I. Start the exam by click the “Start” button
NUCLEIC ACIDS- Part 16
See all quizzes of NUCLEIC ACIDS- Part 16 here:
1 Yeast artificial chromosome can be used
to amplify DNA sequences of the size
(A) Upto 10 kb (B) Upto 45 kb
(C) Upto 100 kb (D) Upto 1,000 kb
2. DNA finger printing is based on the
presence in DNA of
(A) Constant number of tandem repeats
(B) Varibale number of tandem repeats
(C) Non-repititive sequences in each DNA
(D) Introns in eukaryotic DNA
3. All the following statements about
restriction fragment length polymorphism
are true except
(A) It results from mutations in restriction sites
(B) Mutations in restriction sites can occur in
coding or non-coding regions of DNA
(C) It is inherited in Mendelian fashion
(D) It can be used to diagnose any genetic
disease
4. Inborn errors of urea cycle can cause all
the following except
(A) Vomiting (B) Ataxia
(C) Renal failure (D) Mental retardation
5. Hyperammonaemia type I results from
congenital absence of
(A) Glutamate dehydrogenase
(B) Carbamoyl phosphate synthetase
(C) Ornithine transcarbamoylase
(D) None of these
6. Congenital deficiency of ornithine
transcarbamoylase causes
(A) Hyperammonaemia type I
(B) Hyperammonaemia type II
(C) Hyperornithinaemia
(D) Citrullinaemia
7. A ketogenic amino acid among the following
is
(A) Leucine (B) Serine
(C) Threonine (D) Proline
8. Carbon skeleton of the following amino
acid can serve as a substance for
gluconeogenesis
(A) Cysteine (B) Aspartate
(C) Glutamate (D) All of these
9. N-Formiminoglutamate is a metabolite of
(A) Glutamate (B) Histidine
(C) Tryptophan (D) Methionine
10. Methylmalonyl CoA is a metabolite of
(A) Valine (B) Leucine
(C) Isoleucine (D) All of these
11. Homogentisic acid is formed from
(A) Homoserine (B) Homocysteine
(C) Tyrosine (D) Tryptophan
12. Maple syrup urine disease results from
absence or serve deficiency of
(A) Homogentisate oxidase
(B) Phenylalanine hydroxylase
(C) Branched chain amino acid transaminase
(D) None of these
13. Which of the following is present as a
marker in lysosomal enzymes to direct
them to their destination?
(A) Glucose-6-phosphate
(B) Mannose-6-phosphate
(C) Galactose-6-phosphate
(D) N-Acetyl neuraminic acid
14. Marfan’s syndrome results from a
mutation in the gene coding:
(A) Collagen (B) Elastin
(C) Fibrillin (D) Keratin
15. All the following statements about
fibronectin are true except
(A) It is glycoprotein
(B) It is a triple helix
(C) It is present in extra cellular matrix
(D) It binds with integrin receptors of cell
16. Fibronectin has binding sites for all of the
following except
(A) Glycophorin (B) Collagen
(C) Heparin (D) Integrin receptor
17. Fibronectin is involved in
(A) Cell adhension (B) Cell movement
(C) Both (A) and (B) (D) None of these
18. Glycoproteins are marked for destruction
by removal of their
(A) Oligosaccharide prosthetic group
(B) Sialic acid residues
(C) Mannose residues
(D) N-terminal amino acids
19. Glycophorin is present in cell membranes of
(A) Erythrocytes (B) Platelets
(C) Neutrophils (D) Liver
20. Selectins are proteins that can recognise
specific
(A) Carbohydrates (B) Lipids
(C) Amino acids (D) Nucleotides
21. Hunter’s syndrome results from absence of
(A) Hexosaminidase A
(B) Iduronate sulphatase
(C) Neuraminidase
(D) Arylsulphatase B
22. A cancer cell is characterized by
(A) Uncontrolled cell division
(B) Invasion of neighbouring cells
(C) Spread to distant sites
(D) All of these
23. If DNA of a cancer cell is introduced into a
normal cell, the recipient cell
(A) Destroys the DNA
(B) Loses its ability to divide
(C) Dies
(D) Changes into a cancer cell
24. A normal cell can be transformed into a
cancer cell by all of the following except
(A) Ionising radiation
(B) Mutagenic chemicals
(C) Oncogenic bacteria
(D) Some viruses
25. Proto-oncogens are present in
(A) Oncoviruses
(B) Cancer cells
(C) Healthy human cells
(D) Prokaryotes
26. All the following statements about protooncogenes
are true except
(A) They are present in human beings
(B) They are present in healthy cells
(C) Proteins encoded by them are essential
(D) They are expressed only when a healthy cell
has been transformed into a cancer cell
27. Various oncogens may encode all of the
following except:
(A) Carcinogens
(B) Growth factors
(C) Receptors for growth factors
(D) Signal transducers for growth factors
28. Ras proto-oncogene is converted into
oncogene by
(A) A point mutation
(B) Chromosomal translocation
(C) Insertion of a viral promoter upstream of the
gene
(D) Gene amplification
29. Ras proto-oncogene encodes
(A) Epidermal growth factor (EGF)
(B) Receptor for EGF
(C) Signal transducer for EGF
(D) Nuclear transcription factor
30. P 53 gene:
(A) A proto-oncogene
(B) An oncogene
(C) A tumour suppressor gene
(D) None of these
