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Chronic hepatitis- Part 1
See all quizzes of Chronic hepatitis at here:
Chronic hepatitis- Part 1| Chronic hepatitis- Part 2| Chronic hepatitis- Part 3| Chronic hepatitis- Part 4
1.In chronic hepatitis, hepatic inflammation and necrosis
continue for at least ?
A. 3 months
B. 6 months
C. 9 months
D. 12 months
2.Chronic hepatitis is due to ?
A. Virus
B. Drug-induced
C. Autoimmune
D. All of the above
3.Classification of chronic hepatitis is based on ?
A. Cause
B. Histologic activity, or grade
C. Degree of progression, or stage
D. All of the above
4. Histologic activity index (HAI) scoring for necroinflammatory
activity (grade) is done out of ?
A. 10
B. 14
C. 18
D. 20
5. Histologic activity index (HAI) scoring for fibrosis (stage) is
done out of ?
A. 3
B. 4
C. 6
D. 8
6.Histologic activity index (HAI) scoring for necroinflammatory
activity (grade) includes all except ?
A. Degree of periportal necrosis
B. Portal fibrosis
C. Intralobular necrosis
D. Degree of portal inflammation
7.What percentage of HBV infection acquired at birth will become
chronic ?
A. 10 %
B. 40 %
C. 75 %
D. 90 %
8. What percentage of HBV infection acquired in
immunocompetent young adulthood will become chronic ?
A. ~ 1 %
B. ~ 4 %
C. ~ 7 %
D. ~ 9 %
9.Which of the following has prognostic importance among
adults with chronic hepatitis B ?
A. HBV replication
B. HLA DR3 or DR4 markers
C. AST and ALT
D. Liver histology
10.Replicative phase of chronic HBV infection is characterized
by ?
Harrison’s 18th Ed. 2568
A. Presence of HBeAg in serum
B. HBV DNA levels > 105 – 106 virions/mL
C. Presence of HBcAg in liver
D. All of the above
11. Nonreplicative phase of chronic HBV infection is characterized
by all except ?
A. Absence of HBeAg in serum
B. HBV DNA levels < 103 virions/mL
C. Presence of anti-HBe
D. Presence of HBcAg in liver
12. What percentage of HBeAg-reactive chronic hepatitis B convert
spontaneously from replicative to nonreplicative infection per
year ?
A. ~ 2 – 5 %
B. ~ 5 – 10 %
C. ~ 10 – 15 %
D. ~ 20 – 30 %
13. Most important risk factor for development of cirrhosis & HCC
in chronic HBV infection is ?
A. Levels of HBV DNA
B. Level of HBV replication
C. Levels of aminotransferase activity
D. All of the above
14. HBV inactive carriers is characterized by all except ?
A. Circulating HBsAg
B. Raised serum aminotransferase levels
C. Undetectable HBeAg
D. Almost undetectable levels of HBV DNA
15. Which of the following is not a complication of chronic hepatitis B ?
A. Hyperglobulinemia
B. Immune-complex glomerulonephritis
C. Generalized vasculitis
D. Leukocytoclastic vasculitis
16. HBV DNA can be detected in serum at levels as low as ?
A. 20 IU/mL
B. 40 IU/mL
C. 60 IU/mL
D. 80 IU/mL
17. Histologic improvement is defined as a reduction of 2 or more
points in the histologic activity index at ?
A. Month 3
B. Month 6
C. Year 1
D. Year 2
18. Serum HBV DNA undetectable by PCR is defined as ?
A. < 100 to 200 copies per milliliter
B. < 300 to 400 copies per milliliter
C. < 500 to 1000 copies per milliliter
D. < 1000 to 2000 copies per milliliter
19. Immunity to HBV infection is characterized by all except ?
A. Loss of HBV surface antigen
B. Loss of HBV e antigen
C. Loss of anti-core antigen IgM
D. Loss of anti-core antigen IgG
20. Which of the following differentiates natural immunity by
resolved HBV infection from that which is acquired through
vaccination ?
A. Presence of Anti HBs + IgM anti HBc
B. Presence of Anti HBs + IgG anti HBc
C. Presence of Anti HBs + anti HBe
D. All of the above
21. Which of the following phase is seen almost exclusively in
those who acquired HBV infection vertically or during early
childhood ?
A. Immune tolerance phase
B. Immune clearance phase
C. Inactive carrier phase
D. Reactivation phase
22. Predictor of spontaneous e antigen seroconversion is ?
A. Old age
B. Elevated ALT level
C. Acute exacerbation
D. All of the above
23. Which of the following phase is also called HBV e antigen
negative chronic hepatitis ?
A. Immune tolerance phase
B. Immune clearance phase
C. Inactive carrier phase
D. Reactivation phase
