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Select the ONE answer that is BEST in each case.
1. Hemolytic disruption of the erythrocyte involves
| 1. Hemolytic disruption of the erythrocyte involves A. an alteration in the erythrocyte membrane B. a defect of the hemoglobin molecule C. an antibody coating the erythrocyte D. physical trauma |
| 2. _____ Intravascular hemolysis
A. Destruction of RBCs outside the circulatory blood |
| 3. _____ Extravascular hemolysis A. Destruction of RBCs outside the circulatory blood B. Destruction of RBCs within the circulatory blood |
| 4. Which of the following tests is not useful in determining increased erythrocyte destruction? A. Reticulocyte count B. Total leukocyte count C. Serum haptoglobin D. Unconjugated bilirubin |
| _____ G6PD deficiency
A. Structural membrane defect |
| 6. _____ Hereditary spherocytosis
A. Structural membrane defect |
| 7. _____ Thalassemia
A. Structural membrane defect |
| 8. _____ Pyruvate kinase (PK) deficiency
A. Structural membrane defect |
| 9. _____ Hereditary spherocytosis
A. An overabundance of oval-shaped red cells |
| 10. _____ Hereditary elliptocytosis
A. An overabundance of oval-shaped red cells |
| 11. _____ Hereditary pyropoikilocytosis (HPP)
A. An overabundance of oval-shaped red cells |
| 12. _____ Hereditary stomatocytosis
A. An overabundance of oval-shaped red cells |
| 13. _____ Hereditary xerocytosis A. An overabundance of oval-shaped red cells B. A permeability disorder C. The most common prevalent hereditary hemolytic anemia among people of Northern European descent D. Can be seen in the genetic hemoglobin defect, thalassemia E. A subgroup of common hereditary elliptocytosis |
| 14. Heinz bodies are associated with the congenital hemolytic anemia A. G6PD deficiency B. abetalipoproteinemia C. hereditary spherocytosis D. hemolytic anemias |
| 15. A hemolytic crisis may be precipitated in 10% of American black males suffering from G6PD deficiency by A. fava beans B. primaquine C. quinine D. quinidine |
| 16. What is the most common glycolytic enzyme deficiency associated with the aerobic pathway of erythrocyte metabolism? A. Glucose-6-phosphate dehydrogenase (G6PD) B. Pyruvate kinase (PK) C. Methemoglobin reductase deficiency D. Hexokinase deficiency |
| 17. What is the most common glycolytic enzyme deficiency associated with the anaerobic pathway of erythrocyte metabolism? A. Glucose-6-phosphate dehydrogenase (G6PD) B. Pyruvate kinase (PK) C. Methemoglobin reductase deficiency D. Hexokinase deficiency |
| 18. What laboratory assay would specifi cally indicate a deficiency of G6PD enzyme? A. Heinz bodies on peripheral blood smears B. Reticulocyte count C. Hemoglobin and hematocrit D. Osmotic fragility test |
| 19. What enzyme defi ciency causes methemoglobinemia? A. Glucose-6-phosphate dehydrogenase (G6PD) B. Pyruvate kinase (PK) C. NADH-methemoglobin reductase D. Hexokinase deficiency |
| 20. Acquired hemolytic anemia can be caused by A. chemicals or drugs B. infectious organisms C. antibody reactions D. all of the above |
| 21. The infectious microorganism directly associated with hemolytic uremic syndrome is A. Pasteurella tularensis B. E. coli O157-H7 C. Staphylococcus aureus D. Clostridia botulinum |
| 22. _____ Warm-type autoimmune hemolytic anemia (AIHA)
A. IgM, usually anti-I |
| 23. _____ Cold-type AIHA
A. IgM, usually anti-I |
| 24. _____ Isoimmune hemolytic anemia A. IgM, usually anti-I B. Rh antibodies are the most frequent cause C. Usually occurs in newborn infants |
| 25. The erythrocyte alteration characteristically associated with hemolytic anemias is A. hypochromia B. macrocytosis C. spherocytosis D. burr cells |
| 26. What laboratory procedures would refl ect a typical hemolytic anemia? A. Increased osmotic fragility B. Increased total serum bilirubin C. Increased reticulocyte count, unless hematopoiesis is suppressed D. All of the above |
| 27. Which of the following is not associated with hemolytic anemia? A. Decreased hemoglobin and packed cell volume B. Increased reticulocyte count C. Increased serum haptoglobins D. Decreased erythrocyte survival |
| 28. Paroxysmal nocturnal hemoglobinuria exhibits sensitivity of one population of red blood cells to A. warm antibodies B. cold antibodies C. complement D. either A or B |
| 29. Paroxysmal nocturnal hemoglobinuriaepisodes are usually associated with A. cold temperatures B. hot temperatures C. sleep D. certain foods or drugs |
| 30. The defect in PNH probably is a (an) _____ associated defect of the red cell membrane. A. structural protein B. hemoglobin C. antibody D. enzyme |
