[MCQs] Bleeding and Thrombosis – Part 3

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Bleeding and Thrombosis – Part 1 | Bleeding and Thrombosis – Part 2 | Bleeding and Thrombosis – Part 3

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1.Platelet surface receptor GpIb / IX binds to ?

1. vWF
2. Fibrinogen
3. Collagen
4. All of the above

2. vWF forms a link between collagen fibrils & which of the following platelet receptor ?

1. Gp Ia/IIa
2. Gp Ib/IX
3. Gp VI
4. All of the above

3. Formation of thromboxane A₂ (TXA₂) from arachidonic acid is mediated by enzyme ?

1. Phospholipase C
2. Phospholipase A2
3. Cyclooxygenase
4. All of the above

4. Platelet surface receptor GpIa/IIa binds to ?

1. vWF
2. Fibrinogen
3. Collagen
4. All of the above

5. Platelet surface receptor GpVI / FcyRIIa binds to ?

1. vWF
2. Fibrinogen
3. Collagen
4. All of the above

6. After leaving bone marrow, what proportion of platelets are sequestered in spleen ?

1. One-third
2. One-half
3. Two-thirds
4. Three-fourths

7. The life span of platelets in circulation is about ?

1.  1 to    3 days
2. 3 to 5 days
3. 5 to 7 days
4. 7 to 10 days

8. During menstrual cycle, platelet count rise at what time ?

1. Following ovulation
2. At the onset of menses
3. After completion of menstrual flow
4. Before ovulation

9. During menstrual cycle, platelet count fall at what time ?

1. Following ovulation
2. At the onset of menses
3. After completion of menstrual flow
4. Before ovulation

10. Platelet counts are decreased in which of the following deficiencies ?

1. Severe Iron deficiency
2. Folic acid deficiency
3. Vitamin B12 deficiency
4. All of the above

11. Secondary or reactive thrombocytosis is due to which property of platelets ?

1. Hormonal
2. Acute-phase reactant
3. Enzymatic
4. All of the above

12. Which of the following cytokines interleukins stimulate platelet production in acute inflammation ?

1.  IL-3
2. IL-6
3. IL-11
4. All of the above

13. Mechanism of thrombocytopenia include ?

1.  Decreased bone marrow production
2. Increased splenic sequestration
3. Accelerated destruction
4. All of the above

14. TAR syndrome means ?

1. Thrombocytopenia with absent reticulocytes
2. Thrombocytopenia with  absent renin
3. Thrombocytopenia with absent radii
4. Thrombocytopenia with  abnormal vessels

15. Acute ITP is common in ?

1. Children
2. Adults
3. Elderly
4. All of the above

16. Which of the following appear in the red cells of asplenic individuals ?

1. Macroovalocytes
2. Basophilic stippling
3. Howell-Jolly bodies
4. Target cells

17. Rituximab is what type of a monoclonal antibody ?

1.  Anti-CD19
2. Anti-CD20
3. Anti-CD21
4. Anti-CD22