[MCQ] Liver Transplantation

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Liver Transplantation

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Congratulations - you have completed Liver Transplantation. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Who pioneered liver transplantation ?

A	PW Angus
B	Thomas Starzl
C	JA Fishman
D	KF Murray

Question 1 Explanation:

Pioneered in 1960s by Thomas Starzl at the University of Colorado and, later, at the University of Pittsburgh and by Roy Calne in Cambridge, England, liver transplantation is now performed routinely worldwide. Success measured as 1-year survival has improved from 30% in the 1970s to 90% today.

Question 2

Arteriohepatic dysplasia, with paucity of bile ducts, and congenital malformations, including pulmonary stenosis is called ?

A	Alagille’s syndrome
B	Byler’s disease
C	Caroli’s disease
D	Budd-Chiari syndrome

Question 3

Intrahepatic cholestasis, progressive liver failure, mental and growth retardation is called ?

A	Alagille’s syndrome
B	Byler’s disease
C	Caroli’s disease
D	Budd-Chiari syndrome

Question 4

Multiple cystic dilatations of the intrahepatic biliary tree is called ?

A	Alagille’s syndrome
B	Byler’s disease
C	Caroli’s disease
D	Budd-Chiari syndrome

Question 5

The most common indication for transplantation in children is ?

A	Congenital hepatic fibrosis
B	Biliary atresia
C	Crigler-Najjar disease type I
D	Neonatal hepatitis

Question 5 Explanation:

The most common indication for transplantation in children is biliary atresia.

Question 6

Currently, which of the following is the most common indications for liver transplantation in adults ?

A	Fulminant hepatitis
B	Primary sclerosing cholangitis
C	Chronic hepatitis C
D	Primary biliary cirrhosis

Question 6 Explanation:

Currently, chronic hepatitis C & alcoholic liver disease are the most common indications for liver transplantation, accounting for over 40% of all adult candidates who undergo the procedure

Question 7

Which of the following is not an absolute contraindication for liver transplantation ?

A	Advanced age (>70 years)
B	Metastatic malignancy
C	Active drug abuse
D	Active alcohol abuse

Question 7 Explanation:

Absolute contraindications for transplantation include life-threatening systemic diseases, uncontrolled extrahepatic bacterial or fungal infections, preexisting advanced cardiovascular or pulmonary disease, multiple uncorrectable life-threatening congenital anomalies, metastatic malignancy, and active drug or alcohol abuse. Advanced age (>70 years) should be considered a relative contraindication

Question 8

Cadaver donor livers for liver transplantation are procured primarily from victims of ?

A	Head trauma
B	Jail deaths
C	Suicide deaths
D	Voluntary donors

Question 8 Explanation:

Cadaver donor livers for transplantation are procured primarily from victims of head trauma.

Question 9

Which of the following about cadaver donor livers for liver transplantation is false ?

A	Compatibility in ABO blood group is essential
B	Human leukocyte antigen (HLA) matching is not required
C	University of Wisconsin (UW) solution used for preservation
D	None of the above

Question 10

UNOS stands for ?

A	United Network for Organ Selection
B	United Network for Organ Sharing
C	United Network for Organ Surgery
D	United Network for Organ Substitution

Question 10 Explanation:

UNOS stands for United Network for Organ Sharing. It was adopted in 2002.

Question 11

Liver recipients with what MELD scores experienced higher posttransplantation mortality rates ?

A	< 15
B	< 20
C	< 25
D	< 30

Question 11 Explanation:

Liver recipients with MELD scores <15 experienced higher posttransplantation mortality rates. The MELD scale is continuous, with 34 levels ranging between 6 and 40. Donor organs usually do not become available unless the MELD score exceeds 20.

Question 12

Which immunosuppressive agent can be given after liver transplantation ?

A	Cyclosporine
B	Tacrolimus
C	Mycophenolic acid
D	All of the above

Question 13

Which of the following is true about Cyclosporine ?

A	Isolated from Streptomyces tsukubaensis
B	Calcineurin inhibitor (CNI)
C	Nonnucleoside purine metabolism inhibitor
D	Monoclonal antibodies to T cells

Question 13 Explanation:

Cyclosporine is a calcineurin inhibitor (CNI). It blocks early activation of T cells & is specific for T cell functions that result from the interaction of T cell with its receptor and that involve the calciumdependent signal transduction pathway. Activity of cyclosporine leads to inhibition of lymphokine gene activation, blocking interleukins 2, 3, and 4, tumor necrosis factor , and other lymphokines. Cyclosporine also inhibits B cell functions. This process occurs without affecting rapidly dividing cells in the bone marrow, thus reducing frequency of posttransplantation systemic infections.

Question 14

Which of the following is a macrolide lactone antibiotic ?

A	Cyclosporine
B	Tacrolimus
C	Mycophenolic acid
D	Rapamycin

Question 14 Explanation:

Tacrolimus is a macrolide lactone antibiotic isolated from a Japanese soil fungus, Streptomyces tsukubaensis.

Question 15

Which of the following side effects are not present with use of Tacrolimus, but present with use of Cyclosporine ?

A	Nephrotoxicity
B	Hypertension
C	Hirsutism
D	Diabetes mellitus

Question 15 Explanation:

Tacrolimus does not cause hirsutism or gingival hyperplasia.

Question 16

Which of the following is a nonnucleoside purine metabolism inhibitor ?

A	Cyclosporine
B	Tacrolimus
C	Mycophenolic acid
D	Rapamycin

Question 16 Explanation:

Mycophenolic acid, a nonnucleoside purine metabolism inhibitor derived as a fermentation product from several Penicillium species.

Question 17

Hemolytic uremic syndrome can be associated with ?

A	Cyclosporine
B	Tacrolimus
C	OKT3
D	All of the above

Question 17 Explanation:

Hemolytic uremic syndrome can be associated with cyclosporine, tacrolimus, or OKT3.

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See all quizzes of Liver Transplantation at here:

1. Who pioneered liver transplantation ?
A. PW Angus
B. Thomas Starzl
C. JA Fishman
D. KF Murray

2. Arteriohepatic dysplasia, with paucity of bile ducts, and
congenital malformations, including pulmonary stenosis is
called ?
A. Alagille’s syndrome
B. Byler’s disease
C. Caroli’s disease
D. Budd-Chiari syndrome
3. Intrahepatic cholestasis, progressive liver failure, mental and
growth retardation is called ?
A. Alagille’s syndrome
B. Byler’s disease
C. Caroli’s disease
D. Budd-Chiari syndrome

4. Multiple cystic dilatations of the intrahepatic biliary tree is
called ?
A. Alagille’s syndrome
B. Byler’s disease
C. Caroli’s disease
D. Budd-Chiari syndrome
5. The most common indication for transplantation in children
is ?
A. Congenital hepatic fibrosis
B. Biliary atresia
C. Crigler-Najjar disease type I
D. Neonatal hepatitis
6. Currently, which of the following is the most common
indications for liver transplantation in adults ?
A. Fulminant hepatitis
B. Primary sclerosing cholangitis
C. Chronic hepatitis C
D. Primary biliary cirrhosis

7.Which of the following is not an absolute contraindication for
liver transplantation ?
A. Advanced age (>70 years)
B. Metastatic malignancy
C. Active drug abuse
D. Active alcohol abuse

8. Cadaver donor livers for liver transplantation are procured
primarily from victims of ?
A. Head trauma
B. Jail deaths
C. Suicide deaths
D. Voluntary donors

9. Which of the following about cadaver donor livers for liver
transplantation is false ?
A. Compatibility in ABO blood group is essential
B. Human leukocyte antigen (HLA) matching is not required
C. University of Wisconsin (UW) solution used for preservation
D. None of the above

10. UNOS stands for ?
A. United Network for Organ Selection
B. United Network for Organ Sharing
C. United Network for Organ Surgery
D. United Network for Organ Substitution
UNOS stands for United Network for Organ Sharing. It was adopted in 2002.
11. Liver recipients with what MELD scores experienced higher
posttransplantation mortality rates ?
A. < 15
B. < 20
C. < 25
D. < 30

12. Which immunosuppressive agent can be given after liver
transplantation ?
A. Cyclosporine
B. Tacrolimus
C. Mycophenolic acid
D. All of the above
13. Which of the following is true about Cyclosporine ?
A. Isolated from Streptomyces tsukubaensis
B. Calcineurin inhibitor (CNI)
C. Nonnucleoside purine metabolism inhibitor
D. Monoclonal antibodies to T cells

14. Which of the following is a macrolide lactone antibiotic ?
A. Cyclosporine
B. Tacrolimus
C. Mycophenolic acid
D. Rapamycin

15. Which of the following side effects are not present with use of
Tacrolimus, but present with use of Cyclosporine ?
A. Nephrotoxicity
B. Hypertension
C. Hirsutism
D. Diabetes mellitus

16. Which of the following is a nonnucleoside purine metabolism
inhibitor ?
A. Cyclosporine
B. Tacrolimus
C. Mycophenolic acid
D. Rapamycin

17. Hemolytic uremic syndrome can be associated with ?
A. Cyclosporine
B. Tacrolimus
C. OKT3
D. All of the above

Liver Transplantation

[MCQ] Liver Transplantation

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Liver Transplantation

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