[Immunology] The Serology and Molecular Detection of Viral Infections Quizzes (10 tests)

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[Immunology] The Serology and Molecular Detection of Viral Infections Quizzes (10 tests)
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Select the one best response to each question!

An individual with hepatomegaly, jaundice, and elevated liver enzymes has the following laboratory results: IgM anti-HAV (negative), HBsAg (positive), IgM anti-HBc (positive), and anti-HCV (negative). These findings support a diagnosis of

 

1. An individual with hepatomegaly, jaundice, and elevated liver enzymes has the following laboratory results: IgM anti-HAV (negative), HBsAg (positive), IgM anti-HBc (positive), and anti-HCV (negative). These findings support a diagnosis of
a. hepatitis A.
b. acute hepatitis B.
c. chronic hepatitis B.
d. hepatitis C.
2. Which of the following hepatitis viruses is transmitted by the fecal-oral route?
a. Hepatitis B
b. Hepatitis C
c. Hepatitis D
d. Hepatitis E
3. Quantitative tests for HCV RNA are used to
a. screen for hepatitis C.
b. determine the HCV genotype.
c. differentiate acute HCV infection from chronic HCV infection.
d. monitor hepatitis C patients on antiviral therapy.
4. The serum of an individual who received all doses of the hepatitis B vaccine should contain
a. anti-HBs.
b. anti-HBe.
c. anti-HBc.
d. all of the above.
5. A 12-year-old girl presented to her physician with a sore throat, lymphadenopathy, and fatigue. Her laboratory results were 5000 lymphocytes/L with 10 percent atypical lymphocytes, CMV antibody negative, and heterophile antibody screen negative. These laboratory results
a. confirm a diagnosis of infectious mononucleosis.
b. indicate that the diagnosis is not infectious mononucleosis, because the heterophile antibody screen is negative.
c. suggest a diagnosis of infectious mononucleosis but should be followed by a heterophile antibody titer
to strengthen the diagnosis.
d. suggest a diagnosis of infectious mononucleosis but should be followed by a test for IgM anti-VCA to strengthen the diagnosis.
6. In the laboratory, heterophile antibodies are routinely detected by their reaction with
a. B lymphocytes.
b. bovine erythrocyte antigens.
c. sheep erythrocyte antigens.
d. Epstein-Barr virus antigens.
7. Presence of IgM anti-rubella antibodies in the serum from an infant born with a rash suggests
a. a diagnosis of measles.
b. a diagnosis of German measles.
c. congenital infection with the rubella virus.
d. passive transfer of maternal antibodies to the infant’s serum.
8. A pregnant woman is exposed to a child with a rubella infection. She had no clinical symptoms but had a rubella titer performed. Her antibody titer was 1:8. Three weeks later, the test was repeated, and her titer was 1:128. She still had no clinical symptoms. Was the laboratory finding indicative of rubella infection?
a. No, the titer must be greater than 256 to be significant.
b. No, the change in titer is not significant if no clinical signs are present.
c. Yes, a greater than fourfold rise in titer indicates early infection.
d. Yes, but clinical symptoms must also correlate with laboratory findings.
9. The most common cause of congenital infections is
a. CMV.
b. rubella.
c. VZV.
d. HTLV-I.
10. A positive result on a screening test for HTLV-I antibody
a. is highly specific for HTLV-I infection.
b. should be followed by PCR.
c. must be confirmed by Western blot.
d. must be confirmed by viral culture.

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