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Disorders of the Thyroid Gland- Part 1
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Disorders of the Thyroid Gland- Part 1| Disorders of the Thyroid Gland- Part2| Disorders of the Thyroid Gland- Part 3| Disorders of the Thyroid Gland- Part 4| Disorders of the Thyroid Gland- Part 5
1 Word thyroid is derived from Greek word “thyreos” meaning ?
A. Conical shaped
B. Shield
C. Superficial
D. Essential
2 What is the normal weight of human throid gland ?
A. 6 to 12 grams
B. 12 to 20 grams
C. 20 to 30 grams
D. 30 to 50 grams
3 Thyroid hormone synthesis normally begins at what time of
gestation ?
A. About 6 weeks’
B. About 11 weeks’
C. About 16 weeks’
D. About 21 weeks’
4 Density of C cells in thyroid gland is greatest at ?
A. Junction of upper two-third & lower one-thirds
B. Junction of upper one-third & lower two-thirds
C. Junction of upper & lower halves
D. At the poles
5 Which of the following is thyroid gland developmental
transcription factor ?
A. TTF-1 (NKX2A)
B. TTF-2 (FKHL15)
C. Paired homeobox-8 (PAX-8)
D. All of the above
6 Which of the following surface of thyroid follicular cells is in
contact with bloodstream ?
A. Apical
B. Basolateral
C. Basal
D. Lateral
7 TSH is secreted by the thyrotrope cells of ?
A. Anterior pituitary
B. Posterior pituitary
C. Stalk of pituitary
D. All of the above
8 Most useful physiologic marker of thyroid hormone action is ?
A. T3
B. T4
C. TSH
D. All of the above
9 The size of thyroid-stimulating hormone (TSH) is ?
A. 11-kDa
B. 21-kDa
C. 31-kDa
D. 41-kDa
10 The subunit of thyroid-stimulating hormone (TSH) is common
to which of the following hormones ?
A. Luteinizing hormone
B. Follicle-stimulating hormone
C. Human chorionic gonadotropin (hCG)
D. All of the above
11 The subunit of thyroid-stimulating hormone is common to
which of the following hormones ?
A. Luteinizing hormone
B. Follicle-stimulating hormone
C. Human chorionic gonadotropin (hCG)
D. None of the above
12 The “set-point” in thyroid axis (endocrine feedback loop) is
established by ?
A. TRH
B. TSH
C. T3
D. T4
13 On administration of exogenous TRH, after what time does peak
TSH secretion occur ?
A. About 5 minutes
B. About 10 minutes
C. About 15 minutes
D. About 20 minutes
14 Which of the following about TSH secretion is false ?
A. Released in pulsatile manner
B. Exhibits diurnal rhythm
C. Highest levels occur at night
D. None of the above
15 Plasma half-life of TSH is ?
A. 10 minutes
B. 30 minutes
C. 50 minutes
D. 80 minutes
16 Single measurement of TSH is adequate for assessing its
circulating level because of ?
A. No diurnal variation
B. Relatively long plasma half-life
C. Non pulsatile release
D. Low protein binding
17 T4 & T3 are formed from thyroglobulin by what mechanism ?
A. Coupling
B. Proteolysis
C. Iodination
D. All of the above
18 Which of the following about ingested iodine is false ?
A. Bound to albumin
B. Unbound iodine excreted in urine
C. Iodide uptake is mediated by Na+/I- symporter (NIS)
D. None of the above
19 Na+/I- symporter (NIS) is expressed in all of the following
except ?
A. Thyroid gland
B. Salivary glands
C. Placenta
D. Testicles
20 Iodine transporter – pendrin is located on which surface of thyroid
cells ?
A. Apical
B. Basolateral
C. Basal
D. Lateral
21 Which of the following is false about ‘Pendred syndrome’ ?
A. Due to deficiency of iodine transporter – pendrin
B. Due to mutation of PENDRIN gene
C. Characterized by goiter & sensorineural deafness
D. None of the above
22 Iodine-deficiency data of WHO is based on ?
A. Urinary excretion of iodine
B. Anthropometry
C. Serum levels of thyroid hormones
D. Symptoms & signs
23 Concomitant deficiency of which element contributes to neurologic
manifestations of cretinism ?
A. Mangnese
B. Cobalt
C. Selenium
D. Copper
24 For adults, recommended average daily intake of iodine is ?
A. 100 μg/day
B. 150 μg/day
C. 200 μg/day
D. 250 μg/day
25 For pregnant women, recommended average daily intake of
iodine is ?
A. 100 μg/day
B. 150 μg/day
C. 200 μg/day
D. 250 μg/day
