[MCQ] Schizophrenia- Part 2

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Schizophrenia- Part 2

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Congratulations - you have completed Schizophrenia- Part 2. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

Which of the following diseases can begin with schizophrenialike features ?

A	Frontotemporal dementia
B	Huntington’s disease
C	Alzheimer’s disease
D	All of the above

Question 1 Explanation:

FTD, HD, vascular dementia, Dementia with Lewy bodies (DLB), AD, or leukoencephalopathy can begin with schizophrenia-like features.

Question 2

Which of the following is false about the negative symptoms of schizophrenia ?

A	Carry a poor long-term outcome
B	Respond inadequately to drug treatment
C	Develop prior to positive symptoms
D	None of the above

Question 2 Explanation:

Negative symptoms carry a poor long-term outcome and a respond inadequately to drug treatment. Negative symptoms develop prior to positive symptoms.

Question 3

Which of the following is not a schizophrenia subtype ?

A	Catatonic
B	Atonic
C	Paranoid
D	Residual

Question 3 Explanation:

Four subtypes of schizophrenia are catatonic, paranoid, disorganized, and residual.

Question 4

In which of the following subtypes of schizophrenia, negative symptomatology exists in the absence of delusions, hallucinations, or motor disturbance ?

A	Catatonic
B	Disorganized
C	Paranoid
D	Residual

Question 4 Explanation:

In residual-type subtype of schizophrenia, negative symptomatology exists in the absence of delusions, hallucinations, or motor disturbance.

Question 5

Echolalia or echopraxia os a feature of which of the following subtypes of schizophrenia ?

A	Catatonic
B	Disorganized
C	Paranoid
D	Residual

Question 5 Explanation:

Catatonic subtype patients have profound changes in motor activity, negativism & echolalia or echopraxia.

Question 6

Patients with symptoms of schizophrenia and independent periods of mood disturbance are called ?

A	Schizoaffective disorder
B	Schizophreniform disorder
C	Schizocognitive disorder
D	Schizopolar disorder

Question 6 Explanation:

Patients with symptoms of schizophrenia and independent periods of mood disturbance are termed to have schizoaffective disorder. Schizotypal and schizoid personality disorders refers to individuals who show a lifetime pattern of social & interpersonal deficits (inability to form close interpersonal relationships, eccentric behavior, and mild perceptual distortions).

Question 7

Which of the following genes is associated with schizophrenia ?

A	DISC1
B	NRG1
C	Reelin
D	All of the above

Question 7 Explanation:

Schizophrenia candidate genes include DISC1, NRG1, Reelin, DAOA, DTNBP1, RGS4.

Question 8

What percentage of schizophrenic patients commit suicide ?

A	10 %
B	20 %
C	30 %
D	40 %

Question 8 Explanation:

About 10% of schizophrenic patients commit suicide.

Question 9

Which out of the following prescription medications is frequently associated with symptoms of schizophrenia ?

A	Clonidine
B	Lorazepam
C	Tizanidine
D	Reserpine

Question 9 Explanation:

Most common prescription medications associated with symptoms of schizophrenia are clonidine, quinacrine, and procaine derivatives.

Question 10

Risk factors for schizophrenia include all except ?

A	Summer birth
B	Increasing paternal age
C	Prenatal nutritional deficiency
D	Intrauterine exposure to viral infection.

Question 10 Explanation:

Risk factors for schizophrenia include urban birth, winter birth, migration, increasing paternal age, fetal hypoxia, maternal-fetal Rhesus blood-group incompatibility, prenatal nutritional deficiency & intrauterine exposure to viral infection.

Question 11

Among monozygotic twins, the incidence of schizophrenia is ?

A	~ 25 %
B	~ 50 %
C	~ 75 %
D	~ 100 %

Question 11 Explanation:

Among twins, the incidence of schizophrenia is ~10% in dizygotic twins of affected individuals, and ~50% in monozygotic twins.

Question 12

If both parents are affected with schizophrenia, the risk for offspring is ?

A	20 %
B	40 %
C	60 %
D	80 %

Question 12 Explanation:

If both parents are affected with schizophrenia, the risk for offspring is 40%.

Question 13

Which of the following scales is used for severity of clinical symptoms of schizophrenia ?

A	ESRS
B	BAS
C	PANSS
D	LNS

Question 13 Explanation:

Positive and Negative Syndrome Scale (PANSS) is used for severity of clinical symptoms of schizophrenia. Brown–Peterson procedure and the Letter-Number Sequencing (LNS) task are measures of verbal working memory. Extrapyramidal Symptom Rating Scale (ESRS) and the Barnes Akathisia Scale (BAS) are used to assess movement disorders that occur with antipsychotic medication of schizophrenia.

Question 14

Reduction in volume of which of the following correlate with positive symptoms of schizophrenia ?

A	Medial temporal lobes (MTL)
B	Superior temporal gyrus (STG)
C	Hippocampus
D	Amygdala

Question 14 Explanation:

Reduction in volume of superior temporal gyrus correlate with positive symptoms of schizophrenia while MTL reductions correlate with memory impairment.

Question 15

Term neuroleptic in Greek means ?

A	To straighten the neuron
B	To clasp the neuron
C	To thin the neuron
D	To energise the neuron

Question 15 Explanation:

Term neuroleptic in Greek means “to clasp the neuron”.

Question 16

Which of the following is not a typical antipsychotic drug ?

A	Haloperidol
B	Risperidone
C	Chlorpromazine
D	Thiothixene

Question 17

Which of the following is not an atypical antipsychotic drug ?

A	Ziprasidone
B	Perphenazine
C	Amisulpride
D	Aripiprazole

Question 17 Explanation:

First-generation or “typical” antipsychotic agents include Chlorpromazine, Perphenazine, Trifluoperazine, Thiothixene and Haloperidol. Second-generation or “atypical” antipsychotic agents are Clozapine, Risperidone, Olanzapine, Quetiapine, Ziprasidone, Aripiprazole and Amisulpride. Intramuscular depot preparations available are Fluphenazine decanoate, Haloperidol decanoate, Flupentixol decanoate and Risperidone microspheres

Question 18

Agranulocytosis is a side effect of which of the following antipsychotic drug ?

A	Olanzapine
B	Clozapine
C	Quetiapine
D	Chlorpromazine

Question 19

In UK, Clozaril Patient Monitoring Services (CPMS) monitors patient’s ?

A	Hematological profile
B	Weight gain
C	Lenticular opacities
D	Myocarditis

Question 19 Explanation:

In UK, it is mandatory for all patients receiving Clozapine to register with Clozaril Patient Monitoring Services (CPMS) that monitors patient’s hematological profile.

Question 20

Which of the following antipsychotic drug is unlikely to increase prolactin levels ?

A	Aripiprazole
B	Clozapine
C	Ziprasidone
D	None of the above

Question 21

In schizophrenia, if antipsychotic medications are completely discontinued, the relapse rate is ?

A	1% per month
B	5% per month
C	10% per month
D	20% per month

Question 21 Explanation:

If antipsychotic medications are completely discontinued in schizophrenia, the relapse rate is 60% within 6 months or 10% per month, until eventually almost all patients undergo relapse

Question 22

Use of which of the following is least likely to cause hyperglycemia, weight gain, and hypertriglyceridemia ?

A	Clozapine
B	Ziprasidone
C	Olanzapine
D	Quetiapine

Question 22 Explanation:

Clozapine, olanzapine & quetiapine cause hyperglycemia, weight gain & hypertriglyceridemia more than Ziprasidone.

Question 23

Which of the following may reduce tardive dyskinesia with the use of antipsychotic agents if given early in the syndrome ?

A	Vitamin E
B	Vitamin B12
C	Zinc
D	Calcium

Question 23 Explanation:

Vitamin E may reduce abnormal involuntary movements with the use of antipsychotic agents, if given early in the syndrome.

Question 24

Which of the following is most commonly involved in tardive dyskinesia (TD) ?

A	Tongue
B	Trunk
C	Limbs
D	Respiratory muscles

Question 24 Explanation:

TD comprises of choreiform movements involving mouth, lips & tongue. In severe cases trunk, limbs & respiratory muscles may be affected.

Question 25

Sleep distrubance in chronic schizophrenia includes ?

A	Day-night reversal
B	Sleep fragmentation
C	Insomnia
D	All of the above

Question 26

Which of the following anti-malarials should not be prescribed to patients of schizophrenia ?

A	Quinine
B	Lumefantrine
C	Mefloquine
D	Primaquine

Question 26 Explanation:

Mefloquine should not be prescribed to patients with depression, generalized anxiety disorder, psychosis, schizophrenia, and seizure disorder.

Question 27

Dysthymia best relates to ?

A	Depressive disorder
B	Bipolar disorder
C	Seizure disorder
D	Schizophrenia

Question 27 Explanation:

Mood disorders can be either depressive or bipolar disorders. Depressive disorders include the major & minor depressive disorders and dysthymia

Question 28

Which of the following is one of the most heritable of psychiatric illnesses ?

A	Depressive disorder
B	Bipolar disorder
C	Posttraumatic stress disorder (PTSD)
D	Schizophrenia

Question 28 Explanation:

Bipolar disorder (episodes of mania & depression) is one of the most heritable of psychiatric illnesses, with genetic risk of 80%.

Question 29

Neurovegetative symptoms best relate to ?

A	Depressive disorder
B	Bipolar disorder
C	Posttraumatic stress disorder (PTSD)
D	Schizophrenia

Question 29 Explanation:

Symptoms of depression are referred to as neurovegetative symptoms

Question 30

Deep brain stimulation (DBS) of which of the following elevates mood in normal and depressed individuals ?

A	Subgenual area 23
B	Subgenual area 24
C	Subgenual area 25
D	Subgenual area 26

Question 30 Explanation:

Deep brain stimulation (DBS) of either nucleus accumbens or subgenual area 25 elevates mood in normal and depressed individuals.

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See all quizzes of Schizophrenia- Part 2 here:

1 Which of the following diseases can begin with schizophrenialike
features ?
A. Frontotemporal dementia
B. Huntington’s disease
C. Alzheimer’s disease
D. All of the above

2 Which of the following is false about the negative symptoms of
schizophrenia ?
A. Carry a poor long-term outcome
B. Respond inadequately to drug treatment
C. Develop prior to positive symptoms
D. None of the above

3 Which of the following is not a schizophrenia subtype ?
A. Catatonic
B. Atonic
C. Paranoid
D. Residual

4 In which of the following subtypes of schizophrenia, negative
symptomatology exists in the absence of delusions, hallucinations,
or motor disturbance ?
A. Catatonic
B. Disorganized
C. Paranoid
D. Residual

5 Echolalia or echopraxia os a feature of which of the following
subtypes of schizophrenia ?
A. Catatonic
B. Disorganized
C. Paranoid
D. Residual

6 Patients with symptoms of schizophrenia and independent periods
of mood disturbance are called ?
A. Schizoaffective disorder
B. Schizophreniform disorder
C. Schizocognitive disorder
D. Schizopolar disorder

7 Which of the following genes is associated with schizophrenia ?
A. DISC1
B. NRG1
C. Reelin
D. All of the above

8 What percentage of schizophrenic patients commit suicide ?
A. 10 %
B. 20 %
C. 30 %
D. 40 %

9 Which out of the following prescription medications is frequently
associated with symptoms of schizophrenia ?
A. Clonidine
B. Lorazepam
C. Tizanidine
D. Reserpine

10 Risk factors for schizophrenia include all except ?
A. Summer birth
B. Increasing paternal age
C. Prenatal nutritional deficiency
D. Intrauterine exposure to viral infection.

11 Among monozygotic twins, the incidence of schizophrenia is ?
A. ~ 25 %
B. ~ 50 %
C. ~ 75 %
D. ~ 100 %

12 If both parents are affected with schizophrenia, the risk for offspring
is ?
A. 20 %
B. 40 %
C. 60 %
D. 80 %

13 Which of the following scales is used for severity of clinical
symptoms of schizophrenia ?
A. ESRS
B. BAS
C. PANSS
D. LNS

14 Reduction in volume of which of the following correlate with
positive symptoms of schizophrenia ?
A. Medial temporal lobes (MTL)
B. Superior temporal gyrus (STG)
C. Hippocampus
D. Amygdala

15 Term neuroleptic in Greek means ?
A. To straighten the neuron
B. To clasp the neuron
C. To thin the neuron
D. To energise the neuron

16 Which of the following is not a typical antipsychotic drug ?
A. Haloperidol
B. Risperidone
C. Chlorpromazine
D. Thiothixene
17 Which of the following is not an atypical antipsychotic drug ?
A. Ziprasidone
B. Perphenazine
C. Amisulpride
D. Aripiprazole

18 Agranulocytosis is a side effect of which of the following
antipsychotic drug ?
A. Olanzapine
B. Clozapine
C. Quetiapine
D. Chlorpromazine
19 In UK, Clozaril Patient Monitoring Services (CPMS) monitors
patient’s ?
A. Hematological profile
B. Weight gain
C. Lenticular opacities
D. Myocarditis

20 Which of the following antipsychotic drug is unlikely to increase
prolactin levels ?
A. Aripiprazole
B. Clozapine
C. Ziprasidone
D. None of the above
21 In schizophrenia, if antipsychotic medications are completely
discontinued, the relapse rate is ?
A. 1% per month
B. 5% per month
C. 10% per month
D. 20% per month

22 Use of which of the following is least likely to cause hyperglycemia,
weight gain, and hypertriglyceridemia ?
A. Clozapine
B. Ziprasidone
C. Olanzapine
D. Quetiapine

23 Which of the following may reduce tardive dyskinesia with the
use of antipsychotic agents if given early in the syndrome ?
A. Vitamin E
B. Vitamin B12
C. Zinc
D. Calcium

24 Which of the following is most commonly involved in tardive
dyskinesia (TD) ?
A. Tongue
B. Trunk
C. Limbs
D. Respiratory muscles

25 Sleep distrubance in chronic schizophrenia includes ?
A. Day-night reversal
B. Sleep fragmentation
C. Insomnia
D. All of the above
26 Which of the following anti-malarials should not be prescribed to
patients of schizophrenia ?
A. Quinine
B. Lumefantrine
C. Mefloquine
D. Primaquine

27 Dysthymia best relates to ?
Harrison’s 18th Ed. 3524
A. Depressive disorder
B. Bipolar disorder
C. Seizure disorder
D. Schizophrenia

28 Which of the following is one of the most heritable of psychiatric
illnesses ?
A. Depressive disorder
B. Bipolar disorder
C. Posttraumatic stress disorder (PTSD)
D. Schizophrenia

29 Neurovegetative symptoms best relate to ?
A. Depressive disorder
B. Bipolar disorder
C. Posttraumatic stress disorder (PTSD)
D. Schizophrenia

30 Deep brain stimulation (DBS) of which of the following elevates
mood in normal and depressed individuals ?
A. Subgenual area 23
B. Subgenual area 24
C. Subgenual area 25
D. Subgenual area 26

Schizophrenia

[MCQ] Schizophrenia- Part 2

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Schizophrenia- Part 2

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