[MCQ] Peptic Ulcer Disease- Part 1

I. Start the exam by click the “Start” button

Peptic Ulcer Disease- Part 1

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Start

Congratulations - you have completed Peptic Ulcer Disease- Part 1. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

Rumination is best related to ?

A	Nausea
B	Vomiting
C	Regurgitation
D	All of the above

Question 1 Explanation:

Rumination refers to repeated voluntary regurgitation of stomach contents, which may be rechewed and reswallowed.

Question 2

Under normal conditions, frequency of slow wave cycles in the stomach is ?

A	3 cycles / minute
B	6 cycles / minute
C	9 cycles / minute
D	12 cycles / minute

Question 3

Under normal conditions, frequency of slow wave cycles in the duodenum is ?

A	4 cycles / minute
B	8 cycles / minute
C	11 cycles / minute
D	15 cycles / minute

Question 3 Explanation:

Under normal conditions, distally migrating gut contractions, the slow wave, occur at 3 cycles/ minute in the stomach and 11 cycles/minute in duodenum.

Question 4

Which of the following is termed the chemoreceptor trigger zone ?

A	Area postrema
B	Nucleus tractus solitarius
C	Dorsal vagal nuclei
D	Phrenic nuclei

Question 4 Explanation:

Area postrema, a medullary nucleus, responds to bloodborne emetic stimuli and is termed the chemoreceptor trigger zone.

Question 5

Which of the following act on the area postrema ?

A	Uremia
B	Hypoxia
C	Ketoacidosis
D	All of the above

Question 5 Explanation:

Uremia, hypoxia, and ketoacidosis act on the area postrema and are emetogenic.

Question 6

Neurotransmitter that mediate induction of vomiting in labyrinthine disorders is ?

A	Muscarinic M1 receptors
B	Histaminergic H2 receptors
C	Serotonin 5-HT3 receptors
D	Dopamine D2 receptors

Question 6 Explanation:

Neurotransmitters that mediate induction of vomiting in labyrinthine disorders is vestibular muscarinic M 1 and histaminergic H1 receptors, whereas vagal afferent stimuli activate serotonin 5-HT 3 receptors. Area postrema is richly served by nerves acting on 5-HT3, M1, H1, and dopamine D 2 subtypes.

Question 7

Gastroparesis occurs after which of the following ?

A	Pancreatic adenocarcinoma
B	Mesenteric vascular insufficiency
C	Scleroderma
D	All of the above

Question 7 Explanation:

Gastroparesis or a delay in gastric emptying of food occurs after vagotomy, with pancreatic adenocarcinoma, with mesenteric vascular insufficiency, or in systemic diseases such as diabetes, scleroderma, and amyloidosis. Anorexia nervosa, bulimia nervosa, anxiety, and depression may cause significant nausea that may be associated with delayed gastric emptying

Question 8

Gastroparesis does not occur with which of the following ?

A	Diabetes
B	Amyloidosis
C	Scleroderma
D	Cyclic vomiting syndrome

Question 8 Explanation:

Cyclic vomiting syndrome produces periodic discrete episodes of relentless nausea & vomiting and has a strong association with migraine headaches. Cyclic vomiting is most common in children, although adult cases occur in association with rapid gastric emptying & with chronic cannabis use.

Question 9

Which of the following drugs is a highly emetogenic agent ?

A	Digoxin
B	Oral contraceptives
C	Cisplatin
D	Erythromycin

Question 9 Explanation:

Acute emesis from intensely emetogenic cisplatin is mediated by 5-HT3 pathways

Question 10

What proportion of pregnant women experience nausea in the first trimester ?

A	25 %
B	50 %
C	70 %
D	90 %

Question 10 Explanation:

Nausea affects 70% of pregnant women in first trimester

Question 11

Relief of abdominal pain by emesis is characteristic of ?

A	Pancreatitis
B	Zenker’s diverticulum
C	Gastric obstruction
D	Intestinal obstruction

Question 12

Which of the following antiemetic agent is a Serotonin5-HT3 antagonist ?

A	Meclizine
B	Meclizine
C	Mirtazapine
D	Dimenhydrinate

Question 12 Explanation:

Antiemetic agent ondansetron and granisetron are Serotonin5-HT3 antagonists. Meclizine & dimenhydrinate are antihistamines. Scopolamine is an anticholinergic drug

Question 13

Which of the following is a combined 5-HT4 agonist and D2 antagonist ?

A	Metoclopramide
B	Domperidone
C	Erythromycin
D	Octreotide

Question 13 Explanation:

Metoclopramide is a combined 5-HT4 agonist & D2 antagonist. Domperidone is a D2 antagonist. Erythromycin increases gastroduodenal motility by action on receptors for motilin. Somatostatin analogue octreotide induces propagative small intestinal motor complexes.

Question 14

Which of the following is a Neurokinin NK1 antagonist ?

A	Aprepitant
B	Kevetiracetam
C	Cyproheptadine
D	Sumatriptan

Question 14 Explanation:

Aprepitant is a neurokinin NK1 antagonist that has antiemetic & antinausea effects during acute and delayed periods after chemotherapy.

Question 15

Gastric pits of stomach branch into ?

A	1 or 2 gastric glands
B	3 or 4 gastric glands
C	4 or 5 gastric glands
D	6 or 7 gastric glands

Question 15 Explanation:

Microscopic gastric pits (foveolus) of gastric epithelial lining branch into four or five gastric glands made up of highly specialized epithelial cells.

Question 16

Which of the following cells is found deepest in the oxyntic gastric gland ?

A	Mucous neck cells
B	Parietal cells
C	Endocrine cells
D	Chief cells

Question 17

Parietal cell is also known as ?

A	Mucous cell
B	Oxyntic cell
C	Endocrine cell
D	Enterochromaffin-like (ECL) cell

Question 17 Explanation:

Parietal cell is also known as oxyntic cell and is found in neck, or isthmus, or in oxyntic gland

Question 18

Peptic ulcer disease (PUD) occurs due to constant attack on gastroduodenal mucosa by all noxious agents except ?

A	Acid
B	Pepsin
C	Bile acids
D	Salivary amylase

Question 19

PUD occurs due to constant attack on gastroduodenal mucosa by all noxious agents except ?

A	Pancreatic enzymes
B	Alcohol
C	Virus
D	Bacteria

Question 19 Explanation:

PUD occurs due to constant attack on gastroduodenal mucosa by endogenous noxious agents like acid, pepsin, bile acids, pancreatic enzymes or exogenous substances like medications, alcohol & bacteria.

Question 20

Which of the following is an element of gastric mucosal defense system ?

A	Preepithelial
B	Epithelial
C	Subepithelial
D	All of the above

Question 20 Explanation:

Gastric mucosal defense is a 3-level barrier composed of preepithelial, epithelial & subepithelial elements

Question 21

First line of defense of gastric epithelium is ?

A	Mucus layer
B	Bicarbonate-phospholipid layer
C	Phospholipid layer
D	Mucus-bicarbonate-phospholipid layer

Question 21 Explanation:

The first line of defense of gastric epithelium is a mucus-bicarbonate-phospholipid layer that serves as a physicochemical barrier. Surface epithelial cells provide the next line of defense

Question 22

Surface epithelial cells generate which of the following ?

A	Heat shock proteins
B	Trefoil factor family (TFF) peptides
C	Cathelicidins
D	All of the above

Question 22 Explanation:

Surface epithelial cells generate heat shock proteins that prevent protein denaturation, trefoil factor family peptides and cathelicidins, which play a role in surface cell protection and regeneration

Question 23

Trefoil factor family (TFF) peptides were formerly known as ?

A	C-domain peptides
B	D-domain peptides
C	G-domain peptides
D	P-domain peptides

Question 23 Explanation:

Trefoil factor family (TFF) peptides were formerly called P-domain peptides promote wound healing in the gut through epithelial restitution. TFF peptides are found in mucous membranes of stomach, conjunctiva, Brunner’s glands, intestine, salivary glands, uterus, and respiratory tract

Question 24

Cathelicidin is best related to ?

A	P-domain peptides
B	Antimicrobial peptides (AMPs)
C	Angiogenesis
D	All of the above

Question 24 Explanation:

Antimicrobial peptides (AMPs) have the capacity to rapidly inactivate infectious agents. The two major AMP families in mammals are the defensins and cathelicidin peptides

Question 25

Restitution of gastric mucosa means ?

A	Proliferation of damaged gastric mucosa
B	Regeneration of damaged gastric mucosa
C	Migration of normal gastric epithelium to damaged areas
D	All of the above

Question 25 Explanation:

Restitution is migration of gastric epithelial cells bordering site of injury when preepithelial barrier is breached

Question 26

Which of the following statements about restitution is false ?

A	Occurs independent of cell division
B	Requires uninterrupted blood flow
C	Requires an alkaline pH in surroundings
D	None of the above

Question 26 Explanation:

Restitution occurs independent of cell division and requires uninterrupted blood flow and an alkaline pH in the surrounding environment.

Question 27

Restitution of gastric mucosa is modulated by ?

A	Epidermal growth factor (EGF)
B	Transforming growth factor alpha (TGF-)
C	Fibroblast growth factor (FGF)
D	All of the above

Question 27 Explanation:

Growth factors like epidermal growth factor (EGF), transforming growth factor (TGF) alpha and basic fibroblast growth factor (FGF) modulate restitution.

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 27 questions to complete.

←

List

→

Return

Shaded items are complete.

1	2	3	4	5
6	7	8	9	10
11	12	13	14	15
16	17	18	19	20
21	22	23	24	25
26	27	End

Return

See all quizzes of Peptic Ulcer Disease at here:

1.Rumination is best related to ?
A. Nausea
B. Vomiting
C. Regurgitation
D. All of the above

2. Under normal conditions, frequency of slow wave cycles in
the stomach is ?
A. 3 cycles / minute
B. 6 cycles / minute
C. 9 cycles / minute
D. 12 cycles / minute
3. Under normal conditions, frequency of slow wave cycles in the
duodenum is ?
A. 4 cycles / minute
B. 8 cycles / minute
C. 11 cycles / minute
D. 15 cycles / minute

4. Which of the following is termed the chemoreceptor trigger
zone ?
A. Area postrema
B. Nucleus tractus solitarius
C. Dorsal vagal nuclei
D. Phrenic nuclei
5 .Which of the following act on the area postrema ?
A. Uremia
B. Hypoxia
C. Ketoacidosis
D. All of the above

6. Neurotransmitter that mediate induction of vomiting in
labyrinthine disorders is ?
A. Muscarinic M
1 receptors
B. Histaminergic H2 receptors
C. Serotonin 5-HT3 receptors
D. Dopamine D2 receptors

7. Gastroparesis occurs after which of the following ?
A. Pancreatic adenocarcinoma
B. Mesenteric vascular insufficiency
C. Scleroderma
D. All of the above

8. Gastroparesis does not occur with which of the following ?
A. Diabetes
B. Amyloidosis
C. Scleroderma
D. Cyclic vomiting syndrome

9. Which of the following drugs is a highly emetogenic agent ?
A. Digoxin
B. Oral contraceptives
C. Cisplatin
D. Erythromycin

10. What proportion of pregnant women experience nausea in the
first trimester ?
A. 25 %
B. 50 %
C. 70 %
D. 90 %

11. Relief of abdominal pain by emesis is characteristic of ?
A. Pancreatitis
B. Zenker’s diverticulum
C. Gastric obstruction
D. Intestinal obstruction

12. Which of the following antiemetic agent is a Serotonin5-HT3
antagonist ?
A. Meclizine
B. Granisetron

C. Mirtazapine
D. Dimenhydrinate

13. Which of the following is a combined 5-HT4 agonist and D2
antagonist ?
A. Metoclopramide
B. Domperidone
C. Erythromycin
D. Octreotide

14. Which of the following is a Neurokinin NK1 antagonist ?
A. Aprepitant
B. Kevetiracetam
C. Cyproheptadine
D. Sumatriptan

15. Gastric pits of stomach branch into ?
A. 1 or 2 gastric glands
B. 3 or 4 gastric glands
C. 4 or 5 gastric glands
D. 6 or 7 gastric glands

16. Which of the following cells is found deepest in the oxyntic
gastric gland ?
A. Mucous neck cells
B. Parietal cells
C. Endocrine cells
D. Chief cells
17. Parietal cell is also known as ?
A. Mucous cell
B. Oxyntic cell
C. Endocrine cell
D. Enterochromaffin-like (ECL) cell

18. Peptic ulcer disease (PUD) occurs due to constant attack on
gastroduodenal mucosa by all noxious agents except ?
A. Acid
B. Pepsin
C. Bile acids
D. Salivary amylase

20. PUD occurs due to constant attack on gastroduodenal mucosa
by all noxious agents except ?
A. Pancreatic enzymes
B. Alcohol
C. Virus
D. Bacteria

21. Which of the following is an element of gastric mucosal defense
system ?
A. Preepithelial
B. Epithelial
C. Subepithelial
D. All of the above

22. First line of defense of gastric epithelium is ?
A. Mucus layer
B. Bicarbonate-phospholipid layer
C. Phospholipid layer
D. Mucus-bicarbonate-phospholipid layer

23. Surface epithelial cells generate which of the following ?
A. Heat shock proteins
B. Trefoil factor family (TFF) peptides
C. Cathelicidins
D. All of the above

23. Trefoil factor family (TFF) peptides were formerly known as ?
A. C-domain peptides
B. D-domain peptides
C. G-domain peptides
D. P-domain peptides

24. Cathelicidin is best related to ?
A. P-domain peptides
B. Antimicrobial peptides (AMPs)
C. Angiogenesis
D. All of the above

25 Restitution of gastric mucosa means ?
A. Proliferation of damaged gastric mucosa
B. Regeneration of damaged gastric mucosa
C. Migration of normal gastric epithelium to damaged areas
D. All of the above

26.Which of the following statements about restitution is false ?
A. Occurs independent of cell division
B. Requires uninterrupted blood flow
C. Requires an alkaline pH in surroundings
D. None of the above

27. Restitution of gastric mucosa is modulated by ?
A. Epidermal growth factor (EGF)
B. Transforming growth factor alpha (TGF-)
C. Fibroblast growth factor (FGF)
D. All of the above

Peptic Ulcer Disease

[MCQ] Peptic Ulcer Disease- Part 1

I. Start the exam by click the “Start” button

Peptic Ulcer Disease- Part 1

Share this:

Related

[MCQ] Diseases of the Esophagus- Part 3

[MCQ] Peptic Ulcer Disease- Part 2

You may also like

Leave a Comment Cancel Reply