[MCQ] Rheumatoid Arthritis-Rabies- Part 1

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Rheumatoid Arthritis-Rabies- Part 1

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Question 1

World Rabies Day is on ?

A	August 05
B	September 07
C	October 11
D	November 12

Question 2

In Greek, word “lyssa” means ?

A	Rabies
B	Bullet
C	Animal
D	Death

Question 2 Explanation:

In Greek, lyssa means rabies

Question 3

Rabies is a disease of ?

A	Autonomic nervous system
B	Peripheral nervous system
C	Central nervous system
D	All of the above

Question 3 Explanation:

Rabies is an acute viral disease of the central nervous system (CNS)

Question 4

Rabies manifests most often as ?

A	Meningitis
B	Encephalitis
C	Peripheral neuritis
D	All of the above

Question 4 Explanation:

Rabies manifests most often as encephalitis.

Question 5

Rabies virus belongs to which family of viruses ?

A	Coronaviridae
B	Flaviviridae
C	Rhabdoviridae
D	Arenaviridae

Question 5 Explanation:

Rhabdos means “rodlike”. Rabies virus belongs to the order Mononegavirales, viruses with a nonsegmented, negative-stranded RNA genomes. Within this group, viruses with a distinct “bullet” shape are classified in the Rhabdoviridae family, which includes three genera of animal viruses, Lyssavirus, Ephemerovirus and Vesiculovirus. Genus Lyssavirus includes rabies virus, Lagos bat, Mokola virus, Duvenhage virus, European bat virus 1 & 2 and Australian bat virus.

Question 6

Which of the following is not a characteristic of rabies virus ?

A	Bullet shaped
B	Enveloped
C	Single-strand RNA
D	Positive polarity

Question 6 Explanation:

Rabies virus is bullet shaped, enveloped, single-strand RNA virus of negative polarity. The first step in viral replication is synthesis of full-length copies (postive strands) of the viral genome.

Question 7

Rabies virus genome encodes which of the follwoing proteins ?

A	Nucleoprotein
B	Matrix protein
C	Glycoprotein
D	All of the above

Question 7 Explanation:

Rabies is an RNA virus. Rabies virus genome consists of 11,932 nucleotides and encodes five proteins - nucleocapsid (N), matrix protein (M), glycoprotein (G), phosphoprotein (P) and a large RNA polymerase protein (L).

Question 8

Rabies virus variants can be distinguished by the sequence of ?

A	Nucleocapsid gene
B	Matrix protein gene
C	Glycoprotein gene
D	Polymerase protein gene

Question 8 Explanation:

Each animal reservoir harbors one or more distinct rabies virus variants that can be distinguished by the sequence of the nucleocapsid gene.

Question 9

Rabies is not found in mammals in which of the following regions of the world ?

A	Arctic
B	Antarctica
C	Tasmania
D	Newzealand

Question 9 Explanation:

Rabies is found in mammals in all regions of the world except Antarctica.

Question 10

Sylvatic rabies is propagated by ?

A	Foxes
B	Wolves
C	Bats
D	All of the above

Question 10 Explanation:

Sylvatic rabies is propagated by skunks, foxes, raccoons, mongooses, wolves, and bats

Question 11

The main reservoir of rabies throughout the world is ?

A	Domestic dog
B	Bats
C	Cats
D	Wolves

Question 11 Explanation:

The main reservoir of rabies throughout the world is the domestic dog.

Question 12

In United States, the domestic animal most commonly infected with rabies is ?

A	Domestic dog
B	Bat
C	Cat
D	Wolve

Question 12 Explanation:

In the United States, the domestic animal most commonly infected with rabies is the cat.

Question 13

Which particular bat-associated rabies virus is implicated in most human cases ?

A	Kn/Ps
B	Ln/Ps
C	Mn/Ps
D	nn/Ps

Question 13 Explanation:

It is observed that a particular bat-associated rabies virus is implicated in most human cases - Ln/ Ps (Lasionycteris noctivagans), which is associated with silver-haired and eastern pipistrelle bats

Question 14

Upon inoculation of skin by rabies virus-laden saliva, initial viral replication occurs in ?

A	Epidermal cells of skin
B	Dorsal spinal ganglia
C	Cortical gray matter
D	Striated muscle cells

Question 14 Explanation:

After inoculation of rabies virus through skin, initial viral replication occurs within striated muscle cells at the site of inoculation.

Question 15

Which neurotransmitter receptor

A	Acetylcholine
B	Norepinephrine
C	Serotonin
D	Dopamine

Question 15 Explanation:

Rabies virus binds to nicotinic acetylcholine receptors at neuromuscular junctions, and acetylcholine receptor blockade inhibits rabies virus attachment. Neural cell adhesion molecule and p75NTR neurotrophin receptor may be receptors for rabies virus

Question 16

The incubation period of rabies is ?

A	20 days to >1 year
B	21 days to >1 year
C	60 days to >1 year
D	90 days to >1 year

Question 16 Explanation:

Incubation period of rabies is exceedingly variable, from 20 days to 90 days but may be >1 year

Question 17

Rabies virus spreads centripetally to CNS at a rate of ?

A	1 - 50 mm/day
B	50 - 150 mm/day
C	100 - 400 mm/day
D	400 - 700 mm/day

Question 17 Explanation:

After entering sensory and motor neurons, rabies virus spreads centripetally at a rate of 100 - 400 mm/day or ~250 mm/day via fast axonal transport to the spinal cord or brainstem.

Question 18

In CNS, rabies virus replicates almost exclusively within ?

A	Gray matter
B	White matter
C	CSF
D	Venous sinuses

Question 18 Explanation:

In CNS, rabies virus replicates almost exclusively within the gray matter.

Question 19

Which of the following is least evident in the gray matter infected by the rabies virus ?

A	Inflammatory changes
B	Degenerative changes
C	Neuronal death
D	All of the above

Question 19 Explanation:

Once the virus enters the CNS, it spreads rapidly throughout the gray matter via established neuroanatomic connections. There are inflammatory changes, but there are few degenerative changes involving neurons and little evidence of neuronal death.

Question 20

From CNS, rabies virus passes centrifugally to other tissues via ?

A	Blood
B	Skin
C	Autonomic nerves
D	Motor nerves

Question 20 Explanation:

From CNS, rabies virus passes centrifugally along sensory and autonomic nerves to other tissues like salivary glands, adrenal medulla, kidneys, lungs, liver, skeletal muscles, skin, and heart.

Question 21

Rates of infection & mortality from rabies are highest from bites on ?

A	Hands and arms
B	Legs
C	Face
D	Abdomen

Question 21 Explanation:

Rates of infection and mortality from rabies are highest from bites on face, intermediate from bites on hands & arms and lowest from bites on legs.

Question 22

Eosinophilic cytoplasmic inclusions within neurons of CNS in rabies are called ?

A	Bunina bodies
B	Nissel bodies
C	Negri bodies
D	Lewy bodies

Question 22 Explanation:

The most characteristic pathologic finding of rabies in CNS is the formation of eosinophilic cytoplasmic inclusions called Negri bodies within neurons.

Question 23

In brain, Negri bodies are found in ?

A	Ammon’s horn
B	Hypothalamus
C	Purkinje cells of cerebellum
D	All of the above

Question 23 Explanation:

Negri bodies are most commonly present in Purkinje cells of cerebellum and in pyramidal cells in hippocampus, and less frequently seen in cortical neurons and in brainstem. In 1903, Dr. Adelchi Negri reported round or oval inclusions within cytoplasm of nerve cells of animals infected with rabies. Negri bodies can also be found in neurons of salivary glands or tongue

Question 24

Which of the following about Negri bodies is false ?

A	Absence of Negri bodies excludes rabies
B	Negri bodies are cytoplasmic inclusions
C	Rare in infections due to laboratory variants of rabies virus
D	Represent nucleocapsids of rabies virus

Question 24 Explanation:

Absence of Negri bodies does not exclude the diagnosis of rabies.

Question 25

Babes nodules are best related to ?

A	Apoptotic neurons
B	Vanishing nodules
C	Microglial nodules
D	Degenerative neurons

Question 25 Explanation:

Pathology studies show mild inflammatory changes in the CNS in rabies, with mononuclear inflammatory infiltration in the leptomeninges, perivascular regions, and parenchyma, including microglial nodules called Babes nodules.

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See all quizzes of Rheumatoid Arthritis-Rabies- Part 1 here:

1 World Rabies Day is on ?
A. August 05
B. September 07
C. October 11
D. November 12
2 In Greek, word “lyssa” means ?
A. Rabies
B. Bullet
C. Animal
D. Death

2 Rabies is a disease of ?
A. Autonomic nervous system
B. Peripheral nervous system
C. Central nervous system
D. All of the above

3 Rabies manifests most often as ?
A. Meningitis
B. Encephalitis
C. Peripheral neuritis
D. All of the above

4 Rabies virus belongs to which family of viruses ?
A. Coronaviridae
B. Flaviviridae
C. Rhabdoviridae
D. Arenaviridae

5 Which of the following is not a characteristic of rabies virus ?
A. Bullet shaped
B. Enveloped
C. Single-strand RNA
D. Positive polarity

6 Rabies virus genome encodes which of the follwoing
proteins ?
A. Nucleoprotein
B. Matrix protein
C. Glycoprotein
D. All of the above

7 Rabies virus variants can be distinguished by the sequence
of ?
A. Nucleocapsid gene
B. Matrix protein gene
C. Glycoprotein gene
D. Polymerase protein gene

8 Rabies is not found in mammals in which of the following regions
of the world ?
A. Arctic
B. Antarctica
C. Tasmania
D. Newzealand

9 Sylvatic rabies is propagated by ?
A. Foxes
B. Wolves
C. Bats
D. All of the above

10 The main reservoir of rabies throughout the world is ?
A. Domestic dog
B. Bats
C. Cats
D. Wolves

11 In United States, the domestic animal most commonly infected
with rabies is ?
A. Domestic dog
B. Bat
C. Cat
D. Wolve

12 Which particular bat-associated rabies virus is implicated in most
human cases ?
A. Kn/Ps
B. Ln/Ps
C. Mn/Ps
D. nn/Ps

13 Upon inoculation of skin by rabies virus-laden saliva, initial viral
replication occurs in ?
A. Epidermal cells of skin
B. Dorsal spinal ganglia
C. Cortical gray matter
D. Striated muscle cells

14 Which neurotransmitter receptors is implicated in rabies virus
attachment and internalization ?
A. Acetylcholine
B. Norepinephrine
C. Serotonin
D. Dopamine

15 The incubation period of rabies is ?
A. 20 days to >1 year
B. 21 days to >1 year
C. 60 days to >1 year
D. 90 days to >1 year

16 Rabies virus spreads centripetally to CNS at a rate of ?
A. 1 – 50 mm/day
B. 50 – 150 mm/day
C. 100 – 400 mm/day
D. 400 – 700 mm/day

17 In CNS, rabies virus replicates almost exclusively within ?
A. Gray matter
B. White matter
C. CSF
D. Venous sinuses

18 Which of the following is least evident in the gray matter infected
by the rabies virus ?
A. Inflammatory changes
B. Degenerative changes
C. Neuronal death
D. All of the above

19 From CNS, rabies virus passes centrifugally to other tissues
via ?
A. Blood
B. Skin
C. Autonomic nerves
D. Motor nerves

20 Rates of infection & mortality from rabies are highest from bites
on ?
A. Hands and arms
B. Legs
C. Face
D. Abdomen

21 Eosinophilic cytoplasmic inclusions within neurons of CNS in
rabies are called ?
A. Bunina bodies
B. Nissel bodies
C. Negri bodies
D. Lewy bodies

22 In brain, Negri bodies are found in ?
A. Ammon’s horn
B. Hypothalamus
C. Purkinje cells of cerebellum
D. All of the above

23 Which of the following about Negri bodies is false ?
A. Absence of Negri bodies excludes rabies
B. Negri bodies are cytoplasmic inclusions
C. Rare in infections due to laboratory variants of rabies virus
D. Represent nucleocapsids of rabies virus

24 Babes nodules are best related to ?
A. Apoptotic neurons
B. Vanishing nodules
C. Microglial nodules
D. Degenerative neurons

Rheumatoid Arthritis-Rabies

[MCQ] Rheumatoid Arthritis-Rabies- Part 1

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Rheumatoid Arthritis-Rabies- Part 1

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