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Alzheimer’s disease- Part 1
See all quizzes of Alzheimer’s disease at here:
Alzheimer’s disease- Part 1| Alzheimer’s disease- Part 2| Alzheimer’s disease- Part 3| Alzheimer’s disease- Part 4
1 Alois Alzheimer belonged to which nation ?
A. Spain
B. Germany
C. Poland
D. Sweden
2 Which of the following President of United States of America
suffered from Alzheimer’s disease ?
A. Richard Nixon
B. Lyndon B. Johnson
C. Gerald Ford
D. Ronald Reagan
3What percentage of mild cognitive impairment individuals will
progress to Alzheimer’s disease (AD) in 4 years ?
A. ~ 20 %
B. ~ 30 %
C. ~ 40 %
D. ~ 50 %
3 Cognitive changes of AD characteristically begin with ?
A. Memory impairment
B. Language deficit
C. Visuospatial deficit
D. Any of the above
4 Term mild cognitive impairment (MCI) is applied when memory
loss falls how many standard deviations below normal on
standardized memory tests ?
A. 0.5
B. 1.0
C. 1.5
D. 2.0
5 In the middle stages of AD, which of the following remains intact
?
A. Social graces
B. Routine behavior
C. Superficial conversation
D. All of the above
6 Which of the following is rare in AD ?
A. Hyperactive tendon reflexes
B. Myoclonic jerks
C. Resting tremor
D. Delusion
7 The typical duration of Alzheimer’s disease is ?
A. 2 – 3 years
B. 4 – 6 years
C. 6 – 8 years
D. 8 – 10 years
8 Neuroimaging studies in AD may show atrophy in ?
A. Medial temporal lobes
B. Lateral and medial parietal lobes
C. Lateral frontal cortex
D. All of the above
9 Risk factors for AD are ?
A. Old age
B. Positive family history
C. Female gender
D. All of the above
10 Most severe pathology in Alzheimer’s disease is found in ?
A. Hippocampus
B. Temporal cortex
C. Nucleus basalis of Meynert
D. All of the above
11 In Alzheimer’s disease, which of the following neurotransmitters
in cerebral cortex are decreased ?
A. Acetylcholine
B. Norepinephrine
C. Serotonin
D. All of the above
12 Which of the following statements is true about microscopic
findings in Alzheimer’s disease ?
A. Neuritic plaques contain A amyloid
B. Silver staining neurofibrillary tangles in cytoplasm
C. A amyloid in arterial walls of cerebral blood vessels
D. All of the above
13 Which of the following clinical features of Alzheimer’s disease
occurs in the later phases of the disease ?
A. Amnesic type of memory impairment
B. Deterioration of language
C. Visuospatial deficits
D. Gait disturbances
14 In Alzheimer’s disease, the neuritic plaque contains ?
A. A amyloid
B. Apo 4
C. antichymotrypsin
D. All of the above
15 Which of the following statements is true about A amyloid in
Alzheimer’s disease ?
A. Neuritic plaques contains A amyloid
B. It is a protein of 39 – 42 amino acids
C. Derived proteolytically from amyloid precursor protein
D. All of the above
16 A peptide results from cleavage of amyloid precursor protein
(APP) by ?
A. secretase
B. secretase
C. secretase
D. All of the above
17 Which of the following products of Amyloid precursor protein
(APP) is neurotoxic ?
A. A42
B. A40
C. P3
D. All of the above
18 of which peptide is most neurotoxic ?
A. A36
B. A38
C. A40
D. A42
19 In Alzheimer’s disease, neuritic plaque is surrounded by ?
Harrison’s 17th Ed. 2541
A. Debris of degenerating neurons
B. Microglia
C. Macrophages
D. All of the above
20 In Alzheimer’s disease, amyloid angiopathy may lead to ?
A. Microhemorrhages
B. Large lobar hemorrhages
C. Ischemic infarctions
D. All of the above
21 Neurofibrillary tangles (NFTs) in Alzheimer’s disease is
characterized by all except ?
Harrison’s 18th Ed. 3306
A. Found in neuronal cytoplasm
B. Paired helical & twisted neurofilaments
C. Represent abnormally phosphorylated tau protein
D. Gold staining