[MCQs] Bleeding and Thrombosis – Part 1

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Bleeding and Thrombosis – Part 1 | Bleeding and Thrombosis – Part 2 | Bleeding and Thrombosis – Part 3

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1. In the human hemostatic system, procoagulant forces include ?

1. Platelet adhesion
2. Platelet aggregation
3. Fibrin  clot formation
4. All of the above

2. The major components of the hemostatic system are ?

1. Platelets, monocytes and red cells
2. Plasma proteins
3. Vessel wall
4. All of the above

3. Formed element of blood that is not a component of the hemostatic system is ?

1. NeutrophilNeutrophil
2. Monocyte
3. Red cell
4. Platelet
5.  

4. Platelet adhesion is mediated primarily by ?

1. von Willebrand factor (vWF)
2. Gp IIb/IIIa
3. Gp Ia/IIa
4. Fibronectin

5. Which of the following is false about von Willebrand factor (VWF) ?

1. Large multimeric protein
2. Present in plasma
3. Present in extracellular matrix of subendothelial vessel wall
4. None of the above

6. Which of the following is released from activated platelets ?

1. Epinephrine
2. Thrombin
3. Adenosine diphosphate
4. All of the above

7. Most abundant receptor on the platelet surface is ?

1. Gp Ia/IIa
2. Gp Ib/IX
3. Gp IIb/IIIa
4. Gp VI

8. Platelet surface receptor GpIIB / IIIa binds to ?

1. Thrombospondin
2. Fibrinogen
3. Collagen
4. All of the above

9. Surface of each platelet has how many GpIIb / IIIa binding sites ?

1. ~ 10,000
2. ~ 25,000
3. ~ 50,000
4. ~ 100,000

10. Tissue factor (TF) is present on ?

1. Subendothelial cellular components of vessel wall
2. Circulating microparticles from monocytes
3. Circulating microparticles from platelets
4. All of the above

11.Which of the following is a serine protease factor ?

1. III
2. VIIa
3. IX
4. X

12. Essential cofactor for conversion of prothrombin to thrombin   is ?

1. Va
2. VIIa
3. IX
4. X

13. Which of the following in endothelial cells has antithrombotic effect ?

1. Prostacyclin
2. Nitric oxide
3. EctoADPase/CD39
4. All of the above

14. Anticoagulant factor produced by endothelial cells is ?

1. Heparan proteoglycans
2. Antithrombin
3. Thrombomodulin
4. All of the above

15. Which of the following produced by  endothelial cells acts  as an anticoagulant ?

1. Plasminogen activator inhibitor
2. Thrombomodulin
3. Prostacyclin
4. Nitric oxide

16. Endothelial cells activate fibrinolytic mechanisms through the production of ?

1. Tissue plasminogen activator 1
2. Urokinase
3. Plasminogen activator inhibitor
4. All of the above

17. Which of the following best relates to heparin ?

1. Antithrombin III
2. Protein C
3. Protein S
4. All of the above

18. Which of the following becomes an anticoagulant when it is activated by thrombin ?

1. Antithrombin III
2. Protein C
3. Protein S
4. Tissue factor pathway inhibitor (TFPI)

19. Which of the following about thrombomodulin is false ?

1. Transmembrane proteoglycan binding site for thrombin on endothelial cell surface
2. Thrombin-induced activation of protein C occurs physiologically on thrombomodulin
3. Anticoagulant factor from endothelial cell
4. None of the above

20. Activated protein C acts as an anticoagulant by cleaving and inactivating activated factor ?

1. II
2. V
3. VI
4. X

21. Which of the following relates to protein S ?

1. Cofactor
2. Glycoprotein
3. Vitamin K dependent posttranslational modification
4. All of the above

22. Which of the following inhibits TF / FVIIa / FXa complex ?

1. Activated protein C
2. Protein S
3. Tissue factor pathway inhibitor (TFPI)
4. All of the above

23. Tissue factor pathway inhibitor (TFPI) be released by ?

1. Heparin
2. Streptokinase
3. Urokinase
4. All of the above

24.Plasminogen activators (tPA & uPA) cleave which bond of plasminogen to generate the active enzyme plasmin ?

1. Arg460 – Val461
2. Arg560 – Val561
3. Arg660 – Val661
4. Arg760 – Val761

25. “Fibrin specific” activity of plasmin is due to its ?

1. Arginine-binding sites
2. Lysine-binding sites
3. Valine-binding sites
4. Leucine-binding sites

26. Physiologic regulation of fibrinolysis is done by ?

1. Plasminogen activator inhibitors (PAI-1 & PAI-2)
2. Thrombin-activatable fibrinolysis inhibitor (TAFI)
3. a₂-antiplasmin
4. All of the above

27. Which of the following antiplasmin inhibits plasmin ?

1. a₁ antiplasmin
2. a₂ antiplasmin
3. a₃ antiplasmin
4. a₄ antiplasmin

28. Epistaxis is the most common symptom in ?

1. Hemophilia A
2. Ehlers-Danlos syndrome
3. Hereditary hemorrhagic telangiectasia
4. Cushing’s syndrome

29. Menorrhagia is a common symptom in women with ?

1. VWD
2. Factor XI deficiency
3. Symptomatic carriers of hemophilia A
4. All of the above

30. Which of the following is called a “life-threatening site of bleeding” ?

1. Bleeding into oropharynx
2. Bleeding into central nervous system
3. Bleeding into retroperitoneum
4. All of the above

31. Which of the following about clopidogrel is false ?

1. Thienopyridine
2. Inhibits ADP-mediated platelet aggregation
3. Can precipitate or exacerbate bleeding symptoms
4. None of the above

32. Herb with potential anti-platelet activity is ?

1. Ginger
2. Turmeric
3. Garlic
4. All of the above