[MCQs] Disorders of granulocytes & monocytes - Part 1

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Disorders of granulocytes & monocytes- Part 1

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Question 1

Which of the following is a leukocyte ?

A	Natural killer (NK) cel
B	B lymphocyte
C	Monocyte
D	All of the above

Question 1 Explanation:

Leukocytes include neutrophils, T and B lymphocytes, natural killer (NK) cells, monocytes, eosinophils, and basophils.

Question 2

Which of the following statements about leukocytes is false ?

A	Derived from common stem cell in bone marrow
B	Derived from common stem cell in bone marrow
C	Derived from common stem cell in bone marrow
D	None of the above

Question 2 Explanation:

Leukocytes are derived from a common stem cell in bone marrow. Three-fourths of nucleated cells of bone marrow are committed to production of leukocytes. Leukocyte maturation in the marrow is under the regulatory control of colony-stimulating factors (CSFs) & interleukins (ILs).

Question 3

Minimum number of stem cells necessary to support hematopoiesis is ?

A	100 to 200
B	200 to 300
C	300 to 400
D	400 to 500

Question 3 Explanation:

Minimum number of stem cells necessary to support hematopoiesis is 400 - 500 at any one time

Question 4

Colony-stimulating factors are produced by ?

A	Monocytes
B	Tissue macrophages
C	Stromal cells
D	All of the above

Question 4 Explanation:

Human blood monocytes, tissue macrophages & stromal cells produce CSFs, hormones required for growth of monocytes & neutrophils in bone marrow

Question 5

In a 80 kg person, how many neutrophils are produced by hematopoietic system per day ?

A	~ 0.3 x 1011
B	~ 1.3 x 1011
C	~ 2.3 x 1011
D	~ 3.3 x 1011

Question 5 Explanation:

~ 3.3 x 1011

Question 6

Maturation from metamyelocyte to neutrophil takes how many days ?

A	2 days
B	5 days
C	7 days
D	10 days

Question 6 Explanation:

Proliferation phase through the metamyelocyte takes ~1 week, while maturation phase from metamyelocyte to mature neutrophil takes ~1 week

Question 7

Which of the following is the largest cell in size ?

A	Myeloblast
B	Promyelocyte
C	Myelocyte
D	Metamyelocyte

Question 8

Primary or azurophil granules are present in ?

A	Myeloblast
B	Promyelocyte
C	Myelocyte
D	All of the above

Question 8 Explanation:

Classic lysosomal granules called the primary or azurophil granules are found in promyelocyte

Question 9

Primary or azurophil granules contain ?

A	Hydrolases
B	Cathepsin G
C	Myeloperoxidase
D	All of the above

Question 9 Explanation:

Primary granules contain hydrolases, elastase, myeloperoxidase, cathepsin G, cationic proteins, bactericidal/permeability-increasing protein & defensins

Question 10

Which of the following azurophil granules has broad antimicrobial activity against bacteria, fungi & certain enveloped viruses ?

A	Hydrolases
B	Cathepsin G
C	Myeloperoxidase
D	Defensins

Question 10 Explanation:

Defensins in azurophil granules have a broad antimicrobial activity against bacteria, fungi, and certain enveloped viruses

Question 11

Specific or secondary granules are present in ?

A	Myeloblast
B	Promyelocyte
C	Myelocyte
D	Myelocyte

Question 12

Secondary granules contain all except ?

A	Acid hydrolases
B	Lactoferrin
C	Vitamin B 12 binding protein
D	Histaminase

Question 12 Explanation:

Myelocyte synthesises specific or secondary granules which contains lactoferrin, vitamin B12

Question 13

Packaging of secondary granule contents during myelopoiesis is controlled by ?

A	CCAAT/enhancer binding protein-
B	CCAAT/enhancer binding protein-
C	CCAAT/enhancer binding protein-
D	CCAAT/enhancer binding protein-

Question 13 Explanation:

Packaging of secondary granule contents during myelopoiesis is controlled by CCAAT/enhancer binding protein-.

Question 14

Excessive segmentation of nucleus of neutrophils is a manifestation of ?

A	Folate or vitamin B 12 deficiency
B	Iron deficiency
C	Thalassemia
D	Repeated blood transfusion

Question 14 Explanation:

Nucleus of neutrophils normally contains up to four segments. Excessive segmentation (>5 nuclear lobes) is seen in folate or vitamin B12 deficiency & congenital neutropenia syndrome of warts, hypogammaglobulinemia, infections & myelokathexis (WHIM).

Question 15

Which of the following is false about ‘Pelger-Huet anomaly’ ?

A	Benign disorder
B	Majority of granulocytes are bilobed
C	Nucleus has spectacle-like configuration
D	None of the above

Question 15 Explanation:

Pelger-Hüet anomaly is a benign inherited disorder. Majority of granulocytes are bilobed (hyposegmented neutrophils). Nucleus has a spectacle-like, or “pince-nez” configuration

Question 16

Under normal conditions, what proportion of neutrophil pool is in the bone marrow ?

A	~ 20 %
B	~ 50 %
C	~ 70 %
D	~ 90 %

Question 17

Under normal conditions, what proportion of neutrophil pool is in the circulation ?

A	~ 2 %
B	~ 20 %
C	~ 50 %
D	~ 90 %

Question 17 Explanation:

Normally, ~90% of the neutrophil pool is in bone marrow, 2 - 3% in circulation (freely flowing & marginated), & remainder in tissues.

Question 18

Marginated leukocytes are maximum in ?

A	Lungs
B	Spleen
C	Liver
D	Kidneys

Question 18 Explanation:

Circulating pool of neutrophils exists in two dynamic compartments: one freely flowing and one marginated. Freely flowing pool is ~half the neutrophils in basal state and is composed of those cells that are in the blood and not in contact with endothelium. Marginated leukocytes are those that are in close physical contact with endothelium. Due to extensive capillary bed (~1000 capillaries per alveolus) in pulmonary circulation, margination occurs because the capillaries are about the same size as a mature neutrophil.

Question 19

“Rolling” of the neutrophil along the endothelial surface is a function of ?

A	electins
B	Integrins
C	Intercellular adhesion molecules
D	Opsonins

Question 19 Explanation:

Selectins are glycoproteins expressed on neutrophils & endothelial cells and cause a lowaffinity interaction resulting in “rolling” of neutrophil along the endothelial surface.

Question 20

Neutrophils “stick” to the endothelium through ?

A	Selectins
B	Integrins
C	Intercellular adhesion molecules
D	Opsonins

Question 20 Explanation:

n response to chemotactic stimuli from injured tissues or bacterial products, neutrophil adhesiveness increases and they “stick” to the endothelium through integrins. Integrins are leukocyte glycoproteins that bind to specific endothelial receptors [intercellular adhesion molecules (ICAM) 1 & 2]

Question 21

Diapedesis involves which of the following ?

A	PECAM 1
B	Anaphylatoxins
C	Vascular endothelial growth factor (VEGF)
D	Prostaglandins E & I

Question 21 Explanation:

Process of migration into tissues is called diapedesis and involves crawling of neutrophils between postcapillary endothelial cells that open junctions between adjacent cells to permit leukocyte passage. Diapedesis involves platelet/endothelial cell adhesion molecule (PECAM) 1 (CD31) expressed on emigrating leukocyte & endothelial cells.

Question 22

In the healthy adult, most neutrophils leave the body by ?

A	Migration through mucous membrane of GI tract
B	Apoptosis
C	Phagocytosis
D	All of the above

Question 22 Explanation:

In the healthy adult, most neutrophils leave the body by migration through the mucous membrane of the gastrointestinal tract.

Question 23

Normally, neutrophils spend how much time in circulation ?

A	2 to 3 hours
B	6 to 7 hours
C	12 to 24 hours
D	24 to 36 hours

Question 23 Explanation:

Normally, neutrophils spend a short time in circulation (half-life, 6 - 7 hours)

Question 24

Senescent neutrophils are cleared from the circulation by macrophages in ?

A	Kidneys
B	Lung
C	GI tract
D	Thymus

Question 24 Explanation:

Senescent neutrophils are cleared from the circulation by macrophages in the lung and spleen

Question 25

Characteristic green color to pus is due to ?

A	Collagenase
B	Elastase
C	Myeloperoxidase
D	All of the above

Question 25 Explanation:

Myeloperoxidase confers the characteristic green color to pus and may participate in turning off the inflammatory process by inactivating chemoattractants and immobilizing phagocytic cells

Question 26

Which of the following is not a group of chemokines ?

A	C
B	CC
C	CCC
D	CXC

Question 26 Explanation:

Four major groups of chemokines are recognized based on cysteine structure near N terminus: C, CC, CXC, and CXXXC. C chemokine (lymphotactin) is T cell tropic. CC chemokines (MIP-1) attract lymphocytes, monocytes, eosinophils, & basophils. CXC cytokines (IL-8) attract neutrophils. CXXXC chemokine (fractalkine) attracts neutrophils, monocytes, & T cells

Question 27

Susceptibility to infectious diseases increases sharply when neutrophil counts fall below ?

A	1000 cells/µL
B	2000 cells/µL
C	3000 cells/µL
D	4000 cells/µL

Question 27 Explanation:

Susceptibility to infectious diseases increases sharply when neutrophil counts fall <1000 cells/µL

Question 28

Inflammatory process is absent, when absolute neutrophil count (ANC) falls below ?

A	< 100 cells / µL
B	< 200 cells / µL
C	< 500 cells / µL
D	< 1000 cells / µL

Question 28 Explanation:

When absolute neutrophil count (band forms & mature neutrophils combined) is <200/µL, the inflammatory process is absent.

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See all quizzes of the Disorders of granulocytes & monocytes at here:

Disorders of granulocytes & monocytes part 1 | Disorders of granulocytes & monocytes part 2 | Disorders of granulocytes & monocytes part 3

II. Preview all questions below

1.Which of the following is a leukocyte ?
A. Natural killer (NK) cell
B. B lymphocyte
C. Monocyte
D. All of the above

2. Which of the following statements about leukocytes is false ?
A. Derived from common stem cell in bone marrow
B. Threefourths of nucleated cells of bone marrow are committed to leukocyte production
C. Their maturation in marrow is regulated by colony stimulating factors & interleukins
D. None of the above

3. Minimum number of stem cells necessary to support hematopoiesis is ?
A. 100 to 200
B. 200 to 300
C. 300 to 400
D. 400 to 500

4. Colony-stimulating factors are produced by ?
A. Monocytes
B. Tissue macrophages
C. Stromal cells
D. All of the above

5. In a 80 kg person, how many neutrophils are produced by hematopoietic system per day ?
A. ~ 0.3 x 1011
B. ~ 1.3 x 1011
C. ~ 2.3 x 1011
D. ~ 3.3 x 1011

6. Maturation from metamyelocyte to neutrophil takes how many days ?
A. 2 days

B. 5 days
C. 7 days
D. 10 days

7. Which of the following is the largest cell in size ?
A. Myeloblast
B. Promyelocyte
C. Myelocyte
D. Metamyelocyte

8. Primary or azurophil granules are present in ?
A. Myeloblast
B. Promyelocyte
C. Myelocyte
D. All of the above

9. Primary or azurophil granules contain ?
A. Hydrolases
B. Cathepsin G
C. Myeloperoxidase
D. All of the above

10. Which of the following azurophil granules has broad antimicrobial activity against bacteria, fungi & certain enveloped viruses ?
A. Hydrolases
B. Cathepsin G
C. Myeloperoxidase
D. Defensins

11. Specific or secondary granules are present in ?
A. Myeloblast
B. Promyelocyte
C. Myelocyte
D. All of the above

12. Secondary granules contain all except ?
A. Acid hydrolases
B. Lactoferrin
C. Vitamin B12 binding protein
D. Histaminase

13. Packaging of secondary granule contents during myelopoiesis is controlled by ?
A. CCAAT/enhancer binding protein-
B. CCAAT/enhancer binding protein-
C. CCAAT/enhancer binding protein-
D. CCAAT/enhancer binding protein-

14 .Excessive segmentation of nucleus of neutrophils is a manifestation of ?
A. Folate or vitamin B
12 deficiency
B. Iron deficiency
C. Thalassemia
D. Repeated blood transfusion

15. Which of the following is false about ‘Pelger-Huet anomaly’ ?
A. Benign disorder
B. Majority of granulocytes are bilobed
C. Nucleus has spectacle-like configuration
D. None of the above

16. Under normal conditions, what proportion of neutrophil pool is in the bone marrow ?
A. ~ 20 %
B. ~ 50 %
C. ~ 70 %
D. ~ 90 %

17. Under normal conditions, what proportion of neutrophil pool is in the circulation ?
A. ~ 2 %
B. ~ 20 %
C. ~ 50 %
D. ~ 90 %

18. Marginated leukocytes are maximum in ?
A. Lungs
B. Spleen
C. Liver
D. Kidneys

19. “Rolling” of the neutrophil along the endothelial surface is a function of ?
A. Selectins
B. Integrins
C. Intercellular adhesion molecules
D. Opsonins

20. Neutrophils “stick” to the endothelium through ?
A. Selectins
B. Integrins
C. Intercellular adhesion molecules
D. Opsonins

21. Diapedesis involves which of the following ?
A. PECAM 1
B. Anaphylatoxins
C. Vascular endothelial growth factor (VEGF)
D. Prostaglandins E & I

22. In the healthy adult, most neutrophils leave the body by ?
A. Migration through mucous membrane of GI tract
B. Apoptosis
C. Phagocytosis
D. All of the above

23. Normally, neutrophils spend how much time in circulation ?
A. 2 to 3 hours
B. 6 to 7 hours
C. 12 to 24 hours
D. 24 to 36 hours

24. Senescent neutrophils are cleared from the circulation by macrophages in ?
A. Kidneys
B. Lung
C. GI tract
D. Thymus

25. Characteristic green color to pus is due to ?
A. Collagenase
B. Elastase
C. Myeloperoxidase
D. All of the above

26. Which of the following is not a group of chemokines ?
A. C
B. CC
C. CCC
D. CXC

27. Susceptibility to infectious diseases increases sharply when neutrophil counts fall below ?

A. 1000 cells/µL
B. 2000 cells/µL
C. 3000 cells/µL
D. 4000 cells/µL

28. Inflammatory process is absent, when absolute neutrophil count (ANC) falls below ?
A. < 100 cells / µL
B. < 200 cells / µL
C. < 500 cells / µL
D. < 1000 cells / µL

[MCQs] Disorders of granulocytes & monocytes – Part 1

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Disorders of granulocytes & monocytes- Part 1

II. Preview all questions below

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