[MCQ Typhoid-Part 2

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Typhoid-Part 2

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Question 1

Yield of blood cultures for S. typhi is high during ?

A	First week
B	Second week
C	Third week
D	Fourth week

Question 1 Explanation:

Yield of blood cultures is high (90%) during 1st week of infection & decreases to 50% by 3rd week.

Question 2

Yield of stool cultures for S. typhi is high during ?

A	First week
B	Second week
C	Third week
D	All of the above

Question 2 Explanation:

Stool cultures become positive during III week of infection in untreated patients.

Question 3

Rate of chronic carriers of S. typhi is higher for all except ?

A	Men
B	Gall bladder infection with S. haematobium
C	Cholelithiasis
D	Carcinoma of gall bladder

Question 3 Explanation:

Chronic carriage of S typhi is more common among women, infants, and persons with biliary abnormalities or concurrent gall bladder infection with Schistosoma haematobium

Question 4

Which of the following drugs is ineffective in treating enteric fever ?

A	First generation cephalosporins
B	Second generation cephalosporins
C	Aminoglycosides
D	All of the above

Question 4 Explanation:

1st & 2nd generation cephalosporins & aminoglycosides are ineffective in treating clinical infections

Question 5

Appropriate oral antibiotic treatment should be given for what duration in chronic carriage of Salmonella ?

A	6 weeks
B	12 weeks
C	16 weeks
D	24 weeks

Question 5 Explanation:

Patients with chronic carriage of Salmonella are treated for 4-6 weeks with an appropriate oral antibiotic.

Question 6

Chronic carriers is defined as excretion of S. typhi in urine or stools for ?

A	3 months
B	6 months
C	> 1 year
D	> 2 year

Question 6 Explanation:

Chronic asymptomatic carriers are defined as individuals who excrete S. typhi in their stools or urine for more than a year.

Question 7

In immunocompetent patients, relapse rate in enteric fever is ?

A	~ 2 %
B	~ 5 %
C	~ 10 %
D	~ 20 %

Question 8

Which of the following typhoid vaccines is given orally ?

A	Whole-cell vaccine
B	Ty21a
C	ViCPS
D	Vi-rEPA

Question 9

Which of the following is an attenuated S. typhi vaccine ?

A	Whole-cell vaccine
B	Ty21a
C	ViCPS
D	Vi-rEPA

Question 10

Which of the following S. typhi vaccines has higher incidence of side effects ?

A	Whole-cell vaccine
B	Ty21a
C	ViCPS
D	Vi-rEPA

Question 10 Explanation:

Ty21a is an oral live attenuated S. Typhi vaccine (given on days 1, 3, 5, & 7, with a booster every 5 years). Vi CPS is a parenteral vaccine consisting of purified Vi polysaccharide from the bacterial capsule (given in 1 dose, with a booster every 2 years). The old parenteral whole-cell typhoid/ paratyphoid A and B vaccine is no longer licensed, largely because of significant side effects. An acetone-killed whole-cell vaccine is available only for use by the US military. In Vi-rEPA vaccine, Vi is bound to a nontoxic recombinant protein.

Question 11

Minimum age for vaccination for Ty21a is ?

A	1 years
B	3 years
C	4 years
D	6 years

Question 11 Explanation:

Minimal age for vaccination for Ty21a is 6 years.

Question 12

Minimum age for vaccination for Vi CPS is ?

A	1 years
B	2 years
C	4 years
D	6 years

Question 12 Explanation:

Minimal age for vaccination for Vi CPS is 2 years.

Question 13

Which of the following vaccines is licensed for paratyphoid fever ?

A	Whole-cell vaccine
B	Ty21a
C	ViCPS
D	None of the above

Question 13 Explanation:

Currently, there is no licensed vaccine for paratyphoid fever.

Question 14

Vi-rEPA vaccine is best related to which of the following ?

A	Xanthomas
B	Cold urticaria
C	Pseudomonas aeruginosa exotoxin A
D	Hypergammaglobulinemia

Question 14 Explanation:

In Vi-rEPA vaccine, Vi is bound to a nontoxic recombinant protein that is identical to Pseudomonas aeruginosa exotoxin A.

Question 15

Which of the following S. typhi vaccines has best 3-year cumulative efficacy ?

A	Whole-cell vaccine
B	Ty21a
C	ViCPS
D	All of the above

Question 16

Which of the following HLA-linked genes is associated with protection against complicated typhoid fever ?

A	HLA-DQB1*0201-3
B	HLA-DQB1*0401/2
C	HLA-DRQB1*04
D	HLA-DRB1*12

Question 16 Explanation:

HLA-linked genes play an important role in determining susceptibility or resistance to typhoid. HLADRB1* 0301/6/8, HLA-DQB1*0201-3, and tumour necrosis factor a (TNFA*2-308) were associated with susceptibility to typhoid fever, and HLA-DRQB1*04 and HLA-DQB1*0401/2 and TNFA*1(-308) were associated with lower risk. HLA-DRB1*12 is associated with protection against complicated typhoid fever.

Question 17

Number of predicted genes in a complete DNA sequence of a multidrug resistant S. typhi isolate CT18 is ?

A	4599
B	5599
C	6599
D	7599

Question 17 Explanation:

Number of predicted genes in a complete DNA sequence of a multidrug resistant S typhi isolate CT18 is 4599.

Question 18

Number of predicted genes in a complete DNA sequence of a multidrug resistant S. typhi isolate CT18 is ?

A	4599
B	5599
C	6599
D	7599

Question 18 Explanation:

Number of predicted genes in a complete DNA sequence of a multidrug resistant S typhi isolate CT18 is 4599.

Question 19

The nationality of Georges-Fernand-Isidor Widal was ?

A	German
B	French
C	British
D	Norwegian

Question 20

Salmonella typhi strain used to prepare S. typhi O and S. typhi H antigens is ?

A	701
B	801
C	901
D	1001

Question 20 Explanation:

Salmonella typhi strain used to prepare S. typhi O and S. typhi H antigens is 901.

Question 21

Which of the following about Widal test is false ?

A	Highest serum dilution producing positive agglutination is taken as titre
B	Agglutination of O antigen appears as “matt” or “carpet”
C	Agglutination of H antigens appears as loose or wooly
D	None of the above

Question 22

Chloramphenicol was introduced for the treatment of typhoid fever in ?

A	1948
B	1954
C	1961
D	1966

Question 22 Explanation:

Chloramphenicol was introduced for the treatment of typhoid fever in 1948.

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See all quizzes of Typhoid-Part 2 here:

1 Yield of blood cultures for S. typhi is high during ?
A. First week
B. Second week
C. Third week
D. Fourth week

2 Yield of stool cultures for S. typhi is high during ?
A. First week
B. Second week
C. Third week
D. All of the above

3 Rate of chronic carriers of S. typhi is higher for all except ?
A. Men
B. Gall bladder infection with S. haematobium
C. Cholelithiasis
D. Carcinoma of gall bladder

4 Which of the following drugs is ineffective in treating enteric
fever ?
A. First generation cephalosporins
B. Second generation cephalosporins
C. Aminoglycosides
D. All of the above

5 Appropriate oral antibiotic treatment should be given for what
duration in chronic carriage of Salmonella ?
A. 6 weeks
B. 12 weeks
C. 16 weeks
D. 24 weeks

6 Chronic carriers is defined as excretion of S. typhi in urine or
stools for ?
A. 3 months
B. 6 months
C. > 1 year
D. > 2 year

7 In immunocompetent patients, relapse rate in enteric fever is ?
A. ~ 2 %
B. ~ 5 %
C. ~ 10 %
D. ~ 20 %
8 Which of the following typhoid vaccines is given orally ?
A. Whole-cell vaccine
B. Ty21a
C. ViCPS
D. Vi-rEPA
9 Which of the following is an attenuated S. typhi vaccine ?
A. Whole-cell vaccine
B. Ty21a
C. ViCPS
D. Vi-rEPA
10 Which of the following S. typhi vaccines has higher incidence of
side effects ?
A. Whole-cell vaccine
B. Ty21a
C. ViCPS
D. Vi-rEPA

11 Minimum age for vaccination for Ty21a is ?
A. 1 years
B. 3 years
C. 4 years
D. 6 years

12 Minimum age for vaccination for Vi CPS is ?
A. 1 years
B. 2 years
C. 4 years
D. 6 years

13 Which of the following vaccines is licensed for paratyphoid
fever ?
A. Whole-cell vaccine
B. Ty21a
C. ViCPS
D. None of the above.
14 Vi-rEPA vaccine is best related to which of the following ?
A. Xanthomas
B. Cold urticaria
C. Pseudomonas aeruginosa exotoxin A
D. Hypergammaglobulinemia

15 Which of the following S. typhi vaccines has best 3-year cumulative
efficacy ?
A. Whole-cell vaccine
B. Ty21a
C. ViCPS
D. All of the above
16 Which of the following HLA-linked genes is associated with
protection against complicated typhoid fever ?
A. HLA-DQB1*0201-3
B. HLA-DQB1*0401/2
C. HLA-DRQB1*04
D. HLA-DRB1*12

17 Number of predicted genes in a complete DNA sequence of a
multidrug resistant S. typhi isolate CT18 is ?
A. 4599
B. 5599
C. 6599
D. 7599

18 The nationality of Georges-Fernand-Isidor Widal was ?
A. German
B. French
C. British
D. Norwegian

19 Salmonella typhi strain used to prepare S. typhi O and S. typhi H
antigens is ?
A. 701
B. 801
C. 901
D. 1001

20 Which of the following about Widal test is false ?
A. Highest serum dilution producing positive agglutination is
taken as titre
B. Agglutination of O antigen appears as “matt” or “carpet”
C. Agglutination of H antigens appears as loose or wooly
D. None of the above
21 Chloramphenicol was introduced for the treatment of typhoid
fever in ?
A. 1948
B. 1954
C. 1961
D. 1966

Typhoid

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Typhoid-Part 2

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