[MCQ] HIV / AIDS- Part 10

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HIV / AIDS- Part 10

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Congratulations - you have completed HIV / AIDS- Part 10. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Which of the following regarding TB in HIV patient is false ?

A	HIV infection increases risk of active TB by 100x
B	Rifabutin is substituted for rifampin in those receiving HIV protease inhibitors
C	Rifabutin is substituted for rifampin in those receiving NNRTI’s
D	None of the above

Question 1 Explanation:

HIV infection increases the risk of developing active TB by a factor of 100. Therapy for TB is generally the same in HIV-infected patient as in HIV-negative patient. Rifabutin should be substituted for rifampin in patients receiving HIV protease inhibitors or nonnucleoside reverse transcriptase inhibitors

Question 2

Runyon classification of Nontuberculous Mycobacteria (NTM) is based on ?

A	Colony number
B	Colony size
C	Colony shape
D	Colony pigmentation

Question 2 Explanation:

Runyon classification of Nontuberculous Mycobacteria (NTM) is based on colony pigmentation.

Question 3

Which of the following is a rapidly growing NTM species ?

A	M. avium
B	M. kansasii
C	M. fortuitum
D	M. marinum

Question 3 Explanation:

Rapidly growing NTM species are M. abscessus, M. fortuitum, and M. chelonae, while slowgrowing species include M. avium, M. kansasii, M. ulcerans, and M. marinum.

Question 4

Therapy for MAC include all except ?

A	Clarithromycin
B	Ethambutol
C	Pyrazinamide
D	Rifabutin

Question 4 Explanation:

Therapy for MAC is clarithromycin with ethambutol. Rifabutin, ciprofloxacin, or amikacin is added in patients with extensive disease.

Question 5

Due primarily to HIV infection, which is the most common clinically significant cardiac finding ?

A	Pericardial effusion
B	Nonbacterial thrombotic endocarditis
C	Left atrial myxoma
D	Dilated cardiomyopathy

Question 5 Explanation:

Due primarily to HIV infection, dilated cardiomyopathy with CHF (HIV-associated cardiomyopathy is the most common clinically significant finding. The most common form of heart disease in HIV patients is coronary heart disease

Question 6

Oral lesions in HIV infection include ?

A	Thrush
B	Hairy leukoplakia
C	Aphthous ulcers
D	All of the above

Question 6 Explanation:

Oral lesions in HIV infection include thrush (Candida), hairy leukoplakia (EBV), and aphthous ulcers.

Question 7

Which of the following about oral hairy leukoplakia is false ?

A	Found along lateral borders of tongue
B	Not considered a premalignant condition
C	Associated with florid replication of EBV
D	None of the above

Question 8

Esophagitis associated with a single large ulcer is typical of ?

A	Candida
B	CMV
C	HSV
D	KS

Question 8 Explanation:

In HIV infection, esophagitis associated with a single large ulcer occurs in CMV infection, HSV infection is associated with multiple small ulcers.

Question 9

Which of the following hepatitis virus infections are seen with increased frequency in patients with HIV infection ?

A	Hepatitis A
B	Hepatitis B
C	Hepatitis C
D	All of the above

Question 9 Explanation:

Hepatitis A virus infection is not seen with an increased frequency in patients with HIV infection. Co-infection with hepatitis B, C, D, E, & G viruses is common

Question 10

HIV infection co-infected with which of the following virus has a decreased rate of progression to AIDS ?

A	Hepatitis B virus
B	Hepatitis C virus
C	Hepatitis D virus
D	Hepatitis G virus

Question 10 Explanation:

Patients with HIV infection co-infected with hepatitis G virus have a decreased rate of progression to AIDS.

Question 11

Which of the following drugs is used in the treatment of HIV and HBV co-infection ?

A	Emtricitabine
B	Adefovir / Tenofovir
C	Entecavir
D	All of the above

Question 11 Explanation:

Lamivudine, emtricitabine, or adefovir/tenofovir and entecavir are used in the treatment of HIV and HBV co-infection.

Question 12

A syndrome similar to Gilbert’s syndrome appears with the use of which of the following ARV drug ?

A	Nevirapine
B	Indinavir
C	Emtricitabine
D	Tenofovir

Question 12 Explanation:

Nevirapine is associated with fatal fulminant & cholestatic hepatitis, hepatic necrosis, & hepatic failure. Indinavir & atazanavir may cause mild - moderate elevations in serum bilirubin in a syndrome similar to Gilbert’s syndrome.

Question 13

Features of lipodystrophy in HIV patients receiving HAART are ?

A	Increased plasma triglycerides
B	Increased total cholesterol
C	Increased apolipoprotein B
D	All of the above

Question 13 Explanation:

Features of lipodystrophy in HIV patients receiving HAART are elevations in plasma triglycerides, total cholesterol & apolipoprotein B, as well as hyperinsulinemia & hyperglycemia.

Question 14

Which of the following ARV drug is a thymidine analogue ?

A	Zidovudine
B	Lamivudine
C	Nevirapine
D	Efavirenz

Question 15

Most commonly used drug for lipodystrophy in HIV patients receiving HAART is ?

A	Atorvastatin
B	Cholestyramine
C	Ezetimibe
D	Nicotinic acid

Question 15 Explanation:

Most commonly used drug for lipodystrophy in HIV patients receiving HAART is either gemfibrozil or atorvastatin. Others may cause drug interactions.

Question 16

Persistent generalized lymphadenopathy is defined enlarged lymph nodes in two or more extrainguinal sites, without an obvious cause for ?

A	> 1 month
B	> 3 months
C	> 6 months
D	> 9 months

Question 16 Explanation:

PGL is defined as presence of enlarged lymph nodes (>1 cm) in two or more extrainguinal sites for >3 months without an obvious cause.

Question 17

Typical hematological laboratory finding in Zidovudine therapy is ?

A	Reduced hematocrit
B	Elevated mean corpuscular volume (MCV)
C	Increased rouleaux formation
D	All of the above

Question 17 Explanation:

A characteristic feature of zidovudine therapy is an elevated mean corpuscular volume (MCV).

Question 18

HIV-infected individuals with which of the following are at increased risk for AIDS encephalopathy & peripheral neuropathy ?

A	ApoA-I
B	ApoB-100
C	ApoE4 allele
D	ApoJ

Question 18 Explanation:

HIV-infected individuals with the E4 allele for apo E are at increased risk for AIDS encephalopathy and peripheral neuropathy.

Question 19

During asymptomatic phase of HIV infection, CSF findings are abnormal in what percentage of patients ?

A	~ 25 %
B	~ 50 %
C	~ 70 %
D	~ 90 %

Question 19 Explanation:

During asymptomatic phase of HIV infection, CSF findings are abnormal in ~ 90 % of patients

Question 20

Which of the following is the most common CSF abnormality in HIV infection ?

A	Pleocytosis
B	Detection of viral RNA
C	Elevated CSF protein
D	Evidence of intrathecal synthesis of anti-HIV antibodies

Question 20 Explanation:

CSF abnormalities in HIV infection include pleocytosis (50-65%), detection of viral RNA (~75%), elevated CSF protein (35%), and evidence of intrathecal synthesis of anti-HIV antibodies (90%).

Question 21

Which of the following about aseptic meningitis in HIV infection is false ?

A	VII cranial nerve most often involved
B	Normal glucose level in CSF
C	Resolves spontaneously within 2 - 4 weeks
D	More common following development of AIDS

Question 21 Explanation:

Aseptic meningitis in HIV infection is immune-mediated and is seen in any but the very late stages of HIV infection i.e. rare following development of AIDS.

Question 22

Which of the following is included as an AIDS-defining condition ?

A	AIDS dementia complex or HIV encephalopathy
B	Cryptococcus neoformans meningitis
C	Reactivation of Chagas’ disease
D	All of the above

Question 23

Which of the following is included as an AIDS-defining condition ?

A	Histoplasmosis
B	Generalized wasting
C	Invasive cervical cancer
D	All of the above

Question 24

Which of the following is uncommon in AIDS dementia complex ?

A	Aphasia
B	Apraxia
C	Agnosia
D	All of the above

Question 24 Explanation:

In contrast to “cortical” dementia (Alzheimer’s disease), aphasia, apraxia, and agnosia are uncommon in HIV encephalopathy, also called HIV-associated dementia or AIDS dementia complex. It is also called “subcortical dementia”.

Question 25

HIV encephalopathy or AIDS dementia complex is characterized by ?

A	Dementia
B	Motor abnormalities
C	Behavioral abnormalities
D	All of the above

Question 25 Explanation:

Usually a late complication of HIV infection, AIDS dementia complex is characterized by dementia (subcortical), motor and behavioral abnormalities.

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See all quizzes of HIV / AIDS- Part 10 here:

1 Which of the following regarding TB in HIV patient is false ?
A. HIV infection increases risk of active TB by 100x
B. Rifabutin is substituted for rifampin in those receiving HIV
protease inhibitors
C. Rifabutin is substituted for rifampin in those receiving NNRTI’s
D. None of the above

2 Runyon classification of Nontuberculous Mycobacteria (NTM) is
based on ?
A. Colony number
B. Colony size
C. Colony shape
D. Colony pigmentation

3 Which of the following is a rapidly growing NTM species ?
A. M. avium
B. M. kansasii
C. M. fortuitum
D. M. marinum

4 Therapy for MAC include all except ?
A. Clarithromycin
B. Ethambutol
C. Pyrazinamide
D. Rifabutin

5 Due primarily to HIV infection, which is the most common
clinically significant cardiac finding ?
A. Pericardial effusion
B. Nonbacterial thrombotic endocarditis
C. Left atrial myxoma
D. Dilated cardiomyopathy

6 Oral lesions in HIV infection include ?
A. Thrush
B. Hairy leukoplakia
C. Aphthous ulcers
D. All of the above

7 Which of the following about oral hairy leukoplakia is false ?
A. Found along lateral borders of tongue
B. Not considered a premalignant condition
C. Associated with florid replication of EBV
D. None of the above
8 Esophagitis associated with a single large ulcer is typical of ?
A. Candida
B. CMV
C. HSV
D. KS

9 Which of the following hepatitis virus infections are seen with
increased frequency in patients with HIV infection ?
A. Hepatitis A
B. Hepatitis B
C. Hepatitis C
D. All of the above

10 HIV infection co-infected with which of the following virus has a
decreased rate of progression to AIDS ?
A. Hepatitis B virus
B. Hepatitis C virus
C. Hepatitis D virus
D. Hepatitis G virus

11 Which of the following drugs is used in the treatment of HIV and
HBV co-infection ?
A. Emtricitabine
B. Adefovir / Tenofovir
C. Entecavir
D. All of the above

12 A syndrome similar to Gilbert’s syndrome appears with the use of
which of the following ARV drug ?
A. Nevirapine
B. Indinavir
C. Emtricitabine
D. Tenofovir

13 Features of lipodystrophy in HIV patients receiving HAART are ?
A. Increased plasma triglycerides
B. Increased total cholesterol
C. Increased apolipoprotein B
D. All of the above

14 Which of the following ARV drug is a thymidine analogue ?
Harrison’s 18th Ed. 1554
A. Zidovudine
B. Lamivudine
C. Nevirapine
D. Efavirenz

15 Most commonly used drug for lipodystrophy in HIV patients
receiving HAART is ?
A. Atorvastatin
B. Cholestyramine
C. Ezetimibe
D. Nicotinic acid

16 Persistent generalized lymphadenopathy is defined enlarged lymph
nodes in two or more extrainguinal sites, without an obvious
cause for ?
A. > 1 month
B. > 3 months
C. > 6 months
D. > 9 months

17 Typical hematological laboratory finding in Zidovudine therapy
is ?
A. Reduced hematocrit
B. Elevated mean corpuscular volume (MCV)
C. Increased rouleaux formation
D. All of the above

18 HIV-infected individuals with which of the following are at
increased risk for AIDS encephalopathy & peripheral
neuropathy ?
A. ApoA-I
B. ApoB-100
C. ApoE4 allele
D. ApoJ

19 During asymptomatic phase of HIV infection, CSF findings are
abnormal in what percentage of patients ?
A. ~ 25 %
B. ~ 50 %
C. ~ 70 %
D. ~ 90 %

20 Which of the following is the most common CSF abnormality in
HIV infection ?
A. Pleocytosis
B. Detection of viral RNA
C. Elevated CSF protein
D. Evidence of intrathecal synthesis of anti-HIV antibodies

21 Which of the following about aseptic meningitis in HIV infection
is false ?
A. VII cranial nerve most often involved
B. Normal glucose level in CSF
C. Resolves spontaneously within 2 – 4 weeks
D. More common following development of AIDS

22 Which of the following is included as an AIDS-defining
condition ?
A. AIDS dementia complex or HIV encephalopathy
B. Cryptococcus neoformans meningitis
C. Reactivation of Chagas’ disease
D. All of the above
23 Which of the following is included as an AIDS-defining
condition ?
A. Histoplasmosis
B. Generalized wasting
C. Invasive cervical cancer
D. All of the above
24 Which of the following is uncommon in AIDS dementia complex ?
A. Aphasia
B. Apraxia
C. Agnosia
D. All of the above

25 HIV encephalopathy or AIDS dementia complex is characterized
by ?
A. Dementia
B. Motor abnormalities
C. Behavioral abnormalities
D. All of the above

HIV / AIDS

[MCQ] HIV / AIDS- Part 10

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HIV / AIDS- Part 10

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