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You are here: Home / Laboratory Quizzes / [MCQs] Hemoglobinopathies and Thalassemias Quizzes

[MCQs] Hemoglobinopathies and Thalassemias Quizzes

May 13, 2019 May 19, 2019 MedQuizzes 0 Comment

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The most common complaint associated with sickle cell anemia?

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Deoxyhemoglobin C has

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One of the two most common monogenetic diseases of man is

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What estimated percentage of black Americans are heterozygous for Hb S?

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The characteristic hemoglobin concentration in a patient’s silent state with heterozygous b-thalassemia is

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The incidence of Hb E hemoglobinopathy is highest in

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What factors contribute to the sickling of erythrocytes in sickle cell anemia crisis?

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If a patient with sickle cell anemia is in an acute crisis state, peripheral blood smears may exhibit

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Thalassemias are characterized by

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The peripheral blood smear in silent state patients with a-thalassemia typically appears as

Correct! Wrong!

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In the hemoglobinopathies, a trait is described as

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In sickle cell disease the abnormality is related to

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The common denominator in the hemoglobinopathies is that all are

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Homozygous b-thalassemia patients have

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Most unstable hemoglobins

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What is the primary risk to thalassemia major patients who receive frequent and multiple blood transfusions?

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Hemoglobinopathies can be classified as

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Normal adult hemoglobin contains the following components: Hb A (95% to 98%), Hb A2 (2% to 3%), Hb A1 (3% to 6%), and Hb F (<1%).

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In a-type thalassemia, with three inactive a genes, which of the following is characteristic?

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In sickle cell anemia the cause is

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Hemoglobinopathies and Thalassemias
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1. The common denominator in the hemoglobinopathies
is that all are
A. structural defects in the erythrocyte membrane
B. metabolic defects in the erythrocytic physiology
C. inherited or genetic defects related to hemoglobin
D. acquired defects related to hemoglobin
2. Hemoglobinopathies can be classified as
A. abnormal hemoglobin globulin structure
B. a defect of hemoglobin globulin synthesis
C. a combination of defects of both structure and synthesis
D. all of the above
3. Normal adult hemoglobin contains the following components: Hb A (95% to 98%), Hb A2 (2% to 3%), Hb A1
(3% to 6%), and Hb F (<1%).
A. True
B. False
4. In the hemoglobinopathies, a trait is described as
A. heterozygous and asymptomatic
B. heterozygous and symptomatic
C. homozygous and asymptomatic
D. homozygous and symptomatic
5. In sickle cell anemia the cause is
A. a change of a single nucleotide (GAT to GTT)
B. the substitution of valine for glutamic acid at the sixth
position on the beta chain of the hemoglobin molecule
C. not genetic
D. both A and B
6. In sickle cell disease the abnormality is related to
A. the rate of synthesis of hemoglobin
B. an abnormal molecular structure of hemoglobin
C. an acquired defect
D. a membrane dysfunction
7. One of the two most common monogenetic diseases of
man is
A. sickle cell trait
B. sickle cell anemia
C. a-thalassemia
D. Hb SC disease
8. If a patient with sickle cell anemia is in an acute crisis
state, peripheral blood smears may exhibit
A. leptocytes
B. drepanocytes
C. ovalocytes
D. stomatocytes
9. What estimated percentage of black Americans are
heterozygous for Hb S?
A. 4%
B. 8%
C. 12%
D. More than 25%
10. What factors contribute to the sickling of erythrocytes
in sickle cell anemia crisis?
A. Increase in blood pH and increase in oxygen
B. Extremely hot weather
C. Extremely reduced oxygen and increased acidity in
the blood
D. Sickling is spontaneous
11. The most common complaint associated with sickle cell
anemia?
A. Acute pain
B. Organ or tissue failure
C. Stroke
D. All of the above
12. Thalassemias are characterized by
A. abnormal amino acid sequence of the hemoglobin
molecules
B. defective iron synthesis
C. absence or decrease in synthesis of one or more
globlin subunits
D. skeletal membrane defects
13. Homozygous b-thalassemia patients have
A. no manifestations of anemia
B. only mild anemia
C. moderate anemia
D. severe transfusion-dependent anemia
14. In a-type thalassemia, with three inactive a genes, which
of the following is characteristic?
A. Hb A2
B. Hb A
C. Hb H
D. Hb F and A2
15. What is the primary risk to thalassemia major patients
who receive frequent and multiple blood transfusions?
A. Iron overload
B. Citrate toxicity
C. Polycythemia
D. Hyperviscosity
16. The peripheral blood smear in silent state patients with
a-thalassemia typically appears as
A. normochromic, normocytic
B. microcytic, hypochromic
C. macrocytic, normocytic
D. macrocytic, hypochromic
17. The characteristic hemoglobin concentration in a
patient’s silent state with heterozygous b-thalassemia is
A. Hb A level normal
B. Hb A2 increased
C. Hb A2 level decreased
D. Hb F level increased
18. Deoxyhemoglobin C has
A. decreased solubility
B. increased solubility
C. the ability to form intracellular crystals
D. both A and C
19. The incidence of Hb E hemoglobinopathy is highest in
A. Southeast Asia
B. China
C. Vietnam
D. Native Americans
20. Most unstable hemoglobins
A. are inherited autosomal dominant disorders
B. result from amino acid substitutions or deletions
C. are hemoglobin variants
D. all of the above

 

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