[MCQ] Alzheimer’s disease- Part 4

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Alzheimer’s disease- Part 4

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Question 1

In Huntington’s disease (HD), which of the following is predominantly atrophied ?

A	Striatum
B	Cerebellum
C	Hippocampus
D	Mamillary bodies

Question 1 Explanation:

Neuropathology of HD consists of widespread cerebral atrophy with prominent involvement of striatum and cerebral cortex.

Question 2

Which of the following is not a feature of normal-pressure hydrocephalus (NPH) ?

A	Abnormal gait
B	Dementia
C	Chorea
D	Urinary incontinence

Question 2 Explanation:

Clinical triad of normal-pressure hydrocephalus (NPH) includes abnormal gait (ataxic or apractic), mild to moderate dementia and urinary incontinence.

Question 3

Cortical atrophy is not a feature of ?

A	AD
B	FTD
C	NPH
D	CJD

Question 3 Explanation:

In NPH, neuroimaging shows enlarged lateral ventricles (hydrocephalus) with little or no cortical atrophy with a patent aqueduct of Sylvius suggesting communicating hydrocephalus.

Question 4

Which of the following is not a MRI feature of Normal-pressure hydrocephalus ?

A	Stretching of corpus callosum
B	Elevation of the floor of third ventricle
C	Enlargement of the aqueduct
D	Dilation of the lateral ventricle

Question 4 Explanation:

MRI feature of normal-pressure hydrocephalus (NPH) include dilation of lateral ventricle, stretching of corpus callosum, depression of the floor of third ventricle, enlargement of the patent aqueduct (communicating hydrocephalus).

Question 5

Which of the following is a feature of gait abnormality in NPH ?

A	External hip rotation
B	Low foot clearance
C	Short strides
D	All of the above

Question 5 Explanation:

Characteristic “magnetic” gait with external hip rotation, low foot clearance and short strides, along with prominent truncal sway or instability, favors NPH.

Question 6

Dementia & seizures in Marchiafava-Bignami disease is related to ?

A	Male
B	Italian
C	Drinkers of red wine
D	All of the above

Question 7

Which of the following degenerates in Marchiafava-Bignami disease ?

A	Caudate nucleus
B	Thalamus
C	Corpus callosum
D	Substantia nigra

Question 7 Explanation:

Marchiafava-Bignami disease consists of dementia and seizures with degeneration of corpus callosum in male Italian drinkers of red wine

Question 8

Which of the following is not related to Wernicke’s encephalopathy ?

A	Confusion
B	Seizure
C	Ataxia
D	Diplopia

Question 8 Explanation:

Clinical presentation of Wernicke’s encephalopathy include confusion, ataxia, & diplopia due to ophthalmoplegia.

Question 9

Thiamine deficiency damages which of the following ?

A	Thalamus
B	Mammillary bodies
C	Midline cerebellum
D	All of the above

Question 9 Explanation:

Thiamine (vitamin B1) deficiency damages thalamus, mammillary bodies, midline cerebellum, periaqueductal grey matter of midbrain, peripheral nerves and trochlear & abducens nuclei.

Question 10

In Thiamine deficiency, damage to which of the following correlates most closely with memory loss ?

A	Dorsomedial thalamus
B	Mammillary bodies
C	Midline cerebellum
D	Periaqueductal grey matter of midbrain

Question 10 Explanation:

In thiamine deficiency, damage to dorsomedial thalamus correlates most closely with memory loss.

Question 11

Which of the following is related to Korsakoff’s psychosis ?

A	Prolonged untreated thiamine deficiency
B	Irreversible dementia
C	Amnestic syndrome
D	All of the above

Question 11 Explanation:

Prolonged untreated thiamine deficiency results in irreversible dementia / amnestic syndrome (Korsakoff’s psychosis) or even death.

Question 12

In Vitamin B12 deficiency, damage occurs to ?

A	Posterior columns
B	Corticospinal tracts
C	Peripheral nerves
D	All of the above

Question 12 Explanation:

In Vitamin B12 deficiency, damage occur to posterior columns, corticospinal tracts, peripheral nerves and cerebral myelinated fibers (dementia).

Question 13

In Vitamin B12 deficiency, neurologic damage is related to ?

A	Inhibition of -aminolevulinic acid dehydrase
B	Deficiency of S-adenosyl methionine
C	Elevated plasma levels of A amyloid
D	All of the above

Question 13 Explanation:

Mechanism of neurologic damage in Vitamin B12 deficiency is related to deficiency of S-adenosyl methionine which is required for methylation of myelin phospholipids

Question 14

Limbic encephalitis best relates to ?

A	Primary neoplasms of CNS
B	Metastatic neoplasms of CNS
C	Paraneoplastic syndrome
D	Isolated vasculitis of CNS

Question 14 Explanation:

A paraneoplastic syndrome of dementia associated with occult carcinoma (small cell lung cancer) is termed limbic encephalitis in which confusion, agitation, seizures, poor memory, emotional changes, and frank dementia may occur

Question 15

Which of the following chronic metal exposure can lead to choreoathetosis ?

A	Chronic mercury poisoning
B	Aluminum poisoning
C	Chronic arsenic intoxication
D	Chronic lead poisoning

Question 15 Explanation:

Chronic mercury poisoning produces dementia, peripheral neuropathy, ataxia, and tremulousness that may progress to choreoathetosis.

Question 16

Mees’ lines are best related to ?

A	Chronic mercury poisoning
B	Aluminum poisoning
C	Chronic arsenic intoxication
D	Chronic lead poisoning

Question 16 Explanation:

Mees’ lines are transverse white lines of the fingernails seen in chronic arsenic intoxication

Question 17

Which of the following chronic metal exposure can lead to myoclonic jerks ?

A	Chronic mercury poisoning
B	Aluminum poisoning
C	Chronic arsenic intoxication
D	Chronic lead poisoning

Question 17 Explanation:

Dialysis dementia syndrome due to aluminum overexposure is associated with confusion, aphasia, memory loss, agitation, and, later, lethargy and stupor. Speech arrest and myoclonic jerks are common and associated with severe and generalized EEG changes

Question 18

“Dementia pugilistica” is related to which of the following ?

A	Nonconvulsive seizure disorder
B	Transient global amnesia (TGA)
C	Chronic metal exposure
D	Recurrent head trauma in professional boxers

Question 18 Explanation:

Recurrent head trauma in professional boxers may lead to dementia, called the “punch drunk” syndrome or dementia pugilistica.

Question 19

In Transient global amnesia (TGA), which of the following memory types is lost ?

A	Working
B	Episodic
C	Remote
D	All of the above

Question 19 Explanation:

Transient global amnesia is characterized by sudden onset of a severe episodic memory deficit in the setting of an emotional stimulus or physical exertion, in persons over age 50 years.

Question 20

Along with dementia, myoclonus is a feature of which of the following disease ?

A	Neuronal cerebrolipofuscinoses
B	Creutzfeldt - Jakob disease
C	Corticobasal degeneration (CBD)
D	All of the above

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See all quizzes of Alzheimer’s disease at here:

Alzheimer’s disease- Part 1| Alzheimer’s disease- Part 2| Alzheimer’s disease- Part 3| Alzheimer’s disease- Part 4

1 In Huntington’s disease (HD), which of the following is
predominantly atrophied ?
A. Striatum
B. Cerebellum
C. Hippocampus
D. Mamillary bodies

2 Which of the following is not a feature of normal-pressure
hydrocephalus (NPH) ?
A. Abnormal gait
B. Dementia
C. Chorea
D. Urinary incontinence

3 Cortical atrophy is not a feature of ?
A. AD
B. FTD
C. NPH
D. CJD

4 Which of the following is not a MRI feature of Normal-pressure
hydrocephalus ?
A. Stretching of corpus callosum
B. Elevation of the floor of third ventricle
C. Enlargement of the aqueduct
D. Dilation of the lateral ventricle

5 Which of the following is a feature of gait abnormality in
NPH ?
A. External hip rotation
B. Low foot clearance
C. Short strides
D. All of the above

6 Dementia & seizures in Marchiafava-Bignami disease is related to ?
A. Male
B. Italian
C. Drinkers of red wine
D. All of the above
7 Which of the following degenerates in Marchiafava-Bignami
disease ?
A. Caudate nucleus
B. Thalamus
C. Corpus callosum
D. Substantia nigra

8 Which of the following is not related to Wernicke’s
encephalopathy ?
A. Confusion
B. Seizure
C. Ataxia
D. Diplopia

9 Thiamine deficiency damages which of the following ?
A. Thalamus
B. Mammillary bodies
C. Midline cerebellum
D. All of the above

10 In Thiamine deficiency, damage to which of the following
correlates most closely with memory loss ?
A. Dorsomedial thalamus
B. Mammillary bodies
C. Midline cerebellum
D. Periaqueductal grey matter of midbrain

11 Which of the following is related to Korsakoff’s psychosis ?
A. Prolonged untreated thiamine deficiency
B. Irreversible dementia
C. Amnestic syndrome
D. All of the above

12 In Vitamin B12 deficiency, damage occurs to ?
A. Posterior columns
B. Corticospinal tracts
C. Peripheral nerves
D. All of the above

13 In Vitamin B12 deficiency, neurologic damage is related to ?
A. Inhibition of -aminolevulinic acid dehydrase
B. Deficiency of S-adenosyl methionine
C. Elevated plasma levels of A amyloid
D. All of the above

14 Limbic encephalitis best relates to ?
A. Primary neoplasms of CNS
B. Metastatic neoplasms of CNS
C. Paraneoplastic syndrome
D. Isolated vasculitis of CNS

15 Which of the following chronic metal exposure can lead to
choreoathetosis ?
A. Chronic mercury poisoning
B. Aluminum poisoning
C. Chronic arsenic intoxication
D. Chronic lead poisoning

16 Mees’ lines are best related to ?
A. Chronic mercury poisoning
B. Aluminum poisoning
C. Chronic arsenic intoxication
D. Chronic lead poisoning

17 Which of the following chronic metal exposure can lead to
myoclonic jerks ?
A. Chronic mercury poisoning
B. Aluminum poisoning
C. Chronic arsenic intoxication
D. Chronic lead poisoning

18 “Dementia pugilistica” is related to which of the following ?
A. Nonconvulsive seizure disorder
B. Transient global amnesia (TGA)
C. Chronic metal exposure
D. Recurrent head trauma in professional boxers

19 In Transient global amnesia (TGA), which of the following memory
types is lost ?
A. Working
B. Episodic
C. Remote
D. All of the above

20 Along with dementia, myoclonus is a feature of which of the
following disease ?
A. Neuronal cerebrolipofuscinoses
B. Creutzfeldt – Jakob disease
C. Corticobasal degeneration (CBD)
D. All of the above

Alzheimer’s disease

[MCQ] Alzheimer’s disease- Part 4

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Alzheimer’s disease- Part 4

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