[MCQs] Disorders of granulocytes & monocytes - Part 2

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Disorders of granulocytes & monocytes- Part 2

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Question 1

Neutropenia can be due to ?

A	Depressed production
B	Increased peripheral destruction
C	Excessive peripheral pooling
D	All of the above

Question 1 Explanation:

Neutropenia can be due to depressed production, increased peripheral destruction, or excessive peripheral pooling

Question 2

Which of the following drugs cause neutropenia due to decreased production ?

A	Carbamazepine
B	Clozapine
C	Antithyroid drugs
D	All of the above

Question 2 Explanation:

drugs cause neutropenia due to decreased production include alkylating agents (nitrogen mustard, busulfan, chlorambucil, cyclophosphamide), antimetabolites (methotrexate, 6-mercaptopurine, 5- flucytosine), antibiotics (chloramphenicol, penicillins, sulfonamides), phenothiazines, tranquilizers (meprobamate), anticonvulsants (carbamazepine), antipsychotics (clozapine), certain diuretics, anti-inflammatory agents, antithyroid drugs.

Question 3

Which of the following drugs act as haptens to cause neutropenia due to peripheral destruction ?

A	Alpha methyldopa
B	Phenylbutazone
C	Mercurial diuretics
D	All of the above

Question 3 Explanation:

Drugs that act as haptens to cause neutropenia due to peripheral destruction include aminopyrine, alpha methyldopa, phenylbutazone, mercurial diuretics, some phenothiazines

Question 4

Which of the following is a cause of neutropenia due to peripheral pooling (Transient neutropenia) ?

A	Overwhelming bacterial infection (acute endotoxemia)
B	Hemodialysis
C	Cardiopulmonary bypass
D	All of the above

Question 5

Congenital forms of neutropenia include ?

A	Kostmann’s syndrome
B	Shwachman-Diamond syndrome
C	WHIM syndrome
D	All of the above

Question 5 Explanation:

Congenital forms of neutropenia include Kostmann’s syndrome, cartilage-hair hypoplasia syndrome, Shwachman-Diamond syndrome, WHIM syndrome and hereditary cyclic neutropenia

Question 6

Kostmann’s syndrome is due to mutations in ?

A	Potassium voltage-gated channel gene KCNA1
B	PKD-1 gene
C	Anti-apoptosis gene HAX-1
D	GJB2 gene

Question 6 Explanation:

Kostmann’s syndrome is due to mutations in anti-apoptosis gene HAX-1

Question 7

Which of the following is associated with pancreatic insufficiency ?

A	Kostmann’s syndrome
B	Shwachman-Diamond syndrome
C	WHIM syndrome
D	All of the above

Question 7 Explanation:

Shwachman-Diamond syndrome is associated with pancreatic insufficiency and is due to mutations in the Shwachman-Bodian-Diamond syndrome gene SBDS.

Question 8

Felty’s syndrome include all except ?

A	Rheumatoid arthritis
B	Hepatomegaly
C	Splenomegaly
D	Neutropenia

Question 8 Explanation:

Rheumatoid arthritis, splenomegaly & neutropenia form the triad of Felty’s syndrome. Neutropenia is due to antibodies produced by spleen that shorten neutrophil life span, while large granular lymphocytes (LGL) can attack marrow neutrophil precursors.

Question 9

Neutrophilia results from ?

A	Increased neutrophil production
B	Increased marrow release
C	Defective margination
D	All of the above

Question 9 Explanation:

Neutrophilia is due to increased neutrophil production & marrow release or defective margination

Question 10

Persistent neutrophilia with what level of raised cell counts is called leukemoid reaction ?

A	> 10000 to 30000 / µL
B	> 30000 to 50000 / µ
C	> 50000 to 75000 / µL
D	> 75000 to 100000 / µL

Question 11

Which of the following is false about leukemoid reaction ?

A	Neutrophil cell count > 30000 to 50000 / µL
B	Circulating neutrophils are mature
C	Circulating neutrophils are clonally derived
D	None of the above

Question 11 Explanation:

Persistent neutrophilia with cell counts of 30,000 - 50,000/µL is called a leukemoid reaction. In leukemoid reaction, circulating neutrophils are usually mature & not clonally derived.

Question 12

Which of the following drugs can cause neutrophilia ?

A	Meprobamate
B	Lithium
C	Phenothiazines
D	Phenylbutazone

Question 12 Explanation:

Epinephrine, glucocorticoids, nonsteroidal anti-inflammatory agents, lithium, , granulocyte colonystimulating factor (G-CSF) can cause neutrophilia

Question 13

Which of the following about leukocyte adhesion deficiency (LAD) 1 & 2 is false ?

A	Autosomal dominant traits
B	Inability of neutrophils to exit circulation
C	Leukocytosis
D	Increased susceptibility to infection

Question 13 Explanation:

LAD 1 & 2 are autosomal recessive traits leading to inability of neutrophils to exit circulation to sites of infection, leukocytosis & increased susceptibility to infection

Question 14

Patients with leukocyte adhesion deficiency 1 (LAD 1) have mutations in ?

A	CD18
B	CD31
C	CD34
D	CD62

Question 14 Explanation:

Patients with LAD1 have mutations in CD18. CD18 gene is located on distal chromosome 21q

Question 15

Which of the following is called “Congenital disorder of glycosylation IIc (CDGIIc)” ?

A	Leukocyte adhesion deficiency 1 (LAD 1)
B	Leukocyte adhesion deficiency 2 (LAD 2)
C	Leukocyte adhesion deficiency 3 (LAD 3)
D	None of the above

Question 15 Explanation:

LAD 2 is also known as congenital disorder of glycosylation IIc (CDGIIc) due to mutation in a GDP-fucose transporter (SLC35C1).

Question 16

In neutrophils, which of the following is seen in severe acute bacterial infections ?

A	Toxic granulations
B	Dohle bodies
C	Large neutrophil vacuoles
D	All of the above

Question 16 Explanation:

In severe acute bacterial infection toxic granulations (immature or abnormally staining azurophil granules), Döhle bodies (cytoplasmic inclusions which are fragments of ribosome-rich endoplasmic reticulum) & large neutrophil vacuoles (pinocytosed or internalized membrane) are seen

Question 17

Which of the following is false about ‘Dohle body’ ?

A	Discrete, blue-staining nongranular areas found in periphery of cytoplasm of neutrophils
B	Found in infections and other toxic states
C	Aggregates of rough endoplasmic reticulum
D	None of the above

Question 17 Explanation:

Döhle bodies are discrete, blue-staining nongranular areas found in periphery of cytoplasm of neutrophil in infections & toxic states. They are aggregates of rough endoplasmic reticulum

Question 18

For lymphocytes, “CD” stands for ?

A	Clonal determinant
B	Cluster determinant
C	Capsule determinant
D	Cell determinant

Question 19

Which of the following is false about Chédiak-Higashi syndrome (CHS) ?

A	Autosomal recessive inheritance
B	Defects in lysosomal transport protein LYST
C	Abnormal packaging & disbursement of granules
D	None of the above

Question 19 Explanation:

HS is a systemic disease with autosomal recessive inheritance due to defects in the lysosomal transport protein LYST required for normal packaging and disbursement of granules, encoded by the gene CHS1 at 1q42. Characterized by the presence of giant lysosomes within leukocytes.

Question 20

Patients with Chédiak-Higashi syndrome (CHS) may have which of the following ?

A	Seizure
B	Blindness
C	Nystagmus
D	Tremors

Question 20 Explanation:

Patients with CHS have nystagmus, partial oculocutaneous albinism, and an increased frequency of infections. Patients may develop a severe disabling peripheral neuropathy in adulthood. Vitamin C supplementation is useful in Chédiak-Higashi syndrome. Hematopoietic cell transplantation can cure patients of CHS.

Question 21

Leukocytes from patients with chronic granulomatous disease (CGD) have severely diminished production of ?

A	Hydrogen peroxide
B	Nitric oxide
C	IL-1
D	TNF-alpha

Question 21 Explanation:

Leukocytes from patients with CGD have severely diminished hydrogen peroxide production

Question 22

Frequency of which of the following is increased in CGD ?

A	Immune thrombocytopenic purpura (ITP)
B	Juvenile rheumatoid arthritis
C	Discoid lupus
D	All of the above

Question 23

Mononuclear phagocyte system is composed of ?

A	Monoblasts
B	Promonocyte
C	Monocytes
D	All of the above

Question 23 Explanation:

Mononuclear phagocyte system is composed of monoblasts, promonocytes, monocytes and tissue macrophages.

Question 24

Monocytes have a half-life in the blood of ?

A	1 to 3 hours
B	6 to 7 hours
C	12 to 24 hours
D	24 to 36 hours

Question 24 Explanation:

Monocytes have a half-life in blood of 12 - 24 hours

Question 25

“Big eaters” is the term used for ?

A	Neutrophils
B	Monocytes
C	Macrophages
D	None of the above

Question 25 Explanation:

Macrophages are called “big eaters”. They differentiate from blood monocytes that arrive in tissues

Question 26

Function of macrophage secreted product - IL-1 is ?

A	Initiating fever in hypothalamus
B	Mobilizing leukocytes from bone marrow
C	Activating lymphocytes & neutrophils
D	All of the above

Question 26 Explanation:

Functions of IL-1 include initiating fever in hypothalamus, mobilizing leukocytes from bone marrow and activating lymphocytes & neutrophils

Question 27

TNF- duplicates the function of which of the following ?

A	IL-1
B	IL-8
C	IL-12
D	IL-18

Question 27 Explanation:

TNF- is a pyrogen that duplicates many actions of IL-1. It plays significant role in the pathogenesis of gram-negative shock.

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See all quizzes of the Disorders of granulocytes & monocytes at here:

Disorders of granulocytes & monocytes part 1 | Disorders of granulocytes & monocytes part 2 | Disorders of granulocytes & monocytes part 3

II. Preview all questions below

1.Neutropenia can be due to ?
A. Depressed production
B. Increased peripheral destruction
C. Excessive peripheral pooling
D. All of the above
2. Which of the following drugs cause neutropenia due to decreased production ?
A. Carbamazepine
B. Clozapine
C. Antithyroid drugs
D. All of the above

3. Which of the following drugs act as haptens to cause neutropenia due to peripheral destruction ?
A. Alpha methyldopa
B. Phenylbutazone
C. Mercurial diuretics
D. All of the above
.
4. Which of the following is a cause of neutropenia due to peripheral pooling (Transient neutropenia) ?
A. Overwhelming bacterial infection (acute endotoxemia)
B. Hemodialysis
C. Cardiopulmonary bypass
D. All of the above

5. Congenital forms of neutropenia include ?

A. Kostmann’s syndrome
B. Shwachman-Diamond syndrome
C. WHIM syndrome
D. All of the above

6. Kostmann’s syndrome is due to mutations in ?
A. Potassium voltage-gated channel gene KCNA1
B. PKD-1 gene
C. Anti-apoptosis gene HAX-1
D. GJB2 gene

7. Which of the following is associated with pancreatic insufficiency ?
A. Kostmann’s syndrome
B. Shwachman-Diamond syndrome
C. WHIM syndrome
D. All of the above

8. Felty’s syndrome include all except ?
A. Rheumatoid arthritis
B. Hepatomegaly
C. Splenomegaly
D. Neutropenia

9. Neutrophilia results from ?
A. Increased neutrophil production
B. Increased marrow release
C. Defective margination
D. All of the above

10. Persistent neutrophilia with what level of raised cell counts is called leukemoid reaction ?
A. > 10000 to 30000 / µL
B. > 30000 to 50000 / µL
C. > 50000 to 75000 / µL
D. > 75000 to 100000 / µL
11. Which of the following is false about leukemoid reaction ?
A. Neutrophil cell count > 30000 to 50000 / µL
B. Circulating neutrophils are mature
C. Circulating neutrophils are clonally derived
D. None of the above

12. Which of the following drugs can cause neutrophilia ?
A. Meprobamate
B. Lithium
C. Phenothiazines
D. Phenylbutazone

13. Which of the following about leukocyte adhesion deficiency (LAD) 1 & 2 is false ?
A. Autosomal dominant traits
B. Inability of neutrophils to exit circulation
C. Leukocytosis
D. Increased susceptibility to infection

14. Patients with leukocyte adhesion deficiency 1 (LAD 1) have mutations in ?
A. CD18
B. CD31
C. CD34
D. CD62

15. Which of the following is called “Congenital disorder of glycosylation IIc (CDGIIc)” ?
Harrison’s 18th Ed. 479
A. Leukocyte adhesion deficiency 1 (LAD 1)
B. Leukocyte adhesion deficiency 2 (LAD 2)
C. Leukocyte adhesion deficiency 3 (LAD 3)
D. None of the above

16. In neutrophils, which of the following is seen in severe acute bacterial infections ?
A. Toxic granulations
B. Dohle bodies
C. Large neutrophil vacuoles
D. All of the above

17. Which of the following is false about ‘Dohle body’ ?
A. Discrete, blue-staining nongranular areas found in periphery of cytoplasm of neutrophils
B. Found in infections and other toxic states
C. Aggregates of rough endoplasmic reticulum
D. None of the above

18. For lymphocytes, “CD” stands for ?
A. Clonal determinant
B. Cluster determinant
C. Capsule determinant
D. Cell determinant

19. Which of the following is false about Chédiak-Higashi syndrome (CHS) ?
A. Autosomal recessive inheritance
B. Defects in lysosomal transport protein LYST
C. Abnormal packaging & disbursement of granules
D. None of the above

20. Patients with Chédiak-Higashi syndrome (CHS) may have which of the following ?
A. Seizure
B. Blindness
C. Nystagmus
D. Tremors

21. Leukocytes from patients with chronic granulomatous disease (CGD) have severely diminished production of ?
A. Hydrogen peroxide
B. Nitric oxide
C. IL-1
D. TNF-alpha

22. Frequency of which of the following is increased in CGD ?
A. Immune thrombocytopenic purpura (ITP)
B. Juvenile rheumatoid arthritis
C. Discoid lupus
D. All of the above

23. Mononuclear phagocyte system is composed of ?
A. Monoblasts
B. Promonocytes
C. Monocytes
D. All of the above

24. Monocytes have a half-life in the blood of ?
A. 1 to 3 hours
B. 6 to 7 hours
C. 12 to 24 hours
D. 24 to 36 hours

25. “Big eaters” is the term used for ?
A. Neutrophils
B. Monocytes
C. Macrophages
D. None of the above

26. Function of macrophage secreted product – IL-1 is ?
A. Initiating fever in hypothalamus

B. Mobilizing leukocytes from bone marrow
C. Activating lymphocytes & neutrophils
D. All of the above

27. TNF- duplicates the function of which of the following ?
A. IL-1
B. IL-8
C. IL-12
D. IL-18

[MCQs] Disorders of granulocytes & monocytes – Part 2

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Disorders of granulocytes & monocytes- Part 2

II. Preview all questions below

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[MCQs] Disorders of granulocytes & monocytes – Part 1

[MCQs] Disorders of granulocytes & monocytes – Part 3

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