AChRs
at NM junctions by which mechanism ?
A. Endocytosis of the receptors
B. Blockade of the active site of AChR
C. Damage to postsynaptic muscle membrane
D. All of the above
11 Pathogenic anti-AChR antibody in myasthenia gravis is ?
A. IgA
B. IgG
C. IgM
D. IgE
12 Thymus is abnormal in what proportion of patients with MG ?
A. 25 %
B. 50 %
C. 75 %
D. 100 %
13 Thymoma along with which of the following is called Good’s
syndrome ?
A. Pure red cell aplasia
B. Hypogammaglobulinemia
C. Systemic lupus erythematosus
D. Ulcerative colitis
14 Staging system for thymomas is named after ?
A. Atkin
B. Falkson
C. Masaoka
D. Tomaszek
15 Thymoma and / or myasthenia gravis is associated with which of
the following ?
A. Pemphigus Vulgaris
B. Pemphigus Foliaceus
C. Paraneoplastic Pemphigus
D. Bullous Pemphigoid
16 In myasthenia gravis, which of the following spirometric statement
is false ?
A. Normal FRC
B. Low TLC
C. Elevated RV
D. Normal FVC
17 Type of respiratory failure in MG is usually ?
A. Type I
B. Type II
C. Type III
D. Type IV
18 Myasthenia gravis is related to which of the following ?
A. Neuromyelitis optica (NMO)
B. M component on electrophoretic analysis
C. Hyperthyroidism
D. All of the above
19 Which of the following about myasthenia gravis is false ?
A. Women more affected than men
B. Lids & extraocular muscles involved early
C. Limb weakness is proximal and asymmetric
D. Deep tendon reflexes diminished
20 Fluctuating ptosis that worsens late in the day is typical of ?
A. Myasthenia gravis
B. Glaucoma
C. Optic nerve glioma
D. Orbital cellulitis
21 Which of the following is an eye related finding in myasthenia
gravis ?
A. Pupils are always normal
B. Diplopia is intermittent & variable
C. Diplopia is not confined to any single ocular motor nerve
D. None of the above
22 Cause of episodic generalized weakness is ?
A. Myasthenia gravis
B. Lambert-Eaton myasthenic syndrome
C. Multiple sclerosis
D. All of the above
