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Alzheimer’s disease- Part 2
See all quizzes of Alzheimer’s disease at here:
Alzheimer’s disease- Part 1| Alzheimer’s disease- Part 2| Alzheimer’s disease- Part 3| Alzheimer’s disease- Part 4
1 Tau protein is characterized by all except ?
A. It is a microtubule associated protein
B. Functions to assemble and stabilize microtubules
C. In Alzheimer’s disease, it is hypophosphorylated
D. Progressive supranuclear palsy may represent a tau
pathologic process
2 Tau protein has pathological significance in which of the following
disorders ?
A. Alzheimer’s disease
B. Frontotemporal dementia
C. Progressive supranuclear palsy
D. All of the above
3 APP gene implicated in the pathogenesis of Alzheimer’s disease
is present on which chromosome ?
A. Chromosome 9
B. Chromosome 11
C. Chromosome 18
D. Chromosome 21
4 Presenilin-1 (PS-1) gene implicated in the pathogenesis of
Alzheimer’s disease is present on which chromosome ?
A. Chromosome 9
B. Chromosome 11
C. Chromosome 14
D. Chromosome 21
5 Presenilin-2 (PS-2) gene implicated in the pathogenesis of
Alzheimer’s disease is present on which chromosome ?
A. Chromosome 1
B. Chromosome 11
C. Chromosome 14
D. Chromosome 21
6 Which of the following about S182 & STM2 is false ?
A. Cytoplasmic neuronal proteins
B. Widely expressed throughout nervous system
C. Homologous to cell-trafficking protein – sel 12
D. None of the above
7 Mutations in which of the following gene causes early-onset
Familial Alzheimer’s disease (FAD) ?
A. APP
B. Presenilin-1 (PS-1)
C. Presenilin-2 (PS-2)
D. Apo gene
8 Apo gene implicated in the pathogenesis of Alzheimer’s disease
is present on which chromosome ?
A. Chromosome 1
B. Chromosome 11
C. Chromosome 19
D. Chromosome 21
9 Gene implicated in pathogenesis of Alzheimer’s disease is ?
A. APP
B. Presenilin-1 (PS-1) & Presenilin-2 (PS-2)
C. Apo gene
D. All of the above
AD genes include APP, Presenilin-1 (PS-1), Presenilin-2 (PS-2) and Apo gene.
10 Mutations in which gene is the most common cause of late-onset
familial & sporadic forms of Alzheimer’s disease ?
A. APP
B. Presenilin-1 (PS-1)
C. Presenilin-2 (PS-2)
D. Apo gene
11 Age of onset of sporadic & familial forms of AD is modulated by
which allelic variants of apolipoprotein ?
A. 2
B. 3
C. 4
D. All of the above
12 For Alzheimer’s disease, which allelic variant of apolipoprotein
is protective ?
A. 2
B. 3
C. 4
D. All of the above
13 Carrying of which APO allele nearly doubles the lifetime risk of
Alzheimer’s disease ?
A. APO 2
B. APO 3
C. APO 4
D. None of the above
14 Apo 4 allele associated with which of the following diseases ?
A. AD
B. FTD
C. DLB
D. CJD
15 Which of the following gene is implicated in AD pathogenesis ?
A. Clusterin (CLU)
B. Phosphatidylinositol-binding clathrin assembly protein
(PICALM)
C. Complement component (3b/4b) receptor 1 (CR1)
D. All of the above
16 Adults with which of the following consistently develop typical
neuropathologic hallmarks of AD ?
A. Klienfelter syndrome
B. Turner syndrome
C. Down’s syndrome
D. All of the above
17Which of the underementioned drug for Alzheimer’s disease is a
cholinesterase inhibitor ?
A. Tacrine
B. Donepezil
C. Rivastigmine
D. All of the above
18 Which of the underementioned drug for Alzheimer’s disease is a
cholinesterase inhibitor ?
A. Galantamine
B. Donepezil
C. Rivastigmine
D. All of the above
19Which of the following acts on N-methyl-D-aspartate (NMDA)
channels ?
A. Donepezil
B. Rivastigmine
C. Memantine
D. Galantamine
20 Which of the following drugs is contraindicated in patients with
Parkinson’s disease ?
A. Galantamine
B. Donepezil
C. Rivastigmine
D. Haloperidol
21 Which of the following drugs is associated with an increased risk
of stroke ?
A. Galantamine
B. Donepezil
C. Rivastigmine
D. Risperidone
23 Which of the following drug has been discarded due to
hepatotoxicity ?
A. Donepezil
B. Rivastigmine
C. Tacrine
D. Galantamine
24 Tarenflurbil and Semagacestat are ?
A. Estrogen analogues
B. Vaccines
C. Gamma secretase inhibitors
D. HMG-CoA reductase inhibitors
