[Immunology] The Spirochete Diseases Quizzes (17 tests)

Select the one best response to each question!

Treponema pallidum and Borrelia burgdorferi can be distinguished from each other on the basis of which of the following?

Only T. pallidum has axial filaments.

Only B. burgdorferi has an outer sheath.

Only B. burgdorferi can be grown in the laboratory on artificial media.

Only T. pallidum stimulates IgM production to the membrane proteins.

Correct! Wrong!

False-positive nontreponemal tests for syphilis may be due to which of the following?

Infectious mononucleosis

Systemic lupus

Pregnancy

All of the above

Correct! Wrong!

In the fluorescent treponemal antibody absorption (FTAABS) test, what is the purpose of absorption with Reiter treponemes?

It removes reactivity with lupus antibody.

It prevents cross-reactivity with antibody to other T. pallidum subspecies.

It prevents cross-reactivity with antibody to nonpathogenic treponemes.

All of the above.

Correct! Wrong!

Which test is recommended for testing cerebrospinal fluid for detection of neurosyphilis?

RPR

VDRL

FTA-ABS

Enzyme immunoassay

Correct! Wrong!

Advantages of direct fluorescent antibody testing to T. pallidum include all of the following except

reading is less subjective than with dark-field testing.

monoclonal antibody makes the reaction very specific

slides can be prepared for later reading.

careful specimen collection is less important than in dark-field testing.

Correct! Wrong!

Which of the following is true of reagin?

It can be detected in all patients with primary syphilis.

It is antibody directed against cardiolipin.

Reagin tests remain positive after successful treatment.

It is only found in patients with syphilis.

Correct! Wrong!

Which syphilis test detects specific treponemal antibodies?

RPR

VDRL

FTA-ABS

Agglutination

Correct! Wrong!

Which of the following is true of treponemal tests for syphilis?

Please select 2 correct answers

They are usually negative in the primary stage.

Titers decrease with successful treatment.

In large-volume testing, they should be used as screening tests.

They are subject to a greater number of false positives than reagin tests.

Correct! Wrong!

An RPR test done on a 19-year-old woman as part of a prenatal workup was negative but exhibited a rough appearance. What should the technologist do next?

Report the result out as negative.

Do a VDRL test.

Send the sample for confirmatory testing.

Make serial dilutions and do a titer.

Correct! Wrong!

Treponemal EIA tests for syphilis are characterized by all of the following except

Please select 2 correct answers

they are adaptable to automation.

they are useful in diagnosing secondary or tertiary syphilis.

subjectivity in reading is eliminated.

they can be used to distinguish between IgG and IgM antibodies.

Correct! Wrong!

Which of the following tests is the most specific during the early phase of Lyme disease?

IFA

EIA

Immunoblotting

Isolation of the spirochete

Correct! Wrong!

False-positive serological tests for Lyme disease may be due to all of the following except

shared antigens between Borrelia groups.

cross-reactivity of antibodies.

resemblance of flagellar antigen to that of Treponema organisms.

a patient in the early stage of the disease.

Correct! Wrong!

Advantages of PCR testing for syphilis include all of the following except

it is extremely specific.

many false positives are eliminated.

testing of serum is extremely sensitive.

it can be used on CSF

Correct! Wrong!

A 24-year-old man who had just recovered from infectious mononucleosis had evidence of a genital lesion. His RPR test was positive. What should the technologist do next?

Report out as false positive.

Do a confirmatory treponemal test.

Do a VDRL.

Have the patient return in 2 weeks for a repeat test

Correct! Wrong!

A 15-year-old girl returned from a camping trip. Approximately a week after her return, she discovered a small red area on her leg that had a larger red ring around it. Her physician had her tested for Lyme disease, but the serological test was negative. What is the best explanation for these results?

She definitely does not have Lyme disease.

The test was not performed correctly.

Antibody response is often below the level of detection in early stages.

Too much antibody was present, causing a false negative.

Correct! Wrong!

Which of the following is a true statement about late manifestations of Lyme disease?

Treatment cannot reverse complications.

Both central and peripheral nervous systems may be affected.

Cardiac or neurological damage occurs in all cases.

Arthritis appears only in elderly patients.

Correct! Wrong!

Problems encountered in IFA testing for Lyme disease include all of the following except

cross-reactivity with antibodies to syphilis.

false negatives in the later stages of disease.

false positives with rheumatoid factor.

subjectivity in the reading of fluorescent patterns.

Correct! Wrong!

[Immunology] The Spirochete Diseases Quizzes (17 tests)

You need to try more!

You are pretty good!

You are very good!

1. Treponema pallidum and Borrelia burgdorferi can be distinguished from each other on the basis of which of the following?
a. Only T. pallidum has axial filaments.
b. Only B. burgdorferi has an outer sheath.
c. Only B. burgdorferi can be grown in the laboratory on artificial media.
d. Only T. pallidum stimulates IgM production to the membrane proteins.

2. False-positive nontreponemal tests for syphilis may be due to which of the following?
a. Infectious mononucleosis
b. Systemic lupus
c. Pregnancy
d. All of the above

3. In the fluorescent treponemal antibody absorption (FTAABS) test, what is the purpose of absorption with Reiter treponemes?
a. It removes reactivity with lupus antibody.
b. It prevents cross-reactivity with antibody to other T. pallidum subspecies.
c. It prevents cross-reactivity with antibody to nonpathogenic treponemes.
d. All of the above.

4. Which test is recommended for testing cerebrospinal fluid for detection of neurosyphilis?
a. RPR
b. VDRL
c. FTA-ABS
d. Enzyme immunoassay

5. Advantages of direct fluorescent antibody testing to T. pallidum include all of the following except
a. reading is less subjective than with dark-field testing.
b. monoclonal antibody makes the reaction very specific.
c. slides can be prepared for later reading.
d. careful specimen collection is less important than in dark-field testing.

6. Which of the following is true of reagin?
a. It can be detected in all patients with primary syphilis.
b. It is antibody directed against cardiolipin.
c. Reagin tests remain positive after successful treatment.
d. It is only found in patients with syphilis.

7. Which syphilis test detects specific treponemal antibodies?
a. RPR
b. VDRL
c. FTA-ABS
d. Agglutination

8. Which of the following is true of treponemal tests for syphilis?
a. They are usually negative in the primary stage.
b. Titers decrease with successful treatment.
c. In large-volume testing, they should be used as screening tests.
d. They are subject to a greater number of false positives than reagin tests.

9. An RPR test done on a 19-year-old woman as part of
a prenatal workup was negative but exhibited a rough appearance. What should the technologist do next?
a. Report the result out as negative.
b. Do a VDRL test.
c. Send the sample for confirmatory testing.
d. Make serial dilutions and do a titer.

10. Treponemal EIA tests for syphilis are characterized by all of the following except
a. they are adaptable to automation.
b. they are useful in diagnosing secondary or tertiary syphilis.
c. subjectivity in reading is eliminated.
d. they can be used to distinguish between IgG and IgM antibodies.

11. Which of the following tests is the most specific during the early phase of Lyme disease?
a. IFA
b. EIA
c. Immunoblotting
d. Isolation of the spirochete

12. False-positive serological tests for Lyme disease may be due to all of the following except
a. shared antigens between Borrelia groups.
b. cross-reactivity of antibodies.
c. resemblance of flagellar antigen to that of Treponema organisms.
d. a patient in the early stage of the disease.

13. Advantages of PCR testing for syphilis include all of the following except
a. it is extremely specific.
b. many false positives are eliminated.
c. testing of serum is extremely sensitive.
d. it can be used on CSF

14. A 24-year-old man who had just recovered from infectious mononucleosis had evidence of a genital lesion. His RPR test was positive. What should the technologist do next?
a. Report out as false positive.
b. Do a confirmatory treponemal test.
c. Do a VDRL.
d. Have the patient return in 2 weeks for a repeat test

15. A 15-year-old girl returned from a camping trip. Approximately a week after her return, she discovered
a small red area on her leg that had a larger red ring around it. Her physician had her tested for Lyme disease, but the serological test was negative. What is the best explanation for these results?
a. She definitely does not have Lyme disease.
b. The test was not performed correctly.
c. Antibody response is often below the level of detection in early stages.
d. Too much antibody was present, causing a false negative.

16. Which of the following is a true statement about late manifestations of Lyme disease?
a. Treatment cannot reverse complications.
b. Both central and peripheral nervous systems may be affected.
c. Cardiac or neurological damage occurs in all cases.d. Arthritis appears only in elderly patients.

17. Problems encountered in IFA testing for Lyme disease include all of the following except
a. cross-reactivity with antibodies to syphilis.
b. false negatives in the later stages of disease.
c. false positives with rheumatoid factor.
d. subjectivity in the reading of fluorescent patterns.

[Immunology] The Spirochete Diseases Quizzes (17 tests)

Select the one best response to each question!

Treponema pallidum and Borrelia burgdorferi can be distinguished from each other on the basis of which of the following?

False-positive nontreponemal tests for syphilis may be due to which of the following?

In the fluorescent treponemal antibody absorption (FTAABS) test, what is the purpose of absorption with Reiter treponemes?

Which test is recommended for testing cerebrospinal fluid for detection of neurosyphilis?

Advantages of direct fluorescent antibody testing to T. pallidum include all of the following except

Which of the following is true of reagin?

Which syphilis test detects specific treponemal antibodies?

Which of the following is true of treponemal tests for syphilis?

An RPR test done on a 19-year-old woman as part of a prenatal workup was negative but exhibited a rough appearance. What should the technologist do next?

Treponemal EIA tests for syphilis are characterized by all of the following except

Which of the following tests is the most specific during the early phase of Lyme disease?

False-positive serological tests for Lyme disease may be due to all of the following except

Advantages of PCR testing for syphilis include all of the following except

A 24-year-old man who had just recovered from infectious mononucleosis had evidence of a genital lesion. His RPR test was positive. What should the technologist do next?

Which of the following is a true statement about late manifestations of Lyme disease?

Problems encountered in IFA testing for Lyme disease include all of the following except

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