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If a patient with sickle cell anemia is in an acute crisis state, peripheral blood smears may exhibit
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What estimated percentage of black Americans are heterozygous for Hb S?
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Most unstable hemoglobins
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What factors contribute to the sickling of erythrocytes in sickle cell anemia crisis?
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In a-type thalassemia, with three inactive a genes, which of the following is characteristic?
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Hemoglobinopathies can be classified as
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The characteristic hemoglobin concentration in a patient’s silent state with heterozygous b-thalassemia is
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The common denominator in the hemoglobinopathies is that all are
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Thalassemias are characterized by
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In sickle cell anemia the cause is
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The most common complaint associated with sickle cell anemia?
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In the hemoglobinopathies, a trait is described as
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The peripheral blood smear in silent state patients with a-thalassemia typically appears as
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Deoxyhemoglobin C has
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One of the two most common monogenetic diseases of man is
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Normal adult hemoglobin contains the following components: Hb A (95% to 98%), Hb A2 (2% to 3%), Hb A1 (3% to 6%), and Hb F (<1%).
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What is the primary risk to thalassemia major patients who receive frequent and multiple blood transfusions?
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In sickle cell disease the abnormality is related to
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Homozygous b-thalassemia patients have
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The incidence of Hb E hemoglobinopathy is highest in
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Hemoglobinopathies and Thalassemias
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| 1. The common denominator in the hemoglobinopathies is that all are A. structural defects in the erythrocyte membrane B. metabolic defects in the erythrocytic physiology C. inherited or genetic defects related to hemoglobin D. acquired defects related to hemoglobin |
| 2. Hemoglobinopathies can be classified as A. abnormal hemoglobin globulin structure B. a defect of hemoglobin globulin synthesis C. a combination of defects of both structure and synthesis D. all of the above |
| 3. Normal adult hemoglobin contains the following components: Hb A (95% to 98%), Hb A2 (2% to 3%), Hb A1 (3% to 6%), and Hb F (<1%). A. True B. False |
| 4. In the hemoglobinopathies, a trait is described as A. heterozygous and asymptomatic B. heterozygous and symptomatic C. homozygous and asymptomatic D. homozygous and symptomatic |
| 5. In sickle cell anemia the cause is A. a change of a single nucleotide (GAT to GTT) B. the substitution of valine for glutamic acid at the sixth position on the beta chain of the hemoglobin molecule C. not genetic D. both A and B |
| 6. In sickle cell disease the abnormality is related to A. the rate of synthesis of hemoglobin B. an abnormal molecular structure of hemoglobin C. an acquired defect D. a membrane dysfunction |
| 7. One of the two most common monogenetic diseases of man is A. sickle cell trait B. sickle cell anemia C. a-thalassemia D. Hb SC disease |
| 8. If a patient with sickle cell anemia is in an acute crisis state, peripheral blood smears may exhibit A. leptocytes B. drepanocytes C. ovalocytes D. stomatocytes |
| 9. What estimated percentage of black Americans are heterozygous for Hb S? A. 4% B. 8% C. 12% D. More than 25% |
| 10. What factors contribute to the sickling of erythrocytes in sickle cell anemia crisis? A. Increase in blood pH and increase in oxygen B. Extremely hot weather C. Extremely reduced oxygen and increased acidity in the blood D. Sickling is spontaneous |
| 11. The most common complaint associated with sickle cell anemia? A. Acute pain B. Organ or tissue failure C. Stroke D. All of the above |
| 12. Thalassemias are characterized by A. abnormal amino acid sequence of the hemoglobin molecules B. defective iron synthesis C. absence or decrease in synthesis of one or more globlin subunits D. skeletal membrane defects |
| 13. Homozygous b-thalassemia patients have A. no manifestations of anemia B. only mild anemia C. moderate anemia D. severe transfusion-dependent anemia |
| 14. In a-type thalassemia, with three inactive a genes, which of the following is characteristic? A. Hb A2 B. Hb A C. Hb H D. Hb F and A2 |
| 15. What is the primary risk to thalassemia major patients who receive frequent and multiple blood transfusions? A. Iron overload B. Citrate toxicity C. Polycythemia D. Hyperviscosity |
| 16. The peripheral blood smear in silent state patients with a-thalassemia typically appears as A. normochromic, normocytic B. microcytic, hypochromic C. macrocytic, normocytic D. macrocytic, hypochromic |
| 17. The characteristic hemoglobin concentration in a patient’s silent state with heterozygous b-thalassemia is A. Hb A level normal B. Hb A2 increased C. Hb A2 level decreased D. Hb F level increased |
| 18. Deoxyhemoglobin C has A. decreased solubility B. increased solubility C. the ability to form intracellular crystals D. both A and C |
| 19. The incidence of Hb E hemoglobinopathy is highest in A. Southeast Asia B. China C. Vietnam D. Native Americans |
| 20. Most unstable hemoglobins A. are inherited autosomal dominant disorders B. result from amino acid substitutions or deletions C. are hemoglobin variants D. all of the above |
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