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Glomerular Diseases- Part 5
See all quizzes of Glomerular Diseases at here:
1.From the earliest stages of microalbuminuria, it takes how many
years to reach end-stage renal disease (ESRD)?
A. 5 – 10 years
B. 10 – 20 years
C. 20 – 30 years
D. > 30 years
2. Renal vein thrombosis is common in patients with nephrotic syndrome due to ?
A. Membranous glomerulopathy
B. Membranoproliferative glomerulonephritis
C. Amyloidosis
D. All of the above
3. Clinical features that suggest acute renal vein thrombosis include all except ?
A. Sudden onset of flank or abdominal pain
B. Gross hematuria
C. Right-sided varicocele
D. Acute decline in GFR
4. Congo red stains are positive ?
A. AA & AL amyloidosis
B. Fibrillary-Immunotactoid Glomerulopathy
C. Light chain deposition disease
D. All of thr above
AA and AL amyloid fibrils are detectable with Congo red.
5. Which of the following best relates to Fabry’s Disease ?
A. Glucosylceramide
B. Galactosylceramide
C. Globotriaosylceramide
D. Ceramide
6. Clinical manifestations of Fabry’s disease include all except ?
A. Angiokeratomas
B. Corneal and lenticular opacities
C. Small-vessel disease of the kidney
D. Macrocephaly
7. Angiokeratomas is a clinical feature of ?
A. Fabry’s disease
B. -Mannosidosis
C. Fucosidosis
D. All of the above
8. In Fabry’s disease, angiokeratomas are most dense ?
A. Over nape of the neck
B. Over finger tips
C. Between umbilicus and knees
D. Over forehead
9. “Zebra bodies” is a histopathological hallmark of ?
A. Fabry’s disease
B. -Mannosidosis
C. Fucosidosis
D. All of the above
10. In Fabry’s disease, neutral glycosphingolipids accumulate in which orgenelle of glomerular cells ?
A. Mitochondria
B. Golgi apparatus
C. Lysosome
D. Nucleus
11. Which of the following statements about ‘Nail–patella syndrome’ is false ?
A. It an autosomal dominant disease
B. Abnormal gene is located on long arm of chromosome 9
C. Multiple osseous abnormalities primarily affect elbows and knees, and nail dysplasia
D. None of the above
12. Which of the following statements about ‘Nail–patella syndrome’ is false ?
A. Glomerular basement membrane is thickened with splitting and fibrillar collagen deposits
B. Caused by loss-of-function mutations in LMX1B
C. LMX1B is expressed in kidney primarily by podocytes
D. None of the above
13. After what duration does HIV-associated nephropathy begin ?
A. ~ 3 months
B. ~ 6 months
C. ~ 1 year
D ~ 2.5 years
14. HIV infection is most commonly associated with which of the following glomerulopathies ?
A. Aggresive focal segmental glomerulosclerosis
B. Acute diffuse proliferative glomerulonephritis
C. IgA nephropathy
D. Membranous glomerulopathy
15. Term HIV-associated nephropathy (HIVAN) is used for ?
A. Aggresive focal segmental glomerulosclerosis
B. Acute diffuse proliferative glomerulonephritis
C. IgA nephropathy
D. Membranous glomerulopathy
16. Which of the following is false for HIV-associated nephropathy (HIVAN) ?
A. May be the first manifestation of HIV infection
B. More common in blacks
C. More frequent in intravenous drug abusers
D. Slow clinical course
17. HIV patients with FSGS present with nephrotic-range proteinuria & hypoalbuminemia but without ?
A. Hypertension
B. Edema
C. Hyperlipidemia
D. All of the above
18. Which of the following is an inflammatory glomerulopathy ?
A. Focal proliferative glomerulonephritis
B. Diffuse proliferative glomerulonephritis
C. Crescentic glomerulonephritis
D. All of the above
19. Which of the following is false about inflammatory glomerulopathy ?
A. Nephrotic-type
B. RBC in urine
C. RBC cast in urine
D. Leucocyte in urine
20. Nephrotic-range proteinuria can be found in all except ?
A. Membranous glomerulopathy
B. Minimal change disease (MCD)
C. Focal proliferative glomerulonephritis
D. Focal and segmental glomerulosclerosis (FSGS)
21. Which of the following cells of kidney do not proliferate ?
A. Mesangial cells
B. Endothelial cells
C. Visceral epithelial cells
D. All of the above
22. ‘Crescents’ are composed of ?
A. Infiltrating monocytes
B. Proliferating parietal epithelial cells
C. Fibrin
D. All of the above
23. Intrarenal vasoconstrictors include all except ?
A. Leukotrienes
B. Nitric oxide
C. Thromboxanes
D. Platelet-activating factor
