[MCQs] Hemolytic Anemias

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[MCQs] Hemolytic Anemias
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Select the ONE answer that is BEST in each case.

1. Hemolytic disruption of the erythrocyte involves

 

1. Hemolytic disruption of the erythrocyte involves
A. an alteration in the erythrocyte membrane
B. a defect of the hemoglobin molecule
C. an antibody coating the erythrocyte
D. physical trauma
2. _____ Intravascular hemolysis

A. Destruction of RBCs outside the circulatory blood
B. Destruction of RBCs within the circulatory blood

3. _____ Extravascular hemolysis
A. Destruction of RBCs outside the circulatory blood
B. Destruction of RBCs within the circulatory blood
4. Which of the following tests is not useful in determining increased erythrocyte destruction?
A. Reticulocyte count
B. Total leukocyte count
C. Serum haptoglobin
D. Unconjugated bilirubin
_____ G6PD deficiency

A. Structural membrane defect
B. Erythrocytic enzyme defect
C. Defect of the hemoglobin molecule

6. _____ Hereditary spherocytosis

A. Structural membrane defect
B. Erythrocytic enzyme defect
C. Defect of the hemoglobin molecule

7. _____ Thalassemia

A. Structural membrane defect
B. Erythrocytic enzyme defect
C. Defect of the hemoglobin molecule

8. _____ Pyruvate kinase (PK) deficiency

A. Structural membrane defect
B. Erythrocytic enzyme defect
C. Defect of the hemoglobin molecule

9. _____ Hereditary spherocytosis

A. An overabundance of oval-shaped red cells
B. A permeability disorder
C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. Can be seen in the genetic hemoglobin defect, thalassemia
E. A subgroup of common hereditary elliptocytosis

10. _____ Hereditary elliptocytosis

A. An overabundance of oval-shaped red cells
B. A permeability disorder
C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. Can be seen in the genetic hemoglobin defect, thalassemia
E. A subgroup of common hereditary elliptocytosis

11. _____ Hereditary pyropoikilocytosis (HPP)

A. An overabundance of oval-shaped red cells
B. A permeability disorder
C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. Can be seen in the genetic hemoglobin defect, thalassemia
E. A subgroup of common hereditary elliptocytosis

12. _____ Hereditary stomatocytosis

A. An overabundance of oval-shaped red cells
B. A permeability disorder
C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. Can be seen in the genetic hemoglobin defect, thalassemia
E. A subgroup of common hereditary elliptocytosis

13. _____ Hereditary xerocytosis
A. An overabundance of oval-shaped red cells
B. A permeability disorder
C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent
D. Can be seen in the genetic hemoglobin defect, thalassemia
E. A subgroup of common hereditary elliptocytosis
14. Heinz bodies are associated with the congenital hemolytic anemia
A. G6PD deficiency
B. abetalipoproteinemia
C. hereditary spherocytosis
D. hemolytic anemias
15. A hemolytic crisis may be precipitated in 10% of American black males suffering from G6PD deficiency by
A. fava beans
B. primaquine
C. quinine
D. quinidine
16. What is the most common glycolytic enzyme deficiency  associated with the aerobic pathway of erythrocyte metabolism?
A. Glucose-6-phosphate dehydrogenase (G6PD)
B. Pyruvate kinase (PK)
C. Methemoglobin reductase deficiency
D. Hexokinase deficiency
17. What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism?
A. Glucose-6-phosphate dehydrogenase (G6PD)
B. Pyruvate kinase (PK)
C. Methemoglobin reductase deficiency
D. Hexokinase deficiency
18. What laboratory assay would specifi cally indicate a deficiency of G6PD enzyme?
A. Heinz bodies on peripheral blood smears
B. Reticulocyte count
C. Hemoglobin and hematocrit
D. Osmotic fragility test
19. What enzyme defi ciency causes methemoglobinemia?
A. Glucose-6-phosphate dehydrogenase (G6PD)
B. Pyruvate kinase (PK)
C. NADH-methemoglobin reductase
D. Hexokinase deficiency
20. Acquired hemolytic anemia can be caused by
A. chemicals or drugs
B. infectious organisms
C. antibody reactions
D. all of the above
21. The infectious microorganism directly associated with hemolytic uremic syndrome is
A. Pasteurella tularensis
B. E. coli O157-H7
C. Staphylococcus aureus
D. Clostridia botulinum
22. _____ Warm-type autoimmune hemolytic anemia (AIHA)

A. IgM, usually anti-I
B. Rh antibodies are the most frequent cause
C. Usually occurs in newborn infants

23. _____ Cold-type AIHA

A. IgM, usually anti-I
B. Rh antibodies are the most frequent cause
C. Usually occurs in newborn infants

24. _____ Isoimmune hemolytic anemia
A. IgM, usually anti-I
B. Rh antibodies are the most frequent cause
C. Usually occurs in newborn infants
25. The erythrocyte alteration characteristically associated with hemolytic anemias is
A. hypochromia
B. macrocytosis
C. spherocytosis
D. burr cells
26. What laboratory procedures would refl ect a typical hemolytic anemia?
A. Increased osmotic fragility
B. Increased total serum bilirubin
C. Increased reticulocyte count, unless hematopoiesis is suppressed
D. All of the above
27. Which of the following is not associated with hemolytic anemia?
A. Decreased hemoglobin and packed cell volume
B. Increased reticulocyte count
C. Increased serum haptoglobins
D. Decreased erythrocyte survival
28. Paroxysmal nocturnal hemoglobinuria exhibits sensitivity of one population of red blood cells to
A. warm antibodies
B. cold antibodies
C. complement
D. either A or B
29. Paroxysmal nocturnal hemoglobinuriaepisodes are usually associated with
A. cold temperatures
B. hot temperatures
C. sleep
D. certain foods or drugs
30. The defect in PNH probably is a (an) _____ associated defect of the red cell membrane.
A. structural protein
B. hemoglobin
C. antibody
D. enzyme

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