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Transfusion Biology and Therapy- Part 3
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Transfusion Biology and Therapy- Part 1 |Transfusion Biology and Therapy- Part 2 |Transfusion Biology and Therapy- Part 3
1.Most frequent reaction associated with transfusion of cellular blood components is ?
A. Febrile Nonhemolytic Transfusion Reaction (FNHTR)
B. Allergic Reactions
C. Anaphylactic Reaction
D. Graft-versus-host disease (GVHD)
2. Urticarial reactions are related to which of the following components of transfused blood ?
A. RBC
B. Platelets
C. Plasma proteins
D. Leucocytes
3. Patients with which of the following are at risk for anaphylactic reactions associated with plasma transfusion ?
A. IgA deficiency
B. IgG deficiency
C. IgE deficiency
D. IgM deficiency
4. Alloantibodies directed against which of the following RBC antigens does result in hemolysis ?
A. Rh
B. Kell
C. I
D. Duffy
5. Which of the following can occur after blood / blood product transfusion ?
A. Graft-versus-host disease (GVHD)
B. Hypothermia
C. Thrombocytopenia
D. All of the above
6. Transfusion-associated GVHD (TA-GVHD) is characterized by ?
A. Marrow aplasia & pancytopenia
B. Resistance to immunosuppressive therapies
C. Clinical manifestations appear at 8 – 10 days
D. All of the above
5. Transfusion-related acute lung injury (TRALI) occurs within how many hours after blood transfusion ?
A. 6 hours
B. 12 hours
C. 24 hours
D. 48 hours
.
6. Cause of TRALI usually is ?
A. High-titer anti-HLA antibodies in recepient plasma
B. Low-titer anti-HLA antibodies in donor plasma
C. High-titer anti-HLA antibodies in donor plasma
D. HPA-1a on the platelet glycoprotein IIIa receptor
7. Iron content in each unit of RBCs transfusion is ?
A. 100 to 125 mg of iron
B. 125 to 150 mg of iron
C. 150 to 200 mg of iron
D. 200 to 250 mg of iron
8. Symptoms and signs of iron overload are common after how many units of RBCs transfusion ?
A. 10
B. 20
C. 50
D. 100
9. Transient hypotension during blood transfusion is more common in those taking ?
A. Angiotensin-converting enzyme (ACE) inhibitors
B. Beta blockers
C. Calcium channel blockers
D. All of the above
9. Nucleic acid amplification testing (NAT) is used to prevent which of the following complications of transfusion ?
A. Transfusion-associated GVHD
B. Infectious complications
C. Transfusion-related acute lung injury (TRALI)
D. All of the above
10. Which of the following carries the least risk of transmission through blood transfusion ?
A. Hepatitis B
B. Hepatitis C
C. HIV-1
D. HIV-2
11. To detect HIV-1 infection, donor blood is tested for ?
A. p24 antigen
B. Glycoprotein 120
C. Glycoprotein 41
D. All of the above
12. Bacteria most commonly implicated in contamination of red cells during blood transfusion is ?
A. Staphylococcus aureus
B. Klebsiella pneumoniae
C. Yersinia enterocolitica
D. Staphylococcus epidermidis
13. Parasitic diseases that can be transmitted by blood transfusion include ?
A. Malaria
B. Babesiosis
C. Chagas’ disease
D. All of the above
14. Perfluorocarbons are best known as ?
A. Oxygen-carrying blood substitutes
B. Protein substitutes
C. Fat substitutes
D. Iron chelators
15. Specialized tissues that sense local oxygen tension include ?
A. Glomus cells of the carotid body
B. Neuroepithelial bodies in the lungs
C. Chromaffin cells of the fetal adrenal medulla
D. All of the above
16. Specialized tissues that sense local oxygen tension include ?
A. Smooth-muscle cells of the resistance pulmonary arteries
B. Fetoplacental arteries
C. Ductus arteriosus
D. All of the above
17. What are Howell–Jolly bodies ?
A. Nuclear fragments
B. Hemosiderin-containing granules
C. Altered ribosomes
D. All of the above
18. What are Pappenheimer bodies ?
A. Nuclear fragments
B. Hemosiderin-containing granules
C. Altered ribosomes
D. All of the above
19. What is basophilic stippling or punctate basophilia ?
A. Nuclear fragments
B. Hemosiderin-containing granules
C. Altered ribosomes
D. All of the above
20. Microspherocytes can be found in ?
A. Spherocytic hemolytic anemia
B. Microangiopathic hemolytic anemia
C. Burns
D. All of the above