[MCQ] Alzheimer’s disease- Part 3

I. Start the exam by click the “Start” button

Alzheimer’s disease- Part 3

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Alzheimer’s disease- Part 3. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

EEG studies are most useful for the diagnosis of ?

A	Alzheimer’s disease
B	Frontotemporal dementia
C	Parkinson’s disease
D	Creutzfeldt - Jakob disease

Question 1 Explanation:

Abnormal periodic EEG discharges & cortical / basal ganglia abnormalities on diffusion-weighted MRI are unique diagnostic features of CJD.

Question 2

“Leukoaraiosis” refers to ?

A	White skin tags
B	White lines around umblicus
C	Diffuse white matter disease
D	White nails

Question 2 Explanation:

Leukoaraiosis or subcortical arteriosclerotic leukoencephalopathy or Binswanger’s disease is a diffuse white matter disease which presents with dementia with lacunar infarctions found on MRI. Term Binswanger’s disease should be used with caution, because it does not clearly identify a single entity.

Question 3

Cerebral vascular disease is a common cause of dementia in ?

A	Asia
B	Britain
C	Spain
D	North America

Question 3 Explanation:

Cerebral vascular disease is a more common cause of dementia in Asia than in Europe & North Ame

Question 4

Which of the following white matter diseases also present with dementia ?

A	Adult metachromatic leukodystrophy
B	Progressive multifocal leukoencephalopathy
C	CADASIL
D	All of the above

Question 4 Explanation:

White matter diseases that also present with dementia include adult metachromatic leukodystrophy (arylsulfatase A deficiency), progressive multifocal leukoencephalopathy (JC virus infection) & cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy (CADASIL).

Question 5

Which of the following statements about Frontotemporal dementia (FTD) is false ?

A	Begins in fifth to seventh decade
B	More common in men than women
C	Behavioral symptoms predominate in early stages
D	None of the above

Question 5 Explanation:

FTD begins in V to VII decades. It is more common in men than women. Unlike AD, behavioral symptoms predominate in early stages of FTD.

Question 6

In FTD, mutations occur in which of the following genes ?

A	Valosin
B	MAPT
C	GRN
D	All of the above

Question 6 Explanation:

The most common autosomal dominantly inherited mutations causing FTD involve the MAPT (causing loss of function in tau molecule) or GRN genes (altering progranulin protein gene), both on chromosome 17 and both associated with parkinsonian features. Mutations in valosin-containing protein (chromosome 9) and charged multivesicular body protein 2b (CHMP2b) genes (chromosome 3) also lead to rare autosomal dominant forms of familial FTD.

Question 7

TDP-43 stands for ?

A	TAR DNA binding protein 43
B	TAR depleted protein 43
C	TAR dense protein 43
D	TAR divided protein 43

Question 7 Explanation:

TDP-43 stands for TAR DNA binding protein 43.

Question 8

Which of the following statements about frontotemporal dementia is false ?

A	Memory and visuospatial skills relatively spared
B	Cholinergic system is relatively spared
C	Marked atrophy of temporal and/or frontal lobes
D	None of the above

Question 8 Explanation:

In FTD, memory & visuospatial skills are relatively spared. Distinguishing anatomic hallmark of FTD is a focal atrophy of frontal, insular, and/or temporal cortex. Cholinergic system is spared in FTD.

Question 9

Primary progressive aphasia is related to ?

A	FTD
B	PSP
C	CBD
D	Motor neuron disease

Question 9 Explanation:

The left-hemisphere presentation of FTD is called primary progressive aphasia with nonfluent and semantic variants.

Question 10

Which of the following best relates to Pick bodies ?

A	Astrocytic plaque
B	Intraneuronal cytoplasmic inclusions
C	Ballooned neuro
D	All of the above

Question 10 Explanation:

Pick’s disease is characterized by selective involvement of anterior frontal & temporal neocortex and pathologically by intraneuronal cytoplasmic inclusions (Pick bodies) which are argyrophilic, staining positively with the Bielschowsky silver method and also with immunostaining for tau.

Question 11

Progressive supranuclear palsy (PSP) involves which of the following ?

A	Brainstem
B	Basal ganglia
C	Limbic struct
D	All of the above

Question 11 Explanation:

Progressive supranuclear palsy (PSP) is a degenerative disease that involves the brainstem, basal ganglia, limbic structures, and selected areas of cortex.

Question 12

PSP begins with which of the following ?

A	Frequent falls
B	Symmetrical axial rigidity
C	Dementia
D	Seizure

Question 12 Explanation:

PSP begins with falls and vertical supranuclear gaze paresis or nonfluent aphasia and progresses to symmetrical rigidity and dementia. Frequent unexplained and sometimes spectacular falls are common secondary to a combination of axial rigidity, inability to look down, and bad judgment.

Question 13

Globose tangles best relate to ?

A	HD
B	FTD
C	CBD
D	AD

Question 13 Explanation:

In FTD, there occurs accumulation of hyperphosphorylated tau within neurons and glia called globose tangles.

Question 14

“Alien hand” phenomenon is a feature of ?

A	PSP
B	DLB
C	CBD
D	AD

Question 14 Explanation:

In cortical basal degeneration (CBD), apraxia of one arm and hand is called the alien hand.

Question 15

Glial plaques with tau inclusions are pathognomonic of ?

A	PSP
B	DLB
C	CBD
D	AD

Question 15 Explanation:

Glial plaques with tau inclusions are pathognomonic of CBD.

Question 16

Which of the following is rarely familial ?

A	HD
B	FTD
C	CBD
D	AD

Question 16 Explanation:

CBD is rarely familial.

Question 17

Which of the following is a characteristic feature of Dementia with Lewy Bodies (DLB) ?

A	Seizure
B	Symmetrical axial rigidity
C	Visual hallucinations
D	Auditory hallucinations

Question 17 Explanation:

DLB is characterized by visual hallucinations, parkinsonism, fluctuating alertness, falls and REM sleep behavior disorder.

Question 18

In DLB, Lewy bodies are found in ?

A	Cerebral cortex
B	Amygdala
C	Substantia nigra
D	All of the above

Question 18 Explanation:

Key neuropathologic feature of DLB is the presence of Lewy bodies throughout the cortex, amygdala, cingulated cortex, and substantia nigra.

Question 19

Which of the following about Lewy bodies is false ?

A	Intraneuronal cytoplasmic inclusions
B	Stain with periodic acid–Schiff (PAS) & ubiquitin
C	Composed of straight neurofilaments 7 to 20 nm long
D	None of the above

Question 20

George Huntington belonged to which country ?

A	Great Britain
B	America
C	Australia
D	Canada

Question 20 Explanation:

Huntington’s disease (HD) was described by George Huntington, an American physician in 1872. Huntington’s gene is single, causal gene and an accurate genetic test for HD is available

Question 21

Huntington’s disease (HD) is caused by mutations in the Huntington’s gene on the ?

A	Short arm of chromosome 4
B	Long arm of chromosome 4
C	Short arm of chromosome 5
D	Long arm of chromosome 5

Question 21 Explanation:

HD is caused by mutations in the Huntington’s gene on the short arm of chromosome 4.

Question 22

“Huntingtin” is a ?

A	Cell membrane protein
B	Cytoplasmic protein
C	Nuclear protein
D	Nuclear membrane protein

Question 22 Explanation:

Huntingtin gene (HTT) encodes the highly conserved cytoplasmic protein huntingtin which is present in all neurons

Question 23

Chorea is a characteristic feature of which of the following ?

A	Dementia with Lewy Bodies (DLB)
B	Huntington’s disease (HD)
C	Cortical basal degeneration (CBD)
D	Creutzfeldt-Jakob disease (CJD)

Question 23 Explanation:

HD is an autosomal dominant, degenerative brain disorder characterized by chorea, behavioral disturbance & frontal executive disorder in IV or V decade. Memory is frequently not impaired.

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 23 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	End

Return

See all quizzes of Alzheimer’s disease at here:

Alzheimer’s disease- Part 1| Alzheimer’s disease- Part 2| Alzheimer’s disease- Part 3| Alzheimer’s disease- Part 4

1 EEG studies are most useful for the diagnosis of ?
A. Alzheimer’s disease
B. Frontotemporal dementia
C. Parkinson’s disease
D. Creutzfeldt – Jakob disease

2“Leukoaraiosis” refers to ?
A. White skin tags
B. White lines around umblicus
C. Diffuse white matter disease
D. White nails

3 Cerebral vascular disease is a common cause of dementia in ?
A. Asia
B. Britain
C. Spain
D. North America

4 Which of the following white matter diseases also present with
dementia ?
A. Adult metachromatic leukodystrophy
B. Progressive multifocal leukoencephalopathy
C. CADASIL
D. All of the above

5 Which of the following statements about Frontotemporal dementia
(FTD) is false ?
A. Begins in fifth to seventh decade
B. More common in men than women
C. Behavioral symptoms predominate in early stages
D. None of the above

6 In FTD, mutations occur in which of the following genes ?
A. Valosin
B. MAPT
C. GRN
D. All of the above

7 TDP-43 stands for ?
A. TAR DNA binding protein 43
B. TAR depleted protein 43
C. TAR dense protein 43
D. TAR divided protein 43

8 Which of the following statements about frontotemporal dementia
is false ?
A. Memory and visuospatial skills relatively spared
B. Cholinergic system is relatively spared
C. Marked atrophy of temporal and/or frontal lobes
D. None of the above

9 Primary progressive aphasia is related to ?
A. FTD
B. PSP
C. CBD
D. Motor neuron disease

10 Which of the following best relates to Pick bodies ?
A. Astrocytic plaque
B. Intraneuronal cytoplasmic inclusions
C. Ballooned neurons
D. All of the above

12 Progressive supranuclear palsy (PSP) involves which of the
following ?
A. Brainstem
B. Basal ganglia
C. Limbic structures
D. All of the above

13 PSP begins with which of the following ?
A. Frequent falls
B. Symmetrical axial rigidity
C. Dementia
D. Seizure

14 Globose tangles best relate to ?
A. HD
B. FTD
C. CBD
D. AD

15 “Alien hand” phenomenon is a feature of ?
A. PSP
B. DLB
C. CBD
D. AD

16 Glial plaques with tau inclusions are pathognomonic of ?
A. PSP
B. DLB
C. CBD
D. AD

17 Which of the following is rarely familial ?
A. HD
B. FTD
C. CBD
D. AD

18 Which of the following is a characteristic feature of Dementia with
Lewy Bodies (DLB) ?
A. Seizure
B. Symmetrical axial rigidity
C. Visual hallucinations
D. Auditory hallucinations

19 In DLB, Lewy bodies are found in ?
A. Cerebral cortex
B. Amygdala
C. Substantia nigra
D. All of the above

20 Which of the following about Lewy bodies is false ?
A. Intraneuronal cytoplasmic inclusions
B. Stain with periodic acid–Schiff (PAS) & ubiquitin
C. Composed of straight neurofilaments 7 to 20 nm long
D. None of the above

21 George Huntington belonged to which country ?
A. Great Britain
B. America
C. Australia
D. Canada

22 Huntington’s disease (HD) is caused by mutations in the
Huntington’s gene on the ?
A. Short arm of chromosome 4
B. Long arm of chromosome 4
C. Short arm of chromosome 5
D. Long arm of chromosome 5

23 “Huntingtin” is a ?
A. Cell membrane protein
B. Cytoplasmic protein
C. Nuclear protein
D. Nuclear membrane protein

24 Chorea is a characteristic feature of which of the following ?
A. Dementia with Lewy Bodies (DLB)
B. Huntington’s disease (HD)
C. Cortical basal degeneration (CBD)
D. Creutzfeldt-Jakob disease (CJD)

Alzheimer’s disease

[MCQ] Alzheimer’s disease- Part 3

I. Start the exam by click the “Start” button

Alzheimer’s disease- Part 3

Share this:

Related

[MCQ] Alzheimer’s disease- Part 2

[MCQ] Alzheimer’s disease- Part 4

You may also like

Leave a Comment Cancel Reply