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Guillain-Barré syndrome (GBS)- Part 1
See all quizzes of Guillain-Barré syndrome (GBS) – Part 1 here:
1 Guillain-Barré syndrome was first described in which year ?
N Engl J Med 2012;366:2294-304
A. 1869
B. 1898
C. 1916
D. 1934
2 Miller Fisher syndrome was first reported in which year ?
A. 1923
B. 1943
C. 1956
D. 1966
3 Feature not typical of Guillain-Barre syndrome is ?
A. Acute onset
B. Males & females are at equal risk
C. Autoimmune
D. Polyradiculoneuropathy
4 Facial diparesis is present in what proportion of GBS patients ?
A. 10 %
B. 20 %
C. 50 %
D. 80 %
5 Which of the following is not typical of Guillain-Barre syndrome
?
A. Fever & constitutional symptoms are absent at onset
B. Lower cranial nerves are frequently involved
C. DTRs disappear within first few days of onset
D. Bladder dysfunction is a prominent feature
6 In GBS, clinical worsening reaches a plateau in how many weeks
of onset ?
A. 1 week
B. 4 weeks
C. 8 weeks
D. 12 weeks
7 Limited or regional GBS syndromes include ?
A. Acute motor axonal neuropathy (AMAN)
B. Acute motor sensory axonal neuropathy (AMSAN)
C. Miller Fisher syndrome (MFS)
D. All of the above
8 Which of the following is the most common form of GBS ?
A. Acute inflammatory demyelinating polyradiculoneuropathy
B. Acute axonal motor disorder
C. Acute sensory & motor axonal neuropathy
D. Miller Fisher syndrome (MFS)
9 Nationality of Charles Miller Fisher was ?
A. Canadian
B. American
C. British
D. Brazilian
10 Which of the following is a demyelinating disorder ?
A. Acute motor axonal neuropathy (AMAN)
B. Acute motor sensory axonal neuropathy (AMSAN)
C. Miller Fisher syndrome (MFS)
D. All of the above
11 Organisms involved in antecedent infections in Guillain-Barre
syndrome include ?
A. Campylobacter jejuni
B. Human herpes virus
C. Cytomegalovirus
D. All of the above
12 Which of the following vaccinations could predispose to Guillain-
Barre syndrome ?
A. Swine influenza vaccine
B. Influenza vaccine
C. Older type rabies vaccine
D. All of the above
13 Guillain-Barre syndrome occurs more frequently in patients with
following diseases except ?
A. Hodgkin’s disease
B. Chronic myeloid leukemia
C. HIV-seropositive individuals
D. Systemic lupus erythematosus
14 Which of the following statements is false about GBS ?
A. Both cellular & humoral immune mechanisms involved
B. Analogous to experimental allergic neuritis (EAN)
C. Molecular mimicry mechanism
D. None of the above
15 Which of the following is the critical event in the development of
GBS ?
A. B cells recognize glycoconjugates on C. jejuni
B. Activation of B cells T cell
C. Escape of activated B cells from Peyer’s patches into
regional lymph nodes
D. All of the above
16 Which of the following is false about Miller Fisher syndrome ?
A. Anti-GQ1b antibodies are found in > 90% patients
B. IgG titers are highest early in the course
C. Areflexia of limbs without weakness
D. None of the above
17 Which of the following antiganglioside antibody is common in
GBS ?
A. Anti GM1
B. Anti GM2
C. Anti GM3
D. Anti GM4
18 Which of the following is most relevant to Gangliosides ?
A. Lectin
B. Heparan
C. Ceramide
D. Mannose
19 Which of the following is a Ganglioside ?
A. GM1
B. GD1a
C. GT1a
D. All of the above
20 Which of the following is a central nervous system variant of
Miller Fisher syndrome ?
A. Anti-Hu–Associated Paraneoplastic Encephalitis (PEM)
B. Bickerstaff’s brain-stem encephalitis
C. Post–infectious brainstem encephalitis
D. All of the above
21 Which of the following gangliosides is strongly expressed at the
nodes of Ranvier ?
A. GM1
B. GT1a
C. GQ1b
D. All of the above
22 IgG autoantibodies to GQ1b cross-react with which of the
following ?
A. GM1
B. GD1a
C. GT1a
D. All of the above
23 The anti-GQ1b antibody syndrome includes which of the following
?
A. Bickerstaff’s brain-stem encephalitis
B. Miller Fisher syndrome
C. Pharyngeal–cervical–brachial weakness
D. All of the above
24 GQ1b is strongly expressed in which of the following cranial
nerves ?
A. Oculomotor nerve
B. Trochlear nerve
C. Abducens nerve
D. All of the above
25 In demyelinating GBS, basis for flaccid paralysis & sensory
disturbance is ?
A. Conduction block
B. Neurodegeneration
C. Apoptosis
D. All of the above
26 CSF findings in Guillain-Barre syndrome include all except ?
A. Elevated CSF proteins
B. CSF protein elevated by end of first week
C. No pleocytosis
D. CSF is normal when symptoms are present for < 6 hours