[MCQ] Rheumatoid Arthritis- Part 1

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See all quizzes of Rheumatoid Arthritis- Part 1 here:

1 Rheumatoid arthritis (RA) is a chronic disease of ?
A. Bone
B. Joints
C. Muscle
D. Multisystem

2 Which of the following is false about established RA ?
A. Persistent inflammatory synovitis
B. Involves peripheral joints in a symmetric distribution
C. Cartilage damage & bone erosions
D. None of the above

3 The hallmark of rheumatoid arthritis is ?
A. Synovial inflammation
B. Cartilage damage
C. Bone erosions
D. Systemic manifestations

4 Synovial membrane in rheumatoid arthritis is characterized
by ?
A. Hyperplasia
B. Increased vascularity
C. Infiltrate of inflammatory cells
D. All of the above

5 Age of onset of RA is most frequent during which decade of life ?
A. II and III
B. III and IV
C. IV and V
D. V and VI

6 The incidence of RA decreases after the age of ?
A. 45
B. 55
C. 65
D. 75

7 Women are affected by RA approximately how many times more
often than men ?
A. Two times
B. Three times
C. Four times
D. Five times

8 Which of the following is a major genetic risk factor for RA ?
A. HLA-DR2 (DR1*1501)
B. HLA-DR3 (DR1*0301)
C. HLA-DR4 (DR1*0401)
D. HLA-DR5 (DR1*1101)

9 Which of the following is regarded as susceptibility gene for RA ?
A. PTPN22
B. FcRL3
C. CTLA4
D. All of the above

10 Which of the following susceptibility genes for RA does not convey
risk for other autoimmune diseases ?
A. PTPN22
B. FcRL3
C. CTLA4
D. PADI4

11 Earliest lesion in rheumatoid synovitis is ?
A. Decrease in number of synovial lining cells
B. Increase in number of synovial lining cells
C. Decrease in size of synovial lining cells
D. Increase in size of synovial lining cells

12 Predominant infiltrating cell in RA is ?
A. T lymphocyte
B. B lymphocyte
C. Macrophages
D. Dendritic cells

13 In rheumatoid synovium, CD4+ and CD8+ T cells express the
early activation antigen called ?
A. CD49
B. CD59
C. CD69
D. CD79

14 Enzymes like collagenase & cathepsins are produced by ?
A. Activated mast cells
B. Activated synovial fibroblasts
C. Activated mesenchymal stromal cells
D. Osteoclasts

15 Activity of chemokines & cytokines result in which of the features
of rheumatoid synovitis ?
A. Synovial tissue inflammation
B. Synovial fluid inflammation
C. Systemic manifestations of RA
D. All of the above

16 Which of the following about rheumatoid arthritis is false ?
A. Immune mediated disease
B. Damage initiated by CD4+ T cells
C. Hallmark is synovial inflammation
D. None of the above
17 TNF- blocking drugs used for rheumatoid arthritis are ?
A. Etanercept
B. Infliximab
C. Adalimumab
D. All of the above
18 TNF-, an inflammatory cytokine, is released by ?
A. Activated monocytes
B. Macrophages
C. T lymphocytes
D. All of the above
19 The two receptors of TNF- are ?
A. Type 1 TNF receptor (p50) & type 2 TNF receptor (p70)
B. Type 1 TNF receptor (p55) & type 2 TNF receptor (p75)
C. Type 1 TNF receptor (p60) & type 2 TNF receptor (p80)
D. Type 1 TNF receptor (p65) & type 2 TNF receptor (p85)

20 Which of the following cytokines drive inflammation in rheumatoid
arthritis ?
A. Interleukin-1
B. Interleukin-6
C. TNF
D. All of the above

21 Rheumatoid factor is produced by ?
A. B cell
B. T cell
C. Macrophage
D. Dendritic cell

22 Which of the following is an antiinflammatory cytokine ?
A. Interleukin-1
B. Interleukin-6
C. Interleukin-10
D. TNF