[MCQ] Disorders of the Testes and Male Reproductive System- Part 2

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Disorders of the Testes and Male Reproductive System- Part 2

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Question 1

Testosterone is metabolized predominantly in ?

A	Liver
B	Skeletal muscle
C	Prostate
D	Skin

Question 1 Explanation:

Testosterone is metabolized predominantly in liver. Some degradation occurs in prostate & skin.

Question 2

In liver, testosterone is converted enzymatically to all except ?

A	Androsterone
B	Androstenedione
C	Dihydrotestosterone (DHT)
D	3--androstanediol

Question 2 Explanation:

In the liver, testosterone is converted into androsterone, etiocholanolone, DHT, and 3 - androstanediol. After glucuronidation or sulfation, they are excreted by the kidneys.

Question 3

Androgen receptor (AR) is structurally related to the nuclear receptors for ?

A	Estrogen
B	Glucocorticoids
C	Progesterone
D	All of the above

Question 3 Explanation:

AR is structurally related to nuclear receptors for estrogen, glucocorticoids & progesterone.

Question 4

Gene encoding androgen receptor (AR) is located on ?

A	Short arm of X chromosome
B	Long arm of X chromosome
C	Short arm of chromosome 9
D	Long arm of chromosome 9

Question 4 Explanation:

AR is encoded by a gene on the long arm of X chromosome.

Question 5

Which of the following about androgen receptor is false ?

A	Distributed in both cytoplasm & nucleus
B	Is a ligand-regulated transcription factor
C	Testosterone binds to AR with half the affinity of DHT
D	None of the above

Question 6

Total length of seminiferous tubules is about ?

A	100 meters
B	300 meters
C	400 meters
D	600 meters

Question 6 Explanation:

Seminiferous tubules are convoluted, closed loops with both ends emptying into rete testis which is a network of progressively larger efferent ducts that ultimately form epididymis. Seminiferous tubules are ~ 600 meters in length 7 form ~two-thirds of testis volume.

Question 7

Primary spermatocytes are derived from ?

A	Type A spermatogonia
B	Type B spermatogonia
C	Type C spermatogonia
D	Type D spermatogonia

Question 7 Explanation:

Primary spermatocytes are derived from type B spermatogonia.

Question 8

Which of the following serves as stem cells capable of selfrenewal ?

A	Type A spermatogonia
B	Type B spermatogonia
C	Type C spermatogonia
D	Type D spermatogonia

Question 8 Explanation:

A pool of type A spermatogonia serve as stem cells capable of self-renewal.

Question 9

Which of the following is false about spermiogenesis ?

A	Chromatin condensation
B	Shedding of an acrosome
C	Elongation of cytoplasm
D	Formation of a tail

Question 9 Explanation:

Spermiogenesis is a differentiation process involving chromatin condensation, acquisition of an acrosome, elongation of cytoplasm & formation of a tail.

Question 10

Sertoli cells produce which of the following ?

A	Inhibin B
B	Testosterone
C	FSH
D	All of the above

Question 10 Explanation:

Sertoli cells produce inhibin B, an inhibitor of FSH.

Question 11

Process of formation of mature spermatozoa from germ cells takes about how many days ?

A	24 days
B	44 days
C	74 days
D	94 days

Question 11 Explanation:

Complete differentiation process into mature sperm requires 74 days. The spermatozoa spend an additional 21 days in epididymis, where they undergo further maturation & capacitation.

Question 12

Normal adult testes produces how many sperms per day ?

A	~25 million
B	~50 million
C	~75 million
D	~100 million

Question 12 Explanation:

Normal adult testes produce >100 million sperm per day.

Question 13

Which of the following statements is false ?

A	Advanced age does not influence testicular size
B	Varicocele is more common on left side
C	In Klinefelter syndrome testicular volume is markedly reduced
D	None of the above

Question 14

Mild male factor infertility is defined as a sperm count of ?

A	5 - 10 x 106/mL & normal motility
B	10 - 15 x 106/mL & normal motility
C	15 - 20 x 106/mL & normal motility
D	20 - 25 x 106/mL & normal motility

Question 15

Severe male factor infertility is defined as a sperm count of ?

A	< 10 x 106/mL & 40% motility
B	< 10 x 106/mL & 30% motility
C	< 10 x 106/mL & 20% motility
D	< 10 x 106/mL & 10% motility

Question 15 Explanation:

Men with mild male factor infertility have sperm count of 15 - 20 x 106/mL & normal motility), moderate male factor infertility have 10 - 15 x 106/mL & 20 - 40% motility, while those with a severe defect have sperm count of < 10 x 106/mL & 10% motility.

Question 16

Which of the following is an androgen-dependent event ?

A	Early morning erections
B	Frequency & intensity of sexual thoughts
C	Frequency of masturbation or intercourse
D	All of the above

Question 17

In eunuchoid proportions, which of the following is true ?

A	Arm span is less than height
B	Arm span is equal to height
C	Arm span is greater than height
D	Any of the above

Question 17 Explanation:

Eunuchoid proportions are defined as an arm span >2 cm greater than height & suggest that androgen deficiency occurred before epiphyseal fusion

Question 18

“Prader orchidometer” is used to measure ?

A	Testicular volume
B	Testicular length
C	Testicular area
D	Testicular density

Question 18 Explanation:

Testicular volume is best assessed by using a Prader orchidometer.

Question 19

Length of normal testes ranges from ?

A	1.5 to 2.5 cm
B	2.0 to 3.0 cm
C	3.0 to 4.0 cm
D	3.5 to 5.5 cm

Question 20

Normal adult testicular volume is about ?

A	5 to 12 mL
B	12 to 25 mL
C	25 to 40 mL
D	40 to 65 mL

Question 20 Explanation:

Testicular volume is best assessed by Prader orchidometer. Testes range from 3.5 - 5.5 cm in length, which corresponds to a volume of 12 - 25 mL. Advanced age does not influence testicular size.

Question 21

Which of the following statements is false ?

A	Elevated LH indicates primary defect at testicular level
B	Increased FSH indicates damage to seminiferous tubules
C	Inhibin B levels are reduced with seminiferous tubule damage
D	None of the above

Question 21 Explanation:

In men with a low testosterone level, an LH level can distinguish primary (high LH) versus secondary (low or inappropriately normal LH) hypogonadism. Elevated LH level indicates a primary defect at testicular level. Low or inappropriately normal LH level suggests a defect at the hypothalamic-pituitary level. Increased FSH suggests damage to the seminiferous tubules. Inhibin B, a Sertoli cell product that suppresses FSH, is reduced with seminiferous tubule damage.

Question 22

Which of the following is false about GnRH stimulation testing ?

A	IV administration of 100 μg of GnRH
B	Measure LH & FSH at baseline
C	Measure LH & FSH at 30 & 60 min
D	Acceptable response is a twofold increase in LH & FSH

Question 22 Explanation:

The GnRH test is performed by measuring LH and FSH concentrations at baseline and at 30 & 60 minutes after IV administration of 100 g of GnRH. A minimally acceptable response is a twofold LH increase and a 50% FSH increase

Question 23

Range of testosterone in healthy young men is ?

A	50 to 180 ng/dL
B	180 to 225 ng/dL
C	225 to 300 ng/dL
D	300 to 1000 ng/dL

Question 23 Explanation:

Testosterone concentration in healthy young men ranges from 300 to 1000 ng/dL. Alterations in SHBG levels can affect total testosterone levels.

Question 24

Bioavailable testosterone refers to ?

A	Total testosterone
B	Unbound testosterone + testosterone bound to albumin
C	Unbound testosterone
D	Testosterone bound to albumin

Question 24 Explanation:

Bioavailable testosterone refers to unbound testosterone + testosterone loosely bound to albumin

Question 25

What proportion of circulating testosterone is unbound or free ?

A	0.05 to 0.3 %
B	0.3 to 0.8 %
C	0.5 to 3 %
D	2.5 to 8 %

Question 25 Explanation:

Most circulating testosterone is bound to SHBG & to albumin. Only 0.5 - 3% of circulating testosterone is unbound or “free”.

Question 26

Which of the following about hCG stimulation test is false ?

A	Administer 150 to 400 IU of hCG intramuscularly
B	Measure testosterone levels at 0,24, 48, 72 & 120 hours
C	In adult men, acceptable response is a doubling of testosterone concentration
D	In prepubertal boys, an increase in testosterone to >150ng/dL indicates the presence of testicular tissue

Question 26 Explanation:

Administer 1500 to 4000 IU of hCG intramuscularly.

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See all quizzes of Disorders of the Testes and Male Reproductive System at here:

Disorders of the Testes and Male Reproductive System- Part 1| Disorders of the Testes and Male Reproductive System- Part 2|Disorders of the Testes and Male Reproductive System- Part 3|Disorders of the Testes and Male Reproductive System- Part 4|Disorders of the Testes and Male Reproductive System- Part 5|Disorders of the Testes and Male Reproductive System- Part 6

1.Sex hormone binding globulin (SHBG) concentrations are
increased by all except ?
A. Estrogen administration
B. Hyperthyroidism
C. Insulin
D. Aging

2. Testosterone is metabolized predominantly in ?
A. Liver
B. Skeletal muscle
C. Prostate
D. Skin

3. In liver, testosterone is converted enzymatically to all except ?
A. Androsterone
B. Androstenedione
C. Dihydrotestosterone (DHT)
D. 3--androstanediol

4. Androgen receptor (AR) is structurally related to the nuclear
receptors for ?
A. Estrogen
B. Glucocorticoids
C. Progesterone
D. All of the above

5. Gene encoding androgen receptor (AR) is located on ?
A. Short arm of X chromosome
B. Long arm of X chromosome
C. Short arm of chromosome 9
D. Long arm of chromosome 9

6. Which of the following about androgen receptor is false ?
A. Distributed in both cytoplasm & nucleus
B. Is a ligand-regulated transcription factor
C. Testosterone binds to AR with half the affinity of DHT
D. None of the above
7. Total length of seminiferous tubules is about ?
A. 100 meters
B. 300 meters
C. 400 meters
D. 600 meters

8. Primary spermatocytes are derived from ?
A. Type A spermatogonia
B. Type B spermatogonia
C. Type C spermatogonia
D. Type D spermatogonia

9. Which of the following serves as stem cells capable of selfrenewal ?
A. Type A spermatogonia
B. Type B spermatogonia
C. Type C spermatogonia
D. Type D spermatogonia

10. Which of the following is false about spermiogenesis ?
A. Chromatin condensation
B. Shedding of an acrosome
C. Elongation of cytoplasm
D. Formation of a tail

11. Sertoli cells produce which of the following ?
A. Inhibin B
B. Testosterone
C. FSH
D. All of the above

12. Process of formation of mature spermatozoa from germ cells
takes about how many days ?
A. 24 days
B. 44 days
C. 74 days
D. 94 days

13. Normal adult testes produces how many sperms per day ?
A. ~25 million
B. ~50 million
C. ~75 million
D. ~100 million

14. Which of the following statements is false ?
A. Advanced age does not influence testicular size
B. Varicocele is more common on left side
C. In Klinefelter syndrome testicular volume is markedly reduced
D. None of the above
15. Mild male factor infertility is defined as a sperm count of ?
A. 5 – 10 x 106/mL & normal motility
B. 10 – 15 x 106/mL & normal motility
C. 15 – 20 x 106/mL & normal motility
D. 20 – 25 x 106/mL & normal motility
16. Severe male factor infertility is defined as a sperm count of ?
A. < 10 x 106/mL & 40% motility
B. < 10 x 106/mL & 30% motility
C. < 10 x 106/mL & 20% motility
D. < 10 x 106/mL & 10% motility

17. Which of the following is an androgen-dependent event ?
A. Early morning erections
B. Frequency & intensity of sexual thoughts
C. Frequency of masturbation or intercourse
D. All of the above
18. In eunuchoid proportions, which of the following is true ?
A. Arm span is less than height
B. Arm span is equal to height
C. Arm span is greater than height
D. Any of the above

19. “Prader orchidometer” is used to measure ?
A. Testicular volume
B. Testicular length
C. Testicular area
D. Testicular density

20. Length of normal testes ranges from ?
A. 1.5 to 2.5 cm
B. 2.0 to 3.0 cm
C. 3.0 to 4.0 cm
D. 3.5 to 5.5 cm
21.Normal adult testicular volume is about ?
A. 5 to 12 mL
B. 12 to 25 mL
C. 25 to 40 mL
D. 40 to 65 mL

22. Which of the following statements is false ?
A. Elevated LH indicates primary defect at testicular level
B. Increased FSH indicates damage to seminiferous tubules
C. Inhibin B levels are reduced with seminiferous tubule damage
D. None of the above

23. Which of the following is false about GnRH stimulation testing ?
A. IV administration of 100 μg of GnRH
B. Measure LH & FSH at baseline
C. Measure LH & FSH at 30 & 60 min
D. Acceptable response is a twofold increase in LH & FSH

24. Range of testosterone in healthy young men is ?
A. 50 to 180 ng/dL
B. 180 to 225 ng/dL
C. 225 to 300 ng/dL
D. 300 to 1000 ng/dL

25. Bioavailable testosterone refers to ?
A. Total testosterone
B. Unbound testosterone + testosterone bound to albumin
C. Unbound testosterone
D. Testosterone bound to albumin

26. What proportion of circulating testosterone is unbound or free ?
A. 0.05 to 0.3 %
B. 0.3 to 0.8 %
C. 0.5 to 3 %
D. 2.5 to 8 %

27. Which of the following about hCG stimulation test is false ?
A. Administer 150 to 400 IU of hCG intramuscularly
B. Measure testosterone levels at 0,24, 48, 72 & 120 hours
C. In adult men, acceptable response is a doubling of
testosterone concentration
D. In prepubertal boys, an increase in testosterone to >150
ng/dL indicates the presence of testicular tissue

Disorders of the Testes and Male Reproductive System

[MCQ] Disorders of the Testes and Male Reproductive System- Part 2

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Disorders of the Testes and Male Reproductive System- Part 2

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