[Immunology] Nature of Antigens and the Major Histocompatibility Complex Quizzes (10 questions)

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[Immunology] Nature of Antigens and the Major Histocompatibility Complex Quizzes (10 questions)
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Select the one best response to each question!

All of the following are characteristic of a good immunogen except

 

1. All of the following are characteristic of a good immunogen except
a. internal complexity.
b. large molecular weight.
c. the presence of numerous epitopes.
d. found on host cells.
2. Which of the following best describes a hapten?
a. Not able to react with antibody
b. Antigenic only when coupled to a carrier
c. Has multiple determinant sites
d. A large chemically complex molecule
3. Which would be the best immunogen?
a. Protein with a molecular weight of 200,000
b. Nylon
c. Polysaccharide with a molecular weight of 250,000
d. Protein with a molecular weight of 175,000
4. All of the following describe an epitope except
a. same as an antigenic determinant site.
b. area of an immunogen recognized by T cells.
c. consists of sequential amino acids only.
d. key portion of the immunogen
5. Adjuvents act by which of the following methods?
a. Complex to antigen to increase its size
b. Prevent rapid escape from the tissues
c. Increase processing of antigen
d. All of the above
6. A heterophile antigen is one that
a. is a self-antigen.
b. exists in unrelated plants or animals.
c. has been used previously to stimulate antibody response.

d. is from the same species but is different from the host.

7. Which of the following is true of MHC (HLA) class II antigens?
a. They are found on all nucleated cells.
b. They are found on B cells and macrophages.
c. They all originate at one locus.
d. They are coded for on chromosome 9.
8. MHC molecules are associated with which of the following?
a. Graft rejection
b. Autoimmune diseases
c. Determining to which antigens an individual responds
d. All of the above
9. Which of the following best describes the role of TAP?
a. They bind to class II molecules to help block the antigen-binding site.
b. They bind to class I proteins in proteosomes.
c. They transport peptides into the lumen of the endoplasmic reticulum.
d. They help cleave peptides for transport to endosomes.
10. An individual is recovering from a bacterial infection and tests positive for antibodies to a protein normally found in the cytoplasm of this bacterium. Which of the following statements is true of this situation?
a. Class I molecules have presented bacterial antigen to CD8 T cells.
b. Class I molecules have presented bacterial antigen to CD4 T cells.
c. Class II molecules have presented bacterial antigen to CD4 T cells.
d. B cells have recognized bacterial antigen without help from T cells.

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