[MCQ] Acute viral hepatitis- Part 4

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Acute viral hepatitis- Part 4

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Congratulations - you have completed Acute viral hepatitis- Part 4. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

HBV escape mutants best relate to which of the following ?

A	Single base substitution
B	Single base addition
C	Single amino acid substitution
D	Single amino acid addition

Question 1 Explanation:

In escape mutants of HBV there occurs a single amino acid substitution, from glycine to arginine at position 145 of the immunodominant “a” determinant common to all subtypes of HBsAg. This change in HBsAg leads to a loss of neutralizing activity by anti-HBs. This HBV/a mutant is seen in active and passive immunization, and in liver transplant recipients who underwent the procedure for hepatitis B and who were treated with a high-potency human monoclonal anti-HBs preparation.

Question 2

Extrahepatic site where Hepatitis B antigen and HBV DNA has been identified is ?

A	Bone marrow
B	Spleen
C	Pancreas
D	All of the above

Question 2 Explanation:

Although not associated with tissue injury, extrahepatic site where Hepatitis B antigens and HBV DNA have been identified include lymph nodes, bone marrow, circulating lymphocytes, spleen, and pancreas.

Question 3

Which of the following is a member of the genus Deltavirus ?

A	Hepatitis D virus
B	Marburg virus
C	California encephalitis virus
D	All of the above

Question 3 Explanation:

Delta hepatitis agent (HDV) is the only member of the genus Deltavirus

Question 4

Which of the following is false about delta hepatitis virus ?

A	Defective RNA virus
B	35- to 37-nm in size
C	1700-nucleotide genome
D	Has antigenic homology with HBV antigens

Question 4 Explanation:

HDV is a defective RNA virus that coinfects with and requires the helper function of HBV for its replication & expression. It is formalin-sensitive, 35- to 37-nm virus with a hybrid structure. Its genome is a 1700-nucleotide, circular, single-strand RNA. Delta antigen bears no antigenic homology with any of the HBV antigens.

Question 5

The delta core of HDV is “encapsidated” by an outer envelope of ?

A	HBcAg
B	HBsAg
C	HBeAg
D	Any of the above

Question 6

The single-stranded RNA genome of HDV is homologous to an extent with which gene of HBV ?

A	S
B	C
C	P
D	X

Question 6 Explanation:

HDV genome is a small, 1700-nucleotide, circular, single-strand RNA of negative polarity that is nonhomologous with HBV DNA, except for a small area of the polymerase gene

Question 7

HDV RNA requires which of the following for its replication ?

A	Host RNA polymerase I
B	Viral RNA polymerase I
C	Host RNA polymerase II
D	. Viral RNA polymerase II

Question 7 Explanation:

HDV RNA requires host RNA polymerase II for its replication via RNA-directed RNA synthesis by transcription of genomic RNA to a complementary antigenomic (plus strand) RNA. The antigenomic RNA, in turn, serves as a template for subsequent genomic RNA synthesis.

Question 8

Which of the following is false about delta hepatitis virus ?

A	HDV antigen is expressed in hepatocyte nuclei
B	Intracellular replication of HDV RNA can occur without HBV
C	Duration of HDV infection determined by duration of HBV infection
D	In acute HDV infection, anti-HDV detected before symptoms appear

Question 8 Explanation:

In acute HDV infection, anti-HDV is detected 30-40 days after symptoms appear

Question 9

Which of the following is an HDV protein ?

A	HDAg
B	HDsAg
C	HDeAg
D	All of the above

Question 9 Explanation:

HDV RNA has only one open reading frame, and delta antigen (HDAg), a product of the antigenomic strand is the only known HDV protein.

Question 10

Which of the following hepatitis was earlier called “non-A, non B hepatitis” ?

A	Hepatitis A
B	Hepatitis B
C	Hepatitis C
D	Hepatitis E

Question 10 Explanation:

Before its identification, Hepatitis C virus was labeled as “non-A, non-B hepatitis”.

Question 11

Hepatitis C virus was first identified in which year ?

A	1986
B	1989
C	1992
D	1995

Question 11 Explanation:

Hepatitis C virus was first identified in 1989

Question 12

Which of the following is a member of family Flaviviridae ?

A	Yellow fever virus
B	Dengue virus
C	Hepatitis C virus
D	All of the above

Question 12 Explanation:

Members of family Flaviviridae are Yellow fever virus, Dengue virus, St. Louis encephalitis virus, West Nile virus, Hepatitis C virus (HCV) and Hepatitis G virus. HCV however is the only member of the genus Hepacivirus in the family Flaviviridae

Question 13

Which of the following is the structural gene in hepatitis C virus genome ?

A	C
B	E1
C	E2
D	All of the above

Question 13 Explanation:

The three structural genes at the 5' end of hepatitis C virus genome are C - which codes for nucleocapsid, and E1 and E2 - which code for envelope glycoproteins.

Question 14

In hepatitis C virus genome, which of the following functions as an ion channel ?

A	C
B	E1
C	E2
D	p7

Question 14 Explanation:

Placed adjacent to the structural proteins, p7 is a membrane protein that appears to function as an ion channel

Question 15

Which of the following nonstructural regions of hepatitis C virus genome codes for RNA-dependent RNA polymerase ?

A	NS3
B	NS4
C	NS5A
D	NS5B

Question 15 Explanation:

At 3' end are six nonstructural (NS) regions, NS2, which codes for a cysteine protease; NS3, which codes for a serine protease and an RNA helicase; NS4 and NS4B; NS5A; and NS5B, which codes for an RNA-dependent RNA polymerase.

Question 16

Which of the following is false about HCV ?

A	40 - 60 nm in diameter
B	9600-nucleotide RNA virus
C	Its half-life is 2.7 hours
D	None of the above

Question 17

Which of the following is false about HCV ?

A	HCV enters hepatocyte via CD81 receptor
B	HCV infection does not induce lasting immunity against reinfection
C	Most sensitive indicator of HCV infection is the presence of HCV RNA
D	None of the above

Question 18

HCV masquerades as which of the following ?

A	Viroid
B	Nucleocapsid protein
C	Lipoprotein
D	CD81 receptor

Question 18 Explanation:

HCV masquerades as a lipoprotein

Question 19

Number of HCV genotypes identified is ?

A	2
B	3
C	4
D	6

Question 20

HCV genotypes differ one from another in sequence homology by ?

A	10 %
B	20 %
C	30 %
D	40 %

Question 20 Explanation:

Genotypes differ one from another in sequence homology by 30%. Those with less differences in sequence homology are referred to as quasispecies.

Question 21

HCV RNA is reported as ?

A	International units (IUs) per milliliter
B	Microgram per milliliter
C	Copies per milliliter
D	Virions per milliliter

Question 21 Explanation:

HCV RNA is reported as international units (IUs) per milliliter.

Question 22

Which of the following is the first detectable event during acute hepatitis C progressing to chronicity ?

A	HCV RNA
B	HCV DNA
C	Elevated alanine aminotrans ferase (ALT)
D	Elevation and appearance of anti-HCV

Question 22 Explanation:

During acute hepatitis C progressing to chronicity, HCV RNA is the first detectable event, preceding alanine aminotransferase (ALT) elevation and the appearance of anti-HCV

Question 23

“Epidemic, non-A, non-B hepatitis” relates to which of the following ?

A	Hepatitis A
B	Hepatitis B
C	Hepatitis C
D	Hepatitis E

Question 24

In India, most common cause of acute hepatitis is ?

A	Hepatitis A
B	Hepatitis B
C	Hepatitis C
D	Hepatitis E

Question 24 Explanation:

In India, enterically transmitted HEV is the most common cause of acute hepatitis

Question 25

Which of the following about HEV is false ?

A	Enveloped virus
B	Single-stranded, positive-sense RNA genome
C	Single-stranded, positive-sense RNA genome
D	Genome contains three open reading frames (ORFs)

Question 25 Explanation:

HEV is a small (32- to 34-nm), nonenveloped virus with a single-strand, positive-sense RNA genome (7.6 kb in length) which contains three partially overlapping open reading frames (ORFs) bracketed by short 5’ and 3’ nontranslated regions

Question 26

ORF1 encodes which of the following nonstructural proteins ?

A	Methyl transferase (MT)
B	Cysteine protease (Pro)
C	Helicase (Hel)
D	All of the above

Question 26 Explanation:

ORF1 encodes nonstructural proteins namely methyl transferase (MT), cysteine protease (Pro), helicase (Hel), and RNA polymerase (Pol). ORF1 also encodes three regions of unknown function (Y, H, and X).

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See all quizzes of Acute viral hepatitis at here:

1. HBV escape mutants best relate to which of the following ?
A. Single base substitution
B. Single base addition
C. Single amino acid substitution
D. Single amino acid addition

2. Extrahepatic site where Hepatitis B antigen and HBV DNA has
been identified is ?
A. Bone marrow
B. Spleen
C. Pancreas
D. All of the above

3. Which of the following is a member of the genus Deltavirus ?
A. Hepatitis D virus
B. Marburg virus
C. California encephalitis virus
D. All of the above
4. Which of the following is false about delta hepatitis virus ?
A. Defective RNA virus
B. 35- to 37-nm in size
C. 1700-nucleotide genome
D. Has antigenic homology with HBV antigens

5. The delta core of HDV is “encapsidated” by an outer envelope of ?
A. HBcAg
B. HBsAg
C. HBeAg
D. Any of the above

6. The single-stranded RNA genome of HDV is homologous to an
extent with which gene of HBV ?
A. S
B. C
C. P
D. X

7. HDV RNA requires which of the following for its replication ?
A. Host RNA polymerase I
B. Viral RNA polymerase I
C. Host RNA polymerase II
D. Viral RNA polymerase II

8. Which of the following is false about delta hepatitis virus ?
A. HDV antigen is expressed in hepatocyte nuclei
B. Intracellular replication of HDV RNA can occur without HBV
C. Duration of HDV infection determined by duration of HBV
infection
D. In acute HDV infection, anti-HDV detected before symptoms appear
In acute HDV infection, anti-HDV is detected 30-40 days after symptoms appear.
9. Which of the following is an HDV protein ?
A. HDAg
B. HDsAg
C. HDeAg
D. All of the above

10. Which of the following hepatitis was earlier called “non-A, non B hepatitis” ?
A. Hepatitis A
B. Hepatitis B
C. Hepatitis C
D. Hepatitis E
11. Hepatitis C virus was first identified in which year ?
A. 1986
B. 1989
C. 1992
D. 1995

12. Which of the following is a member of family Flaviviridae ?
A. Yellow fever virus
B. Dengue virus
C. Hepatitis C virus
D. All of the above

13. Which of the following is the structural gene in hepatitis C
virus genome ?
A. C
B. E1
C. E2
D. All of the above

14. In hepatitis C virus genome, which of the following functions
as an ion channel ?
A. C
B. E1
C. E2
D. p7

15. Which of the following nonstructural regions of hepatitis C
virus genome codes for RNA-dependent RNA polymerase ?
A. NS3
B. NS4
C. NS5A
D. NS5B

14. Which of the following is false about HCV ?
A. 40 – 60 nm in diameter
B. 9600-nucleotide RNA virus
C. Its half-life is 2.7 hours
D. None of the above
15. Which of the following is false about HCV ?
A. HCV enters hepatocyte via CD81 receptor
B. HCV infection does not induce lasting immunity against
reinfection
C. Most sensitive indicator of HCV infection is the presence of
HCV RNA
D. None of the above

16. The single-stranded RNA genome of HDV is homologous to an
extent with which gene of HBV ?
A. S
B. C
C. P
D. X

17. HDV RNA requires which of the following for its replication ?
A. Host RNA polymerase I
B. Viral RNA polymerase I
C. Host RNA polymerase II
D. Viral RNA polymerase II

18. Which of the following is false about delta hepatitis virus ?
A. HDV antigen is expressed in hepatocyte nuclei
B. Intracellular replication of HDV RNA can occur without HBV
C. Duration of HDV infection determined by duration of HBV
infection
D. In acute HDV infection, anti-HDV detected before symptoms appear
In acute HDV infection, anti-HDV is detected 30-40 days after symptoms appear.
19. Which of the following is an HDV protein ?
A. HDAg
B. HDsAg
C. HDeAg
D. All of the above

20. Which of the following hepatitis was earlier called “non-A, non
B hepatitis” ?
A. Hepatitis A
B. Hepatitis B
C. Hepatitis C
D. Hepatitis E

21. Hepatitis C virus was first identified in which year ?
A. 1986
B. 1989
C. 1992
D. 1995

22. Which of the following is a member of family Flaviviridae ?
A. Yellow fever virus
B. Dengue virus
C. Hepatitis C virus
D. All of the above

23. Which of the following is the structural gene in hepatitis C
virus genome ?
A. C
B. E1
C. E2
D. All of the above

24. In hepatitis C virus genome, which of the following functions
as an ion channel ?
A. C
B. E1
C. E2
D. p7

25. Which of the following nonstructural regions of hepatitis C
virus genome codes for RNA-dependent RNA polymerase ?
A. NS3
B. NS4
C. NS5A
D. NS5B

24. Which of the following is false about HCV ?
A. 40 – 60 nm in diameter
B. 9600-nucleotide RNA virus
C. Its half-life is 2.7 hours
D. None of the above
25. Which of the following is false about HCV ?
A. HCV enters hepatocyte via CD81 receptor
B. HCV infection does not induce lasting immunity against
reinfection
C. Most sensitive indicator of HCV infection is the presence of
HCV RNA
D. None of the above above

26. HCV masquerades as which of the following ?
A. Viroid
B. Nucleocapsid protein
C. Lipoprotein
D. CD81 receptor
HCV masquerades as a lipoprotein.
27. Number of HCV genotypes identified is ?
A. 2
B. 3
C. 4
D. 6

28. HCV genotypes differ one from another in sequence homology by ?
A. 10 %
B. 20 %
C. 30 %
D. 40 %

Acute viral hepatitis

[MCQ] Acute viral hepatitis- Part 4

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Acute viral hepatitis- Part 4

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