[MCQ] Interstitial Lung Diseases- Part 2

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Interstitial Lung Diseases- Part 2

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Congratulations - you have completed Interstitial Lung Diseases- Part 2. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rated as %%RATING%%

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Question 1

HRCT finding that goes against the diagnosis of idiopathic pulmonary fibrosis is ?

A	Extensive ground-glass abnormality
B	Nodular opacities with upper or mid-zone predominance
C	Prominent hilar or mediastinal lymphadenopathy
D	All of the above

Question 1 Explanation:

HRCT findings that suggest an alternative diagnosis to IPF include extensive ground-glass abnormality, nodular opacities, upper or mid-zone predominance & prominent hilar or mediastinal lymphadenopathy

Question 2

Pulmonary-function test in patients with idiopathic pulmonary fibrosis will show ?

A	Reduction in total lung capacity
B	Reduction in functional residual capacity
C	Reduction in residual volume
D	All of the above

Question 2 Explanation:

Most forms of ILD produce a restrictive defect with reduced total lung capacity (TLC), functional residual capacity, and residual volume. FEV1 and FVC are reduced, but these changes are related to the decreased TLC. FEV 1/FVC ratio is usually normal or increased. Lung volumes decrease as lung stiffness worsens with disease progression

Question 3

Which of the following about decreased DlCO in most ILDs is false ?

A	Common nonspecific finding in most ILDs
B	Due to mismatching of ventilation & perfusion (V./Q.)
C	Does not correlate with disease stage
D	None of the above

Question 4

Which of the following is rare in arterial blood gas analysis in ILDs ?

A	Normal resting arterial blood gas
B	Hypoxemia
C	Carbon dioxide (CO2) retention
D	Respiratory alkalosis

Question 4 Explanation:

Carbon dioxide (CO2) retention is rare and is a manifestation of end-stage ILD.

Question 5

Which of the following is a bronchoalveolar lavage (BAL) finding in sarcoidosis ?

A	Eosinophils > 25%
B	Hemosiderin-laden macrophages
C	CD4 : CD8 ratio > 3.5
D	Atypical hyperplastic type II pneumocytes

Question 6

Decreased CD4:CD8 ratio in bronchoalveolar lavage (BAL) is a feature of ?

A	Organizing pneumonia
B	Eosinophilic lung disease
C	Hypersensitivity pneumonitis
D	Pulmonary Langerhans cell histiocytosis

Question 7

Which of the following is false about idiopathic pulmonary fibrosis ?

A	Most common form of idiopathic interstitial pneumonia
B	Has a distinctly poor response to therapy
C	Has a bad prognosis
D	None of the above

Question 8

Usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia, organizing pneumonia etc are categories of ILD based on ?

A	Clinical presentation
B	Radiological findings
C	Histopathologic patterns
D	Response to treatment

Question 9

Histologic hallmark of Usual interstitial pneumonia (UIP) is ?

A	Alternating areas of normal lung & interstitial inflammation
B	Foci of proliferating fibroblasts
C	Dense collagen fibrosis
D	All of the above

Question 9 Explanation:

The histologic hallmark and chief diagnostic criterion of UIP is a heterogeneous appearance at low magnification with alternating areas of normal lung, interstitial inflammation, foci of proliferating fibroblasts, dense collagen fibrosis, and honeycomb changes affecting peripheral, subpleural parenchyma most severely. Lesion is idiopathic and not associated with another condition

Question 10

Treatment options in Usual interstitial pneumonia (UIP) patient include all except ?

A	Azathioprine
B	Interferon alpha
C	Colchicine
D	Pirfenidone

Question 11

In the treatment of Usual interstitial pneumonia (UIP), which of the following is an antifibrotic agents ?

A	Colchicine
B	Pirfenidone
C	Interferon gamma-1b
D	All of the above

Question 11 Explanation:

Treatment options for Usual interstitial pneumonia (UIP) include glucocorticoids, cytotoxic agents like azathioprine, cyclophosphamide & antifibrotic agents like colchicine, pirfenidone, or interferon -1b.

Question 12

Which of the following drug is effective in acute exacerbations of IPF ?

A	Glucocorticoids
B	Azathioprine
C	Interferon gamma-1b
D	None of the above

Question 12 Explanation:

No therapy has been found to be effective in the management of acute exacerbations of IPF

Question 13

Which of the following about Idiopathic Nonspecific Interstitial Pneumonia (NSIP) is false ?

A	Good prognosis
B	Presents at a younger age
C	Occurs in women who have never smoked
D	None of the above

Question 13 Explanation:

Idiopathic NSIP is a subacute restrictive process with presentation similar to IPF, most common in women of younger age who have never smoked

Question 14

Laboratory feature of NSIP is ?

A	Honeycombing
B	Uniformity of interstitial involvement
C	Traction bronchiectasis
D	Pleural calcification

Question 14 Explanation:

HRCT of NSIP shows bilateral, subpleural ground-glass opacities. Honeycombing is unusual. Key histopathologic features are uniformity of interstitial involvement across biopsy section

Question 15

Hamman Rich Syndrome is the name given to ?

A	Acute interstitial pneumonia (AIP)
B	Hypersensitivity pneumonitis
C	Desquamative interstitial pneumonia (DIP)
D	Respiratory bronchiolitis

Question 15 Explanation:

Hamman Rich Syndrome refers to Acute interstitial pneumonia (AIP).

Question 16

Which of the following is a fulminant form of ILD ?

A	Acute interstitial pneumonia (AIP)
B	Hypersensitivity pneumonitis
C	Desquamative interstitial pneumonia (DIP)
D	Respiratory bronchiolitis

Question 16 Explanation:

AIP is a fulminant form of lung injury characterized histologically by diffuse alveolar damage on lung biopsy. Onset of drug-Induced ILD may be abrupt and fulminant, or insidious

Question 17

AIP is similar in presentation to ?

A	Spontaneous pneumothorax
B	Acute respiratory distress syndrome (ARDS)
C	Bronchial asthma
D	CHF

Question 17 Explanation:

AIP is similar in presentation to acute respiratory distress syndrome (ARDS).

Question 18

Which of the following is known as idiopathic BOOP ?

A	Cryptogenic Organizing Pneumonia
B	Desquamative interstitial pneumonia
C	Respiratory bronchiolitis
D	Lymphocytic interstitial pneumonia

Question 18 Explanation:

Cryptogenic Organizing Pneumonia (COP) is also known as idiopathic BOOP (bronchiolitis obliterans with organizing pneumonia).

Question 19

Which of the following ILD is associated with cigarette smoking ?

A	Desquamative Interstitial Pneumonia (DIP)
B	Respiratory Bronchiolitis - Associated ILD (RB-ILD)
C	Pulmonary Langerhans Cell Histiocytosis (PLCH)
D	All of the above

Question 20

Which of the following is false about Desquamative interstitial pneumonia (DIP) ?

A	Found exclusively in cigarette smokers
B	Macrophages in intraalveolar spaces
C	Minimal interstitial fibrosis
D	Has a worse prognosis than IPF

Question 20 Explanation:

DIP occurs exclusively in cigarette smokers. Histologic hallmark is extensive accumulation of macrophages in intraalveolar spaces with minimal interstitial fibrosis. DIP has a better prognosis than IPF.

Question 21

Which of the following about Pulmonary Langerhans Cell Histiocytosis (PLCH) is false ?

A	Smoking-related
B	HRCT shows nodules & thin-walled cysts
C	Increased DLCO
D	Persistent / progressive disease

Question 21 Explanation:

Persistent / progressive disease

Question 22

Radiographic features of PLCH include all except ?

A	Reticular or nodular opacities
B	Bizarre-shaped, thin-walled upper zone cysts
C	Honeycombing
D	Sparing of the costophrenic angles

Question 22 Explanation:

CxR of PLCH include a ill-defined or stellate nodules, reticular or nodular opacities, bizarre-shaped upper zone thin-walled cysts & sparing of costophrenic angles. Honeycombing is a feature of IPF

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See all quizzes of Obstructive Pulmonary Disease at here:

1.HRCT finding that goes against the diagnosis of idiopathic pulmonary fibrosis is ?
A. Extensive ground-glass abnormality
B. Nodular opacities with upper or mid-zone predominance
C. Prominent hilar or mediastinal lymphadenopathy
D. All of the above

2. Pulmonary-function test in patients with idiopathic pulmonary fibrosis will show ?
A. Reduction in total lung capacity
B. Reduction in functional residual capacity

C. Reduction in residual volume
D. All of the above

3. Which of the following about decreased DlCO in most ILDs is false ?
A. Common nonspecific finding in most ILDs
B. Due to mismatching of ventilation & perfusion (V./Q.)
C. Does not correlate with disease stage
D. None of the above
4. Which of the following is rare in arterial blood gas analysis in ILDs ?
A. Normal resting arterial blood gas
B. Hypoxemia
C. Carbon dioxide (CO2) retention
D. Respiratory alkalosis

5. Which of the following is a bronchoalveolar lavage (BAL) finding in sarcoidosis ?
A. Eosinophils > 25%
B. Hemosiderin-laden macrophages
C. CD4 : CD8 ratio > 3.5
D. Atypical hyperplastic type II pneumocytes
6. Decreased CD4:CD8 ratio in bronchoalveolar lavage (BAL) is a feature of ?
A. Organizing pneumonia
B. Eosinophilic lung disease
C. Hypersensitivity pneumonitis
D. Pulmonary Langerhans cell histiocytosis
7. Which of the following is false about idiopathic pulmonary fibrosis ?
A. Most common form of idiopathic interstitial pneumonia
B. Has a distinctly poor response to therapy
C. Has a bad prognosis
D. None of the above
8. Usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia, organizing pneumonia etc are categories of ILD based on ?
A. Clinical presentation
B. Radiological findings
C. Histopathologic patterns
D. Response to treatment

9. Histologic hallmark of Usual interstitial pneumonia (UIP) is ?
A. Alternating areas of normal lung & interstitial inflammation
B. Foci of proliferating fibroblasts
C. Dense collagen fibrosis
D. All of the above

10. Treatment options in Usual interstitial pneumonia (UIP) patient include all except ?
A. Azathioprine
B. Interferon alpha
C. Colchicine
D. Pirfenidone
11. In the treatment of Usual interstitial pneumonia (UIP), which of the following is an antifibrotic agents ?
A. Colchicine
B. Pirfenidone
C. Interferon gamma-1b
D. All of the above

12. Which of the following drug is effective in acute exacerbations of IPF ?
A. Glucocorticoids
B. Azathioprine
C. Interferon gamma-1b
D. None of the above

13. Which of the following about Idiopathic Nonspecific Interstitial Pneumonia (NSIP) is false ?
A. Good prognosis
B. Presents at a younger age
C. Occurs in women who have never smoked
D. None of the above

14. Laboratory feature of NSIP is ?
A. Honeycombing
B. Uniformity of interstitial involvement
C. Traction bronchiectasis

D. Pleural calcification

15. Hamman Rich Syndrome is the name given to ?
A. Acute interstitial pneumonia (AIP)
B. Hypersensitivity pneumonitis
C. Desquamative interstitial pneumonia (DIP)
D. Respiratory bronchiolitis

16. Which of the following is a fulminant form of ILD ?
A. Acute interstitial pneumonia (AIP)
B. Hypersensitivity pneumonitis
C. Desquamative interstitial pneumonia (DIP)
D. Respiratory bronchiolitis

17. AIP is similar in presentation to ?
A. Spontaneous pneumothorax
B. Acute respiratory distress syndrome (ARDS)
C. Bronchial asthma
D. CHF

18. Which of the following is known as idiopathic BOOP ?
A. Cryptogenic Organizing Pneumonia
B. Desquamative interstitial pneumonia
C. Respiratory bronchiolitis
D. Lymphocytic interstitial pneumonia

19. Which of the following ILD is associated with cigarette smoking ?
A. Desquamative Interstitial Pneumonia (DIP)
B. Respiratory Bronchiolitis – Associated ILD (RB-ILD)
C. Pulmonary Langerhans Cell Histiocytosis (PLCH)
D. All of the above
20. Which of the following is false about Desquamative interstitial pneumonia (DIP) ?
A. Found exclusively in cigarette smokers
B. Macrophages in intraalveolar spaces
C. Minimal interstitial fibrosis
D. Has a worse prognosis than IPF

21. Which of the following about Pulmonary Langerhans Cell Histiocytosis (PLCH) is false ?
A. Smoking-related
B. HRCT shows nodules & thin-walled cysts
C. Increased DLCO
D. Persistent / progressive disease

22. Radiographic features of PLCH include all except ?
A. Reticular or nodular opacities
B. Bizarre-shaped, thin-walled upper zone cysts
C. Honeycombing
D. Sparing of the costophrenic angles

Interstitial Lung Diseases

[MCQ] Interstitial Lung Diseases- Part 2

I. Start the exam by click the “Start” button

Interstitial Lung Diseases- Part 2

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[MCQ] Interstitial Lung Diseases- Part 1

[MCQ] Sarcoidosis- Part 1

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