[MCQ] Malaria- Part 4

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See all quizzes of Malaria- Part 4 here:

1 Quinine kills the gametocytes of all except ?
A. P. vivax
B. P. ovale
C. P. malariae
D. P. falciparum
2 In China, artemisinin is also called ?
A. Qingli
B. Qinghaosu
C. Qingchao
D. Qingshi

3 Chinese government scientists worked on which secret
project that developed artemisinins or qinghaosu
derivatives ?
A. Project 521
B. Project 522
C. Project 523
D. Project 524

4 Researchers in China isolated the active artemisinin compounds
from the plant named ?
A. Artemisia genia
B. Artemisia annua
C. Artemisia gripe
D. Artemisia duova
5 Active metabolite of artesunate and artemether is ?
A. Monohydroartemisinin
B. Dihydroartemisinin
C. Trihydroartemisinin
D. Tetrahydroartemisinin

6 Active metabolite of ‘Proguanil’ is ?
A. Guanil
B. Cycloguanil
C. Pentaguanil
D. Guanyldehyde
7 Which antimalarial drug has good absorption ?
A. Halofantrine
B. Lumefantrine
C. Atovaquone
D. Artesunate
8 Which antimalarial drug kills all stages of gametocyte development
of P. falciparum ?
A. Halofantrine
B. Quinine
C. Primaquine
D. Artesunate

9 Halofantrine should not be used with which of the following
antimalarial drug ?
A. Chloroquine
B. Quinine
C. Mefloquine
D. All of the above
10 Halofantrine is not be used with which of the following drug ?
A. Tricyclic antidepressants
B. Terfenadine
C. Astemizole
D. All of the above

11 Chloroquine can cause retinopathy when its cumulative dose exceeds ?
A. > 10 gram
B. > 50 gram
C. > 75 gram
D. > 100 gram
12 In quartan malaria, regular fever patterns are evident every ?
A. 2 days
B. 3 days
C. 4 days
D. 5 days
13 In malaria, Quinine causes hypoglycemia due to ?
A. Failure of hepatic gluconeogenesis
B. Stimulation of pancreatic insulin secretion
C. Decreased glucagon secretion
D. All of the above
14 Optimal therapeutic range for quinine in severe malaria is ?
A. 0.6 to 1.2 mg/mL
B. 2 to 4 mg/mL
C. 8 to 15 mg/mL
D. 25 to 35 mg/mL

15 Main quinine binding plasma protein is ?
A. 1-Acid Glycoprotein (1-AGP)
B. 1-Acid Glycoprotein (1-AGP)
C. 1-Acid Glycoprotein (1-AGP)
D. 1-Acid Glycoprotein (1-AGP)

16 Which of the following tests have no role in the diagnosis of malaria ?
A. Plasmodium LDH test
B. PfHRP2
C. Acridine orange staining
D. Polymerase chain reaction

17 What level of parasitemia is associated with an increased risk of
severe malaria ?
A. > 20000 parasites/μL
B. > 40000 parasites/μL
C. > 80000 parasites/μL
D. > 100000 parasites/μL

18 Which of the following test indicates that the illness is falciparum
malaria, even if the blood smear is negative ?
A. Positive PfHRP1 test
B. Positive PfHRP2 test
C. Positive PfHRP3 test
D. Positive PfHRP4 test
19 Parasite count/μL can be calculated by ?
A. Parasitized RBCs (%) x Hemoglobin x 1256
B. Parasitized RBCs (%) x Hematocrit x 1256
C. Parasitized RBCs (%) x Reticulocyte count x 1256
D. Parasitized RBCs (%) x Platelet count x 1256
20 Parasite count/μL can be calculated by ?
A. Asexual parasites/200 WBCs x 10
B. Asexual parasites/200 WBCs x 20
C. Asexual parasites/200 WBCs x 30
D. Asexual parasites/200 WBCs x 40
21 Exchange transfusion for severe malaria is indicated for
parasitemia levels of ?
A. > 2 %
B. > 5 %
C. > 10 %
D. > 15 %

22 Which of the following antimalarials is safe in pregnancy ?
Harrison’s 18th Ed. 1702
A. Chloroquine
B. Primaquine
C. Doxycycline
D. Atovaquone-proguanil
23 If the first PBF is negative & malaria is strongly suspected, repeat
blood smears should be performed at least every ?
A. 3 – 6 hours for 1 day
B. 12 – 24 hours for 1 days
C. 12 – 24 hours for 2 days
D. 12 – 24 hours for 3 days

24 Treatment of choice for the “benign” human malarias in southern
Asia is ?
A. Chloroquine
B. Quinine
C. Artesunate
D. Mefloquine

25 Which of the following about blackwater fever is false ?
A. Massive intravascular haemolysis & haemoglobinuria
B. Quinine administration
C. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
D. None of the above

26 In endemic areas, WHO recommends which of the following as
first-line treatment for uncomplicated falciparum malaria
everywhere ?
A. Artemisinin
B. Artemisinin-based combinations
C. Chloroquine
D. Mefloquine

27 Which of the following is a water-soluble antimalarial ?
A. Artemether
B. Artemotil (arteether)
C. Artesunate
D. All of the above