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Autoimmune hepatitis
See all quizzes of Autoimmune hepatitis at here:
1. Autoimmune hepatitis is a kind of ?
A. Acute hepatitis
B. Subacute hepatitis
C. Chronic hepatitis
D. Any of the above
2. Which of the following is prominent in cases of autoimmune
hepatitis ?
A. Extrahepatic features of autoimmunity
B. Serologic abnormalities
C. Immunologic abnormalities
D. All of the above
3. Which class of serum globulins is elevated in autoimmune
hepatitis ?
A. Alpha globulin
B. Beta globulin
C. Gamma globulin
D. Delta globulin
4. Which of the following virus has been implicated in
pathogenesis of autoimmune hepatitis ?
A. Hepatitis viruses
B. Measles virus
C. Epstein–Barr virus
D. All of the above
5. Which of the following drug has been implicated in
pathogenesis of autoimmune hepatitis ?
N Engl J Med 2006;354:54-66
A. Minocycline
B. Atorvastatin
C. Interferon
D. All of the above
6. Autoimmune disorder that occur with increased frequency in
autoimmune hepatitis patients is ?
A. Thyroiditis
B. Rheumatoid arthritis
C. Autoimmune hemolytic anemia
D. All of the above
7. Which of the following autoantibody is present in patients of
autoimmune hepatitis ?
A. Antinuclear antibodies (ANAs)
B. Anti-LKM
C. Antibodies to soluble liver antigen/liver pancreas antigen
D. All of the above
8.Which of the following statements about anti soluble liver
antigen is false ?
A. Associated with a more severe disease course
B. Present in nonhepatic autoimmune disorders
C. Target of anti-SLA is tRNP(Ser)Sec
D. Specific serologic marker for autoimmune liver diseases
9. Extrahepatic manifestation of autoimmune hepatitis is ?
A. Arthritis
B. Cutaneous vasculitis
C. Glomerulonephritis
D. All of the above
10. In autoimmune hepatitis, immunoregulatory dysfunction of
which of the following occurs ?
A. CD8+CD24+ regulatory T cells
B. CD8+CD25+ regulatory T cells
C. CD4+CD24+ regulatory T cells
D. CD4+CD25+ regulatory T cells
11. Scurfin is the protein product of which gene ?
A. FOXP1 gene
B. FOXP2 gene
C. FOXP3 gene
D. FOXP4 gene
12. Type 1 autoimmune hepatitis is associated with which HLA-DR
serotype ?
A. HLA-DR1
B. HLA-DR2
C. HLA-DR3
D. None of the above
13. Type 2 autoimmune hepatitis is associated with which HLA
haplotype ?
A. HLA-DRB1
B. HLA-DRB2
C. HLA-DRB3
D. HLA-DRB4
14. Feature of HLA-DR3 associated autoimmune hepatitis include ?
A. Early-onset
B. Severe form
C. In girls and young women
D. All of the above
15. Feature of HLA-DR4 associated autoimmune hepatitis include ?
A. Common in adults
B. Extrahepatic manifestations
C. Better response to corticosteroid therapy
D. All of the above
16. Type I autoimmune hepatitis is associated with which of the
following antibodies ?
A. Antinuclear antibodies (ANA)
B. Atypical perinuclear antineutrophilic cytoplasmic antibodies
C. Antiactin antibodies
D. All of the above
17. Which of the following is the most specific autoantibody
identified in type 1 autoimmune hepatitis ?
A. Antiactin antibodies
B. SLA/LP autoantibodies
C. Antinuclear antibodies (ANA)
D. Anti-LKM1
18. Type II autoimmune hepatitis is associated with which of the
following antibodies ?
A. Antinuclear antibodies (ANA)
B. Antiactin antibodies
C. Anti-LKM1
D. Atypical perinuclear antineutrophilic cytoplasmic antibodies
19. Type II autoimmune hepatitis is associated with which of the
following antibodies ?
A. Antinuclear antibodies (ANA)
B. Antiactin antibodies
C. Anti-liver cytosol 1 (anti–LC-1)
D. Atypical perinuclear antineutrophilic cytoplasmic antibodies
20. In type II autoimmune hepatitis, the anti-LKM1 antibody is
directed against which cytochrome ?
A. P450 2D6
B. P450 2C9
C. P450 2C19
D. P450 3A
21. Anti-LKM antibody seen in Type II autoimmune hepatitis is
also seen in which of the following ?
A. Drug-induced hepatitis
B. Chronic hepatitis C
C. Chronic hepatitis D
D. All of the above
22. Type III autoimmune hepatitis is associated with which of the
following antibodies ?
A. Antinuclear antibodies (ANA)
B. Antibodies to soluble liver antigen/liver pancreas antigen
C. Anti-LKM1
D. All of the above
23. Which of the following feature goes against the diagnosis of
autoimmune hepatitis ?
A. Female gender
B. Predominant aminotransferase elevation
C. Mitochondrial antibodies
D. Globulin level elevation
24. Which of the following is false about histopathological features
of liver in autoimmune hepatitis ?
A. Mononuclear-cell infiltrate
B. Interface hepatitis or piecemeal necrosis
C. Sparing of the biliary tree
D. None of the above
25. Mainstay of management in autoimmune hepatitis is ?
A. Azathioprine
B. Glucocorticoid
C. Cyclosporine
D. Mycophenolate mofetil
26. Severe autoimmune hepatitis is defined as ?
A. Serum AST >= 10 times upper limit of normal
B. Serum AST >= 5 times upper limit of normal and gamma
globulin level >= twice normal
C. Bridging necrosis or multiacinar necrosis on liver biopsy
D. All of the above
27. Therapy for autoimmune hepatitis should continue for at
least ?
A. 3 – 6 months
B. 6 – 12 months
C. 12 – 18 months
D. 18 – 24 months
