I. Start the exam by click the “Start” button
Schizophrenia- Part 1
See all quizzes of Schizophrenia- Part 1 here:
1 Which of the following is related to schizophrenia ?
A. Split personality
B. Multiple-personality
C. ‘Functional’ psychosis
D. None of the above
2 Which of the following term was used to address schizophrenia
in past ?
A. Frontotemporal dementia
B. Dementia with Lewy bodies
C. Dementia praecox
D. Conversion reaction
3 Out of the following, who performed original research in
schizophrenia ?
A. Maurer D
B. Sachs GS
C. Kraepelin E
D. Kohn R
4 Worldwide lifetime prevalence of schizophrenia is ?
A. 1 %
B. 2 %
C. 3 %
D. 4 %
5 Schizophrenia presents typically in ?
Harrison’s 18th Ed. 3542
A. Early childhood
B. Late adolescence
C. Middle age
D. Old age
6 Which of the following about schizophrenia is false ?
A. Equal prevalence rates in men & women
B. Peak age of onset is in III decade of life
C. Rate of completed suicide is about 10%
D. None of the above
7 Mostly, people do not get schizophrenia after the age of ?
A. 15 years
B. 25 years
C. 35 years
D. 45 years
8 Area of the brain that are predominantly and consistently affected
in schizophrenia is ?
A. Amygdala
B. Anterior & medial nuclei of thalamus
C. Dorsolateral prefrontal cortex (DLPFC)
D. All of the above
9 Which of the following cortical layers is thinner than normal in
schizophrenia ?
A. I
B. II
C. IV
D. V
10 Which of the following is not a structural abnormality in brain of
schizophrenia individuals ?
A. Ventricular enlargement
B. Absence of glial proliferation
C. Reduction in neuropil
D. Decreased volume of Nucleus accumbens
11 Which of the following recreational drugs can mimic symptoms
of schizophrenia in healthy individuals ?
A. Amphetamine
B. Phencyclidine (PCP)
C. Lysergic acid diethylamide (LSD)
D. All of the above
12 Which of the following is related to the increased occurrence of
schizophrenia ?
A. Tsunami
B. Plague epidemic
C. Nuclear holocaust in Japan
D. Dutch hunger winter
13 The most prevalent excitatory transmitter in brain is ?
A. GABA
B. Glutamate
C. Serotonin
D. Dopamine
14 Most prevalent inhibitory transmitter in brain is ?
A. GABA
B. Glutamate
C. Serotonin
D. Dopamine
15 Serotonergic neurons in the CNS are found primarily in ?
A. Midline raphe nuclei
B. Locus coeruleus
C. Striatum
D. Thalamus
16 Principal site for synthesis of norepinephrine in human brain is ?
A. Midline raphe nuclei
B. Locus coeruleus
C. Striatum
D. Thalamus
17 Which of the following is a dopamine pathway in the brain ?
A. Mesolimbic
B. Mesocortical
C. Nigrostriatal
D. All of the above
18 Dopaminergic fibers in brain arise in which of the following ?
A. Amygdala
B. Hippocampus
C. Ventral tegmental area (VTA)
D. Nucleus accumbens
19 Which of the following dopamine receptor subtype is excitatory ?
A. D1
B. D2
C. D3
D. D4
20 Which of the following dopamine receptor subtype is most
abundant in nucleus accumbens ?
A. D1
B. D2
C. D3
D. D4
21 Schizophrenia is characterized by ?
A. Hypodopaminergia in mesocortical neurons
B. Hyperdopaminergia in mesocortical neurons
C. Hypodopaminergia in mesolimbic neurons
D. None of the above
22 Which of the following is an ionotropic glutamate receptor ?
A. AMPA
B. Kainate
C. NMDA
D. All of the above
23 AMPA-receptor subunits are derived from which of the following
genes ?
A. GluR4
B. GluR5
C. GluR6
D. GluR7
24 Glycine co-agonist essential for glutamatergic transmission is ?
A. Tyrosine
B. Serenine
C. Melanin
D. D-serine
25 Serotonin is produced from ?
A. Arginine
B. L-tryptophan
C. Histidine
D. Leucine
26 Which of the following hallucinogen is a 5-HT agonist ?
A. Amphetamine
B. LSD (lysergic acid diethylamide)
C. Ketamine
D. All of the above
27 GABA is synthesized from ?
A. Glutamic acid
B. Butyric acid
C. Sialic acid
D. Glycine
28 Which of the following is a pathognomonic feature of
schizophrenia ?
A. Perturbations of language
B. Perturbations of perception
C. Perturbations of thinking
D. None of the above
29 Which of the following is not a typical feature of schizophrenia ?
A. Bizzare psychosis
B. Frequent mood disturbances
C. Hypervigilance
D. Altered short term memory
Features that preclude the diagnosis of schizophrenia are
