[MCQ] Acute viral hepatitis- Part 2

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Acute viral hepatitis- Part 2

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Congratulations - you have completed Acute viral hepatitis- Part 2. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Which of the following statements about overlapping genes in Hepatitis B virus is false ?

A	S gene codes for HBsAg
B	P gene codes for DNA polymerase
C	C gene codes for HBeAg & HBcAg
D	X gene codes for HBeAg

Question 1 Explanation:

The S gene codes for the “major” envelope protein, HBsAg. The largest gene, P, codes for DNA polymerase. C gene codes for nucleocapsid proteins - HBeAg and HBcAg. X gene codes for HBxAg which can transactivate the transcription of cellular and viral genes

Question 2

Which particulate form of HBV is most numerous in blood ?

A	22-nm
B	27-nm
C	42-nm
D	All of the above

Question 2 Explanation:

Of the three particulate forms of HBV, the most numerous are the 22-nm particles, which appear as spherical or long filamentous forms. These are antigenically indistinguishable from outer surface or envelope protein of HBV and are thought to represent excess viral envelope protein

Question 3

Which is the common group-reactive antigen in different HBsAg subdeterminants ?

A	a
B	b
C	c
D	d

Question 3 Explanation:

In different HBsAg subdeterminants, common group-reactive antigen, “a” is shared by all HBsAg isolates

Question 4

Number of genotypes if Hepatitis B isolates is ?

A	4
B	8
C	12
D	16

Question 4 Explanation:

In 1988, hepatitis B virus (HBV) was classified into four genotypes by a sequence divergence in the entire genome exceeding 8%, and designated by capital letters of the alphabet from A to D. Later four more were added from E to H. Genotype H is phylogenetically closely related to genotype F

Question 5

Genotypes of HBV were defined by a sequence divergence greater than what percentage in the entire genome ?

A	2
B	4
C	6
D	8

Question 5 Explanation:

Genotypes of HBV were defined by a sequence divergence greater than 8% in the entire genome

Question 6

Which of the following is not a major serotype of HBV ?

A	add
B	adw
C	ayr
D	ayw

Question 6 Explanation:

HBV virus is divided into 4 major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A-H) according to overall nucleotide sequence variation of the genome. Genotypes of HBV were defined by a sequence divergence > 8% in the entire genome. HBsAg serotypes adw, adr, ayw and ayr are readily determined by immunological methods, and they were regarded the phenotypic expression of HBV genotypes. All HBV isolates of genotype A or B isolates were adw and all genotype D isolates were ayw. Isolates of genotype C were heterogeneous and covered adw, adr and ayr.

Question 7

The protein product of S region in Hepatitis B virus is ?

A	Major protein
B	Middle protein
C	Large protein
D	All of the above

Question 8

The protein product of S gene in Hepatitis B virus is ?

A	Major protein
B	Middle protein
C	Large protein
D	All of the above

Question 9

The protein product of S region plus pre-S2 region in Hepatitis B virus is ?

A	Major protein
B	Middle protein
C	Large protein
D	All of the above

Question 10

The protein product of pre-S1 plus pre-S2 plus S regions in Hepatitis B virus is ?

A	Major protein
B	Middle protein
C	Large protein
D	All of the above

Question 10 Explanation:

The envelope protein, HBsAg, is the product of the S gene of HBV. HBsAg gene is one long open reading frame but contains 3 in frame “start” (ATG) codons that divide the gene into 3 sections, preS1, pre-S2, and S. S gene codes for the “major” envelope protein - HBsAg. “Large” protein is the product of pre-S1 + pre-S2 + S. “Middle” protein is the product of pre-S2 + S.

Question 11

HBsAg is also called ?

A	Major protein
B	Middle protein
C	Large protein
D	All of the above

Question 11 Explanation:

The S gene codes for the “major” envelope protein, HBsAg.

Question 12

Which of the following is not a nucleocapsid protein ?

A	HBsAg
B	HBeAg
C	HBcAg
D	All of the above

Question 12 Explanation:

The C gene codes for two nucleocapsid proteins, HBeAg and HBcAg. If translation is initiated at the precore region of C gene, the protein product is HBeAg, while if translation begins with the core region of C gene, HBcAg is the protein product.

Question 13

Which of the following represents excess virus coat material ?

A	HBsAg
B	HBeAg
C	HBcAg
D	HBxAg

Question 14

In Hepatitis B virus, which of the following is a ‘secreted’ nucleocapsid protein ?

A	HBsAg
B	HBeAg
C	HBcAg
D	HBxAg

Question 14 Explanation:

HBeAg is a soluble, secreted nucleocapsid protein. HBeAg provides a convenient, readily detectable, qualitative marker of HBV replication and relative infectivity. HBeAg has a signal peptide that binds it to the smooth endoplasmic reticulum and leads to its secretion into the circulation.

Question 15

Which of the following is qualitative marker of HBV replication & relative infectivity ?

A	HBsAg
B	HBeAg
C	HBcAg
D	HBxAg

Question 15 Explanation:

HBsAg-positive serum containing HBeAg is highly infectious and associated with presence of hepatitis B virions than HBeAg-negative or anti-HBe-positive serum. Anti-HBeAg positivity usually indicates low infectivity and no replication, unless patient is precore mutant.

Question 16

Persistence of HBeAg in serum beyond how many months of acute infection is predictive of chronic infection ?

A	1 month
B	2 month
C	3 month
D	Any of the above

Question 16 Explanation:

HBeAg appears transiently and early during acute hepatitis B infection. Persistence of HBeAg in serum beyond the first three months of acute infection may be predictive of the development of chronic infection.

Question 17

Which of the following particles of HBV do not circulate in the serum ?

A	HBsAg
B	HBcAg
C	HBeAg
D	All of the above

Question 17 Explanation:

HBcAg is intracellular. When in serum, it is within an HBsAg coat. Therefore, naked HBcAg particles do not circulate in serum and are not detectable routinely in serum of patients with HBV infection

Question 18

Hepatitis B patients contain which of the following circulating antibodies ?

A	Anti-HBe Ag
B	Anti-HBs Ag
C	Anti HBcAg
D	All of the above

Question 18 Explanation:

Hepatitis B patients contain circulating antibodies against HBcAg (hepatitis B core antigen), & develop antibodies against HBeAg & HBsAg (anti-HBe & anti-HBs) at later stages.

Question 19

Which of the following HBV genes codes for DNA polymerase ?

A	S
B	C
C	P
D	X

Question 19 Explanation:

Gene P of the HBV genes is the largest and codes for DNA polymerase which has both DNAdependent DNA polymerase and RNA-dependent reverse transcriptase activities

Question 20

Which of the following is a nonparticulate protein of HBV ?

A	HBeAg
B	HBcAg
C	HBcAg
D	All of the above

Question 21

Which of the following HBV antigens stimulates HBV reverse transcription and HBV DNA replication ?

A	HBsAg
B	HBsAg
C	HBcAg
D	HBxAg

Question 21 Explanation:

Hepatitis B x antigen (HBxAg) activates signal-transduction pathways that lead to stimulation of HBV reverse transcription and HBV DNA replication.

Question 22

Expression of which of the following HBV antigens induces programmed cell death (apoptosis) ?

A	HBsAg
B	HBsAg
C	HBcAg
D	HBxAg

Question 22 Explanation:

Expression of HBxAg induces programmed cell death (apoptosis).

Question 23

Clinical association is observed between expression of which of the following & severe chronic hepatitis & hepatocellular carcinoma ?

A	HBsAg
B	HBsAg
C	HBcAg
D	HBxAg

Question 23 Explanation:

Because HBxAg transactivation enhances replication of HBV, clinical association is observed between its expression with severe chronic hepatitis and hepatocellular carcinoma.

Question 24

Which of the following is transactivated by expression of HBxAg ?

A	Transcription & replication of HIV
B	Transactivation of human interferon gene
C	Transactivation of class I major histocompatibility genes
D	All of the above

Question 25

Which of the following statements is true ?

A	Circulating HBsAg precedes elevations of SGOT/SGPT
B	Circulating HBsAg follow elevations of SGOT/SGPT
C	Circulating HBsAg coincide with elevations of SGOT/SGPT
D	None of the above

Question 25 Explanation:

Circulating HBsAg precedes elevations of serum aminotransferase activity and clinical symptoms by 2 - 6 weeks and remains detectable during the entire icteric or symptomatic phase of acute hepatitis B and beyond

Question 26

After the onset of jaundice, HBsAg rarely persists beyond how many months ?

A	1 months
B	3 months
C	6 months
D	9 months

Question 26 Explanation:

In typical cases, HBsAg becomes undetectable 1 - 2 months after the onset of jaundice and rarely persists beyond 6 months

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See all quizzes of Acute viral hepatitis at here:

1.Which of the following statements about overlapping genes in
Hepatitis B virus is false ?
A. S gene codes for HBsAg
B. P gene codes for DNA polymerase
C. C gene codes for HBeAg & HBcAg
D. X gene codes for HBeAg

2. Which particulate form of HBV is most numerous in blood ?
A. 22-nm
B. 27-nm
C. 42-nm
D. All of the above

3. Which is the common group-reactive antigen in different HBsAg
subdeterminants ?
A. a
B. b
C. c
D. d

4. Number of genotypes if Hepatitis B isolates is ?
A. 4
B. 8
C. 12
D. 16

5. Genotypes of HBV were defined by a sequence divergence
greater than what percentage in the entire genome ?
A. 2
B. 4
C. 6
D. 8

6. Which of the following is not a major serotype of HBV ?
A. add
B. adw
C. ayr
D. ayw

7. The protein product of S region in Hepatitis B virus is ?
A. Major protein
B. Middle protein
C. Large protein
D. All of the above
8. The protein product of S gene in Hepatitis B virus is ?
A. Major protein
B. Middle protein
C. Large protein
D. All of the above
9. The protein product of S region plus pre-S2 region in Hepatitis
B virus is ?
A. Major protein
B. Middle protein
C. Large protein
D. All of the above
10. The protein product of pre-S1 plus pre-S2 plus S regions in
Hepatitis B virus is ?
A. Major protein
B. Middle protein
C. Large protein
D. All of the above

11. HBsAg is also called ?
A. Major protein
B. Middle protein
C. Large protein
D. All of the above

12. Which of the following is not a nucleocapsid protein ?

A. HBsAg
B. HBeAg
C. HBcAg
D. All of the above

13. Which of the following represents excess virus coat material ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg
14. In Hepatitis B virus, which of the following is a ‘secreted’
nucleocapsid protein ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg

15. Which of the following is qualitative marker of HBV replication
& relative infectivity ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg

16. Persistence of HBeAg in serum beyond how many months of
acute infection is predictive of chronic infection ?
A. 1 month
B. 2 month
C. 3 month
D. Any of the above

17. Which of the following particles of HBV do not circulate in the
serum ?
A. HBsAg
B. HBcAg
C. HBeAg
D. All of the above

18. Hepatitis B patients contain which of the following circulating
antibodies ?
A. Anti-HBe Ag
B. Anti-HBs Ag
C. Anti HBcAg
D. All of the above

19. Which of the following HBV genes codes for DNA polymerase ?
A. S
B. C
C. P
D. X

20. Which of the following is a nonparticulate protein of HBV ?
A. HBeAg
B. HBcAg
C. HBxAg
D. All of the above
21. Which of the following HBV antigens stimulates HBV reverse
transcription and HBV DNA replication ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg

22. Expression of which of the following HBV antigens induces
programmed cell death (apoptosis) ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg

23. Clinical association is observed between expression of which
of the following & severe chronic hepatitis & hepatocellular
carcinoma ?
A. HBsAg
B. HBeAg
C. HBcAg
D. HBxAg

24. Which of the following is transactivated by expression of
HBxAg ?
A. Transcription & replication of HIV
B. Transactivation of human interferon gene
C. Transactivation of class I major histocompatibility genes
D. All of the above
25. Which of the following statements is true ?
A. Circulating HBsAg precedes elevations of SGOT/SGPT
B. Circulating HBsAg follow elevations of SGOT/SGPT
C. Circulating HBsAg coincide with elevations of SGOT/SGPT
D. None of the above

26. After the onset of jaundice, HBsAg rarely persists beyond how
many months ?
A. 1 months
B. 3 months
C. 6 months
D. 9 months

Acute viral hepatitis

[MCQ] Acute viral hepatitis- Part 2

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Acute viral hepatitis- Part 2

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[MCQ] Acute viral hepatitis- Part 3

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