[MCQ] Acute viral hepatitis- Part 6

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[MCQ] Acute viral hepatitis- Part 6

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Congratulations - you have completed [MCQ] Acute viral hepatitis- Part 6. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

William Thomas Councilman (1854-1933) was of which nationality ?

A	British
B	American
C	American
D	Canadian

Question 1 Explanation:

Councilman bodies are named after American pathologist William Thomas Councilman (1854-1933) who discovered them.

Question 2

Councilman bodies are best related to ?

A	Fibrosis
B	Liver cell regeneration
C	Apoptosis
D	Growth arrest

Question 2 Explanation:

Liver cell damage leads to acidophilic degeneration of hepatocytes called Councilman or apoptotic bodies.

Question 3

Which of the following is seen in chronic but not in acute HBV infection ?

A	Acidophilic degeneration of hepatocytes
B	Ballooning of hepatocytes
C	Hepatocyte dropout
D	Ground-glass appearance of cytoplasm

Question 3 Explanation:

Large hepatocytes with a ground-glass appearance of the cytoplasm may be seen in chronic but not in acute HBV infection.

Question 4

Ground-glass appearance of the cytoplasm in chronic HBV infection is due to ?

A	HBsAg
B	HBeAg
C	HBcAg
D	HBxAg

Question 4 Explanation:

Ground-glass appearance of the cytoplasm in chronic HBV infection is due to HBsAg and can be identified histochemically with orcein or aldehyde fuchsin.

Question 5

In hepatitis C, the most remarkable histologic feature is ?

A	Marked increase in activation of sinusoidal lining cells
B	Relative paucity of inflammation
C	Lymphoid aggregates
D	Bile duct lesions

Question 5 Explanation:

In hepatitis C, the histologic lesion is remarkable for a relative paucity of inflammation.

Question 6

Marked cholestasis is a feature of ?

A	HAV
B	HCV
C	HDV
D	HEV

Question 6 Explanation:

Marked cholestasis is a common histologic feature of hepatitis E.

Question 7

What was earlier called bridging hepatic necrosis is also called ?

A	Gradual hepatitis
B	Interface hepatitis
C	Coupled hepatitis
D	Destruction hepatitis

Question 7 Explanation:

In acute hepatitis, bridging hepatic necrosis, also termed subacute or confluent necrosis or interface hepatitis is observed occasionally

Question 8

What was earlier called piecemeal necrosis is now called ?

A	Gradual hepatitis
B	Interface hepatitis
C	Coupled hepatitis
D	Destruction hepatitis

Question 8 Explanation:

Piecemeal necrosis or limiting plate necrosis is now called "interface hepatitis"

Question 9

In bridging hepatic necrosis, the bridge consists of ?

A	Condensed reticulum
B	Inflammatory debris
C	Degenerating liver cells
D	All of the above

Question 9 Explanation:

In bridging hepatic necrosis, the bridge consists of condensed reticulum, inflammatory debris, and degenerating liver cells that span adjacent portal areas, portal to central veins, or central vein to central vein. There is collapse of the reticulin framewor

Question 10

Which of the following is localized to hepatocyte nucleus ?

A	HAV antigen
B	HCV antigen
C	HDV antigen
D	HEV antigen

Question 10 Explanation:

HDV antigen is localized to hepatocyte nucleus, while HAV, HCV & HEV antigens are localized to the cytoplasm

Question 11

Which of the following body fluid from infected persons is most infectious ?

A	Semen
B	Saliva
C	Serum
D	All are equally infectious

Question 11 Explanation:

HBsAg is identified in almost every body fluid from infected persons. Semen & saliva are infectious though less than serum.

Question 12

Which of the following is the mode of HBV transmission ?

A	Percutaneous inoculation
B	Sexual contact
C	Perinatal transmission
D	All of the above

Question 13

What is not true for Hepatitis B virus infections ?

A	Can be transmitted through breast milk
B	Incubation period for acute infection is 45 to 160 days
C	Risk of chronicity in infected neonates is 90 %
D	No known animal reservoirs

Question 13 Explanation:

~10% of HBV infections are acquired in utero. Most infections occur at the time of delivery and early postpartum period & are not related to breast feeding.

Question 14

Perinatal transmission occurs in infants born to HBsAg carrier mothers during ?

A	First trimester of pregnancy
B	Second trimester of pregnancy
C	Third trimester of pregnancy
D	Any of the above

Question 14 Explanation:

Perinatal transmission occurs primarily in infants born to HBsAg carrier mothers or mothers with acute hepatitis B during third trimester of pregnancy or during the early postpartum period.

Question 15

Which of the following mothers almost invariably transmit hepatitis B infection to their offspring ?

A	HBsAg-positive + HBeAg-positive
B	HBsAg-negative + HBeAg-negative
C	HBsAg-positive + HBeAg-negative
D	HBsAg-positive + HBeAg-negative

Question 15 Explanation:

HBsAg positive mothers who are HBeAg-positive almost invariably (>90%) transmit hepatitis B infection to their offspring, whereas HBsAg carrier mothers with anti-HBe rarely (10 - 15%) infect their offspring

Question 16

Likelihood of perinatal transmission of HBV correlates with the presence of ?

A	HBsAg
B	HBcAg
C	HBeAg
D	HBxAg

Question 16 Explanation:

Likelihood of perinatal transmission of HBV correlates with presence of HBeAg. 90% of HBeAgpositive mothers but only 10–15% of anti-HBe-positive mothers transmit HBV infection to their offspring

Question 17

Hepatitis B virus (HBV) chronically infects how many people worldwide ?

A	50 million
B	100 million
C	250 million
D	350 million

Question 17 Explanation:

Hepatitis B virus (HBV) chronically infects over 350 million people worldwide

Question 18

Prevalence of HBV sero-positivity is more in ?

A	Down’s syndrome
B	Lepromatous leprosy
C	Hodgkin’s disease
D	All of the above

Question 18 Explanation:

Prevalence of 5-20% is found in Down’s syndrome, lepromatous leprosy, leukemia, Hodgkin’s disease, polyarteritis nodosa, CKD patients on dialysis and IDUs

Question 19

Risk of acquiring HBV infection from a blood transfusion is ?

A	1 in 50,000
B	1 in 140,000
C	1 in 230,000
D	1 in 320,000

Question 19 Explanation:

1 in 320,000

Question 20

Which of the following about HCV infection is false ?

A	Accounts for 40% of chronic liver disease
B	Most frequent indication for liver transplantation
C	Worldwide, genotype 1 is the most common
D	Breast-feeding increases risk of HCV vertical infection

Question 20 Explanation:

Worldwide, genotype 1 is the most common. Genotype 4 predominates in Egypt; genotype 5 is localized to South Africa, and genotype 6 to Hong Kong. Breast-feeding does not increase the risk of HCV infection between an infected mother and her infant

Question 21

Hepatitis virus with longest incubation period is ?

A	Hepatitis A
B	Hepatitis B
C	Hepatitis C
D	Hepatitis E

Question 22

Hepatitis virus with an incubation period of ~2 weeks is ?

A	Hepatitis A
B	Hepatitis C
C	Hepatitis E
D	All of the above

Question 22 Explanation:

Incubation period in days : HAV - 15-45, mean 30, HBV - 30-180, mean 60-90, HCV - 15-160, mean 50, HDV - 30-180, mean 60-90, HEV - 14-60, mean 40.

Question 23

Viral hepatitis with an insidious onset only is ?

A	Hepatitis A
B	Hepatitis B
C	Hepatitis C
D	Hepatitis C

Question 23 Explanation:

Onset : HAV - acute, HBV - insidious or acute, HCV - insidious, HDV - insidious or acute, HEV - acute

Question 24

Which of the following about presentation of acute viral hepatitis is false ?

A	Constitutional symptoms may precede onset of jaundice by 1 - 2 weeks
B	Dark urine & clay-colored stools occur 1 - 5 days before onset of clinical jaundice
C	Alterations in olfaction and taste
D	None of the above

Question 25

Which of the following is a presentation of acute viral hepatitis ?

A	Splenomegaly
B	Cervical adenopathy
C	Spider angiomas
D	All of the above

Question 26

Acute hepatitis B is self-limited in what proportion of cases ?

A	50 - 69 %
B	69 - 79 %
C	79 - 89 %
D	95 - 99 %

Question 26 Explanation:

Acute hepatitis B is self-limited in 95 - 99% of infections, while hepatitis C is self-limited in only 15%.

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See all quizzes of Acute viral hepatitis at here:

1.lWilliam Thomas Councilman (1854-1933) was of which
nationality ?
A. British
B. American

C. Ireland
D. Canadian

2. Councilman bodies are best related to ?
A. Fibrosis
B. Liver cell regeneration
C. Apoptosis
D. Growth arrest

3. Which of the following is seen in chronic but not in acute HBV
infection ?
A. Acidophilic degeneration of hepatocytes
B. Ballooning of hepatocytes
C. Hepatocyte dropout
D. Ground-glass appearance of cytoplasm

4. Ground-glass appearance of the cytoplasm in chronic HBV
infection is due to ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg

5. In hepatitis C, the most remarkable histologic feature is ?
A. Marked increase in activation of sinusoidal lining cells
B. Relative paucity of inflammation
C. Lymphoid aggregates
D. Bile duct lesions
6. Marked cholestasis is a feature of ?
A. HAV
B. HCV
C. HDV
D. HEV

7. What was earlier called bridging hepatic necrosis is also
called ?
A. Gradual hepatitis
B. Interface hepatitis

C. Coupled hepatitis
D. Destruction hepatitis

8. What was earlier called piecemeal necrosis is now called ?
A. Gradual hepatitis
B. Interface hepatitis
C. Coupled hepatitis
D. Destruction hepatitis

9. In bridging hepatic necrosis, the bridge consists of ?
A. Condensed reticulum
B. Inflammatory debris
C. Degenerating liver cells
D. All of the above

10. Which of the following is localized to hepatocyte nucleus ?
A. HAV antigen
B. HCV antigen
C. HDV antigen
D. HEV antigen

11. Which of the following hepatitis can be transmitted by fecal
oral route ?
A. Hepatitis B
B. Hepatitis C
C. Hepatitis D
D. None of the above

12. Which of the following body fluid from infected persons is
most infectious ?
A. Semen
B. Saliva
C. Serum
D. All are equally infectious

13. Which of the following is the mode of HBV transmission ?
A. Percutaneous inoculation
B. Sexual contact

C. Perinatal transmission
D. All of the above
14. What is not true for Hepatitis B virus infections ?
A. Can be transmitted through breast milk
B. Incubation period for acute infection is 45 to 160 days
C. Risk of chronicity in infected neonates is 90 %
D. No known animal reservoirs

15. Perinatal transmission occurs in infants born to HBsAg carrier
mothers during ?
A. First trimester of pregnancy
B. Second trimester of pregnancy
C. Third trimester of pregnancy
D. Any of the above

16. Which of the following mothers almost invariably transmit
hepatitis B infection to their offspring ?
A. HBsAg-positive + HBeAg-positive
B. HBsAg-negative + HBeAg-negative
C. HBsAg-positive + HBeAg-negative
D. HBsAg-negative + HBeAg-positive
.
17. Likelihood of perinatal transmission of HBV correlates with
the presence of ?
A. HBsAg
B. HBcAg
C. HBeAg
D. HBxAg

18. Hepatitis B virus (HBV) chronically infects how many people
worldwide ?
A. 50 million
B. 100 million
C. 250 million
D. 350 million

19. Prevalence of HBV sero-positivity is more in ?
A. Down’s syndrome
B. Lepromatous leprosy

C. Hodgkin’s disease
D. All of the above

20. Risk of acquiring HBV infection from a blood transfusion is ?
A. 1 in 50,000
B. 1 in 140,000
C. 1 in 230,000
D. 1 in 320,000

21. Which of the following about HCV infection is false ?
A. Accounts for 40% of chronic liver disease
B. Most frequent indication for liver transplantation
C. Worldwide, genotype 1 is the most common
D. Breast-feeding increases risk of HCV vertical infection

22. Hepatitis virus with longest incubation period is ?
A. Hepatitis A
B. Hepatitis B
C. Hepatitis C
D. Hepatitis E
23. Hepatitis virus with an incubation period of ~2 weeks is ?
A. Hepatitis A
B. Hepatitis C
C. Hepatitis E
D. All of the above

24. Viral hepatitis with an insidious onset only is ?
A. Hepatitis A
B. Hepatitis B
C. Hepatitis C
D. Hepatitis E

25. Which of the following about presentation of acute viral
hepatitis is false ?
A. Constitutional symptoms may precede onset of jaundice by 1 – 2 weeks
B. Dark urine & clay-colored stools occur 1 – 5 days before onset of clinical jaundice

C. Alterations in olfaction and taste
D. None of the above
26. Which of the following is a presentation of acute viral hepatitis ?
A. Splenomegaly
B. Cervical adenopathy
C. Spider angiomas
D. All of the above
27. Acute hepatitis B is self-limited in what proportion of cases ?
A. 50 – 69 %
B. 69 – 79 %
C. 79 – 89 %
D. 95 – 99 %

Acute viral hepatitis

[MCQ] Acute viral hepatitis- Part 6

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[MCQ] Acute viral hepatitis- Part 6

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