[MCQs] Transfusion Biology and Therapy- Part 3

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Transfusion Biology and Therapy- Part 3

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Question 1

Most frequent reaction associated with transfusion of cellular blood components is ?

A	Febrile Nonhemolytic Transfusion Reaction (FNHTR)
B	Allergic Reactions
C	Anaphylactic Reaction
D	Graft-versus-host disease (GVHD)

Question 1 Explanation:

Most frequent reaction associated with transfusion of cellular blood components is a febrile nonhemolytic transfusion reaction (FNHTR). Antibodies directed against donor leukocyte & HLA antigens & cytokines released from cells within stored blood components mediate these reactions.

Question 2

Urticarial reactions are related to which of the following components of transfused blood ?

A	RBC
B	Platelets
C	Plasma proteins
D	Leucocytes

Question 2 Explanation:

Urticarial reactions are related to plasma proteins found in transfused components.

Question 3

Patients with which of the following are at risk for anaphylactic reactions associated with plasma transfusion ?

A	IgA deficiency
B	IgG deficiency
C	IgE deficiency
D	IgM deficiency

Question 3 Explanation:

Patients who are IgA-deficient are at risk for anaphylactic reactions associated with plasma transfusion and should therefore receive only IgA-deficient plasma and washed cellular blood components

Question 4

Alloantibodies directed against which of the following RBC antigens does result in hemolysis ?

A	Rh
B	Kell
C	I
D	Duffy

Question 4 Explanation:

I and i are not allelic pairs but are carbohydrate antigens. Alloantibodies directed against other RBC antigens like Rh, Kell, and Duffy may result in hemolysis.

Question 5

Which of the following can occur after blood / blood product transfusion ?

A	Graft-versus-host disease (GVHD)
B	Hypothermia
C	Thrombocytopenia
D	All of the above

Question 5 Explanation:

Predominantly in women, thrombocytopenia may occur 7 - 10 days after platelet transfusion. Platelet-specific antibodies are found in recipient’s serum, and most frequently recognized antigen is HPA-1a found on the platelet glycoprotein IIIa receptor. Antibodies react to both donor & recipient platelets, hence the delay. Treatment with IVIg neutralizes the effector antibodies. Plasmapheresis can be used to remove the antibodies

Question 6

Transfusion-associated GVHD (TA-GVHD) is characterized by ?

A	Marrow aplasia & pancytopenia
B	Resistance to immunosuppressive therapies
C	Clinical manifestations appear at 8 - 10 days
D	All of the above

Question 6 Explanation:

TA-GVHD is characterized by marrow aplasia & pancytopenia. It is highly resistant to treatment with immunosuppressive therapies like glucocorticoids, cyclosporine, antithymocyte globulin & ablative therapy followed by allogeneic bone marrow transplantation. Clinical manifestations appear at 8 - 10 days and death occurs at 3 - 4 weeks posttransfusion.

Question 7

Transfusion-related acute lung injury (TRALI) occurs within how many hours after blood transfusion ?

A	6 hours
B	B. 12 hours
C	C. 24 hours
D	D. 48 hours

Question 7 Explanation:

TRALI, an acute respiratory distress syndrome, occurs within 6 hours after blood transfusion & is characterized by dyspnea & hypoxia due to noncardiogenic pulmonary edema.

Question 8

Cause of TRALI usually is ?

A	High-titer anti-HLA antibodies in recepient plasma
B	Low-titer anti-HLA antibodies in donor plasma
C	High-titer anti-HLA antibodies in donor plasma
D	HPA-1a on the platelet glycoprotein IIIa receptor

Question 8 Explanation:

TRALI usually results from the transfusion of donor plasma that contains high-titer anti-HLA antibodies that bind recipient leukocytes which aggregate in pulmonary vasculature & release mediators that increase capillary permeability.

Question 9

Iron content in each unit of RBCs transfusion is

A	100 to 125 mg of iron
B	125 to 150 mg of iron
C	150 to 200 mg of iron
D	200 to 250 mg of iron

Question 9 Explanation:

Each unit of RBCs contains 200 - 250 mg of iron.

Question 10

Symptoms and signs of iron overload are common after how many units of RBCs transfusion ?

A	10
B	20
C	50
D	100

Question 10 Explanation:

Symptoms and signs of iron overload (endocrine, hepatic, cardiac) are common after 100 units of RBC transfusion (total-body iron load of 20 grams).

Question 11

Transient hypotension during blood transfusion is more common in those taking ?

A	Angiotensin-converting enzyme (ACE) inhibitors
B	Beta blockers
C	Calcium channel blockers
D	All of the above

Question 11 Explanation:

Transient hypotension is noted in transfused patients taking ACE inhibitors due to increased bradykinin levels. Blood products contain bradykinin that is normally degraded by ACE.

Question 12

Nucleic acid amplification testing (NAT) is used to prevent which of the following complications of transfusion ?

A	Transfusion-associated GVHD
B	Infectious complications
C	Transfusion-related acute lung injury (TRALI)
D	All of the above

Question 13

Which of the following carries the least risk of transmission through blood transfusion ?

A	Hepatitis B
B	Hepatitis C
C	HIV-1
D	HIV-2

Question 13 Explanation:

No cases of HIV-2 infection have been reported in the United States since 1992. Other infectious agents rarely associated with transfusion include - Hepatitis A virus, parvovirus B-19, Babesia microti (babesiosis), Borrelia burgdorferi (Lyme disease), Trypanosoma cruzi (Chagas disease), and Treponema pallidum , human herpesvirus-8 and hepatitis G virus

Question 14

To detect HIV-1 infection, donor blood is tested for ?

A	p24 antigen
B	Glycoprotein 120
C	Glycoprotein 41
D	All of the above

Question 14 Explanation:

Donated blood is tested for antibodies to HIV-1, HIV-1 p24 antigen, and HIV RNA using Nucleic acid amplification testing (NAT). Risk of HIV-1 infection per transfusion episode is 1 in 2 million

Question 15

Bacteria most commonly implicated in contamination of red cells during blood transfusion is ?

A	Staphylococcus aureus
B	Klebsiella pneumoniae
C	Yersinia enterocolitica
D	Staphylococcus epidermidis

Question 16

Parasitic diseases that can be transmitted by blood transfusion include ?

A	Malaria
B	Babesiosis
C	Chagas’ disease
D	All of the above

Question 16 Explanation:

Parasitic diseases that can be transmitted by blood transfusion include malaria, babesiosis, Chagas disease. Dengue, chikungunya virus, variant Creutzfeldt-Jakob disease, Anaplasma phagocytophilum, and yellow fever vaccine virus can also be transmitted by blood transfusion.

Question 17

Perfluorocarbons are best known as ?

A	Oxygen-carrying blood substitutes
B	Protein substitutes
C	Fat substitutes
D	Iron chelators

Question 17 Explanation:

Oxygen-carrying blood substitutes, such as perfluorocarbons and aggregated hemoglobin solution, are presently in various stages of clinical trials.

Question 18

Specialized tissues that sense local oxygen tension include ?

A	Glomus cells of the carotid body
B	Neuroepithelial bodies in the lungs
C	Chromaffin cells of the fetal adrenal medulla
D	All of the above

Question 19

Specialized tissues that sense local oxygen tension include ?

A	Smooth-muscle cells of the resistance pulmonary arteries
B	Fetoplacental arteries
C	Ductus arteriosus
D	All of the above

Question 20

What are Howell–Jolly bodies ?

A	Nuclear fragments
B	Hemosiderin-containing granules
C	Altered ribosomes
D	All of the above

Question 21

What are Pappenheimer bodies ?

A	Nuclear fragments
B	Hemosiderin-containing granules
C	Altered ribosomes
D	All of the above

Question 22

What is basophilic stippling or punctate basophilia ?

A	Nuclear fragments
B	Hemosiderin-containing granules
C	Altered ribosomes
D	All of the above

Question 23

Microspherocytes can be found in ?

A	Spherocytic hemolytic anemia
B	Microangiopathic hemolytic anemia
C	Burns
D	All of the above

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II. See all quizzes of the Transfusion Biology and Therapy at here:

Transfusion Biology and Therapy- Part 1 |Transfusion Biology and Therapy- Part 2 |Transfusion Biology and Therapy- Part 3

1.Most frequent reaction associated with transfusion of cellular blood components is ?
A. Febrile Nonhemolytic Transfusion Reaction (FNHTR)
B. Allergic Reactions
C. Anaphylactic Reaction
D. Graft-versus-host disease (GVHD)

2. Urticarial reactions are related to which of the following components of transfused blood ?
A. RBC
B. Platelets
C. Plasma proteins
D. Leucocytes

3. Patients with which of the following are at risk for anaphylactic reactions associated with plasma transfusion ?
A. IgA deficiency
B. IgG deficiency
C. IgE deficiency
D. IgM deficiency

4. Alloantibodies directed against which of the following RBC antigens does result in hemolysis ?
A. Rh
B. Kell

C. I
D. Duffy

5. Which of the following can occur after blood / blood product transfusion ?
A. Graft-versus-host disease (GVHD)
B. Hypothermia
C. Thrombocytopenia
D. All of the above

6. Transfusion-associated GVHD (TA-GVHD) is characterized by ?
A. Marrow aplasia & pancytopenia
B. Resistance to immunosuppressive therapies
C. Clinical manifestations appear at 8 – 10 days
D. All of the above

5. Transfusion-related acute lung injury (TRALI) occurs within how many hours after blood transfusion ?
A. 6 hours
B. 12 hours
C. 24 hours
D. 48 hours
.
6. Cause of TRALI usually is ?
A. High-titer anti-HLA antibodies in recepient plasma
B. Low-titer anti-HLA antibodies in donor plasma
C. High-titer anti-HLA antibodies in donor plasma
D. HPA-1a on the platelet glycoprotein IIIa receptor

7. Iron content in each unit of RBCs transfusion is ?
A. 100 to 125 mg of iron
B. 125 to 150 mg of iron
C. 150 to 200 mg of iron
D. 200 to 250 mg of iron

8. Symptoms and signs of iron overload are common after how many units of RBCs transfusion ?
A. 10
B. 20
C. 50
D. 100

9. Transient hypotension during blood transfusion is more common in those taking ?
A. Angiotensin-converting enzyme (ACE) inhibitors
B. Beta blockers
C. Calcium channel blockers
D. All of the above

9. Nucleic acid amplification testing (NAT) is used to prevent which of the following complications of transfusion ?
A. Transfusion-associated GVHD
B. Infectious complications
C. Transfusion-related acute lung injury (TRALI)
D. All of the above

10. Which of the following carries the least risk of transmission through blood transfusion ?
A. Hepatitis B
B. Hepatitis C
C. HIV-1
D. HIV-2

11. To detect HIV-1 infection, donor blood is tested for ?
A. p24 antigen
B. Glycoprotein 120
C. Glycoprotein 41
D. All of the above

12. Bacteria most commonly implicated in contamination of red cells during blood transfusion is ?
A. Staphylococcus aureus
B. Klebsiella pneumoniae
C. Yersinia enterocolitica
D. Staphylococcus epidermidis

13. Parasitic diseases that can be transmitted by blood transfusion include ?
A. Malaria
B. Babesiosis
C. Chagas’ disease
D. All of the above

14. Perfluorocarbons are best known as ?
A. Oxygen-carrying blood substitutes
B. Protein substitutes
C. Fat substitutes
D. Iron chelators

15. Specialized tissues that sense local oxygen tension include ?
A. Glomus cells of the carotid body
B. Neuroepithelial bodies in the lungs
C. Chromaffin cells of the fetal adrenal medulla
D. All of the above

16. Specialized tissues that sense local oxygen tension include ?
A. Smooth-muscle cells of the resistance pulmonary arteries
B. Fetoplacental arteries
C. Ductus arteriosus
D. All of the above

17. What are Howell–Jolly bodies ?
A. Nuclear fragments
B. Hemosiderin-containing granules
C. Altered ribosomes
D. All of the above

18. What are Pappenheimer bodies ?
A. Nuclear fragments
B. Hemosiderin-containing granules
C. Altered ribosomes
D. All of the above

19. What is basophilic stippling or punctate basophilia ?
A. Nuclear fragments
B. Hemosiderin-containing granules
C. Altered ribosomes
D. All of the above

20. Microspherocytes can be found in ?
A. Spherocytic hemolytic anemia
B. Microangiopathic hemolytic anemia
C. Burns
D. All of the above

Transfusion Biology and Therapy

[MCQs] Transfusion Biology and Therapy- Part 3

I. Start the exam by click the “Start” button

Transfusion Biology and Therapy- Part 3

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